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The map label for this gene is gcp [H]

Identifier: 218884652

GI number: 218884652

Start: 1249751

End: 1250818

Strand: Reverse

Name: gcp [H]

Synonym: DKAM_1341

Alternate gene names: 218884652

Gene position: 1250818-1249751 (Counterclockwise)

Preceding gene: 218884653

Following gene: 218884651

Centisome position: 91.62

GC content: 46.35

Gene sequence:

>1068_bases
ATGCAAAAAATACATGTTCCTGTAAAACTGCCTGAAGGTGTAGAAGGTAAAGAGGTAACAGTACTGGGTATTGAGTCGAC
CAGCCATACACTCGGGGTTGGAGTCCTAAGGTTTTCCAGGGGCAGCGTAGAAATATTGGCAAATATTAGTAGTCAATATA
AACCTGAGAAAGGAGGCATTCACCCTAGGGAAGCCTCACAGCATCACATGAAGAACGCGCCCACTGTGCTCAGGGAGGCA
TTAGGGAAAGCCGGGGTCTCTATGAGAGACATCAACACCGTTACAGTAGCAGTAGGACCTGGTATTGGGCCCTGCCTCAG
GGTTGGTGCGACAATAGCTAGGTTTCTATCTAAATACTTCAACATACCATTAACACCGGTGAATCATGCAGTTGCCCACA
TAGAAATCGGTAAGTTATTCAGCGGCTTCAATGACCCTGTCATAGTATATGTGTCGGGGGGCAATACGATGGTACTTGTT
CAGAAAAATAGCCAGTATAGGGTAATGGGGGAGACGCTTGATATACCATTAGGAAACCTCTTTGACACCTTCACCAGGGA
AATAGGAATAGCTCCACCCTATGTGGTTGATGGGAAGCACGCTATAGATGTATGTGCCGAGTGGAGCCAGGAGTTCCAGC
CCCTTCCATACACGATTAAAGGCAACGATCTAAGCTTCTCGGGTCTCTTAACAGCCGCGTTGAAACTAGCGAAGGAAGCA
AATGGTGGTAAGGAAAGTCTGGGCAGGATATGTAACAGCCTCAGGGAGACAGCCTTCAATATGCTTATCGAGGTATCAGA
AAGAGTGCTCGCGTTAACCAATAAGAAACAGCTCCTACTAGTTGGGGGAGTCGCATCAAACAAGGTGTTGAGATGGAAGA
TGGAGACTCTTACATCCATCTATAACGTAAAATATTATGGTACCCCGCCCGATGTAGCCGGCGATAACGGGGTGATGATA
GCTTATACAGGGCTCCTATTATATCTATATGGTAGGACAAGTAAGCCTGAGGAAACACATGTAAAACAGAGATACAGGAT
TGATGAGGAGGCTTATCCATGGCTCTAA

Upstream 100 bases:

>100_bases
ATGGCACTGCGGCAAATGCAATTACACAGAGTTTGTAAAATAAGATAAAAAGTAGCAGAGACTCTAGATCCCCCTACCCC
TGGTTTTTGAGAGGAAGCCC

Downstream 100 bases:

>100_bases
GCAGTGAGAGCAATCTATGGGGGGCTGAAGCCGTTATATACATAGGTGAGTTCCTGGGTAGAAAAGTAGTCATCAAGAAA
CGTAGGAGTAAGCAATATAG

Product: Putative O-sialoglycoprotein endopeptidase

Products: NA

Alternate protein names: Glycoprotease [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MQKIHVPVKLPEGVEGKEVTVLGIESTSHTLGVGVLRFSRGSVEILANISSQYKPEKGGIHPREASQHHMKNAPTVLREA
LGKAGVSMRDINTVTVAVGPGIGPCLRVGATIARFLSKYFNIPLTPVNHAVAHIEIGKLFSGFNDPVIVYVSGGNTMVLV
QKNSQYRVMGETLDIPLGNLFDTFTREIGIAPPYVVDGKHAIDVCAEWSQEFQPLPYTIKGNDLSFSGLLTAALKLAKEA
NGGKESLGRICNSLRETAFNMLIEVSERVLALTNKKQLLLVGGVASNKVLRWKMETLTSIYNVKYYGTPPDVAGDNGVMI
AYTGLLLYLYGRTSKPEETHVKQRYRIDEEAYPWL

Sequences:

>Translated_355_residues
MQKIHVPVKLPEGVEGKEVTVLGIESTSHTLGVGVLRFSRGSVEILANISSQYKPEKGGIHPREASQHHMKNAPTVLREA
LGKAGVSMRDINTVTVAVGPGIGPCLRVGATIARFLSKYFNIPLTPVNHAVAHIEIGKLFSGFNDPVIVYVSGGNTMVLV
QKNSQYRVMGETLDIPLGNLFDTFTREIGIAPPYVVDGKHAIDVCAEWSQEFQPLPYTIKGNDLSFSGLLTAALKLAKEA
NGGKESLGRICNSLRETAFNMLIEVSERVLALTNKKQLLLVGGVASNKVLRWKMETLTSIYNVKYYGTPPDVAGDNGVMI
AYTGLLLYLYGRTSKPEETHVKQRYRIDEEAYPWL
>Mature_355_residues
MQKIHVPVKLPEGVEGKEVTVLGIESTSHTLGVGVLRFSRGSVEILANISSQYKPEKGGIHPREASQHHMKNAPTVLREA
LGKAGVSMRDINTVTVAVGPGIGPCLRVGATIARFLSKYFNIPLTPVNHAVAHIEIGKLFSGFNDPVIVYVSGGNTMVLV
QKNSQYRVMGETLDIPLGNLFDTFTREIGIAPPYVVDGKHAIDVCAEWSQEFQPLPYTIKGNDLSFSGLLTAALKLAKEA
NGGKESLGRICNSLRETAFNMLIEVSERVLALTNKKQLLLVGGVASNKVLRWKMETLTSIYNVKYYGTPPDVAGDNGVMI
AYTGLLLYLYGRTSKPEETHVKQRYRIDEEAYPWL

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family [H]

Homologues:

Organism=Homo sapiens, GI8923380, Length=340, Percent_Identity=36.1764705882353, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI116812636, Length=330, Percent_Identity=27.8787878787879, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1789445, Length=325, Percent_Identity=30.4615384615385, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI71995670, Length=340, Percent_Identity=36.7647058823529, Blast_Score=214, Evalue=7e-56,
Organism=Caenorhabditis elegans, GI17557464, Length=337, Percent_Identity=27.5964391691395, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322891, Length=369, Percent_Identity=34.6883468834688, Blast_Score=198, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6320099, Length=355, Percent_Identity=28.169014084507, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21357207, Length=353, Percent_Identity=36.8271954674221, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI20129063, Length=344, Percent_Identity=25.2906976744186, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022449
- InterPro:   IPR000905
- InterPro:   IPR017861 [H]

Pfam domain/function: PF00814 Peptidase_M22 [H]

EC number: =3.4.24.57 [H]

Molecular weight: Translated: 38865; Mature: 38865

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKIHVPVKLPEGVEGKEVTVLGIESTSHTLGVGVLRFSRGSVEILANISSQYKPEKGGI
CCEEEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEECHHHCCCCCCCC
HPREASQHHMKNAPTVLREALGKAGVSMRDINTVTVAVGPGIGPCLRVGATIARFLSKYF
CCCCCHHHHHCCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHH
NIPLTPVNHAVAHIEIGKLFSGFNDPVIVYVSGGNTMVLVQKNSQYRVMGETLDIPLGNL
CCCCCCCCCEEEEEEHHHHHCCCCCCEEEEEECCCEEEEEEECCCEEEECCEECCCCHHH
FDTFTREIGIAPPYVVDGKHAIDVCAEWSQEFQPLPYTIKGNDLSFSGLLTAALKLAKEA
HHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHC
NGGKESLGRICNSLRETAFNMLIEVSERVLALTNKKQLLLVGGVASNKVLRWKMETLTSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEEHHHHHHH
YNVKYYGTPPDVAGDNGVMIAYTGLLLYLYGRTSKPEETHVKQRYRIDEEAYPWL
HEEEEECCCCCCCCCCCEEEEHHHHHHHEECCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQKIHVPVKLPEGVEGKEVTVLGIESTSHTLGVGVLRFSRGSVEILANISSQYKPEKGGI
CCEEEEEEECCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCEEEEEECHHHCCCCCCCC
HPREASQHHMKNAPTVLREALGKAGVSMRDINTVTVAVGPGIGPCLRVGATIARFLSKYF
CCCCCHHHHHCCCHHHHHHHHHHCCCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHH
NIPLTPVNHAVAHIEIGKLFSGFNDPVIVYVSGGNTMVLVQKNSQYRVMGETLDIPLGNL
CCCCCCCCCEEEEEEHHHHHCCCCCCEEEEEECCCEEEEEEECCCEEEECCEECCCCHHH
FDTFTREIGIAPPYVVDGKHAIDVCAEWSQEFQPLPYTIKGNDLSFSGLLTAALKLAKEA
HHHHHHHHCCCCCEEECCCHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHC
NGGKESLGRICNSLRETAFNMLIEVSERVLALTNKKQLLLVGGVASNKVLRWKMETLTSI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEEECCCCCCEEEEEHHHHHHH
YNVKYYGTPPDVAGDNGVMIAYTGLLLYLYGRTSKPEETHVKQRYRIDEEAYPWL
HEEEEECCCCCCCCCCCEEEEHHHHHHHEECCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA