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The map label for this gene is yeiA [H]

Identifier: 218883496

GI number: 218883496

Start: 170536

End: 171759

Strand: Direct

Name: yeiA [H]

Synonym: DKAM_0183

Alternate gene names: 218883496

Gene position: 170536-171759 (Clockwise)

Preceding gene: 218883495

Following gene: 218883497

Centisome position: 12.49

GC content: 48.2

Gene sequence:

>1224_bases
GTGGGAGAGTATATGGCTGACCTAAGTGTTGAACTAGCCGGGTTGAAGCTAAGAAACCCGATAATGAATGCTGCCTGTCC
TGTATCAAGGGACGCCGATGCCATGAGGATGTTAATAGATAATGGCGTTGGTGCAGTCGTGGCTAAGACTATAAGTGTGA
AGCCGGCTATAGTCCCACGCCCCAGCATGGCAGCAGTTGATCGTGGATTAGTGAGGGCCCACCTACTGAAAACCCTGAAG
CCTGGCGATGTAAGGATTACGCCGGTGGACAGCGGGAACCACCGCTTCATATATGCTGTTCTTAATGCTGAATTATGGAG
TGATATACCAGCTGAGCATTATTTAGAGAGAGAGTACCCACTTGTTAAGAGTTATTGCGAGGAGAAGGGGGCAGTATTTA
TAGCGAGTATAGGGTATACACCCGAGGAGCTATCTTTGCTCGGCCCGAAGGTTGAGAAAGCCGGCGTCCAGGCGATCGAG
TTTTCAACACATTACATAGGCAGGGATTATCGTCCAGTAATAGAGGCTGCCAAAGCCCTCAGGGAGAGCGTTGACATACC
AATATTTCCGAAACTAAGTCCCTTCACCCCCAACATTCCCGAACTAGTGAAGGAACTTGAGAAAGTGGGCGTTGATGGGA
TCGTTGCTACGAATACTATTGGCCCAGCCCTACACATAGATGTTGAGACCGGCTTACCGATCGTTGGTGGTCCATACGGC
TATGGATGGATGAGCGGCCCAGCCCTTAAGCCACTCGCATTGGCAGTTGTCTCACAGGTAGCTTTGAATACAAAGCTACC
TGTGATAGGTGTTGGAGGGATTAGTAGGGGTGTGGATGTCATAGAGTACTTCATGGCTGGTGCTTCAGCAGTACAGATAT
GTACAGCGGCGTTGATTGAGGGCCCACAGGCATTCGCTAGAATAATTAGGGAGGTGAATGAATGGCTCGATAGACACGGA
TATACAAGTATCCTTGATGTAAAGGGCTTGGCATTGAAGTATTTAAAGCCGGAGCCTAGAAGAGTGTGGGCCCAGCCACC
TGTAGTAGACGAGAAGAAGTGTATTGGATGTGGGTTCTGTGAGCAGGTATGCAACTATGATGCTGTACATGTTGAGGAGT
CAAGTGGTAAGCGTGTTGCAAGGGTTAATATAATGAAATGCTATGGATGTGGATTATGTACAAGTGTATGCCCCACTAGA
GCTATACACTTTATTGAGAAGTAG

Upstream 100 bases:

>100_bases
ATTGATTATGTCTCTCTCCGTCCTGGGGGAGCAGGATTTTTAGTTGCAATGTCAGCGCTTATTTACCTGTTTTAACAATA
TATATCCATAATAAAGGTTG

Downstream 100 bases:

>100_bases
GAGTAGTTTTAATCAGACATCATAATTTTTCTTAATTCTTCATTTTATTGTGTTTATGTAAAAAATCATGTAAGAATTCT
CGTTGATTAGTTTTAAATAT

Product: dihydroorotate dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MGEYMADLSVELAGLKLRNPIMNAACPVSRDADAMRMLIDNGVGAVVAKTISVKPAIVPRPSMAAVDRGLVRAHLLKTLK
PGDVRITPVDSGNHRFIYAVLNAELWSDIPAEHYLEREYPLVKSYCEEKGAVFIASIGYTPEELSLLGPKVEKAGVQAIE
FSTHYIGRDYRPVIEAAKALRESVDIPIFPKLSPFTPNIPELVKELEKVGVDGIVATNTIGPALHIDVETGLPIVGGPYG
YGWMSGPALKPLALAVVSQVALNTKLPVIGVGGISRGVDVIEYFMAGASAVQICTAALIEGPQAFARIIREVNEWLDRHG
YTSILDVKGLALKYLKPEPRRVWAQPPVVDEKKCIGCGFCEQVCNYDAVHVEESSGKRVARVNIMKCYGCGLCTSVCPTR
AIHFIEK

Sequences:

>Translated_407_residues
MGEYMADLSVELAGLKLRNPIMNAACPVSRDADAMRMLIDNGVGAVVAKTISVKPAIVPRPSMAAVDRGLVRAHLLKTLK
PGDVRITPVDSGNHRFIYAVLNAELWSDIPAEHYLEREYPLVKSYCEEKGAVFIASIGYTPEELSLLGPKVEKAGVQAIE
FSTHYIGRDYRPVIEAAKALRESVDIPIFPKLSPFTPNIPELVKELEKVGVDGIVATNTIGPALHIDVETGLPIVGGPYG
YGWMSGPALKPLALAVVSQVALNTKLPVIGVGGISRGVDVIEYFMAGASAVQICTAALIEGPQAFARIIREVNEWLDRHG
YTSILDVKGLALKYLKPEPRRVWAQPPVVDEKKCIGCGFCEQVCNYDAVHVEESSGKRVARVNIMKCYGCGLCTSVCPTR
AIHFIEK
>Mature_406_residues
GEYMADLSVELAGLKLRNPIMNAACPVSRDADAMRMLIDNGVGAVVAKTISVKPAIVPRPSMAAVDRGLVRAHLLKTLKP
GDVRITPVDSGNHRFIYAVLNAELWSDIPAEHYLEREYPLVKSYCEEKGAVFIASIGYTPEELSLLGPKVEKAGVQAIEF
STHYIGRDYRPVIEAAKALRESVDIPIFPKLSPFTPNIPELVKELEKVGVDGIVATNTIGPALHIDVETGLPIVGGPYGY
GWMSGPALKPLALAVVSQVALNTKLPVIGVGGISRGVDVIEYFMAGASAVQICTAALIEGPQAFARIIREVNEWLDRHGY
TSILDVKGLALKYLKPEPRRVWAQPPVVDEKKCIGCGFCEQVCNYDAVHVEESSGKRVARVNIMKCYGCGLCTSVCPTRA
IHFIEK

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 4Fe-4S ferredoxin-type domains [H]

Homologues:

Organism=Homo sapiens, GI119943098, Length=366, Percent_Identity=26.775956284153, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI45006951, Length=157, Percent_Identity=33.1210191082803, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082059, Length=423, Percent_Identity=29.0780141843972, Blast_Score=142, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI71984108, Length=308, Percent_Identity=26.9480519480519, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322633, Length=341, Percent_Identity=25.2199413489736, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24640763, Length=308, Percent_Identity=27.9220779220779, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18858217, Length=308, Percent_Identity=27.9220779220779, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281361352, Length=179, Percent_Identity=33.5195530726257, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI17137316, Length=179, Percent_Identity=33.5195530726257, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR012285 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: NA

Molecular weight: Translated: 44146; Mature: 44015

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEYMADLSVELAGLKLRNPIMNAACPVSRDADAMRMLIDNGVGAVVAKTISVKPAIVPR
CCCCHHCCEEEEECEECCCCHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHEECCCCCCCC
PSMAAVDRGLVRAHLLKTLKPGDVRITPVDSGNHRFIYAVLNAELWSDIPAEHYLEREYP
CCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCHHHHCCCHHHHHHCCCH
LVKSYCEEKGAVFIASIGYTPEELSLLGPKVEKAGVQAIEFSTHYIGRDYRPVIEAAKAL
HHHHHHHCCCCEEEEECCCCHHHHHHCCCCHHHCCCEEEEEHHHHCCCCCHHHHHHHHHH
RESVDIPIFPKLSPFTPNIPELVKELEKVGVDGIVATNTIGPALHIDVETGLPIVGGPYG
HHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCEECCCCC
YGWMSGPALKPLALAVVSQVALNTKLPVIGVGGISRGVDVIEYFMAGASAVQICTAALIE
CCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHC
GPQAFARIIREVNEWLDRHGYTSILDVKGLALKYLKPEPRRVWAQPPVVDEKKCIGCGFC
CHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCHHCCCCCCCCCCCCCCCCHHH
EQVCNYDAVHVEESSGKRVARVNIMKCYGCGLCTSVCPTRAIHFIEK
HHHCCCCEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GEYMADLSVELAGLKLRNPIMNAACPVSRDADAMRMLIDNGVGAVVAKTISVKPAIVPR
CCCHHCCEEEEECEECCCCHHHCCCCCCCCHHHHHHHHHCCCCHHHHHHEECCCCCCCC
PSMAAVDRGLVRAHLLKTLKPGDVRITPVDSGNHRFIYAVLNAELWSDIPAEHYLEREYP
CCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCEEEEEEECCHHHHCCCHHHHHHCCCH
LVKSYCEEKGAVFIASIGYTPEELSLLGPKVEKAGVQAIEFSTHYIGRDYRPVIEAAKAL
HHHHHHHCCCCEEEEECCCCHHHHHHCCCCHHHCCCEEEEEHHHHCCCCCHHHHHHHHHH
RESVDIPIFPKLSPFTPNIPELVKELEKVGVDGIVATNTIGPALHIDVETGLPIVGGPYG
HHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEECCCCCEEEEEECCCCCEECCCCC
YGWMSGPALKPLALAVVSQVALNTKLPVIGVGGISRGVDVIEYFMAGASAVQICTAALIE
CCCCCCCCCHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHC
GPQAFARIIREVNEWLDRHGYTSILDVKGLALKYLKPEPRRVWAQPPVVDEKKCIGCGFC
CHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCCCCHHCCCCCCCCCCCCCCCCHHH
EQVCNYDAVHVEESSGKRVARVNIMKCYGCGLCTSVCPTRAIHFIEK
HHHCCCCEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 1719366 [H]