Click here to switch to the map view.

The map label for this gene is gabT [H]

Identifier: 218884691

GI number: 218884691

Start: 1284040

End: 1285395

Strand: Reverse

Name: gabT [H]

Synonym: DKAM_1380

Alternate gene names: 218884691

Gene position: 1285395-1284040 (Counterclockwise)

Preceding gene: 218884692

Following gene: 218884687

Centisome position: 94.15

GC content: 43.95

Gene sequence:

>1356_bases
ATGGATAATGAGAGACCTGGAAAAGATCTTCAACTCATAGAGAAATATTGGAGACATGTTTCAAGTAGTCAGGGATTCAA
GTATTTTCCCCTGGTGGTTAGTAGGGCAAAGGCGTCGAAGGTATGGGATATAAATGGGAGAGAATATATAGACTTCCTCA
GTAGTGCCGCAACATATAATATAGGTCACAGTAACGAGGAGGTTATCAAAGCCATCAAGGAGCACCTAGATAAATTCATA
CATTACTGTCTCTATTTATACCATGAACCAGTAATAGAATTATCGGAGCTACTTACAGGAATCACGTTGGGAAACCATAG
GAAAAAAGTTGTATTCGGTCTCTCAGGTGGGGATGCTAATGATACAGCGCTTAAAGCCGCGTTCATCTATACCCGTAGAC
CCGGCGTGATATCGTATACTTACTCATACCATGGGACAACAGCTCTTGGGATAGCTGTAGGTGGATCATTCAGGGAGGAG
ATCAGGAAAGCAATACCGTTTAAAGACGTGTACTTCGTGGAGTACCCGGATACATATAGATGTGGTAATATAGAAGACCC
TAGAGAATGCGGCGATCACCACCTTTCAAAATTAGAGGACTTACTGAAGAAGATTAACCCGTCCAGTTTTGCAGCTATAA
TAATGGAGCCCATACAGGGCGATGGCGGAGTATTAGTTCCCCCGGAGAACTATGTTAAAGGCTTATTCAAGCTAGCCAGG
GAAAACGGGATAATAATTATAGATGATGAAGTCCAGACAGGTATGGGTAGGACAGGTAAATGGCTGGCAATAGAGCACTT
TAACGTGGAGCCAGACCTAGTTGTCCTAGGTAAAGCACTAGGGGGAGGTATGCCTATATCAGCTGTTATCGGTAGAAGCG
AAATACTGGATGCCGCGCCGCCTCAAACATTCTTTGCCACCTCAGCCGCACATGCATTATCCTGCGTGGCAGCCATAGCC
ACCATCAAATACATTAAGAATTATAACCTAGTAGAGAAAGCCAGGGAACTCGGCGACTACGCTGTAAAAAGGTTGAATGA
GCTGAAGGAAAAATACGAGATAATTGGCGATGTAAGGGGTAAGGGACTAATGATCGGGGTTGAAATAGTCAAGGAGAAGA
AGCAGAAGATCCCTGACAGAAAAACAGCACTTAAAATAATATGGAGGGCATGGGAGAAAGGGGTAATAATGATGACCTAC
GGTAAATACGGTAATGTCCTGAGGATTGCCCCTCCCCTCGTGATATCAAGGGAGGAACTTGACGCTGGGATAAACATTGT
AGACGAGGCAATCAAGGATGTGTTAGAGGGAAGGGTCCCGGATGATGTAATAAATAAAATGAAAGCATGGGAGTAA

Upstream 100 bases:

>100_bases
CTAGTGCTTGAGATAGTGGCATGGCTCACAGGTAGGAAAAGCCAGCCGGTGAAACCCTCGTAATACCGGGTTGCGGGCTT
GAGTTTCCTGGTGTTATGTA

Downstream 100 bases:

>100_bases
AACATCTCAAACACACATCTTTAATACTTTTTTATATTTTCATTCCTAGGCTAGTATTCAATAGTGCCATGAAAATAGAG
AGGTAGCCGGGCGGGGATTC

Product: pyridoxal phosphate-dependent aminotransferase

Products: NA

Alternate protein names: (S)-3-amino-2-methylpropionate transaminase; GABA aminotransferase; GABA-AT; Gamma-amino-N-butyrate transaminase; GABA transaminase; Glutamate:succinic semialdehyde transaminase; L-AIBAT [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MDNERPGKDLQLIEKYWRHVSSSQGFKYFPLVVSRAKASKVWDINGREYIDFLSSAATYNIGHSNEEVIKAIKEHLDKFI
HYCLYLYHEPVIELSELLTGITLGNHRKKVVFGLSGGDANDTALKAAFIYTRRPGVISYTYSYHGTTALGIAVGGSFREE
IRKAIPFKDVYFVEYPDTYRCGNIEDPRECGDHHLSKLEDLLKKINPSSFAAIIMEPIQGDGGVLVPPENYVKGLFKLAR
ENGIIIIDDEVQTGMGRTGKWLAIEHFNVEPDLVVLGKALGGGMPISAVIGRSEILDAAPPQTFFATSAAHALSCVAAIA
TIKYIKNYNLVEKARELGDYAVKRLNELKEKYEIIGDVRGKGLMIGVEIVKEKKQKIPDRKTALKIIWRAWEKGVIMMTY
GKYGNVLRIAPPLVISREELDAGINIVDEAIKDVLEGRVPDDVINKMKAWE

Sequences:

>Translated_451_residues
MDNERPGKDLQLIEKYWRHVSSSQGFKYFPLVVSRAKASKVWDINGREYIDFLSSAATYNIGHSNEEVIKAIKEHLDKFI
HYCLYLYHEPVIELSELLTGITLGNHRKKVVFGLSGGDANDTALKAAFIYTRRPGVISYTYSYHGTTALGIAVGGSFREE
IRKAIPFKDVYFVEYPDTYRCGNIEDPRECGDHHLSKLEDLLKKINPSSFAAIIMEPIQGDGGVLVPPENYVKGLFKLAR
ENGIIIIDDEVQTGMGRTGKWLAIEHFNVEPDLVVLGKALGGGMPISAVIGRSEILDAAPPQTFFATSAAHALSCVAAIA
TIKYIKNYNLVEKARELGDYAVKRLNELKEKYEIIGDVRGKGLMIGVEIVKEKKQKIPDRKTALKIIWRAWEKGVIMMTY
GKYGNVLRIAPPLVISREELDAGINIVDEAIKDVLEGRVPDDVINKMKAWE
>Mature_451_residues
MDNERPGKDLQLIEKYWRHVSSSQGFKYFPLVVSRAKASKVWDINGREYIDFLSSAATYNIGHSNEEVIKAIKEHLDKFI
HYCLYLYHEPVIELSELLTGITLGNHRKKVVFGLSGGDANDTALKAAFIYTRRPGVISYTYSYHGTTALGIAVGGSFREE
IRKAIPFKDVYFVEYPDTYRCGNIEDPRECGDHHLSKLEDLLKKINPSSFAAIIMEPIQGDGGVLVPPENYVKGLFKLAR
ENGIIIIDDEVQTGMGRTGKWLAIEHFNVEPDLVVLGKALGGGMPISAVIGRSEILDAAPPQTFFATSAAHALSCVAAIA
TIKYIKNYNLVEKARELGDYAVKRLNELKEKYEIIGDVRGKGLMIGVEIVKEKKQKIPDRKTALKIIWRAWEKGVIMMTY
GKYGNVLRIAPPLVISREELDAGINIVDEAIKDVLEGRVPDDVINKMKAWE

Specific function: 4-aminobutyrate (GABA) degradation. [C]

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=436, Percent_Identity=29.3577981651376, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI37574042, Length=437, Percent_Identity=28.8329519450801, Blast_Score=193, Evalue=4e-49,
Organism=Homo sapiens, GI226442705, Length=437, Percent_Identity=28.604118993135, Blast_Score=185, Evalue=6e-47,
Organism=Homo sapiens, GI4557809, Length=420, Percent_Identity=30.952380952381, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI226442709, Length=402, Percent_Identity=28.8557213930348, Blast_Score=175, Evalue=7e-44,
Organism=Homo sapiens, GI24119277, Length=442, Percent_Identity=27.3755656108597, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI284507298, Length=240, Percent_Identity=37.0833333333333, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI188536080, Length=476, Percent_Identity=23.7394957983193, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38679950, Length=476, Percent_Identity=23.7394957983193, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI38679946, Length=476, Percent_Identity=23.7394957983193, Blast_Score=92, Evalue=1e-18,
Organism=Escherichia coli, GI1789016, Length=425, Percent_Identity=34.3529411764706, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1787560, Length=401, Percent_Identity=35.1620947630923, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1788044, Length=402, Percent_Identity=30.8457711442786, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI1789759, Length=407, Percent_Identity=28.7469287469287, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI145693181, Length=440, Percent_Identity=30.9090909090909, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1786349, Length=352, Percent_Identity=26.1363636363636, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1786991, Length=447, Percent_Identity=25.7270693512304, Blast_Score=100, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI32564660, Length=423, Percent_Identity=31.9148936170213, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71992977, Length=421, Percent_Identity=28.7410926365796, Blast_Score=182, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI25144271, Length=414, Percent_Identity=29.951690821256, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=242, Percent_Identity=35.5371900826446, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17541228, Length=433, Percent_Identity=25.4041570438799, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6323470, Length=443, Percent_Identity=30.2483069977427, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6324432, Length=419, Percent_Identity=29.5942720763723, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6321456, Length=374, Percent_Identity=27.2727272727273, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI161085790, Length=462, Percent_Identity=31.6017316017316, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI28574759, Length=465, Percent_Identity=31.6129032258064, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI21356575, Length=433, Percent_Identity=30.715935334873, Blast_Score=201, Evalue=8e-52,
Organism=Drosophila melanogaster, GI21357415, Length=417, Percent_Identity=28.0575539568345, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI281366494, Length=375, Percent_Identity=24.8, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24667139, Length=375, Percent_Identity=24.8, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24667143, Length=375, Percent_Identity=24.8, Blast_Score=79, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004632
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.19; =2.6.1.22 [H]

Molecular weight: Translated: 50447; Mature: 50447

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNERPGKDLQLIEKYWRHVSSSQGFKYFPLVVSRAKASKVWDINGREYIDFLSSAATYN
CCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCEEECCCHHHHHHHHHHHEEC
IGHSNEEVIKAIKEHLDKFIHYCLYLYHEPVIELSELLTGITLGNHRKKVVFGLSGGDAN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
DTALKAAFIYTRRPGVISYTYSYHGTTALGIAVGGSFREEIRKAIPFKDVYFVEYPDTYR
CHHEEEEEEEECCCCEEEEEEECCCCEEEEEEECCHHHHHHHHHCCCCCEEEEECCCCCC
CGNIEDPRECGDHHLSKLEDLLKKINPSSFAAIIMEPIQGDGGVLVPPENYVKGLFKLAR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHH
ENGIIIIDDEVQTGMGRTGKWLAIEHFNVEPDLVVLGKALGGGMPISAVIGRSEILDAAP
CCCEEEECCCHHHCCCCCCCEEEEEECCCCCCCEEEEHHHCCCCCHHHHHCHHHHHCCCC
PQTFFATSAAHALSCVAAIATIKYIKNYNLVEKARELGDYAVKRLNELKEKYEIIGDVRG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KGLMIGVEIVKEKKQKIPDRKTALKIIWRAWEKGVIMMTYGKYGNVLRIAPPLVISREEL
CEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCEEEHHHH
DAGINIVDEAIKDVLEGRVPDDVINKMKAWE
HCCHHHHHHHHHHHHCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MDNERPGKDLQLIEKYWRHVSSSQGFKYFPLVVSRAKASKVWDINGREYIDFLSSAATYN
CCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCCEEECCCHHHHHHHHHHHEEC
IGHSNEEVIKAIKEHLDKFIHYCLYLYHEPVIELSELLTGITLGNHRKKVVFGLSGGDAN
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCCCCCCEEEEEEECCCCCC
DTALKAAFIYTRRPGVISYTYSYHGTTALGIAVGGSFREEIRKAIPFKDVYFVEYPDTYR
CHHEEEEEEEECCCCEEEEEEECCCCEEEEEEECCHHHHHHHHHCCCCCEEEEECCCCCC
CGNIEDPRECGDHHLSKLEDLLKKINPSSFAAIIMEPIQGDGGVLVPPENYVKGLFKLAR
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCEEECCHHHHHHHHHHHH
ENGIIIIDDEVQTGMGRTGKWLAIEHFNVEPDLVVLGKALGGGMPISAVIGRSEILDAAP
CCCEEEECCCHHHCCCCCCCEEEEEECCCCCCCEEEEHHHCCCCCHHHHHCHHHHHCCCC
PQTFFATSAAHALSCVAAIATIKYIKNYNLVEKARELGDYAVKRLNELKEKYEIIGDVRG
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
KGLMIGVEIVKEKKQKIPDRKTALKIIWRAWEKGVIMMTYGKYGNVLRIAPPLVISREEL
CEEEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCEEEHHHH
DAGINIVDEAIKDVLEGRVPDDVINKMKAWE
HCCHHHHHHHHHHHHCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969502; 9384377 [H]