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The map label for this gene is uppS [H]

Identifier: 218884238

GI number: 218884238

Start: 880759

End: 881544

Strand: Direct

Name: uppS [H]

Synonym: DKAM_0927

Alternate gene names: 218884238

Gene position: 880759-881544 (Clockwise)

Preceding gene: 218884235

Following gene: 218884242

Centisome position: 64.51

GC content: 43.26

Gene sequence:

>786_bases
ATGTTATACAAGCTGAGCCCGCGTGTCTTAAAGCCGGTTTATGAAATATATGAGAAATGGCTTTGGATGCAGATACGCAG
AGGGCCCTTTCCAAGACATATAGGTATAATTCCAGATGGAAACAGGAGGTGGGCGAAGAGACTTGGGCTAGACCCCTCAC
TGGGGCATGTTTATGGATACGAGAAAATAAAAGAAGTCCTTAAATGGATATGGGAGCTAAAAATAAGGTATGTAACAATA
TACACCATGAGCACTGAAAACTGCAGGTTCAGAGATGAGCGTGAACGAGAATACTTGTTTAACCTAGCCAGGAAGGGATT
AGCCGAGTTAAAGAACATGAGGGAGATACATGAGAGGAAAGTCAGGGTGAAAGTATTCGGGTCACTGGATCTAGTCCCAG
AGGATATTGTCGTGTTGGCGAGTGAATTAGAGAAGGAGACAGCCAGGTATGATTCATTCCAGCTAAACATAGCGTTATGC
TACGGCGGCAGGCATGAGATAATCGATGCCGTAAAAGCTATTGTGAAAGAGGCGTTAGAGGGTAAAATAGGCCTTGAAGA
TATCAATGAGGAACTATTCAGCAAATACCTTTACACTAATGGAGCACCAGATCCGGATCTAATAATCAGGACCAGCGGGG
AGGAAAGAATCAGTAATTTCCTACTATGGCAGTCAGCCTATAGTGAGCTATATTTCTGTGATGTATTCTGGCCGGAATTC
CGTAAAATAGATTTCTGGAGAGCCATTAGAAGTTACCAGAGGCGTGAAAGAAGGTTTGGTAGATAA

Upstream 100 bases:

>100_bases
GAGCAGTAGTTATATTCCTTAACAATTATTATACCCAATATGGAGAACAGTGATATCGGGGTCAAATGAATTGTACGAGC
TACAGGGATTTCTAATCAAC

Downstream 100 bases:

>100_bases
TATTGTCTTACTGCTCCTCCATGAAATCCTCCGGTTCACCATATATTATCTTGAGCTCGTCGATTGTTAAACGCTTCTTA
CCGCTTGCCTTCTCCAGGAT

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MLYKLSPRVLKPVYEIYEKWLWMQIRRGPFPRHIGIIPDGNRRWAKRLGLDPSLGHVYGYEKIKEVLKWIWELKIRYVTI
YTMSTENCRFRDEREREYLFNLARKGLAELKNMREIHERKVRVKVFGSLDLVPEDIVVLASELEKETARYDSFQLNIALC
YGGRHEIIDAVKAIVKEALEGKIGLEDINEELFSKYLYTNGAPDPDLIIRTSGEERISNFLLWQSAYSELYFCDVFWPEF
RKIDFWRAIRSYQRRERRFGR

Sequences:

>Translated_261_residues
MLYKLSPRVLKPVYEIYEKWLWMQIRRGPFPRHIGIIPDGNRRWAKRLGLDPSLGHVYGYEKIKEVLKWIWELKIRYVTI
YTMSTENCRFRDEREREYLFNLARKGLAELKNMREIHERKVRVKVFGSLDLVPEDIVVLASELEKETARYDSFQLNIALC
YGGRHEIIDAVKAIVKEALEGKIGLEDINEELFSKYLYTNGAPDPDLIIRTSGEERISNFLLWQSAYSELYFCDVFWPEF
RKIDFWRAIRSYQRRERRFGR
>Mature_261_residues
MLYKLSPRVLKPVYEIYEKWLWMQIRRGPFPRHIGIIPDGNRRWAKRLGLDPSLGHVYGYEKIKEVLKWIWELKIRYVTI
YTMSTENCRFRDEREREYLFNLARKGLAELKNMREIHERKVRVKVFGSLDLVPEDIVVLASELEKETARYDSFQLNIALC
YGGRHEIIDAVKAIVKEALEGKIGLEDINEELFSKYLYTNGAPDPDLIIRTSGEERISNFLLWQSAYSELYFCDVFWPEF
RKIDFWRAIRSYQRRERRFGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=239, Percent_Identity=38.9121338912134, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI45580738, Length=239, Percent_Identity=38.9121338912134, Blast_Score=177, Evalue=6e-45,
Organism=Escherichia coli, GI1786371, Length=229, Percent_Identity=36.2445414847162, Blast_Score=151, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI71993029, Length=240, Percent_Identity=36.25, Blast_Score=159, Evalue=1e-39,
Organism=Saccharomyces cerevisiae, GI6319474, Length=220, Percent_Identity=35.4545454545455, Blast_Score=120, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=247, Percent_Identity=27.9352226720648, Blast_Score=86, Evalue=4e-18,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=39.4736842105263, Blast_Score=173, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 31342; Mature: 31342

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYKLSPRVLKPVYEIYEKWLWMQIRRGPFPRHIGIIPDGNRRWAKRLGLDPSLGHVYGY
CCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHCCCCCCCHHHCCH
EKIKEVLKWIWELKIRYVTIYTMSTENCRFRDEREREYLFNLARKGLAELKNMREIHERK
HHHHHHHHHHHHCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRVKVFGSLDLVPEDIVVLASELEKETARYDSFQLNIALCYGGRHEIIDAVKAIVKEALE
EEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHHC
GKIGLEDINEELFSKYLYTNGAPDPDLIIRTSGEERISNFLLWQSAYSELYFCDVFWPEF
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHEEEEEEECHHH
RKIDFWRAIRSYQRRERRFGR
HHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLYKLSPRVLKPVYEIYEKWLWMQIRRGPFPRHIGIIPDGNRRWAKRLGLDPSLGHVYGY
CCEECCHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCCHHHHHHCCCCCCCHHHCCH
EKIKEVLKWIWELKIRYVTIYTMSTENCRFRDEREREYLFNLARKGLAELKNMREIHERK
HHHHHHHHHHHHCEEEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VRVKVFGSLDLVPEDIVVLASELEKETARYDSFQLNIALCYGGRHEIIDAVKAIVKEALE
EEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEEECCHHHHHHHHHHHHHHHHC
GKIGLEDINEELFSKYLYTNGAPDPDLIIRTSGEERISNFLLWQSAYSELYFCDVFWPEF
CCCCHHHHHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHEEEEEEECHHH
RKIDFWRAIRSYQRRERRFGR
HHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11114943 [H]