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The map label for this gene is srp54 [H]

Identifier: 218884721

GI number: 218884721

Start: 1310563

End: 1311912

Strand: Reverse

Name: srp54 [H]

Synonym: DKAM_1410

Alternate gene names: 218884721

Gene position: 1311912-1310563 (Counterclockwise)

Preceding gene: 218884733

Following gene: 218884720

Centisome position: 96.1

GC content: 44.37

Gene sequence:

>1350_bases
ATGGTGTTTGACAATATCAGGAGTGCTTTAACAAGGTTTCTGAAGGGAGGGGACTACGAGAAATCCGTGGAGGAGTTTAT
AAGGGAGCTGCAGAAGGAACTCGTAAGAGCCGATGTTAATTTGAAGCTAGCGGTGGAGATCACTAACAGGATAAAGGAGA
GAGCCCTTAAATCAGAGCCTCCTCCAGGTATTAGTAGGAGAGAATGGTTTATAACAATAGTCTATGAGGAATTAACCAGG
CTCCTAGGTGGTGATAAAAAACCCTCTATAAAGCCGTTGAAGAAGCCGTGGGTTATAATGCTCGTCGGCTTACAGGGTTC
TGGTAAAACTACAACGGCCGCTAAACTAGCATACTTCTATAAGCTAGAGGGCTATAAGGTGGGACTAGTAGCAGCAGACA
CCTTCAGGCCTGCAGCATATACGCAGCTTAAACAACTAGGTGAACAGATAGGCGTACCGGTTTATGGTGAGCCAGATAAT
AATAATGCCGTCTCGATAGCGGTGAAAGGAGTCTCCTTCTTCATTGAAAGGAGAACAGATATTATAATAATAGATACCGC
TGGAAGACACCACAAGGAGGAAGACCTCTTAGATGAAATGAGGAAGATAAGTGAGCAGGTTAAACCAGATGAAGTAATAC
TCGTCATAGATGCATCCATAGGGCAGCAGGCTCATAATATAGCCAAGAAGTTCCATGAAACCACCCCAATAGGCTCTATA
ATAGTCACGAAGCTTGATGGAACGGCTAAAGGTGGAGGCGCGTTATCAGCAGTAGCGGCAACCGGTGCCATGGTGAAATT
TATTGGAACCGGAGAAAAAATAGATGAATTAGAAGTATTCAACCCACCTAGATTCGTCTCGAGAATACTGGGGCTTGGAG
ATATAGAGAGCCTTGTTGAGAAAGTGAGGAGGCTACAACTAGACTTCACGGAGGAGGATGCTAAAAGACTCATCGAGGGA
AAAATAAACATGAGGCTAGTCTACAAGCAACTAGTAAGCCTAAGAAAAATGGGCCCCCTTGCCAAGATAATGCAGATGAT
ACCGGGTCTAGGGGTAAAGCTACCGCTCGAGGTGGATCCAAAACAACTAGAGGTGAAGCTGAGCAAGTGGCTTGCCGCAA
TAAATTCTATGACCTACGAGGAACTCGAGAACCCGGATATCATAGATAAATCCAGGATCAAGAGGATAGCTTATGGAGCC
GGCGTCGAAATCGATGATGTAAGGGAATTACTTAAACAATACGAGCTAATGAAGAAGCTGAGTAAGCAACTACGTAGAAG
AGATATATTAAAGAAACTTGGTATCAAACCCGAGGATCTTAAACTAGAAGAGGAGCCTGGTGGAAGCTAG

Upstream 100 bases:

>100_bases
TCCCACCCCCCGCACCTTCCATTACTCCCTGATCCTGGAGCAATCTGTATACGGTTAAAACCCTGGTTGAGATCCCTATT
TTTGAGGATGGGTGTTGCTT

Downstream 100 bases:

>100_bases
GGATAAGAAGGATTGATGATCATGGAGACCCCTCAACAAAATAGATGTGGAGAACACTGCAGCATCATTGAGACAGCTGC
AAAAATTCTCTCAGAATACC

Product: GTP-binding signal recognition particle SRP54, G- domain-containing protein

Products: NA

Alternate protein names: SRP54 [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MVFDNIRSALTRFLKGGDYEKSVEEFIRELQKELVRADVNLKLAVEITNRIKERALKSEPPPGISRREWFITIVYEELTR
LLGGDKKPSIKPLKKPWVIMLVGLQGSGKTTTAAKLAYFYKLEGYKVGLVAADTFRPAAYTQLKQLGEQIGVPVYGEPDN
NNAVSIAVKGVSFFIERRTDIIIIDTAGRHHKEEDLLDEMRKISEQVKPDEVILVIDASIGQQAHNIAKKFHETTPIGSI
IVTKLDGTAKGGGALSAVAATGAMVKFIGTGEKIDELEVFNPPRFVSRILGLGDIESLVEKVRRLQLDFTEEDAKRLIEG
KINMRLVYKQLVSLRKMGPLAKIMQMIPGLGVKLPLEVDPKQLEVKLSKWLAAINSMTYEELENPDIIDKSRIKRIAYGA
GVEIDDVRELLKQYELMKKLSKQLRRRDILKKLGIKPEDLKLEEEPGGS

Sequences:

>Translated_449_residues
MVFDNIRSALTRFLKGGDYEKSVEEFIRELQKELVRADVNLKLAVEITNRIKERALKSEPPPGISRREWFITIVYEELTR
LLGGDKKPSIKPLKKPWVIMLVGLQGSGKTTTAAKLAYFYKLEGYKVGLVAADTFRPAAYTQLKQLGEQIGVPVYGEPDN
NNAVSIAVKGVSFFIERRTDIIIIDTAGRHHKEEDLLDEMRKISEQVKPDEVILVIDASIGQQAHNIAKKFHETTPIGSI
IVTKLDGTAKGGGALSAVAATGAMVKFIGTGEKIDELEVFNPPRFVSRILGLGDIESLVEKVRRLQLDFTEEDAKRLIEG
KINMRLVYKQLVSLRKMGPLAKIMQMIPGLGVKLPLEVDPKQLEVKLSKWLAAINSMTYEELENPDIIDKSRIKRIAYGA
GVEIDDVRELLKQYELMKKLSKQLRRRDILKKLGIKPEDLKLEEEPGGS
>Mature_449_residues
MVFDNIRSALTRFLKGGDYEKSVEEFIRELQKELVRADVNLKLAVEITNRIKERALKSEPPPGISRREWFITIVYEELTR
LLGGDKKPSIKPLKKPWVIMLVGLQGSGKTTTAAKLAYFYKLEGYKVGLVAADTFRPAAYTQLKQLGEQIGVPVYGEPDN
NNAVSIAVKGVSFFIERRTDIIIIDTAGRHHKEEDLLDEMRKISEQVKPDEVILVIDASIGQQAHNIAKKFHETTPIGSI
IVTKLDGTAKGGGALSAVAATGAMVKFIGTGEKIDELEVFNPPRFVSRILGLGDIESLVEKVRRLQLDFTEEDAKRLIEG
KINMRLVYKQLVSLRKMGPLAKIMQMIPGLGVKLPLEVDPKQLEVKLSKWLAAINSMTYEELENPDIIDKSRIKRIAYGA
GVEIDDVRELLKQYELMKKLSKQLRRRDILKKLGIKPEDLKLEEEPGGS

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=414, Percent_Identity=41.304347826087, Blast_Score=317, Evalue=1e-86,
Organism=Homo sapiens, GI226371618, Length=375, Percent_Identity=42.9333333333333, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI89061728, Length=157, Percent_Identity=49.6815286624204, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI295424842, Length=221, Percent_Identity=27.6018099547511, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI23308697, Length=221, Percent_Identity=27.6018099547511, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1788963, Length=429, Percent_Identity=37.5291375291375, Blast_Score=271, Evalue=5e-74,
Organism=Escherichia coli, GI1789874, Length=264, Percent_Identity=35.2272727272727, Blast_Score=149, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=420, Percent_Identity=39.0476190476191, Blast_Score=306, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI193206261, Length=215, Percent_Identity=28.3720930232558, Blast_Score=85, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6325345, Length=419, Percent_Identity=41.0501193317422, Blast_Score=309, Evalue=8e-85,
Organism=Saccharomyces cerevisiae, GI6320498, Length=226, Percent_Identity=27.8761061946903, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17647949, Length=411, Percent_Identity=40.632603406326, Blast_Score=296, Evalue=2e-80,
Organism=Drosophila melanogaster, GI24641198, Length=220, Percent_Identity=27.7272727272727, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 50384; Mature: 50384

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFDNIRSALTRFLKGGDYEKSVEEFIRELQKELVRADVNLKLAVEITNRIKERALKSEP
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCC
PPGISRREWFITIVYEELTRLLGGDKKPSIKPLKKPWVIMLVGLQGSGKTTTAAKLAYFY
CCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHEEE
KLEGYKVGLVAADTFRPAAYTQLKQLGEQIGVPVYGEPDNNNAVSIAVKGVSFFIERRTD
EECCEEEEEEEECCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEEEHHHHHEECCCC
IIIIDTAGRHHKEEDLLDEMRKISEQVKPDEVILVIDASIGQQAHNIAKKFHETTPIGSI
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEE
IVTKLDGTAKGGGALSAVAATGAMVKFIGTGEKIDELEVFNPPRFVSRILGLGDIESLVE
EEEECCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHH
KVRRLQLDFTEEDAKRLIEGKINMRLVYKQLVSLRKMGPLAKIMQMIPGLGVKLPLEVDP
HHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEECCCCCH
KQLEVKLSKWLAAINSMTYEELENPDIIDKSRIKRIAYGAGVEIDDVRELLKQYELMKKL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SKQLRRRDILKKLGIKPEDLKLEEEPGGS
HHHHHHHHHHHHHCCCCCCCEECCCCCCC
>Mature Secondary Structure
MVFDNIRSALTRFLKGGDYEKSVEEFIRELQKELVRADVNLKLAVEITNRIKERALKSEP
CCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHCCCC
PPGISRREWFITIVYEELTRLLGGDKKPSIKPLKKPWVIMLVGLQGSGKTTTAAKLAYFY
CCCCCCCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEEEEECCCCCCHHHHHHHEEE
KLEGYKVGLVAADTFRPAAYTQLKQLGEQIGVPVYGEPDNNNAVSIAVKGVSFFIERRTD
EECCEEEEEEEECCCCHHHHHHHHHHHHHHCCCEECCCCCCCEEEEEEEHHHHHEECCCC
IIIIDTAGRHHKEEDLLDEMRKISEQVKPDEVILVIDASIGQQAHNIAKKFHETTPIGSI
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCEE
IVTKLDGTAKGGGALSAVAATGAMVKFIGTGEKIDELEVFNPPRFVSRILGLGDIESLVE
EEEECCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHH
KVRRLQLDFTEEDAKRLIEGKINMRLVYKQLVSLRKMGPLAKIMQMIPGLGVKLPLEVDP
HHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCEEECCCCCH
KQLEVKLSKWLAAINSMTYEELENPDIIDKSRIKRIAYGAGVEIDDVRELLKQYELMKKL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SKQLRRRDILKKLGIKPEDLKLEEEPGGS
HHHHHHHHHHHHHCCCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA