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The map label for this gene is serA [H]

Identifier: 218884168

GI number: 218884168

Start: 822943

End: 823884

Strand: Direct

Name: serA [H]

Synonym: DKAM_0857

Alternate gene names: 218884168

Gene position: 822943-823884 (Clockwise)

Preceding gene: 218884166

Following gene: 218884169

Centisome position: 60.28

GC content: 47.13

Gene sequence:

>942_bases
ATGAGTACATACAAGTATAGAGTTCTAGTTGCAAGCCACATTCATGAGAAGGCAATCGAGTTGTTGAGATCAAACGGGTT
TGATGTCACTGTAAGAGAGGAGCCAAGCGAGGATGAATTAGCCTCGATGATAAAGGGGTTCCACGCACTTATAGTCCGTA
GCAAACCCTTGGTCACAAAGAGGGTGATAGAATCATCCGACGTCCTCAAGGTGATCGCTAGAGCCGGTGTGGGATTAGAT
AACATAGATGTCGAAGCTGCTAAAGCCCGGGGGATAGAGGTCATCAATGCCCCTGCATCATCATCGGTGAGCGTTGCGGA
GCTCGCCGTGGGATTAATGATTGCCGTGGCCAGGAAGATAGCCTTCAGTGACAGACGTATGCGGCTTGGCGAGTGGCCGA
AGAAGCAGGCTATGGGGATTGAGTTGAACGGTAAGACCCTTGGTATAATTGGTGCTGGTAGAATAGGCTCAACTGTTGCA
AAGATATGCAGGCTAGGTCTTGGGATGAATATTCTCTATTATGATCTCGGTAGAAATGAACAATTAGAGAGGGAGTTGGG
GGCTAGATACGTTGATCTAGAGACTCTTCTAAAGGAATCAGATGTGGTCTCAATACATGTCCCCCTAACACCTGAAACAC
AACACTTGATAAATGAGAAGAGACTAAGGCTCATGAAGAAAACCGCGATACTTATAAATACCTCGAGGGGGCAGGTGGTA
GACACTAATGCACTTATAAAGGCATTGAAAGAAGGCTGGATTGCTGGTGCCGGGCTAGACGTATTCGAGGAGGAGCCCTT
GCCAAAGGATCATGCATTACTAAAACTTGACAACGTAGTTTTAACTCCGCACATAGGCGCTAGCACTGTGGAGGCGCAGG
AAAAAGCCGGCATAGAGGTTGCTGAGAAAATAATAGACTATTTCAGGAAGCATGGTGCCTAG

Upstream 100 bases:

>100_bases
AGTAATCCTTTCCCAAGCTTTTTCAAGCTGTAAGAGTGGCTATATTCCTTCTTAATATTTTTATTTGGTTGAAGTAATAT
GATATGAGTAGGGGATATAG

Downstream 100 bases:

>100_bases
TTATGAGTAGTGAAGCAGGTAAAGTAATAATTAAGCTACCTAAGACAAGCATCCCCTACAAGTATGTTGAGCCAACACTA
ATAGATGTGGATAAACTGGT

Product: phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSTYKYRVLVASHIHEKAIELLRSNGFDVTVREEPSEDELASMIKGFHALIVRSKPLVTKRVIESSDVLKVIARAGVGLD
NIDVEAAKARGIEVINAPASSSVSVAELAVGLMIAVARKIAFSDRRMRLGEWPKKQAMGIELNGKTLGIIGAGRIGSTVA
KICRLGLGMNILYYDLGRNEQLERELGARYVDLETLLKESDVVSIHVPLTPETQHLINEKRLRLMKKTAILINTSRGQVV
DTNALIKALKEGWIAGAGLDVFEEEPLPKDHALLKLDNVVLTPHIGASTVEAQEKAGIEVAEKIIDYFRKHGA

Sequences:

