Click here to switch to the map view.

The map label for this gene is ubiB [H]

Identifier: 218532184

GI number: 218532184

Start: 4536792

End: 4538357

Strand: Reverse

Name: ubiB [H]

Synonym: Mchl_4296

Alternate gene names: 218532184

Gene position: 4538357-4536792 (Counterclockwise)

Preceding gene: 218532185

Following gene: 218532183

Centisome position: 78.55

GC content: 70.69

Gene sequence:

>1566_bases
ATGATGCTCGGCGCCGTCTTCTACCTCGCCCGCGGCGCCCATGTCGGCTTCGTGCTCGCCCGTGAGGGCGGGCTGGCGCT
GATCGATGCGGCGCAATTGCCGCCGCATCTGCGGCTCGCGCTCAAGCTCGGCCGCTCGCTGGAGCGGCGCGGCATTGCGG
AGGCCCCCGGCGCGAGCCCGCTGGAGCGGGCGCTGACCCGGCTCGGTCCCTCCTACGTCAAGTTCGGCCAGTTCCTGGCA
ACCCGCCCCGACATCGTCGGCATGGCCGCCGCGCGCGATCTGGAGCGGCTTCAGGACCGGGTTCCGCCCTTCCCGCAGGG
GGTGGCGCTGCGCGTGGTCGAGGGGGAACTCGGCAAGCCGGTCCCGGCGCTGTTCACCGCCTTCAGCGAGCCGGTGGCCG
CGGCCTCCATCGCTCAGGTCCACAAGGCGACGGTGCTCGATGCCGACGGCACGCAGCGCACGCTCGCGGTCAAGGTGATG
CGGCCCGGCGTGCGCGAGCGCTTCGCGCGCGACATCCAGGCGATGCGGTTCATGGCCCGCATCGTCAACGCGCTCCTGCC
CGATGCCGAGCGGCTGCGTCCGCGGGAGGTGGTCGAGATCCTGGCCCGCTCCGTCACCATGGAGATGGACCTTCGCCTCG
AAGCGGCGGCGATGTCGGAACTCGCACAGAACACCGCGGGCGACGCGGATTTCCGCACGCCGCGCCCCGAATGGGCCCTG
ACCTCGCGGGACGTGCTGACGAGCGAGTGGATCGACGGCGTGCGCCTCAACGACCGCCCCGGCATCGTCGCGGCGGGCCA
CGACCCGAAGGCGCTCGGCCGCACGGTGATCCAGTCCTTCCTACGACAGGCGATCCGCGACGGCTTCTTCCACGCCGACA
TGCATCCGGGGAACCTGTTCGTCGATCCGCAGGGGCGGCTCGTCGCGGTCGATTTCGGCATCATGGGCCGGCTCGGCCAT
GCCGAGCGGCGCTTCCTCGCCGAGATCCTGCTCGGCTTCATCACCCGCGACTATCGCCGCGTCGCCCAGGTGCATTTCGA
GGCGGGCTACGTGCCGCGCCACCATTCGGTGGATGATTTCGCGCAGGCCATCCGGGCGATCGGCGAGCCGATCCACCAGC
GCCGGGCCGACGAGATCTCGATGGCCAAGGTGCTCACGCTCTTGTTCGACGTGACCGCCCTGTTCGACATGAGCACCCGC
ACCGAGCTGGTGATGCTGCAGAAGACCATGGTGGTGGTGGAGGGCGTCGCCCGCTCGCTCGATCCGCAGCTCGACATGTG
GACCGGCGCCGAACCGGTCGTGCGCTCATGGATCACCCGCCATCTCGGCCCTGTCGGCCGGATCGAGGGCGGCGCCCGTG
CGGCGCTGACCCTCGCCGAGGTCGTCTCCGACATCCCCGACATCGCCCAGCGCATCCGCCGCATCATGATCCGCCTCGAC
GAGGAGGGCTCGCGCGACGTTCAGGTGATAGAGCGGATCGCCCGGCTGGAACGGCGACGCGCGATCTGGTCGACCCTGGC
CCTGTGGGGGATCGCGGTGGGGGCGCTGGTGCTGGCCTTTCGGTAA

Upstream 100 bases:

>100_bases
ATCGTCTTTTTCCGAAAGCCGGAGGCCACCTTTCGGGACGATGCTCTAGCGTCGGTGATCCGGTGCGATCCCTCTTCGAG
CAAATGCCTGTCAGGGTTCG

Downstream 100 bases:

>100_bases
GAGGCCTTCTCGCACCTTGACGCGCGCCCTACGATTCCCCGTTCTGCCCTCATGTCTTCTCCGTCCCCAAAACCCCTCGC
CGGCCGCCGCATCCTCCTGA

Product: 2-polyprenylphenol 6-hydroxylase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MMLGAVFYLARGAHVGFVLAREGGLALIDAAQLPPHLRLALKLGRSLERRGIAEAPGASPLERALTRLGPSYVKFGQFLA
TRPDIVGMAAARDLERLQDRVPPFPQGVALRVVEGELGKPVPALFTAFSEPVAAASIAQVHKATVLDADGTQRTLAVKVM
RPGVRERFARDIQAMRFMARIVNALLPDAERLRPREVVEILARSVTMEMDLRLEAAAMSELAQNTAGDADFRTPRPEWAL
TSRDVLTSEWIDGVRLNDRPGIVAAGHDPKALGRTVIQSFLRQAIRDGFFHADMHPGNLFVDPQGRLVAVDFGIMGRLGH
AERRFLAEILLGFITRDYRRVAQVHFEAGYVPRHHSVDDFAQAIRAIGEPIHQRRADEISMAKVLTLLFDVTALFDMSTR
TELVMLQKTMVVVEGVARSLDPQLDMWTGAEPVVRSWITRHLGPVGRIEGGARAALTLAEVVSDIPDIAQRIRRIMIRLD
EEGSRDVQVIERIARLERRRAIWSTLALWGIAVGALVLAFR

Sequences:

>Translated_521_residues
MMLGAVFYLARGAHVGFVLAREGGLALIDAAQLPPHLRLALKLGRSLERRGIAEAPGASPLERALTRLGPSYVKFGQFLA
TRPDIVGMAAARDLERLQDRVPPFPQGVALRVVEGELGKPVPALFTAFSEPVAAASIAQVHKATVLDADGTQRTLAVKVM
RPGVRERFARDIQAMRFMARIVNALLPDAERLRPREVVEILARSVTMEMDLRLEAAAMSELAQNTAGDADFRTPRPEWAL
TSRDVLTSEWIDGVRLNDRPGIVAAGHDPKALGRTVIQSFLRQAIRDGFFHADMHPGNLFVDPQGRLVAVDFGIMGRLGH
AERRFLAEILLGFITRDYRRVAQVHFEAGYVPRHHSVDDFAQAIRAIGEPIHQRRADEISMAKVLTLLFDVTALFDMSTR
TELVMLQKTMVVVEGVARSLDPQLDMWTGAEPVVRSWITRHLGPVGRIEGGARAALTLAEVVSDIPDIAQRIRRIMIRLD
EEGSRDVQVIERIARLERRRAIWSTLALWGIAVGALVLAFR
>Mature_521_residues
MMLGAVFYLARGAHVGFVLAREGGLALIDAAQLPPHLRLALKLGRSLERRGIAEAPGASPLERALTRLGPSYVKFGQFLA
TRPDIVGMAAARDLERLQDRVPPFPQGVALRVVEGELGKPVPALFTAFSEPVAAASIAQVHKATVLDADGTQRTLAVKVM
RPGVRERFARDIQAMRFMARIVNALLPDAERLRPREVVEILARSVTMEMDLRLEAAAMSELAQNTAGDADFRTPRPEWAL
TSRDVLTSEWIDGVRLNDRPGIVAAGHDPKALGRTVIQSFLRQAIRDGFFHADMHPGNLFVDPQGRLVAVDFGIMGRLGH
AERRFLAEILLGFITRDYRRVAQVHFEAGYVPRHHSVDDFAQAIRAIGEPIHQRRADEISMAKVLTLLFDVTALFDMSTR
TELVMLQKTMVVVEGVARSLDPQLDMWTGAEPVVRSWITRHLGPVGRIEGGARAALTLAEVVSDIPDIAQRIRRIMIRLD
EEGSRDVQVIERIARLERRRAIWSTLALWGIAVGALVLAFR

