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The map label for this gene is mtaD [H]

Identifier: 218883324

GI number: 218883324

Start: 7888

End: 9258

Strand: Direct

Name: mtaD [H]

Synonym: DKAM_0010

Alternate gene names: 218883324

Gene position: 7888-9258 (Clockwise)

Preceding gene: 218883323

Following gene: 218883328

Centisome position: 0.58

GC content: 44.13

Gene sequence:

>1371_bases
GTGTCAAATGTCCTGGTTGTAACAATGAATGATGAGCGACGTATCATAGACCATGGATACATTGCTATTAGAGATGATCG
AATAGTTGATATTGGAGCAGGAGATGGGACCGATAAGTATATCAGTGAGGAAACAATAAATGGTCGTGGCATGATAGCCA
TACCTGGGTTAATGTGTGCACACACCCACTTCTACGGACTCCTTTTGACGGGGAGTCCCTGGTTCTCTAGGATAGAGCCT
CCCACGGATTTCCAGCAGAACCTCCAGAGAATATGGTGGGCCCTAGATGTCGAGTTAACGTATGAAGACGCCTATGCTTC
AGCCCTCATGGGTTCAATATTGTTCGCTAAGTCGGGTGTAACTAATTTCTTCGATAACATTAGTAGTCCAAACGCGATCA
ACGGGGTCTTAGACTATATTGAGAAAGGGGTTAGTGAAGTCGGGATAAGGGGGATAATATCCTATGAAGCAACGCAGAGG
AGAAGTATAGAGGAAGGGATCAGGGGGTTAAAGGAGAATGAGAGATTCATCATGAAAAATAATAGTGATCCCAACAAGCT
GGTGAAAGGAGCTATTTATCTTCATTCAAGCTTCACCGTCACCGATGAATTATTTAGAATGGCCCGTGAAATGGCGGATA
ATCATAGAGCCTTAATAGCGATACACACAGCCGAGGGATTAGTAGATGTCTACCATAATATAGAGAGGTACGGAGTAAGG
CCAGTTGAGAGAATGAAGAAGCTCGGATTCCTCAGAGACGACGTCCACCTGGTGCACTCTGTTAACATCACGGAGGATGA
GCTCTACATTATAAGGGAGACAGGGGCGCATGTGGCTCACAACCCCTTAAGCAATATGTTGAACGCTGTCGGAGTAGCCA
GGGTACCTGAAATGCTTAGGCTGGGGATAAATGTTGGAATAGGTAATGATGGCTATGTCTTTGATCAATTCGAGAACATG
AGGGCAGCATACCTCATCCATAAACTATGGAACAGGGATCCTAGGATACTCACACCTCTCCAGGTATTCGAGATGTCAAC
CATAAACGTAGCGAAAATGTTTCACGTAGAGGATGAATTAGGAAGTATAGAGAAGGGGAAGAAAGCCGATATAGTATTAT
TAAGACCTGAAACGCCTTCAACACCGGTTAACTCACAGACTGTTCTAGGGCATATGATTAATGCTTTCGGCAGTAAAGAC
GTTGACACCGTGATAGTTAATGGTAGAATAATATTGAGGAACCACAGGCTAACCAGGGTTGATGAGGAAAAAGCAGTGGA
ATACGTTCACAGGGTTGTAGAGCGTTTATGGGATCGACTAATGGAGAGAGGTAAATATCAATTAGACTATGTATGCCCTA
GGCAGAAATGA

Upstream 100 bases:

>100_bases
AGCCATTCCGATGTTTCGACTTAAATTTATTTACTTAGCTAAGGTAATATTAAATCAAAGAAGTGGAGGGTATTCCTTGA
GAGAAAAAGTTGACGTACTG

Downstream 100 bases:

>100_bases
GTTTTTAACCAAAAGACCTTTTTACTTATTTACTTCTTCCCTATTCGTTTCTAAGTTTACTGGTTTACCATGTTTCAATA
TGTGTTCAGGTATCTTGTCC

Product: amidohydrolase

Products: NA

Alternate protein names: MTA/SAH deaminase [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSNVLVVTMNDERRIIDHGYIAIRDDRIVDIGAGDGTDKYISEETINGRGMIAIPGLMCAHTHFYGLLLTGSPWFSRIEP
PTDFQQNLQRIWWALDVELTYEDAYASALMGSILFAKSGVTNFFDNISSPNAINGVLDYIEKGVSEVGIRGIISYEATQR
RSIEEGIRGLKENERFIMKNNSDPNKLVKGAIYLHSSFTVTDELFRMAREMADNHRALIAIHTAEGLVDVYHNIERYGVR
PVERMKKLGFLRDDVHLVHSVNITEDELYIIRETGAHVAHNPLSNMLNAVGVARVPEMLRLGINVGIGNDGYVFDQFENM
RAAYLIHKLWNRDPRILTPLQVFEMSTINVAKMFHVEDELGSIEKGKKADIVLLRPETPSTPVNSQTVLGHMINAFGSKD
VDTVIVNGRIILRNHRLTRVDEEKAVEYVHRVVERLWDRLMERGKYQLDYVCPRQK

Sequences:

>Translated_456_residues
MSNVLVVTMNDERRIIDHGYIAIRDDRIVDIGAGDGTDKYISEETINGRGMIAIPGLMCAHTHFYGLLLTGSPWFSRIEP
PTDFQQNLQRIWWALDVELTYEDAYASALMGSILFAKSGVTNFFDNISSPNAINGVLDYIEKGVSEVGIRGIISYEATQR
RSIEEGIRGLKENERFIMKNNSDPNKLVKGAIYLHSSFTVTDELFRMAREMADNHRALIAIHTAEGLVDVYHNIERYGVR
PVERMKKLGFLRDDVHLVHSVNITEDELYIIRETGAHVAHNPLSNMLNAVGVARVPEMLRLGINVGIGNDGYVFDQFENM
RAAYLIHKLWNRDPRILTPLQVFEMSTINVAKMFHVEDELGSIEKGKKADIVLLRPETPSTPVNSQTVLGHMINAFGSKD
VDTVIVNGRIILRNHRLTRVDEEKAVEYVHRVVERLWDRLMERGKYQLDYVCPRQK
>Mature_455_residues
SNVLVVTMNDERRIIDHGYIAIRDDRIVDIGAGDGTDKYISEETINGRGMIAIPGLMCAHTHFYGLLLTGSPWFSRIEPP
TDFQQNLQRIWWALDVELTYEDAYASALMGSILFAKSGVTNFFDNISSPNAINGVLDYIEKGVSEVGIRGIISYEATQRR
SIEEGIRGLKENERFIMKNNSDPNKLVKGAIYLHSSFTVTDELFRMAREMADNHRALIAIHTAEGLVDVYHNIERYGVRP
VERMKKLGFLRDDVHLVHSVNITEDELYIIRETGAHVAHNPLSNMLNAVGVARVPEMLRLGINVGIGNDGYVFDQFENMR
AAYLIHKLWNRDPRILTPLQVFEMSTINVAKMFHVEDELGSIEKGKKADIVLLRPETPSTPVNSQTVLGHMINAFGSKDV
DTVIVNGRIILRNHRLTRVDEEKAVEYVHRVVERLWDRLMERGKYQLDYVCPRQK

Specific function: Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MTA/SAH deaminase family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=395, Percent_Identity=22.5316455696203, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI87082177, Length=433, Percent_Identity=30.9468822170901, Blast_Score=179, Evalue=4e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.28 [H]

Molecular weight: Translated: 51864; Mature: 51733

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNVLVVTMNDERRIIDHGYIAIRDDRIVDIGAGDGTDKYISEETINGRGMIAIPGLMCA
CCCEEEEEECCCCEEEECCEEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEECCHHHH
HTHFYGLLLTGSPWFSRIEPPTDFQQNLQRIWWALDVELTYEDAYASALMGSILFAKSGV
HHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHEEEEEEEEEHHHHHHHHHHHHHHHHCCH
TNFFDNISSPNAINGVLDYIEKGVSEVGIRGIISYEATQRRSIEEGIRGLKENERFIMKN
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCCCEEEEEC
NSDPNKLVKGAIYLHSSFTVTDELFRMAREMADNHRALIAIHTAEGLVDVYHNIERYGVR
CCCHHHHHEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCC
PVERMKKLGFLRDDVHLVHSVNITEDELYIIRETGAHVAHNPLSNMLNAVGVARVPEMLR
HHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LGINVGIGNDGYVFDQFENMRAAYLIHKLWNRDPRILTPLQVFEMSTINVAKMFHVEDEL
HCCEEECCCCCCEECHHHHHHHHHHHHHHHCCCCCEECCHHHHCCCCCCHHHEEEEHHHH
GSIEKGKKADIVLLRPETPSTPVNSQTVLGHMINAFGSKDVDTVIVNGRIILRNHRLTRV
CCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCEEEEECCCCCCC
DEEKAVEYVHRVVERLWDRLMERGKYQLDYVCPRQK
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC
>Mature Secondary Structure 
SNVLVVTMNDERRIIDHGYIAIRDDRIVDIGAGDGTDKYISEETINGRGMIAIPGLMCA
CCEEEEEECCCCEEEECCEEEEECCEEEEECCCCCCCCCCCCCCCCCCEEEEECCHHHH
HTHFYGLLLTGSPWFSRIEPPTDFQQNLQRIWWALDVELTYEDAYASALMGSILFAKSGV
HHHEEEEEEECCCCCCCCCCCCCHHHHHHHHHEEEEEEEEEHHHHHHHHHHHHHHHHCCH
TNFFDNISSPNAINGVLDYIEKGVSEVGIRGIISYEATQRRSIEEGIRGLKENERFIMKN
HHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHCCCCCCEEEEEC
NSDPNKLVKGAIYLHSSFTVTDELFRMAREMADNHRALIAIHTAEGLVDVYHNIERYGVR
CCCHHHHHEEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHCCC
PVERMKKLGFLRDDVHLVHSVNITEDELYIIRETGAHVAHNPLSNMLNAVGVARVPEMLR
HHHHHHHCCCCCCCEEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
LGINVGIGNDGYVFDQFENMRAAYLIHKLWNRDPRILTPLQVFEMSTINVAKMFHVEDEL
HCCEEECCCCCCEECHHHHHHHHHHHHHHHCCCCCEECCHHHHCCCCCCHHHEEEEHHHH
GSIEKGKKADIVLLRPETPSTPVNSQTVLGHMINAFGSKDVDTVIVNGRIILRNHRLTRV
CCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEECCEEEEECCCCCCC
DEEKAVEYVHRVVERLWDRLMERGKYQLDYVCPRQK
CHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12125824 [H]