Click here to switch to the map view.

The map label for this gene is ubiE [H]

Identifier: 218532185

GI number: 218532185

Start: 4538581

End: 4539360

Strand: Reverse

Name: ubiE [H]

Synonym: Mchl_4297

Alternate gene names: 218532185

Gene position: 4539360-4538581 (Counterclockwise)

Preceding gene: 218532186

Following gene: 218532184

Centisome position: 78.56

GC content: 66.92

Gene sequence:

>780_bases
ATGAGCGGAACGGACATCGGAGCCGGCGACAGCGAAGCCACCGCCGATTTCGGCTACGAGCGCGTGCGGCTTTCCGAGAA
GCAGGCCAAGGTGGACGACGTGTTCCGCTCGGTCGCGCGCCGCTACGACCTGATGAACGACCTGATGTCGGGCGGTCTGC
ACCGGGTCTGGAAGTCGCACCTGATCTCGATGCTGCGCCCGTCGCGCACCCGGCCCTACCAGCATCTCGATGTCGCGGGC
GGCACCGGCGACATCGCCTTCCGCACCCTCGAAGCGGGCGGCCCCGAGACCCATGTCACCGTGCTCGATATCAACGAGGC
GATGCTGCGGGTCGGCGCCGAGCGGGCGGGCCACAAGTACGACGGCCGCATCGATTTCGTCACCGGCAATGCCGAGACGC
TGCCGCTGCCGTCGAACCATTTCGACAGCTACACCATCGCCTTCGGCATCCGGAACGTGCCGCGCATCGACGTGGCCCTG
CGCGAGGCGCACCGGGTGCTCAAGCCCGGCGGGCGCTTCCTCTGCCTGGAATTCTCGCGGGTCGACCTGCCGGTGCTGGA
GAAGATCTACGACGCCTACTCCTTCCACGTGATTCCGCGCATCGGCGAGCGGGTGGCGGGCGACCGCGAATCCTACCAGT
ACCTCGTCGAGTCGATCCGCAAGTTCCCCTCCCCCGACAGCTTCGCCCGGATGATCGAGACGGCGGGCTTCAGCCATGTC
AGCCATCGCCGGCTCTCGGGCGGCATCGTCGCGATCCATTCCGGCTGGAAGATTTCTTGA

Upstream 100 bases:

>100_bases
GCCTGCATCCCCGCTGCCGCATGGCGGTTCCAGCCGGCATTCGCTAAGGAGGCTCGGCCGACGCCGTGAGCGGCGACGGG
CGAGCGCAGGGTATGATCGG

Downstream 100 bases:

>100_bases
TTTCTTTCCGATCGCGATCGCTGACGGGCACCTCGGCAGGGCCGGGCCCCGCGGCGCAGGGCACGCCTAGAGCATCGTCC
CGGATATCGGATCCGGGACG

Product: ubiquinone/menaquinone biosynthesis methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 258

Protein sequence:

>259_residues
MSGTDIGAGDSEATADFGYERVRLSEKQAKVDDVFRSVARRYDLMNDLMSGGLHRVWKSHLISMLRPSRTRPYQHLDVAG
GTGDIAFRTLEAGGPETHVTVLDINEAMLRVGAERAGHKYDGRIDFVTGNAETLPLPSNHFDSYTIAFGIRNVPRIDVAL
REAHRVLKPGGRFLCLEFSRVDLPVLEKIYDAYSFHVIPRIGERVAGDRESYQYLVESIRKFPSPDSFARMIETAGFSHV
SHRRLSGGIVAIHSGWKIS

Sequences:

>Translated_259_residues
MSGTDIGAGDSEATADFGYERVRLSEKQAKVDDVFRSVARRYDLMNDLMSGGLHRVWKSHLISMLRPSRTRPYQHLDVAG
GTGDIAFRTLEAGGPETHVTVLDINEAMLRVGAERAGHKYDGRIDFVTGNAETLPLPSNHFDSYTIAFGIRNVPRIDVAL
REAHRVLKPGGRFLCLEFSRVDLPVLEKIYDAYSFHVIPRIGERVAGDRESYQYLVESIRKFPSPDSFARMIETAGFSHV
SHRRLSGGIVAIHSGWKIS
>Mature_258_residues
SGTDIGAGDSEATADFGYERVRLSEKQAKVDDVFRSVARRYDLMNDLMSGGLHRVWKSHLISMLRPSRTRPYQHLDVAGG
TGDIAFRTLEAGGPETHVTVLDINEAMLRVGAERAGHKYDGRIDFVTGNAETLPLPSNHFDSYTIAFGIRNVPRIDVALR
EAHRVLKPGGRFLCLEFSRVDLPVLEKIYDAYSFHVIPRIGERVAGDRESYQYLVESIRKFPSPDSFARMIETAGFSHVS
HRRLSGGIVAIHSGWKIS

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) [H]

COG id: COG2226

COG function: function code H; Methylase involved in ubiquinone/menaquinone biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI116063536, Length=280, Percent_Identity=51.0714285714286, Blast_Score=262, Evalue=3e-70,
Organism=Escherichia coli, GI48994983, Length=249, Percent_Identity=47.7911646586345, Blast_Score=227, Evalue=6e-61,
Organism=Caenorhabditis elegans, GI17557039, Length=246, Percent_Identity=52.0325203252033, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6323526, Length=256, Percent_Identity=47.265625, Blast_Score=220, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24641702, Length=271, Percent_Identity=48.7084870848708, Blast_Score=251, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.-

Molecular weight: Translated: 28930; Mature: 28799

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS01183 UBIE_1 ; PS01184 UBIE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGTDIGAGDSEATADFGYERVRLSEKQAKVDDVFRSVARRYDLMNDLMSGGLHRVWKSH
CCCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
LISMLRPSRTRPYQHLDVAGGTGDIAFRTLEAGGPETHVTVLDINEAMLRVGAERAGHKY
HHHHHCCCCCCCCCEEEECCCCCCEEEEEECCCCCCEEEEEEECHHHHHHHHHHHCCCCC
DGRIDFVTGNAETLPLPSNHFDSYTIAFGIRNVPRIDVALREAHRVLKPGGRFLCLEFSR
CCEEEEEECCCEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECC
VDLPVLEKIYDAYSFHVIPRIGERVAGDRESYQYLVESIRKFPSPDSFARMIETAGFSHV
CCHHHHHHHHHHHHEEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
SHRRLSGGIVAIHSGWKIS
HHHHCCCCEEEEECCCCCC
>Mature Secondary Structure 
SGTDIGAGDSEATADFGYERVRLSEKQAKVDDVFRSVARRYDLMNDLMSGGLHRVWKSH
CCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHH
LISMLRPSRTRPYQHLDVAGGTGDIAFRTLEAGGPETHVTVLDINEAMLRVGAERAGHKY
HHHHHCCCCCCCCCEEEECCCCCCEEEEEECCCCCCEEEEEEECHHHHHHHHHHHCCCCC
DGRIDFVTGNAETLPLPSNHFDSYTIAFGIRNVPRIDVALREAHRVLKPGGRFLCLEFSR
CCEEEEEECCCEECCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECC
VDLPVLEKIYDAYSFHVIPRIGERVAGDRESYQYLVESIRKFPSPDSFARMIETAGFSHV
CCHHHHHHHHHHHHEEEHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCHHH
SHRRLSGGIVAIHSGWKIS
HHHHCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA