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The map label for this gene is 218884720

Identifier: 218884720

GI number: 218884720

Start: 1309204

End: 1310547

Strand: Reverse

Name: 218884720

Synonym: DKAM_1409

Alternate gene names: NA

Gene position: 1310547-1309204 (Counterclockwise)

Preceding gene: 218884721

Following gene: 218884719

Centisome position: 96.0

GC content: 42.78

Gene sequence:

>1344_bases
ATGATCATGGAGACCCCTCAACAAAATAGATGTGGAGAACACTGCAGCATCATTGAGACAGCTGCAAAAATTCTCTCAGA
ATACCCTCTCTGCGATAGATGTCTAGGCCGGGTCTTCGCAAAGAAAGGGATCGAGTTATCCAACGAGGAAAGAGGAAGGG
CTATCAAGACTCTACTAGCGATGAAGCTATACGCAGACTACACTAGTGAAATCATTGATGCCGAGTATATCGGTAAAATA
GCATCAAACACAGGGGATCCCGTTACAAGGCTATATAGAAAAATAACTGACAGAGAGATCTCCGTTAATCCATGCTATAT
ATGTCTCCACAGGGTATCCAGCGATTATATTGATGAAATAGCTAGGAGAGTAGCAGTGAAACTAAGCGAGTTGAATGCGT
CCTCATTCATCATAGGTGTAAAACTGGATAGCGAGGTAGTTAAGAAGGAGCTGGATGTACACGTGTTGGCGGGATTGGAG
TCAAGTGAGTCATTGAAAAACGAGTTGAAACGCGAGATAGGTAAGAGAGTAACTCAACTAACAAATATACCACCTGACTT
TGATAAGCCGGATGTAGTAGTAATAGTGGATGTAAATAAGGACTTCGATTACTCAATACAGACGCAGGTAAACCCAATAC
TGTTAAAGGCGATATATTTCAAGAGAGGGCGTAGAATATCCCATGTACCATGGTTCACAAGCAATGGATCCAGGAAATAC
CCTGAGAGCATACAGGACTTTATAAGGGATAGTATAGCAAGACTCTTCGATGCGCGAGACATTAAAATTCATGCAGCTGG
ACGGGAAGACGTGGATGCTAGAATGCTTGGTTCCGGGAGACCCTTAGTAATAGAGGTTAAAGAACCCGGGTTCAGGAATG
TCGATCTAGACTTGTTAAACTATATACTGGATGATCAATTTATCAAGGTCTCGGTAATAGGGGCCGCAACTAGAAGGGAT
ATTGAGTCTATTAAGGAGGGATCCAGAAAGAGAAGGAAGATATATAGGGTAGCAGTCCTCACCGAGAAGCCAGTATCTGA
AGGGGATCTCGAAAAGCTCTCAAGCTTCTTCAAGGAGAGAAGTGTTAAACAAAGAACACCAACGAGGATACTAAGGAGGA
AAAAGGATCGTGAGAGGATTAAACGGGTATACCGCATCGAAGTTATCAGTATCTCCTCACGGGTTTTCGAGGCATTAATA
TATTGCGATGGCGGCTTATATGTTAAGGAACTAGTGCACTGCGATAATGGACGCACTACCCCTTGTTTCAGTGAGATACT
GGGGACGCCTGCTTATCCATTAGAACTAGATGTACTTTATATTGAGAAGACATGGGATAAATAA

Upstream 100 bases:

>100_bases
GCAACTACGTAGAAGAGATATATTAAAGAAACTTGGTATCAAACCCGAGGATCTTAAACTAGAAGAGGAGCCTGGTGGAA
GCTAGGGATAAGAAGGATTG

Downstream 100 bases:

>100_bases
CTTTATAAGCTGGTTACAGGGGATTTTAGATATAGCGTGTCCAATGGATGCTTAAGCCTGCAGTATGAAAGGTGGAAAAG
ATGGTTAAAGCACCAAAGGG

Product: putative pseudouridylate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MIMETPQQNRCGEHCSIIETAAKILSEYPLCDRCLGRVFAKKGIELSNEERGRAIKTLLAMKLYADYTSEIIDAEYIGKI
ASNTGDPVTRLYRKITDREISVNPCYICLHRVSSDYIDEIARRVAVKLSELNASSFIIGVKLDSEVVKKELDVHVLAGLE
SSESLKNELKREIGKRVTQLTNIPPDFDKPDVVVIVDVNKDFDYSIQTQVNPILLKAIYFKRGRRISHVPWFTSNGSRKY
PESIQDFIRDSIARLFDARDIKIHAAGREDVDARMLGSGRPLVIEVKEPGFRNVDLDLLNYILDDQFIKVSVIGAATRRD
IESIKEGSRKRRKIYRVAVLTEKPVSEGDLEKLSSFFKERSVKQRTPTRILRRKKDRERIKRVYRIEVISISSRVFEALI
YCDGGLYVKELVHCDNGRTTPCFSEILGTPAYPLELDVLYIEKTWDK

Sequences:

