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The map label for this gene is degU [H]

Identifier: 218532598

GI number: 218532598

Start: 4996519

End: 4997229

Strand: Reverse

Name: degU [H]

Synonym: Mchl_4712

Alternate gene names: 218532598

Gene position: 4997229-4996519 (Counterclockwise)

Preceding gene: 218532599

Following gene: 218532596

Centisome position: 86.49

GC content: 68.07

Gene sequence:

>711_bases
ATGCGAATGGCGAAAGAACGGGTCAGGGTCGCCCTGATCGACGACCACCCAATCTTCAGAAGCGGGGTCCGCGGCCTGCT
CGGCGAGACCGCCGGCATCGAGGTCGTCGGAGAGGCGAGCGACGGCCGGCACGCCCTGGATCTGGTCCTCAGGACCAAGC
CCGACGTCGTCATCATGGATATCACCATGACCGGCATGAGCGGCCTTGCGGTGGCGCGTGCGCTCCGGGAAGTGGGCTCC
GCGGTGCACATCGTGTTCCTGACGGTCAACGAAGACCTCGCCTTCGTCGACGAGGCGCTGACCGCGGGGGCCCAGGGCTA
TGTCCTGAAGCGTTCCGCCGGCACCAGCCTGCTGGAGGCCATCGAAGCGGTCGTCTTGGGCGGCCAGTACGTCGATGCCG
AAATGCGCGCGCCGCCTGCGCCGCCCGACCGTACGGAAGCCGGCCCGCCCGCTCCGCATCCCGGCCAGGAGGGCGGCCTC
ACCGCACGGGAGCGCGAGGTGCTCCGGCTCATCGCGCTGGGCATGACGATGAAAGAGGTCAGTCTCGCCATGTCGATCTC
GGCGGCCTCGGTCGACACCTACAAGATCCGCGGCTGCAAGAAGCTCGGCCTTCGGTCCCGCGCCAGCATCGTCCGCTTCG
CGCTCGGGCAAGGCTGGCTCGAGACCGAGAACAGACGCTTGTCGTCGGAGCGGCCACCATCACTGATGTGA

Upstream 100 bases:

>100_bases
CGCGAGCGGCTGACCCTGCTCGGAGGAACGCTCATGATCGAATCGCCTCCCGGCGGCGGGACGACGATTCTGGCGCGATT
GCCGCTGACAGGGGGATGAG

Downstream 100 bases:

>100_bases
GTCTGATCGAGAACCGGCGTTTCGTTTGCGTAGGAGTTGAAACCATCCCATGAGCGGCGCACCCGATCACCTCGTGCGTT
TCATGCGGCACGAAGCGGAC

Product: LuxR family transcriptional regulator

Products: NA

Alternate protein names: Protease production enhancer protein [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MRMAKERVRVALIDDHPIFRSGVRGLLGETAGIEVVGEASDGRHALDLVLRTKPDVVIMDITMTGMSGLAVARALREVGS
AVHIVFLTVNEDLAFVDEALTAGAQGYVLKRSAGTSLLEAIEAVVLGGQYVDAEMRAPPAPPDRTEAGPPAPHPGQEGGL
TAREREVLRLIALGMTMKEVSLAMSISAASVDTYKIRGCKKLGLRSRASIVRFALGQGWLETENRRLSSERPPSLM

Sequences:

>Translated_236_residues
MRMAKERVRVALIDDHPIFRSGVRGLLGETAGIEVVGEASDGRHALDLVLRTKPDVVIMDITMTGMSGLAVARALREVGS
AVHIVFLTVNEDLAFVDEALTAGAQGYVLKRSAGTSLLEAIEAVVLGGQYVDAEMRAPPAPPDRTEAGPPAPHPGQEGGL
TAREREVLRLIALGMTMKEVSLAMSISAASVDTYKIRGCKKLGLRSRASIVRFALGQGWLETENRRLSSERPPSLM
>Mature_236_residues
MRMAKERVRVALIDDHPIFRSGVRGLLGETAGIEVVGEASDGRHALDLVLRTKPDVVIMDITMTGMSGLAVARALREVGS
AVHIVFLTVNEDLAFVDEALTAGAQGYVLKRSAGTSLLEAIEAVVLGGQYVDAEMRAPPAPPDRTEAGPPAPHPGQEGGL
TAREREVLRLIALGMTMKEVSLAMSISAASVDTYKIRGCKKLGLRSRASIVRFALGQGWLETENRRLSSERPPSLM

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=218, Percent_Identity=36.697247706422, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1788222, Length=227, Percent_Identity=31.2775330396476, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1790102, Length=212, Percent_Identity=32.5471698113208, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1786747, Length=206, Percent_Identity=26.2135922330097, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788712, Length=203, Percent_Identity=30.0492610837438, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1787473, Length=198, Percent_Identity=32.8282828282828, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1788546, Length=211, Percent_Identity=26.0663507109005, Blast_Score=72, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25266; Mature: 25266

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMAKERVRVALIDDHPIFRSGVRGLLGETAGIEVVGEASDGRHALDLVLRTKPDVVIMD
CCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCEEEEE
ITMTGMSGLAVARALREVGSAVHIVFLTVNEDLAFVDEALTAGAQGYVLKRSAGTSLLEA
EEECCCHHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHCCCCCEEEECCCCHHHHHH
IEAVVLGGQYVDAEMRAPPAPPDRTEAGPPAPHPGQEGGLTAREREVLRLIALGMTMKEV
HHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHH
SLAMSISAASVDTYKIRGCKKLGLRSRASIVRFALGQGWLETENRRLSSERPPSLM
HHHHEECCCCCCEEEECCHHHHCCCHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRMAKERVRVALIDDHPIFRSGVRGLLGETAGIEVVGEASDGRHALDLVLRTKPDVVIMD
CCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEEEEEECCCCEEEEE
ITMTGMSGLAVARALREVGSAVHIVFLTVNEDLAFVDEALTAGAQGYVLKRSAGTSLLEA
EEECCCHHHHHHHHHHHHCCEEEEEEEEECCCHHHHHHHHHCCCCCEEEECCCCHHHHHH
IEAVVLGGQYVDAEMRAPPAPPDRTEAGPPAPHPGQEGGLTAREREVLRLIALGMTMKEV
HHHHHHCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHH
SLAMSISAASVDTYKIRGCKKLGLRSRASIVRFALGQGWLETENRRLSSERPPSLM
HHHHEECCCCCCEEEECCHHHHCCCHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3136143; 3141378; 3141377; 9384377 [H]