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The map label for this gene is degS [H]

Identifier: 218532599

GI number: 218532599

Start: 4997231

End: 4998445

Strand: Reverse

Name: degS [H]

Synonym: Mchl_4713

Alternate gene names: 218532599

Gene position: 4998445-4997231 (Counterclockwise)

Preceding gene: 218532605

Following gene: 218532598

Centisome position: 86.51

GC content: 70.53

Gene sequence:

>1215_bases
ATGGATCAGAGCGTGGCGACGGCGGCTGGCTCAGGCCCGCTGACCGCGGACGCGGCGCGCGTCCTCGATGCGGTCGATGC
CCCTGTCCTGGTCGTCGCCCGCTCGGGCAGCATCGCCTACGCCAACGATCCCGCCCGCCTGCTGCTGACGCGGGAGGATC
CGTCCCGGACCCATCTGAGCGGTCATACCTCGCGCAACAGCGAGACCTCGCCGGCCGACAAGCACGCGCTCACAGGCAAA
ATCTCGACGGTGTTTCTGGCCCGAGCCAGAGCGACGCGGACGCCGCTTCCCGGCGTGATCGCGATCAAGCGGGGAAGCGG
GATACGCCGTTACCGCTGCCACGGGTTCCGCCTGAACCGGGAGGGGATCGACCCCCTGGTTCTCCTGCGGCTCCTGCCGA
CGCCGGAGATGCGGTTCAATCTTCAGGCGACCGAGGCGGCGATGCTGCGGCGCGAACTCGCCGCGCGCGAGCGCCACCAG
CGCAGCCAGCAGGCGCTGCTGCGCGAGCGTGACCTCCTGCTGGCCGATTTGCGCAGCAGCGCGCAGGCGCGTCTGCGCGC
CGAACGCGACCGGGACGCGGTCCTCGCCCAACTCTATCGCGCGCATCAAGCCGAGCGGGAGCGTCTGGCCCGGGAACTCC
ACGACGAGGCCGGCCAGCAGCTCGCATGGCTGAAGCTTCAGCTCGACCGCCTGCGGCGCGCGCCCTCGCCGACGCAAGTC
GAGGCGATGCTGAAGCAGGTCGATGCGATCTCGGCTAGCCTGCGGCAGGTCGTTCGCGAGCTGCGCCCGGTCACCCTGAC
CGAACTCGGCCTCATCCTCGCCCTGGGCGGCCTCGTGCGCGAATGGTCCGACCAAAGCGCGATCCCCATCGACTTCCAGC
TTTCGGGAACCACGGTCCGCCTCACGCCGGAGATCGAGGTGACGATCTTTCGGCTGGTGCAGGAAGCCCTCACCAACGTC
GTCAAGCACGCGCCGGGGGCGCGCCACGTCTCCGTGACCCTGCAATACGCCAGCACGGGCGTCACCCTGGCGATCGAGGA
CGACGGGCCCGGACTCGCCTGCGAGCAGGCGCACGAGGCGCGGCGGGCGGGCGGCGGCTTCGGACTCGCGGGCATGCGCG
AGCGGCTGACCCTGCTCGGAGGAACGCTCATGATCGAATCGCCTCCCGGCGGCGGGACGACGATTCTGGCGCGATTGCCG
CTGACAGGGGGATGA

Upstream 100 bases:

>100_bases
TGCCGAACGTTCTTGACACGCTTATCGCGCCCTCGCCGGCCCCACGGAACAACACGCGTGGCCGCACGGAGGCGGTGACG
TGTCCGGGGGGGCCTCGTCG

Downstream 100 bases:

>100_bases
GATGCGAATGGCGAAAGAACGGGTCAGGGTCGCCCTGATCGACGACCACCCAATCTTCAGAAGCGGGGTCCGCGGCCTGC
TCGGCGAGACCGCCGGCATC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MDQSVATAAGSGPLTADAARVLDAVDAPVLVVARSGSIAYANDPARLLLTREDPSRTHLSGHTSRNSETSPADKHALTGK
ISTVFLARARATRTPLPGVIAIKRGSGIRRYRCHGFRLNREGIDPLVLLRLLPTPEMRFNLQATEAAMLRRELAARERHQ
RSQQALLRERDLLLADLRSSAQARLRAERDRDAVLAQLYRAHQAERERLARELHDEAGQQLAWLKLQLDRLRRAPSPTQV
EAMLKQVDAISASLRQVVRELRPVTLTELGLILALGGLVREWSDQSAIPIDFQLSGTTVRLTPEIEVTIFRLVQEALTNV
VKHAPGARHVSVTLQYASTGVTLAIEDDGPGLACEQAHEARRAGGGFGLAGMRERLTLLGGTLMIESPPGGGTTILARLP
LTGG

Sequences:

>Translated_404_residues
MDQSVATAAGSGPLTADAARVLDAVDAPVLVVARSGSIAYANDPARLLLTREDPSRTHLSGHTSRNSETSPADKHALTGK
ISTVFLARARATRTPLPGVIAIKRGSGIRRYRCHGFRLNREGIDPLVLLRLLPTPEMRFNLQATEAAMLRRELAARERHQ
RSQQALLRERDLLLADLRSSAQARLRAERDRDAVLAQLYRAHQAERERLARELHDEAGQQLAWLKLQLDRLRRAPSPTQV
EAMLKQVDAISASLRQVVRELRPVTLTELGLILALGGLVREWSDQSAIPIDFQLSGTTVRLTPEIEVTIFRLVQEALTNV
VKHAPGARHVSVTLQYASTGVTLAIEDDGPGLACEQAHEARRAGGGFGLAGMRERLTLLGGTLMIESPPGGGTTILARLP
LTGG
>Mature_404_residues
MDQSVATAAGSGPLTADAARVLDAVDAPVLVVARSGSIAYANDPARLLLTREDPSRTHLSGHTSRNSETSPADKHALTGK
ISTVFLARARATRTPLPGVIAIKRGSGIRRYRCHGFRLNREGIDPLVLLRLLPTPEMRFNLQATEAAMLRRELAARERHQ
RSQQALLRERDLLLADLRSSAQARLRAERDRDAVLAQLYRAHQAERERLARELHDEAGQQLAWLKLQLDRLRRAPSPTQV
EAMLKQVDAISASLRQVVRELRPVTLTELGLILALGGLVREWSDQSAIPIDFQLSGTTVRLTPEIEVTIFRLVQEALTNV
VKHAPGARHVSVTLQYASTGVTLAIEDDGPGLACEQAHEARRAGGGFGLAGMRERLTLLGGTLMIESPPGGGTTILARLP
LTGG

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788812, Length=198, Percent_Identity=32.3232323232323, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87082311, Length=233, Percent_Identity=33.0472103004292, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1787474, Length=201, Percent_Identity=30.8457711442786, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43971; Mature: 43971

Theoretical pI: Translated: 10.76; Mature: 10.76

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQSVATAAGSGPLTADAARVLDAVDAPVLVVARSGSIAYANDPARLLLTREDPSRTHLS
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCEEEECCCEEEEEECCCCCCCCCC
GHTSRNSETSPADKHALTGKISTVFLARARATRTPLPGVIAIKRGSGIRRYRCHGFRLNR
CCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCEEECC
EGIDPLVLLRLLPTPEMRFNLQATEAAMLRRELAARERHQRSQQALLRERDLLLADLRSS
CCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQARLRAERDRDAVLAQLYRAHQAERERLARELHDEAGQQLAWLKLQLDRLRRAPSPTQV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHCCCCCHHH
EAMLKQVDAISASLRQVVRELRPVTLTELGLILALGGLVREWSDQSAIPIDFQLSGTTVR
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEE
LTPEIEVTIFRLVQEALTNVVKHAPGARHVSVTLQYASTGVTLAIEDDGPGLACEQAHEA
ECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEEEECCCCCCCHHHHHHH
RRAGGGFGLAGMRERLTLLGGTLMIESPPGGGTTILARLPLTGG
HHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MDQSVATAAGSGPLTADAARVLDAVDAPVLVVARSGSIAYANDPARLLLTREDPSRTHLS
CCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEEEECCCEEEECCCEEEEEECCCCCCCCCC
GHTSRNSETSPADKHALTGKISTVFLARARATRTPLPGVIAIKRGSGIRRYRCHGFRLNR
CCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEECCEEECC
EGIDPLVLLRLLPTPEMRFNLQATEAAMLRRELAARERHQRSQQALLRERDLLLADLRSS
CCCCHHHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQARLRAERDRDAVLAQLYRAHQAERERLARELHDEAGQQLAWLKLQLDRLRRAPSPTQV
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEHHHHHHHHHHHCCCCCHHH
EAMLKQVDAISASLRQVVRELRPVTLTELGLILALGGLVREWSDQSAIPIDFQLSGTTVR
HHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCEEE
LTPEIEVTIFRLVQEALTNVVKHAPGARHVSVTLQYASTGVTLAIEDDGPGLACEQAHEA
ECCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCCEEEEEECCCCCCCHHHHHHH
RRAGGGFGLAGMRERLTLLGGTLMIESPPGGGTTILARLPLTGG
HHCCCCCCHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]