>Translated_313_residues
MSTYKYRVLVASHIHEKAIELLRSNGFDVTVREEPSEDELASMIKGFHALIVRSKPLVTKRVIESSDVLKVIARAGVGLD
NIDVEAAKARGIEVINAPASSSVSVAELAVGLMIAVARKIAFSDRRMRLGEWPKKQAMGIELNGKTLGIIGAGRIGSTVA
KICRLGLGMNILYYDLGRNEQLERELGARYVDLETLLKESDVVSIHVPLTPETQHLINEKRLRLMKKTAILINTSRGQVV
DTNALIKALKEGWIAGAGLDVFEEEPLPKDHALLKLDNVVLTPHIGASTVEAQEKAGIEVAEKIIDYFRKHGA
>Mature_312_residues
STYKYRVLVASHIHEKAIELLRSNGFDVTVREEPSEDELASMIKGFHALIVRSKPLVTKRVIESSDVLKVIARAGVGLDN
IDVEAAKARGIEVINAPASSSVSVAELAVGLMIAVARKIAFSDRRMRLGEWPKKQAMGIELNGKTLGIIGAGRIGSTVAK
ICRLGLGMNILYYDLGRNEQLERELGARYVDLETLLKESDVVSIHVPLTPETQHLINEKRLRLMKKTAILINTSRGQVVD
TNALIKALKEGWIAGAGLDVFEEEPLPKDHALLKLDNVVLTPHIGASTVEAQEKAGIEVAEKIIDYFRKHGA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=303, Percent_Identity=39.9339933993399, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI6912396, Length=285, Percent_Identity=35.7894736842105, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4557497, Length=260, Percent_Identity=36.9230769230769, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI61743967, Length=260, Percent_Identity=36.9230769230769, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI145580575, Length=260, Percent_Identity=35.3846153846154, Blast_Score=143, Evalue=2e-34,
Organism=Homo sapiens, GI145580578, Length=260, Percent_Identity=35.3846153846154, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI4557499, Length=260, Percent_Identity=35.3846153846154, Blast_Score=142, Evalue=4e-34,
Organism=Escherichia coli, GI1789279, Length=309, Percent_Identity=40.1294498381877, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI87082289, Length=252, Percent_Identity=40.8730158730159, Blast_Score=189, Evalue=1e-49,
Organism=Escherichia coli, GI1787645, Length=237, Percent_Identity=38.3966244725738, Blast_Score=157, Evalue=6e-40,
Organism=Escherichia coli, GI1788660, Length=259, Percent_Identity=30.5019305019305, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87081824, Length=148, Percent_Identity=34.4594594594595, Blast_Score=76, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17532191, Length=312, Percent_Identity=38.1410256410256, Blast_Score=207, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI25147481, Length=258, Percent_Identity=32.9457364341085, Blast_Score=122, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322116, Length=329, Percent_Identity=37.0820668693009, Blast_Score=205, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6320925, Length=324, Percent_Identity=37.962962962963, Blast_Score=202, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6324055, Length=232, Percent_Identity=38.7931034482759, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6324964, Length=329, Percent_Identity=30.3951367781155, Blast_Score=124, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324980, Length=201, Percent_Identity=31.3432835820896, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6325144, Length=371, Percent_Identity=24.5283018867925, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=304, Percent_Identity=26.3157894736842, Blast_Score=83, Evalue=4e-17,
Organism=Drosophila melanogaster, GI19921140, Length=303, Percent_Identity=39.6039603960396, Blast_Score=204, Evalue=8e-53,
Organism=Drosophila melanogaster, GI28574286, Length=301, Percent_Identity=38.5382059800665, Blast_Score=179, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24585516, Length=312, Percent_Identity=31.4102564102564, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI24585514, Length=293, Percent_Identity=35.8361774744027, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI28574282, Length=293, Percent_Identity=35.8361774744027, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI28574284, Length=293, Percent_Identity=35.8361774744027, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI45552429, Length=293, Percent_Identity=35.8361774744027, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI45551003, Length=293, Percent_Identity=35.8361774744027, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI28571528, Length=311, Percent_Identity=35.3697749196142, Blast_Score=148, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24646446, Length=262, Percent_Identity=37.0229007633588, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646448, Length=262, Percent_Identity=37.0229007633588, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646452, Length=262, Percent_Identity=37.0229007633588, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24646450, Length=262, Percent_Identity=37.0229007633588, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI62472511, Length=262, Percent_Identity=37.0229007633588, Blast_Score=146, Evalue=2e-35,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 34295; Mature: 34164

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1 ; PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTYKYRVLVASHIHEKAIELLRSNGFDVTVREEPSEDELASMIKGFHALIVRSKPLVTK
CCCEEEEEHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHH
RVIESSDVLKVIARAGVGLDNIDVEAAKARGIEVINAPASSSVSVAELAVGLMIAVARKI
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AFSDRRMRLGEWPKKQAMGIELNGKTLGIIGAGRIGSTVAKICRLGLGMNILYYDLGRNE
HHCCCCCCCCCCCCHHCCEEEECCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCH
QLERELGARYVDLETLLKESDVVSIHVPLTPETQHLINEKRLRLMKKTAILINTSRGQVV
HHHHHHCCEEECHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEE
DTNALIKALKEGWIAGAGLDVFEEEPLPKDHALLKLDNVVLTPHIGASTVEAQEKAGIEV
EHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCEEEECCEEECCCCCCCHHHHHHHCCHHH
AEKIIDYFRKHGA
HHHHHHHHHHCCC
>Mature Secondary Structure 
STYKYRVLVASHIHEKAIELLRSNGFDVTVREEPSEDELASMIKGFHALIVRSKPLVTK
CCEEEEEHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHH
RVIESSDVLKVIARAGVGLDNIDVEAAKARGIEVINAPASSSVSVAELAVGLMIAVARKI
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHHHHH
AFSDRRMRLGEWPKKQAMGIELNGKTLGIIGAGRIGSTVAKICRLGLGMNILYYDLGRNE
HHCCCCCCCCCCCCHHCCEEEECCCEEEEEECCHHHHHHHHHHHHCCCCEEEEEECCCCH
QLERELGARYVDLETLLKESDVVSIHVPLTPETQHLINEKRLRLMKKTAILINTSRGQVV
HHHHHHCCEEECHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHEEEEECCCCCEE
DTNALIKALKEGWIAGAGLDVFEEEPLPKDHALLKLDNVVLTPHIGASTVEAQEKAGIEV
EHHHHHHHHHHCCCCCCCCCHHCCCCCCCCCCEEEECCEEECCCCCCCHHHHHHHCCHHH
AEKIIDYFRKHGA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]