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The map label for this gene is groL [H]

Identifier: 218531590

GI number: 218531590

Start: 3852584

End: 3854206

Strand: Reverse

Name: groL [H]

Synonym: Mchl_3659

Alternate gene names: 218531590

Gene position: 3854206-3852584 (Counterclockwise)

Preceding gene: 218531591

Following gene: 218531589

Centisome position: 66.71

GC content: 66.91

Gene sequence:

>1623_bases
ATGGCTGCCAAGGACGTGAAATTCTCGGGTGATGCGCGCGAGCGCCTGTTACGCGGCGTCGATATTCTGGCGGATGCCGT
GAAGGTGACGCTGGGGCCGAAGGGCCGCAACGTCGTGATCGAGAAGAGTTTCGGGGCGCCGCGGATCACCAAGGACGGCG
TCACCGTCGCCAAGGAGATCGAGTTGGAGGACCGCTTCGAGAATCTCGGCGCCCAACTCCTGCGCGAAGTCGCCTCGAAG
ACCAACGATCTGGCCGGCGATGGCACCACGACCGCGACCGTGCTCGCCCAGGCGATCGTCCGCGAGGGCGCCAAGGCGGT
GGCGGCGAACTTCAACCCGCTCGACTTGAAGCGCGGCATCGACCTCGCCACCGCCGCCGCCGTGAAGAACATCACCGCCC
GCGCCCGCAAGGTGACCGCCTCCGACGCCATCGCTCAGGTCGGCACAATCTCCGCCAACGGCGACGCCGAGATCGGCCGC
CTCATCGCCGAGGCCGTCGAGCGGGTCGGCAAGGAAGGCGTCATCACGGTGGAGGAGGCCAAGACCGCCGAGACCGAACT
CGATGTCGTAGAGGGCCTGCAATTCGACCGCGGCTATCTCTCGCCGTACTTCGTGACGAACACGGAAAAGCTGATCGCCG
AACTCGACGATCCCTACATCCTGATCCACGAGAAGAAGCTCTCCTCGCTGCAGCCGCTGCTGCCGGTGCTGGAGGCGGTC
GTCCAGTCGAGCCGTCCCCTGCTCATCATCGCCGAGGATGTGGAGGGCGAGGCGCTCGCCACCCTCGTCGTGAACAAGCT
GCGCGGCGGCCTCAAGATCGCGGCGGTGAAGGCTCCGGGCTTCGGCGACCGTCGCAAGGCGATTCTTGAGGACATCGCGA
TCCTCACCAACGGCCAGACCATCTCCGAGGATCTCGGGATCAAGCTCGAGAACGTGTCGCTTCCCCTGCTGGGTCAGGCC
AAGCGGGTGCGCATCGACAAGGAGAGCACCACGATTGTCGACGGAGCGGGGGACAGGGCGCAGATCGACGCGCGCGTCGC
CCAGATCAAGGCGCAGATCGAGGAGACCAGCTCGGACTACGACCGTGAGAAGCTCCAGGAGCGCTTGGCCAAGCTCGCGG
GCGGCGTCGCGGTGATCCGCGTCGGCGGCGCGACCGAGGTCGAGGTCAAGGAGAAGAAGGACCGGGTGGACGACGCGCTC
AACGCCACCCGCGCCGCGATCGAGGAAGGCATCGTTCCGGGCGGCGGCACCGCGCTGCTGCGGGCCAAGGCCGCCGTATC
AGCGCTCAAGAGCGAGAATGCCGATGTGAAGGCCGGCATTAACATCGTGCTCAAGGCGCTCGAAGCGCCGATCCGGCAGA
TCGCGGCCAATGCCGGGGTCGAGGGCTCGATCGTGGTGTCGAAGGTGATCGAGAACGGCTCGGAGACCTTCGGGTTCGAC
GCCCAGACCGAGACCTACGTCGACCTGATCGAGGCCGGCATCGTCGATCCGGCCAAGGTTGTGCGCACGGCACTGCAGGA
CGCGGCCTCGGTCGCCGGCCTGCTGGTGACGACGGAGGCGTTGATCGCCGAGCGGCCGAAGGAGAAGACGCCGCCACTGC
CACCCGGCGGGCCGGACTTCTGA

Upstream 100 bases:

>100_bases
AGGTCGACGGCCAGGACCTCTTGATCCTCAAGGAATCCGACATTCTCGGCGTGATCACCGCCTGAGCAAGCTCTGACGTC
ATCGACAACAGGAGATCGGA

Downstream 100 bases:

>100_bases
TCGCCTGAAGGCCCGAGGTCCGGCGGCGCCGGACCTCGGGCCCCTGGCTGCCGACGGTATTGATGTCCCCTCCCTCATCC
TAAGGTGCCGCGAGGCGATC

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MAAKDVKFSGDARERLLRGVDILADAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELEDRFENLGAQLLREVASK
TNDLAGDGTTTATVLAQAIVREGAKAVAANFNPLDLKRGIDLATAAAVKNITARARKVTASDAIAQVGTISANGDAEIGR
LIAEAVERVGKEGVITVEEAKTAETELDVVEGLQFDRGYLSPYFVTNTEKLIAELDDPYILIHEKKLSSLQPLLPVLEAV
VQSSRPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAILEDIAILTNGQTISEDLGIKLENVSLPLLGQA
KRVRIDKESTTIVDGAGDRAQIDARVAQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDAL
NATRAAIEEGIVPGGGTALLRAKAAVSALKSENADVKAGINIVLKALEAPIRQIAANAGVEGSIVVSKVIENGSETFGFD
AQTETYVDLIEAGIVDPAKVVRTALQDAASVAGLLVTTEALIAERPKEKTPPLPPGGPDF

Sequences:

>Translated_540_residues
MAAKDVKFSGDARERLLRGVDILADAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELEDRFENLGAQLLREVASK
TNDLAGDGTTTATVLAQAIVREGAKAVAANFNPLDLKRGIDLATAAAVKNITARARKVTASDAIAQVGTISANGDAEIGR
LIAEAVERVGKEGVITVEEAKTAETELDVVEGLQFDRGYLSPYFVTNTEKLIAELDDPYILIHEKKLSSLQPLLPVLEAV
VQSSRPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAILEDIAILTNGQTISEDLGIKLENVSLPLLGQA
KRVRIDKESTTIVDGAGDRAQIDARVAQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDAL
NATRAAIEEGIVPGGGTALLRAKAAVSALKSENADVKAGINIVLKALEAPIRQIAANAGVEGSIVVSKVIENGSETFGFD
AQTETYVDLIEAGIVDPAKVVRTALQDAASVAGLLVTTEALIAERPKEKTPPLPPGGPDF
>Mature_539_residues
AAKDVKFSGDARERLLRGVDILADAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEIELEDRFENLGAQLLREVASKT
NDLAGDGTTTATVLAQAIVREGAKAVAANFNPLDLKRGIDLATAAAVKNITARARKVTASDAIAQVGTISANGDAEIGRL
IAEAVERVGKEGVITVEEAKTAETELDVVEGLQFDRGYLSPYFVTNTEKLIAELDDPYILIHEKKLSSLQPLLPVLEAVV
QSSRPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAILEDIAILTNGQTISEDLGIKLENVSLPLLGQAK
RVRIDKESTTIVDGAGDRAQIDARVAQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALN
ATRAAIEEGIVPGGGTALLRAKAAVSALKSENADVKAGINIVLKALEAPIRQIAANAGVEGSIVVSKVIENGSETFGFDA
QTETYVDLIEAGIVDPAKVVRTALQDAASVAGLLVTTEALIAERPKEKTPPLPPGGPDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=531, Percent_Identity=53.1073446327684, Blast_Score=562, Evalue=1e-160,
Organism=Homo sapiens, GI31542947, Length=531, Percent_Identity=53.1073446327684, Blast_Score=562, Evalue=1e-160,
Organism=Escherichia coli, GI1790586, Length=533, Percent_Identity=64.1651031894934, Blast_Score=679, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=528, Percent_Identity=52.2727272727273, Blast_Score=548, Evalue=1e-156,
Organism=Caenorhabditis elegans, GI193210679, Length=210, Percent_Identity=54.7619047619048, Blast_Score=228, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=54.9429657794677, Blast_Score=572, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=55.2182163187856, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=55.2182163187856, Blast_Score=570, Evalue=1e-163,
Organism=Drosophila melanogaster, GI45550936, Length=529, Percent_Identity=51.4177693761815, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550132, Length=529, Percent_Identity=51.4177693761815, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550935, Length=529, Percent_Identity=51.4177693761815, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI17864606, Length=526, Percent_Identity=48.2889733840304, Blast_Score=491, Evalue=1e-139,
Organism=Drosophila melanogaster, GI24584129, Length=533, Percent_Identity=38.2739212007505, Blast_Score=338, Evalue=4e-93,
Organism=Drosophila melanogaster, GI19921262, Length=533, Percent_Identity=38.2739212007505, Blast_Score=338, Evalue=4e-93,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 56960; Mature: 56829

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.2 %Met     (Translated Protein)
0.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
0.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFSGDARERLLRGVDILADAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEI
CCCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCCCCHHHC
ELEDRFENLGAQLLREVASKTNDLAGDGTTTATVLAQAIVREGAKAVAANFNPLDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCHHHHCCC
DLATAAAVKNITARARKVTASDAIAQVGTISANGDAEIGRLIAEAVERVGKEGVITVEEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHCCCCCEEEEECC
KTAETELDVVEGLQFDRGYLSPYFVTNTEKLIAELDDPYILIHEKKLSSLQPLLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
VQSSRPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAILEDIAILTNGQT
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
ISEDLGIKLENVSLPLLGQAKRVRIDKESTTIVDGAGDRAQIDARVAQIKAQIEETSSDY
EHHHHCEEEECCCCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALNATRAAIEEGIVPGGGTALL
CHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKAAVSALKSENADVKAGINIVLKALEAPIRQIAANAGVEGSIVVSKVIENGSETFGFD
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
AQTETYVDLIEAGIVDPAKVVRTALQDAASVAGLLVTTEALIAERPKEKTPPLPPGGPDF
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAKDVKFSGDARERLLRGVDILADAVKVTLGPKGRNVVIEKSFGAPRITKDGVTVAKEI
CCCCCCCCCHHHHHHHHHHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCCCCCHHHC
ELEDRFENLGAQLLREVASKTNDLAGDGTTTATVLAQAIVREGAKAVAANFNPLDLKRGI
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHCCCCCHHHHCCC
DLATAAAVKNITARARKVTASDAIAQVGTISANGDAEIGRLIAEAVERVGKEGVITVEEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHCEECCCCCHHHHHHHHHHHHHCCCCCEEEEECC
KTAETELDVVEGLQFDRGYLSPYFVTNTEKLIAELDDPYILIHEKKLSSLQPLLPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHH
VQSSRPLLIIAEDVEGEALATLVVNKLRGGLKIAAVKAPGFGDRRKAILEDIAILTNGQT
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCE
ISEDLGIKLENVSLPLLGQAKRVRIDKESTTIVDGAGDRAQIDARVAQIKAQIEETSSDY
EHHHHCEEEECCCCCCCCCCCEEEECCCCCEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLAGGVAVIRVGGATEVEVKEKKDRVDDALNATRAAIEEGIVPGGGTALL
CHHHHHHHHHHHHCCEEEEEECCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKAAVSALKSENADVKAGINIVLKALEAPIRQIAANAGVEGSIVVSKVIENGSETFGFD
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCC
AQTETYVDLIEAGIVDPAKVVRTALQDAASVAGLLVTTEALIAERPKEKTPPLPPGGPDF
CCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA