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The map label for this gene is xapA [C]

Identifier: 218884357

GI number: 218884357

Start: 992792

End: 993613

Strand: Direct

Name: xapA [C]

Synonym: DKAM_1046

Alternate gene names: 218884357

Gene position: 992792-993613 (Clockwise)

Preceding gene: 218884356

Following gene: 218884358

Centisome position: 72.72

GC content: 47.45

Gene sequence:

>822_bases
ATGCTGGTCGAGCCCTCTGTGAAAGCCAGCATAGCTATTATAGGGGGAAGCGGGGTATACGATCTCCCAGGTCTAAGTAA
TATAAGAGAGTACAAGGTCTATACCCCATACGGTGCTCCCAGCGATAACATAATAATCGGTGAGCTACGGGGCAAAACCA
TAGCATTCCTACCTAGGCATGGCAGGGGACATAAGATACCGCCCCATAGAATAAACTATAGGGCGAACATATGGGCCCTG
AAGAGTATTGGTGTGAAGTGGGTGATAGCTGTATCAGCTGTGGGAAGCCTTAGGGAAGACTATAGGCCAGGAGACTTTGT
AATACCAGATCAATTCATAGACATGACAAAGGGAGTTAGGGACTTCACGTTCTTCGAGGGTGGAAGAGTTGCACATGTAA
GTATGGCCGACCCATTCTGTGAACACCTCAGGAAGAAAATACTCGAGGCAGCCGCGAGACACCCAGATATAAGGATTCAT
GAAAAGGGAACATACATATGTATAGAGGGGCCTAGATTCAGTACAAGGGCTGAGAGTAGGGTTTGGAAGGAGGTATTTAA
GGCCGATGTGATAGGGATGACCCTCGTGCCGGAGGTCAACCTGGCATGTGAGGCACAGTTATGCTACGCAACAATAGCAA
TGGTCACAGACTACGATGTATGGGCTGAAAAACCCGTTACAGCCGAGGAAGTCGTGAAAACAATGAGAGAGAACACTATT
AAAATCCAGAGACTATTACCGGATATAATAGAGCTATTGAAAGACGAGCCACGTGGAGAGGAGTGTAGCTGTTGCAGGAG
CCTGGAGACAGCTTTAATGTAG

Upstream 100 bases:

>100_bases
TGGAGATATGTATTATAGAGAGGCGCTAAGGATTCTACTAGAGAAAGACATCGTAAAGTATGATCCAGGCAGAGACAAGT
ACTTATTGAAGGTGTGAGAA

Downstream 100 bases:

>100_bases
GGGCTTACCTGGGTAAACTAGGTAAACTAGAGGAGGAAGCTAGGAGCCTATCAAACAATATAAGGAATTTTTTAAGTGAG
ACAGGCTCAAACAGGCTCAT

Product: 5'-methylthioadenosine phosphorylase II

Products: ribose-1-phosphate; xanthine [C]

Alternate protein names: NA

Number of amino acids: Translated: 273; Mature: 273

Protein sequence:

>273_residues
MLVEPSVKASIAIIGGSGVYDLPGLSNIREYKVYTPYGAPSDNIIIGELRGKTIAFLPRHGRGHKIPPHRINYRANIWAL
KSIGVKWVIAVSAVGSLREDYRPGDFVIPDQFIDMTKGVRDFTFFEGGRVAHVSMADPFCEHLRKKILEAAARHPDIRIH
EKGTYICIEGPRFSTRAESRVWKEVFKADVIGMTLVPEVNLACEAQLCYATIAMVTDYDVWAEKPVTAEEVVKTMRENTI
KIQRLLPDIIELLKDEPRGEECSCCRSLETALM

Sequences:

>Translated_273_residues
MLVEPSVKASIAIIGGSGVYDLPGLSNIREYKVYTPYGAPSDNIIIGELRGKTIAFLPRHGRGHKIPPHRINYRANIWAL
KSIGVKWVIAVSAVGSLREDYRPGDFVIPDQFIDMTKGVRDFTFFEGGRVAHVSMADPFCEHLRKKILEAAARHPDIRIH
EKGTYICIEGPRFSTRAESRVWKEVFKADVIGMTLVPEVNLACEAQLCYATIAMVTDYDVWAEKPVTAEEVVKTMRENTI
KIQRLLPDIIELLKDEPRGEECSCCRSLETALM
>Mature_273_residues
MLVEPSVKASIAIIGGSGVYDLPGLSNIREYKVYTPYGAPSDNIIIGELRGKTIAFLPRHGRGHKIPPHRINYRANIWAL
KSIGVKWVIAVSAVGSLREDYRPGDFVIPDQFIDMTKGVRDFTFFEGGRVAHVSMADPFCEHLRKKILEAAARHPDIRIH
EKGTYICIEGPRFSTRAESRVWKEVFKADVIGMTLVPEVNLACEAQLCYATIAMVTDYDVWAEKPVTAEEVVKTMRENTI
KIQRLLPDIIELLKDEPRGEECSCCRSLETALM

Specific function: The Nucleoside Phosphorylases Catalyze The Phosphorolytic Breakdown Of The N-Glycosidic Bond In The Nucleoside Molecule, With The Formation Of The Corresponding Free Bases And Pentose-1-Phosphate. This Protein Can Degrade All Purine Nucleosides Except Ade

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=243, Percent_Identity=48.9711934156379, Blast_Score=220, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI71980569, Length=242, Percent_Identity=43.3884297520661, Blast_Score=182, Evalue=2e-46,
Organism=Saccharomyces cerevisiae, GI6323045, Length=262, Percent_Identity=37.4045801526718, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI20130079, Length=275, Percent_Identity=41.4545454545455, Blast_Score=200, Evalue=7e-52,
Organism=Drosophila melanogaster, GI221459247, Length=267, Percent_Identity=35.5805243445693, Blast_Score=167, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: 2.4.2.- [C]

Molecular weight: Translated: 30660; Mature: 30660

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVEPSVKASIAIIGGSGVYDLPGLSNIREYKVYTPYGAPSDNIIIGELRGKTIAFLPRH
CCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCEEEEEECC
GRGHKIPPHRINYRANIWALKSIGVKWVIAVSAVGSLREDYRPGDFVIPDQFIDMTKGVR
CCCCCCCCCEECEEEEEEEEECCCEEEEHHHHHHHHHHHHCCCCCEECCHHHHHHHCCCC
DFTFFEGGRVAHVSMADPFCEHLRKKILEAAARHPDIRIHEKGTYICIEGPRFSTRAESR
CEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCHHHHH
VWKEVFKADVIGMTLVPEVNLACEAQLCYATIAMVTDYDVWAEKPVTAEEVVKTMRENTI
HHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHH
KIQRLLPDIIELLKDEPRGEECSCCRSLETALM
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MLVEPSVKASIAIIGGSGVYDLPGLSNIREYKVYTPYGAPSDNIIIGELRGKTIAFLPRH
CCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCCEEEEECCCCEEEEEECC
GRGHKIPPHRINYRANIWALKSIGVKWVIAVSAVGSLREDYRPGDFVIPDQFIDMTKGVR
CCCCCCCCCEECEEEEEEEEECCCEEEEHHHHHHHHHHHHCCCCCEECCHHHHHHHCCCC
DFTFFEGGRVAHVSMADPFCEHLRKKILEAAARHPDIRIHEKGTYICIEGPRFSTRAESR
CEEEECCCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCCEEEEECCCCCCHHHHH
VWKEVFKADVIGMTLVPEVNLACEAQLCYATIAMVTDYDVWAEKPVTAEEVVKTMRENTI
HHHHHHHHHHCCEEECCCCCCEEHHHHHHHHHHHHCCCHHHCCCCCCHHHHHHHHHHHHH
KIQRLLPDIIELLKDEPRGEECSCCRSLETALM
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: xanthosine; phosphate [C]

Specific reaction: xanthosine + phosphate = ribose-1-phosphate + xanthine [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]