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The map label for this gene is pyrC [H]

Identifier: 218532558

GI number: 218532558

Start: 4952761

End: 4954098

Strand: Reverse

Name: pyrC [H]

Synonym: Mchl_4672

Alternate gene names: 218532558

Gene position: 4954098-4952761 (Counterclockwise)

Preceding gene: 218532565

Following gene: 218532557

Centisome position: 85.74

GC content: 69.96

Gene sequence:

>1338_bases
ATGGAAGCGCCTTTCGACCTCGTCCTGTCCGGCGGCACGCTGGTGAACCAAGACGGCGAGCATCGTGCCGATCTCGGCAT
CCGCGGCGGACGGGTGGCGGCCATCGGCGACCTCTCGGGTGCTTCGGCGCAGGAGCGGCGCGATTGCCGCGGCCTGCACC
TCCTGCCCGGCGTGATCGACAGCCAGGTGCATTTCCGCGAGCCCGGCCTCGACCACAAGGAAGATCTGGAAACGGGCTCG
CGCGCGGCGGTGATGGGCGGCGTCACGGCGGTGTTCGAGATGCCCAACACCAACCCGCAGACCACGAGCGCCGCAGCACT
CGCCGACAAGGTGGCCCGCGCCCACCACCGGATGCATTGCGACTTCGCCTTCTGGGTCGGCGGCACCCATGAGAATGCCG
GCGAGGTCGCCGCGTTGGAGCGGCTGCCTGCTGCTGCCGGAATCAAGGTGTTCATCGGCTCCTCCACCGGCTCGCTGCTG
GTCGAGGACGATGCCGGCGTGCGCGAAATCCTGAAGCGCATCCGTCGCCGCGCCGCCTTCCACTCGGAAGACGAGCCGAT
GCTGCGCGAGCGCAAGGGCCTTCGCGTGCCCGGCGATGCCGCCTCGCACCCGGTCTGGCGCTCGCCGGAGGTGGCGGTGA
AGGCGACGCAGCGGCTGATCGCGCTCGCGCGGGAGACGGGTGCGCGCATCCACATCCTGCACATCTCGACCGCGGACGAG
ATGCCGATTCTGGCCGAGGCCAAGGATGTCGCCAGCGTCGAGGTGACGCCGCACCACCTGACGATCGACGGGACGGAAGC
CTATGCCCGGCTCGGGACGCTGGTGCAGATGAACCCGCCGGTACGCGACGCCGGGCACCGCGACGGGATCTGGCGCGGTC
TGAGCCAGGGCGTGGTCGATGTGCTCGGCTCCGACCACGCGCCGCACACGCTGGAGGAGAAGGCCAAGCCCTATCCCGAT
TCCCCCTCCGGCATGACCGGCGTGCAGACGCTGGTGCCGATCATGCTCGACCATGTGAATGCCGGCCGGCTCTCGCTCGC
CCGGTTCGTCGATCTGACCAGCGCCGGCCCGAAGCGCCTGTTCGGAATCGCCCGCAAGGGGCGGCTCGCCGTGGGCTACG
ATGCCGACGTGACGGTGGTGGACCTCAAGCGCCGCGAGACGATCCGCAACGAATGGATCGCCTCGAAATGCGGCTGGACG
CCCTATGATGGGCTCACCGTCACCGGCTGGCCGGTGGGCACGGTGGTGCGGGGCACGCCGGTGATGTGGCAGGGCGAGTT
GGCCAACCCCGCACGCGGCGAGGCGGTGGTGTTCGAGGAAGCGCTGCCGACGGGGTAG

Upstream 100 bases:

>100_bases
GCATCTCCTTGAAAGGACGGCGGCGTTGCGCGTGTGGGACGCCTGACATAAGCCGCCGCTATCCTCGTCTCAATCGCACC
ATGCGAACCGGGAGAGCCCG

Downstream 100 bases:

>100_bases
CGCCGCGCCGGGATATCCTATCCGGCGGCAGGCTTTTCGCGAGCCTCCCGCCTGTAAGCCGTTCACTACGAACGGTTGCC
CTGCACCGTTTGGGACGCTC

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MEAPFDLVLSGGTLVNQDGEHRADLGIRGGRVAAIGDLSGASAQERRDCRGLHLLPGVIDSQVHFREPGLDHKEDLETGS
RAAVMGGVTAVFEMPNTNPQTTSAAALADKVARAHHRMHCDFAFWVGGTHENAGEVAALERLPAAAGIKVFIGSSTGSLL
VEDDAGVREILKRIRRRAAFHSEDEPMLRERKGLRVPGDAASHPVWRSPEVAVKATQRLIALARETGARIHILHISTADE
MPILAEAKDVASVEVTPHHLTIDGTEAYARLGTLVQMNPPVRDAGHRDGIWRGLSQGVVDVLGSDHAPHTLEEKAKPYPD
SPSGMTGVQTLVPIMLDHVNAGRLSLARFVDLTSAGPKRLFGIARKGRLAVGYDADVTVVDLKRRETIRNEWIASKCGWT
PYDGLTVTGWPVGTVVRGTPVMWQGELANPARGEAVVFEEALPTG

Sequences:

>Translated_445_residues
MEAPFDLVLSGGTLVNQDGEHRADLGIRGGRVAAIGDLSGASAQERRDCRGLHLLPGVIDSQVHFREPGLDHKEDLETGS
RAAVMGGVTAVFEMPNTNPQTTSAAALADKVARAHHRMHCDFAFWVGGTHENAGEVAALERLPAAAGIKVFIGSSTGSLL
VEDDAGVREILKRIRRRAAFHSEDEPMLRERKGLRVPGDAASHPVWRSPEVAVKATQRLIALARETGARIHILHISTADE
MPILAEAKDVASVEVTPHHLTIDGTEAYARLGTLVQMNPPVRDAGHRDGIWRGLSQGVVDVLGSDHAPHTLEEKAKPYPD
SPSGMTGVQTLVPIMLDHVNAGRLSLARFVDLTSAGPKRLFGIARKGRLAVGYDADVTVVDLKRRETIRNEWIASKCGWT
PYDGLTVTGWPVGTVVRGTPVMWQGELANPARGEAVVFEEALPTG
>Mature_445_residues
MEAPFDLVLSGGTLVNQDGEHRADLGIRGGRVAAIGDLSGASAQERRDCRGLHLLPGVIDSQVHFREPGLDHKEDLETGS
RAAVMGGVTAVFEMPNTNPQTTSAAALADKVARAHHRMHCDFAFWVGGTHENAGEVAALERLPAAAGIKVFIGSSTGSLL
VEDDAGVREILKRIRRRAAFHSEDEPMLRERKGLRVPGDAASHPVWRSPEVAVKATQRLIALARETGARIHILHISTADE
MPILAEAKDVASVEVTPHHLTIDGTEAYARLGTLVQMNPPVRDAGHRDGIWRGLSQGVVDVLGSDHAPHTLEEKAKPYPD
SPSGMTGVQTLVPIMLDHVNAGRLSLARFVDLTSAGPKRLFGIARKGRLAVGYDADVTVVDLKRRETIRNEWIASKCGWT
PYDGLTVTGWPVGTVVRGTPVMWQGELANPARGEAVVFEEALPTG

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=400, Percent_Identity=32.5, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI19923821, Length=447, Percent_Identity=26.8456375838926, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI4503377, Length=449, Percent_Identity=25.8351893095768, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4503375, Length=460, Percent_Identity=26.304347826087, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4503379, Length=446, Percent_Identity=24.2152466367713, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI4503051, Length=449, Percent_Identity=24.2761692650334, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI62422571, Length=449, Percent_Identity=24.2761692650334, Blast_Score=112, Evalue=9e-25,
Organism=Homo sapiens, GI190194363, Length=453, Percent_Identity=25.3863134657837, Blast_Score=108, Evalue=9e-24,
Organism=Escherichia coli, GI1786722, Length=438, Percent_Identity=30.365296803653, Blast_Score=189, Evalue=2e-49,
Organism=Escherichia coli, GI87082175, Length=450, Percent_Identity=28.4444444444444, Blast_Score=162, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI193204318, Length=402, Percent_Identity=29.1044776119403, Blast_Score=157, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI71989490, Length=460, Percent_Identity=25.4347826086956, Blast_Score=124, Evalue=9e-29,
Organism=Caenorhabditis elegans, GI17539558, Length=447, Percent_Identity=23.7136465324385, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI86575075, Length=444, Percent_Identity=24.7747747747748, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=394, Percent_Identity=29.1878172588832, Blast_Score=140, Evalue=6e-34,
Organism=Drosophila melanogaster, GI24642586, Length=400, Percent_Identity=31.25, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI18859883, Length=419, Percent_Identity=28.4009546539379, Blast_Score=123, Evalue=3e-28,
Organism=Drosophila melanogaster, GI221377917, Length=450, Percent_Identity=24.4444444444444, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI17137462, Length=444, Percent_Identity=24.0990990990991, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI24644287, Length=259, Percent_Identity=23.5521235521236, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47836; Mature: 47836

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAPFDLVLSGGTLVNQDGEHRADLGIRGGRVAAIGDLSGASAQERRDCRGLHLLPGVID
CCCCCEEEEECCEEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHCCCCEECCCHHC
SQVHFREPGLDHKEDLETGSRAAVMGGVTAVFEMPNTNPQTTSAAALADKVARAHHRMHC
CCEEECCCCCCCHHHHCCCCCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
DFAFWVGGTHENAGEVAALERLPAAAGIKVFIGSSTGSLLVEDDAGVREILKRIRRRAAF
EEEEEECCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHC
HSEDEPMLRERKGLRVPGDAASHPVWRSPEVAVKATQRLIALARETGARIHILHISTADE
CCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
MPILAEAKDVASVEVTPHHLTIDGTEAYARLGTLVQMNPPVRDAGHRDGIWRGLSQGVVD
CCEEECCCCCEEEEECCCEEEECCHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHH
VLGSDHAPHTLEEKAKPYPDSPSGMTGVQTLVPIMLDHVNAGRLSLARFVDLTSAGPKRL
HHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHH
FGIARKGRLAVGYDADVTVVDLKRRETIRNEWIASKCGWTPYDGLTVTGWPVGTVVRGTP
HHHHCCCCEEECCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCC
VMWQGELANPARGEAVVFEEALPTG
EEEECCCCCCCCCCEEEEECCCCCC
>Mature Secondary Structure
MEAPFDLVLSGGTLVNQDGEHRADLGIRGGRVAAIGDLSGASAQERRDCRGLHLLPGVID
CCCCCEEEEECCEEECCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHCCCCEECCCHHC
SQVHFREPGLDHKEDLETGSRAAVMGGVTAVFEMPNTNPQTTSAAALADKVARAHHRMHC
CCEEECCCCCCCHHHHCCCCCEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCC
DFAFWVGGTHENAGEVAALERLPAAAGIKVFIGSSTGSLLVEDDAGVREILKRIRRRAAF
EEEEEECCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHHHHHHC
HSEDEPMLRERKGLRVPGDAASHPVWRSPEVAVKATQRLIALARETGARIHILHISTADE
CCCCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCC
MPILAEAKDVASVEVTPHHLTIDGTEAYARLGTLVQMNPPVRDAGHRDGIWRGLSQGVVD
CCEEECCCCCEEEEECCCEEEECCHHHHHHHCCEEEECCCCCCCCCCCHHHHHHHHHHHH
VLGSDHAPHTLEEKAKPYPDSPSGMTGVQTLVPIMLDHVNAGRLSLARFVDLTSAGPKRL
HHCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHH
FGIARKGRLAVGYDADVTVVDLKRRETIRNEWIASKCGWTPYDGLTVTGWPVGTVVRGTP
HHHHCCCCEEECCCCCEEEEECHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCC
VMWQGELANPARGEAVVFEEALPTG
EEEECCCCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]