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=279, Percent_Identity=27.5985663082437, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI41393593, Length=275, Percent_Identity=31.2727272727273, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI217035081, Length=234, Percent_Identity=28.6324786324786, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI34147522, Length=254, Percent_Identity=27.9527559055118, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI27363457, Length=344, Percent_Identity=26.453488372093, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI217416386, Length=284, Percent_Identity=28.169014084507, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI2367309, Length=414, Percent_Identity=37.9227053140097, Blast_Score=271, Evalue=6e-74,
Organism=Caenorhabditis elegans, GI17559152, Length=286, Percent_Identity=26.9230769230769, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32565180, Length=351, Percent_Identity=24.7863247863248, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325148, Length=448, Percent_Identity=23.6607142857143, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323282, Length=252, Percent_Identity=24.6031746031746, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24662575, Length=308, Percent_Identity=28.5714285714286, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI22024280, Length=281, Percent_Identity=25.9786476868327, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI18859849, Length=306, Percent_Identity=27.7777777777778, Blast_Score=76, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 57652; Mature: 57652

Theoretical pI: Translated: 10.48; Mature: 10.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLGAVFYLARGAHVGFVLAREGGLALIDAAQLPPHLRLALKLGRSLERRGIAEAPGASP
CHHHHHHHHHCCCCEEEEEEECCCEEEEEHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCH
LERALTRLGPSYVKFGQFLATRPDIVGMAAARDLERLQDRVPPFPQGVALRVVEGELGKP
HHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
VPALFTAFSEPVAAASIAQVHKATVLDADGTQRTLAVKVMRPGVRERFARDIQAMRFMAR
HHHHHHHHHCHHHHHHHHHHHHHHEECCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHH
IVNALLPDAERLRPREVVEILARSVTMEMDLRLEAAAMSELAQNTAGDADFRTPRPEWAL
HHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TSRDVLTSEWIDGVRLNDRPGIVAAGHDPKALGRTVIQSFLRQAIRDGFFHADMHPGNLF
CCHHHHHHHHCCCCEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEE
VDPQGRLVAVDFGIMGRLGHAERRFLAEILLGFITRDYRRVAQVHFEAGYVPRHHSVDDF
ECCCCCEEEEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AQAIRAIGEPIHQRRADEISMAKVLTLLFDVTALFDMSTRTELVMLQKTMVVVEGVARSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
DPQLDMWTGAEPVVRSWITRHLGPVGRIEGGARAALTLAEVVSDIPDIAQRIRRIMIRLD
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EEGSRDVQVIERIARLERRRAIWSTLALWGIAVGALVLAFR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMLGAVFYLARGAHVGFVLAREGGLALIDAAQLPPHLRLALKLGRSLERRGIAEAPGASP
CHHHHHHHHHCCCCEEEEEEECCCEEEEEHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCH
LERALTRLGPSYVKFGQFLATRPDIVGMAAARDLERLQDRVPPFPQGVALRVVEGELGKP
HHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCC
VPALFTAFSEPVAAASIAQVHKATVLDADGTQRTLAVKVMRPGVRERFARDIQAMRFMAR
HHHHHHHHHCHHHHHHHHHHHHHHEECCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHH
IVNALLPDAERLRPREVVEILARSVTMEMDLRLEAAAMSELAQNTAGDADFRTPRPEWAL
HHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
TSRDVLTSEWIDGVRLNDRPGIVAAGHDPKALGRTVIQSFLRQAIRDGFFHADMHPGNLF
CCHHHHHHHHCCCCEECCCCCEEECCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCEE
VDPQGRLVAVDFGIMGRLGHAERRFLAEILLGFITRDYRRVAQVHFEAGYVPRHHSVDDF
ECCCCCEEEEECCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
AQAIRAIGEPIHQRRADEISMAKVLTLLFDVTALFDMSTRTELVMLQKTMVVVEGVARSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHC
DPQLDMWTGAEPVVRSWITRHLGPVGRIEGGARAALTLAEVVSDIPDIAQRIRRIMIRLD
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EEGSRDVQVIERIARLERRRAIWSTLALWGIAVGALVLAFR
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA