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The map label for this gene is gds [H]

Identifier: 218884766

GI number: 218884766

Start: 1347152

End: 1348213

Strand: Reverse

Name: gds [H]

Synonym: DKAM_1455

Alternate gene names: 218884766

Gene position: 1348213-1347152 (Counterclockwise)

Preceding gene: 218884768

Following gene: 218884765

Centisome position: 98.75

GC content: 46.52

Gene sequence:

>1062_bases
ATGAAACTTGTTGAGGACAACTTGAAAACAGTATTTTCAAAACTAAGAGAAGAGGCATCCTCTGTTTCACCGCTTACATA
TGATATTATCGAGATAGCCTCGGATTACACTCTGAGAGGCGGTAAAAGGCTGAGGGCGTTTCTAGCTCTCGTGGGCTACT
GGAGCAGGGAATGGGGAAGCGGTGATCTAGCAACTATAACAAATGTGATGAGTGGGATTGAGCTACTTCAAAGCTATCTC
CTTATACACGATGATGTAATGGATAGGGATGAGCTCCGCCGGGGCGGTCCAACTGTACACGCATGGTTCAGGGATAAATG
TCTAAAAGAGATGAAGGGAGACTGCGTACATTACGGTGATTCACAAGCCATAACAGTTGGAGACTACTTGGAGGCGACAG
CCGTTGAATATATTTCAAGAGCGAATTTACCTGGGGAAACATTAAGAAGGCTACTGGAAACATATAGTAGGGGGTTGAGG
ATGGTCGCCTACGGGCAATACCTAGACGTCCTGCTTTCCAATAAACCACTGGGCAACGTATCCGAGAGAGATGTACTATT
AGTCCACACCCTTAAGACAGCCTCCTACACTATAGAACTACCCTTGCACTTAGGCGTGATAGCATCTGGGAAATACAGTG
AGAAAATACTACGAGAGCTCACCTCCTACGCTATCCCAGCCGGTATAGCGTTCCAGCTGAGAGATGATATCATAGGCCTC
TACGGTGACCCACGGCAGACAGGTAAACCCGTTGGAAGCGATGTCAGGGGTAAGAAAAAGACGCTCCTGGTAGTGAAGGC
GTACGAGCTCGGAGACCGCGAGGTAAGGAGACGGCTAAGTGAGATATATGATGTGCTGAGAACAAATGAAGTAACCCAGG
AACACGTAAAATTCGTACAGGAGATAGTCCGTGAAACAGGCAGCCTGGAATATAATGAGGAGCTGATAAAGAAATATGTG
GAAAACGCCCTGAAAGCACTCGAGGAATCCAAGGAAATATCAGCTCAAGCAGTCAACATATTAAAATGGCTCCTGGAGAA
ACTAGCGTACCGTGAAAAATAG

Upstream 100 bases:

>100_bases
GGTGATATAGGAGCCTAAGCTTATTATTGAAGCCCTTAATAAGAAATATGTGGGTGTATACATGGACCAAATAAATTACG
ATGAGTTGCTGAAATATAGT

Downstream 100 bases:

>100_bases
CACTACAACTCCACGGGTTTGTAAGTGCAAACATGTGGAACAACCAGCCGTCTCTCACTAGGTGCTTATTCCAAGTCATT
TTATATAATTTCATGGATGC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: GGPP synthase; GGPS; (2E,6E)-farnesyl diphosphate synthase; Dimethylallyltranstransferase; Farnesyl diphosphate synthase; Farnesyltranstransferase; Geranyltranstransferase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MKLVEDNLKTVFSKLREEASSVSPLTYDIIEIASDYTLRGGKRLRAFLALVGYWSREWGSGDLATITNVMSGIELLQSYL
LIHDDVMDRDELRRGGPTVHAWFRDKCLKEMKGDCVHYGDSQAITVGDYLEATAVEYISRANLPGETLRRLLETYSRGLR
MVAYGQYLDVLLSNKPLGNVSERDVLLVHTLKTASYTIELPLHLGVIASGKYSEKILRELTSYAIPAGIAFQLRDDIIGL
YGDPRQTGKPVGSDVRGKKKTLLVVKAYELGDREVRRRLSEIYDVLRTNEVTQEHVKFVQEIVRETGSLEYNEELIKKYV
ENALKALEESKEISAQAVNILKWLLEKLAYREK

Sequences:

>Translated_353_residues
MKLVEDNLKTVFSKLREEASSVSPLTYDIIEIASDYTLRGGKRLRAFLALVGYWSREWGSGDLATITNVMSGIELLQSYL
LIHDDVMDRDELRRGGPTVHAWFRDKCLKEMKGDCVHYGDSQAITVGDYLEATAVEYISRANLPGETLRRLLETYSRGLR
MVAYGQYLDVLLSNKPLGNVSERDVLLVHTLKTASYTIELPLHLGVIASGKYSEKILRELTSYAIPAGIAFQLRDDIIGL
YGDPRQTGKPVGSDVRGKKKTLLVVKAYELGDREVRRRLSEIYDVLRTNEVTQEHVKFVQEIVRETGSLEYNEELIKKYV
ENALKALEESKEISAQAVNILKWLLEKLAYREK
>Mature_353_residues
MKLVEDNLKTVFSKLREEASSVSPLTYDIIEIASDYTLRGGKRLRAFLALVGYWSREWGSGDLATITNVMSGIELLQSYL
LIHDDVMDRDELRRGGPTVHAWFRDKCLKEMKGDCVHYGDSQAITVGDYLEATAVEYISRANLPGETLRRLLETYSRGLR
MVAYGQYLDVLLSNKPLGNVSERDVLLVHTLKTASYTIELPLHLGVIASGKYSEKILRELTSYAIPAGIAFQLRDDIIGL
YGDPRQTGKPVGSDVRGKKKTLLVVKAYELGDREVRRRLSEIYDVLRTNEVTQEHVKFVQEIVRETGSLEYNEELIKKYV
ENALKALEESKEISAQAVNILKWLLEKLAYREK

Specific function: Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate which is a precursor of the ether-linked lipids [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI209571584, Length=264, Percent_Identity=26.8939393939394, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI209571582, Length=264, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4503685, Length=264, Percent_Identity=27.2727272727273, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1789578, Length=324, Percent_Identity=26.5432098765432, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1786623, Length=301, Percent_Identity=29.2358803986711, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17508563, Length=282, Percent_Identity=31.2056737588652, Blast_Score=101, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6322294, Length=363, Percent_Identity=28.099173553719, Blast_Score=97, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24651612, Length=349, Percent_Identity=24.0687679083095, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.1; =2.5.1.29; =2.5.1.10 [H]

Molecular weight: Translated: 40069; Mature: 40069

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVEDNLKTVFSKLREEASSVSPLTYDIIEIASDYTLRGGKRLRAFLALVGYWSREWGS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
GDLATITNVMSGIELLQSYLLIHDDVMDRDELRRGGPTVHAWFRDKCLKEMKGDCVHYGD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECC
SQAITVGDYLEATAVEYISRANLPGETLRRLLETYSRGLRMVAYGQYLDVLLSNKPLGNV
CCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCC
SERDVLLVHTLKTASYTIELPLHLGVIASGKYSEKILRELTSYAIPAGIAFQLRDDIIGL
CCCCEEEEEEECCCCEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEHHHHHCC
YGDPRQTGKPVGSDVRGKKKTLLVVKAYELGDREVRRRLSEIYDVLRTNEVTQEHVKFVQ
CCCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
EIVRETGSLEYNEELIKKYVENALKALEESKEISAQAVNILKWLLEKLAYREK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLVEDNLKTVFSKLREEASSVSPLTYDIIEIASDYTLRGGKRLRAFLALVGYWSREWGS
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCC
GDLATITNVMSGIELLQSYLLIHDDVMDRDELRRGGPTVHAWFRDKCLKEMKGDCVHYGD
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCHHHHHHHHHHHHCCCEEEECC
SQAITVGDYLEATAVEYISRANLPGETLRRLLETYSRGLRMVAYGQYLDVLLSNKPLGNV
CCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHCCCCCCCC
SERDVLLVHTLKTASYTIELPLHLGVIASGKYSEKILRELTSYAIPAGIAFQLRDDIIGL
CCCCEEEEEEECCCCEEEEEEEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEHHHHHCC
YGDPRQTGKPVGSDVRGKKKTLLVVKAYELGDREVRRRLSEIYDVLRTNEVTQEHVKFVQ
CCCCCCCCCCCCCCCCCCCCEEEEEEEHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHH
EIVRETGSLEYNEELIKKYVENALKALEESKEISAQAVNILKWLLEKLAYREK
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]