>Translated_447_residues
MIMETPQQNRCGEHCSIIETAAKILSEYPLCDRCLGRVFAKKGIELSNEERGRAIKTLLAMKLYADYTSEIIDAEYIGKI
ASNTGDPVTRLYRKITDREISVNPCYICLHRVSSDYIDEIARRVAVKLSELNASSFIIGVKLDSEVVKKELDVHVLAGLE
SSESLKNELKREIGKRVTQLTNIPPDFDKPDVVVIVDVNKDFDYSIQTQVNPILLKAIYFKRGRRISHVPWFTSNGSRKY
PESIQDFIRDSIARLFDARDIKIHAAGREDVDARMLGSGRPLVIEVKEPGFRNVDLDLLNYILDDQFIKVSVIGAATRRD
IESIKEGSRKRRKIYRVAVLTEKPVSEGDLEKLSSFFKERSVKQRTPTRILRRKKDRERIKRVYRIEVISISSRVFEALI
YCDGGLYVKELVHCDNGRTTPCFSEILGTPAYPLELDVLYIEKTWDK
>Mature_447_residues
MIMETPQQNRCGEHCSIIETAAKILSEYPLCDRCLGRVFAKKGIELSNEERGRAIKTLLAMKLYADYTSEIIDAEYIGKI
ASNTGDPVTRLYRKITDREISVNPCYICLHRVSSDYIDEIARRVAVKLSELNASSFIIGVKLDSEVVKKELDVHVLAGLE
SSESLKNELKREIGKRVTQLTNIPPDFDKPDVVVIVDVNKDFDYSIQTQVNPILLKAIYFKRGRRISHVPWFTSNGSRKY
PESIQDFIRDSIARLFDARDIKIHAAGREDVDARMLGSGRPLVIEVKEPGFRNVDLDLLNYILDDQFIKVSVIGAATRRD
IESIKEGSRKRRKIYRVAVLTEKPVSEGDLEKLSSFFKERSVKQRTPTRILRRKKDRERIKRVYRIEVISISSRVFEALI
YCDGGLYVKELVHCDNGRTTPCFSEILGTPAYPLELDVLYIEKTWDK

Specific function: Unknown

COG id: COG1258

COG function: function code J; Predicted pseudouridylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 THUMP domain [H]

Homologues:

Organism=Homo sapiens, GI207113130, Length=245, Percent_Identity=30.2040816326531, Blast_Score=125, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17537241, Length=255, Percent_Identity=27.4509803921569, Blast_Score=102, Evalue=6e-22,
Organism=Drosophila melanogaster, GI19920442, Length=257, Percent_Identity=32.295719844358, Blast_Score=116, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005912
- InterPro:   IPR020103
- InterPro:   IPR004114 [H]

Pfam domain/function: PF02926 THUMP [H]

EC number: NA

Molecular weight: Translated: 51186; Mature: 51186

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS51165 THUMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMETPQQNRCGEHCSIIETAAKILSEYPLCDRCLGRVFAKKGIELSNEERGRAIKTLLA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
MKLYADYTSEIIDAEYIGKIASNTGDPVTRLYRKITDREISVNPCYICLHRVSSDYIDEI
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHH
ARRVAVKLSELNASSFIIGVKLDSEVVKKELDVHVLAGLESSESLKNELKREIGKRVTQL
HHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
TNIPPDFDKPDVVVIVDVNKDFDYSIQTQVNPILLKAIYFKRGRRISHVPWFTSNGSRKY
CCCCCCCCCCCEEEEEECCCCCCCEEECCCCHHHHHHHHHHCCCEECCCCEEECCCCCCC
PESIQDFIRDSIARLFDARDIKIHAAGREDVDARMLGSGRPLVIEVKEPGFRNVDLDLLN
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCCEEEEECCCCCCCCCHHHHH
YILDDQFIKVSVIGAATRRDIESIKEGSRKRRKIYRVAVLTEKPVSEGDLEKLSSFFKER
HHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHH
SVKQRTPTRILRRKKDRERIKRVYRIEVISISSRVFEALIYCDGGLYVKELVHCDNGRTT
HHHHCCHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
PCFSEILGTPAYPLELDVLYIEKTWDK
HHHHHHHCCCCCCEEEEEEEEEECCCC
>Mature Secondary Structure
MIMETPQQNRCGEHCSIIETAAKILSEYPLCDRCLGRVFAKKGIELSNEERGRAIKTLLA
CCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
MKLYADYTSEIIDAEYIGKIASNTGDPVTRLYRKITDREISVNPCYICLHRVSSDYIDEI
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHH
ARRVAVKLSELNASSFIIGVKLDSEVVKKELDVHVLAGLESSESLKNELKREIGKRVTQL
HHHHHHHHHHCCCCEEEEEEECCHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
TNIPPDFDKPDVVVIVDVNKDFDYSIQTQVNPILLKAIYFKRGRRISHVPWFTSNGSRKY
CCCCCCCCCCCEEEEEECCCCCCCEEECCCCHHHHHHHHHHCCCEECCCCEEECCCCCCC
PESIQDFIRDSIARLFDARDIKIHAAGREDVDARMLGSGRPLVIEVKEPGFRNVDLDLLN
HHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHCCCCCEEEEECCCCCCCCCHHHHH
YILDDQFIKVSVIGAATRRDIESIKEGSRKRRKIYRVAVLTEKPVSEGDLEKLSSFFKER
HHHCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCHHHHHHHHHHH
SVKQRTPTRILRRKKDRERIKRVYRIEVISISSRVFEALIYCDGGLYVKELVHCDNGRTT
HHHHCCHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHCCCCHHHHHHHHCCCCCCC
PCFSEILGTPAYPLELDVLYIEKTWDK
HHHHHHHCCCCCCEEEEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]