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The map label for this gene is hppA [H]

Identifier: 218531340

GI number: 218531340

Start: 3592045

End: 3594177

Strand: Reverse

Name: hppA [H]

Synonym: Mchl_3408

Alternate gene names: 218531340

Gene position: 3594177-3592045 (Counterclockwise)

Preceding gene: 218531341

Following gene: 218531338

Centisome position: 62.21

GC content: 67.18

Gene sequence:

>2133_bases
ATGACCGCACTTTTGCTGATCATCGTGGGCGGGCTCTGCGCCGTTGCCTACGGTGTCGTGACTATCCGTGACGTAATGCG
ACGCGATGCCGGCACCCAGCGCATGCAGGAGATCGCAGGCGCCATCGCCGAGGGCGCACAGGCATATCTCAGGCGCCAAT
ACGCCACGATCGGGATCGTCGGCGTCGTCCTCTTCGTCCTTCTGGCCTACTTTCTCGGCATCAAGGTCGCCATCGGCTTC
CTGATCGGCGCGGTGCTCTCGGGCGCGGCCGGCTTCATCGGCATGAACGTCTCGGTCCGTGCCAATGTCCGCACGGCGCA
GGCCGCCACCCAGTCGCTCGGCGGCGGCCTGGAGGTCGCCTTCAAGTCCGGCGCGGTCACCGGCATGCTGGTGGCGGGCC
TCGCGCTGCTCGGTGTCGCCCTCTACTACCTGTTCCTCACCCGCGGCGCTGGGCTGGCGCCGGGAAGCCGCGAAGTCATC
GACTCGCTGGTGGCGCTTGGCTTCGGCGCCTCGCTGATCTCGATCTTCGCGCGGCTGGGCGGCGGTATCTTCACCAAGGG
TGCTGATGTCGGCGGCGATCTCGTCGGCAAGGTCGAGGCCGGTATTCCCGAAGATGATCCGCGCAACCCCGCCACCATCG
CCGACAACGTGGGCGACAATGTCGGCGACTGCGCCGGCATGGCCGCGGACCTGTTCGAGACCTATGCGGTGACCGTGGTC
GCCACCATGGTGCTTGCCGCGATCTTCTTCGCGGGCAACGCGCCCGTGCTCGAAGCGATGATGATCTACCCGCTCGCCAT
CGGGGCGGCCTGCATCGTCACCTCGATCATCGGCACCTACGCGGTGAAGCTCGGTGCCAACCAGTCGATCATGGGCGCAC
TCTACAAGGGCCTGATCGCGGCGGGTGTGCTCTCGATCGTGGCCATCGCCGGCGTAAATCTCGCGCTGTTCGGCGGGTTC
TCGACCACCTTCACGACGAATACCGGCCTGACCTTCTCTTCGGGTGCCCTGTTCGGTTGCGCGGTGCTCGGCCTCGTCAT
CACCGCGCTGATCGTCGTCATCACCGAGTACTACACCGGCACGAACTTCCGCCCGGTGAAGTCGATCGCGACCGCCTCCG
TCACCGGTCACGGCACCAACGTGATCCAGGGGCTCGCGATCTCGCTCGAATCGACGGCGCTGCCGGCCCTCGTCATCGTG
GCGGGCATCATCTCCACCTACGCGCTGGCCGGCCTGTTCGGCATCGCCATCGCGGTCACGGCGATGCTGGCGCTCGCGGG
CTTCATCGTCGCCCTCGATGCCTTCGGCCCGGTCACCGACAATGCCGGCGGTATCGCCGAGATGGCAGGCCTCCCCGCCG
AGGTGCGCAAGGCGACCGACGCGCTCGATGCGGTCGGCAACACCACCAAGGCCGTCACCAAGGGCTACGCCATCGGCTCG
GCCGGTCTCGGCGCCCTGGTGCTGTTTGCCGCCTATACCTCCGACCTGAACTACTTCATCGCCAATGCCAGCCCGACGCA
GTACCGCTTCTTCCAGGGGGTGAGCGTCGATTTCTCCCTCTCCAATCCCTACGTCGTGGTGGGCCTCCTGCTCGGCGGCC
TGATCCCGTTCCTGTTCGCGGGTATCGCCATGACGGCGGTGGGCCGCGCGGCCGGTGCGGTGGTCGAGGAGGTGCGGCGC
CAGTTCCGCGCCAAGCCTGGCATCATGCAGGGCACCGACCGGCCGGATTACGGCCGCGCGGTGGACATGCTGACCCGGGC
GGCGATCAAGGAGATGATCATCCCCTCGCTGCTTCCGGTGCTCTCGCCCATTGTGATCTTCTTCGTGATCCAGGCGATCG
CGGGCAAGTCGCAGGCTTTCGCCACGGTCGGCGCCTCGCTGCTCGGCGTGATCCTGACCGGCCTCTACGTCGCGATCTCA
ATGACCTCGGGCGGCGGCGCCTGGGACAACGCCAAGAAGTACATCGAGGACGGCCACCACGGCGGCAAGGGCTCGGACGC
GCACAAGGCGGCCGTGACCGGCGACACCGTCGGCGACCCCTACAAGGACACGGCGGGCCCCGCCGTGAACCCGGCGATCA
AGATCACCAACATCATCGCCCTGTTGCTGCTCGCCGTGCTCGCCCACGCCTGA

Upstream 100 bases:

>100_bases
CTCGAGGGAGGGCGCCTGAAGCCGAGCAACGTCGCTGCAACGTTCGACGGCCATTCCGGCCGGGCTCGGCACACCACAAT
CAAAAATCAAGGACGCACGC

Downstream 100 bases:

>100_bases
ACCCGGACAGCGCAAAAAAAGAACCCGCCGCGGTCATCCGCGGCGGGTTCTTTTTTTCAGGACTGAAATTCCAAGAAAAT
CAGTCGCAGTTCTCCTTGGT

Product: membrane-bound proton-translocating pyrophosphatase

Products: NA

Alternate protein names: Membrane-bound proton-translocating pyrophosphatase; Pyrophosphate-energized inorganic pyrophosphatase; H(+)-PPase [H]

Number of amino acids: Translated: 710; Mature: 709

Protein sequence:

>710_residues
MTALLLIIVGGLCAVAYGVVTIRDVMRRDAGTQRMQEIAGAIAEGAQAYLRRQYATIGIVGVVLFVLLAYFLGIKVAIGF
LIGAVLSGAAGFIGMNVSVRANVRTAQAATQSLGGGLEVAFKSGAVTGMLVAGLALLGVALYYLFLTRGAGLAPGSREVI
DSLVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTVV
ATMVLAAIFFAGNAPVLEAMMIYPLAIGAACIVTSIIGTYAVKLGANQSIMGALYKGLIAAGVLSIVAIAGVNLALFGGF
STTFTTNTGLTFSSGALFGCAVLGLVITALIVVITEYYTGTNFRPVKSIATASVTGHGTNVIQGLAISLESTALPALVIV
AGIISTYALAGLFGIAIAVTAMLALAGFIVALDAFGPVTDNAGGIAEMAGLPAEVRKATDALDAVGNTTKAVTKGYAIGS
AGLGALVLFAAYTSDLNYFIANASPTQYRFFQGVSVDFSLSNPYVVVGLLLGGLIPFLFAGIAMTAVGRAAGAVVEEVRR
QFRAKPGIMQGTDRPDYGRAVDMLTRAAIKEMIIPSLLPVLSPIVIFFVIQAIAGKSQAFATVGASLLGVILTGLYVAIS
MTSGGGAWDNAKKYIEDGHHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPAIKITNIIALLLLAVLAHA

Sequences:

>Translated_710_residues
MTALLLIIVGGLCAVAYGVVTIRDVMRRDAGTQRMQEIAGAIAEGAQAYLRRQYATIGIVGVVLFVLLAYFLGIKVAIGF
LIGAVLSGAAGFIGMNVSVRANVRTAQAATQSLGGGLEVAFKSGAVTGMLVAGLALLGVALYYLFLTRGAGLAPGSREVI
DSLVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTVV
ATMVLAAIFFAGNAPVLEAMMIYPLAIGAACIVTSIIGTYAVKLGANQSIMGALYKGLIAAGVLSIVAIAGVNLALFGGF
STTFTTNTGLTFSSGALFGCAVLGLVITALIVVITEYYTGTNFRPVKSIATASVTGHGTNVIQGLAISLESTALPALVIV
AGIISTYALAGLFGIAIAVTAMLALAGFIVALDAFGPVTDNAGGIAEMAGLPAEVRKATDALDAVGNTTKAVTKGYAIGS
AGLGALVLFAAYTSDLNYFIANASPTQYRFFQGVSVDFSLSNPYVVVGLLLGGLIPFLFAGIAMTAVGRAAGAVVEEVRR
QFRAKPGIMQGTDRPDYGRAVDMLTRAAIKEMIIPSLLPVLSPIVIFFVIQAIAGKSQAFATVGASLLGVILTGLYVAIS
MTSGGGAWDNAKKYIEDGHHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPAIKITNIIALLLLAVLAHA
>Mature_709_residues
TALLLIIVGGLCAVAYGVVTIRDVMRRDAGTQRMQEIAGAIAEGAQAYLRRQYATIGIVGVVLFVLLAYFLGIKVAIGFL
IGAVLSGAAGFIGMNVSVRANVRTAQAATQSLGGGLEVAFKSGAVTGMLVAGLALLGVALYYLFLTRGAGLAPGSREVID
SLVALGFGASLISIFARLGGGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTVVA
TMVLAAIFFAGNAPVLEAMMIYPLAIGAACIVTSIIGTYAVKLGANQSIMGALYKGLIAAGVLSIVAIAGVNLALFGGFS
TTFTTNTGLTFSSGALFGCAVLGLVITALIVVITEYYTGTNFRPVKSIATASVTGHGTNVIQGLAISLESTALPALVIVA
GIISTYALAGLFGIAIAVTAMLALAGFIVALDAFGPVTDNAGGIAEMAGLPAEVRKATDALDAVGNTTKAVTKGYAIGSA
GLGALVLFAAYTSDLNYFIANASPTQYRFFQGVSVDFSLSNPYVVVGLLLGGLIPFLFAGIAMTAVGRAAGAVVEEVRRQ
FRAKPGIMQGTDRPDYGRAVDMLTRAAIKEMIIPSLLPVLSPIVIFFVIQAIAGKSQAFATVGASLLGVILTGLYVAISM
TSGGGAWDNAKKYIEDGHHGGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPAIKITNIIALLLLAVLAHA

Specific function: Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force [H]

COG id: COG3808

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004131 [H]

Pfam domain/function: PF03030 H_PPase [H]

EC number: =3.6.1.1 [H]

Molecular weight: Translated: 72028; Mature: 71897

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALLLIIVGGLCAVAYGVVTIRDVMRRDAGTQRMQEIAGAIAEGAQAYLRRQYATIGIV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVLFVLLAYFLGIKVAIGFLIGAVLSGAAGFIGMNVSVRANVRTAQAATQSLGGGLEVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEECCHHHHHHHHHCCCCEEEE
FKSGAVTGMLVAGLALLGVALYYLFLTRGAGLAPGSREVIDSLVALGFGASLISIFARLG
ECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTVV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAAIFFAGNAPVLEAMMIYPLAIGAACIVTSIIGTYAVKLGANQSIMGALYKGLIA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AGVLSIVAIAGVNLALFGGFSTTFTTNTGLTFSSGALFGCAVLGLVITALIVVITEYYTG
HHHHHHHHHHCCCEEEECCCCEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
TNFRPVKSIATASVTGHGTNVIQGLAISLESTALPALVIVAGIISTYALAGLFGIAIAVT
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMLALAGFIVALDAFGPVTDNAGGIAEMAGLPAEVRKATDALDAVGNTTKAVTKGYAIGS
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCC
AGLGALVLFAAYTSDLNYFIANASPTQYRFFQGVSVDFSLSNPYVVVGLLLGGLIPFLFA
CHHHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
GIAMTAVGRAAGAVVEEVRRQFRAKPGIMQGTDRPDYGRAVDMLTRAAIKEMIIPSLLPV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSPIVIFFVIQAIAGKSQAFATVGASLLGVILTGLYVAISMTSGGGAWDNAKKYIEDGHH
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCC
GGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPAIKITNIIALLLLAVLAHA
CCCCCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TALLLIIVGGLCAVAYGVVTIRDVMRRDAGTQRMQEIAGAIAEGAQAYLRRQYATIGIV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GVVLFVLLAYFLGIKVAIGFLIGAVLSGAAGFIGMNVSVRANVRTAQAATQSLGGGLEVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEECCEEEEECCHHHHHHHHHCCCCEEEE
FKSGAVTGMLVAGLALLGVALYYLFLTRGAGLAPGSREVIDSLVALGFGASLISIFARLG
ECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHC
GGIFTKGADVGGDLVGKVEAGIPEDDPRNPATIADNVGDNVGDCAGMAADLFETYAVTVV
CCEEECCCCCCCHHHHHHCCCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHH
ATMVLAAIFFAGNAPVLEAMMIYPLAIGAACIVTSIIGTYAVKLGANQSIMGALYKGLIA
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
AGVLSIVAIAGVNLALFGGFSTTFTTNTGLTFSSGALFGCAVLGLVITALIVVITEYYTG
HHHHHHHHHHCCCEEEECCCCEEEECCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHCC
TNFRPVKSIATASVTGHGTNVIQGLAISLESTALPALVIVAGIISTYALAGLFGIAIAVT
CCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMLALAGFIVALDAFGPVTDNAGGIAEMAGLPAEVRKATDALDAVGNTTKAVTKGYAIGS
HHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCC
AGLGALVLFAAYTSDLNYFIANASPTQYRFFQGVSVDFSLSNPYVVVGLLLGGLIPFLFA
CHHHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHH
GIAMTAVGRAAGAVVEEVRRQFRAKPGIMQGTDRPDYGRAVDMLTRAAIKEMIIPSLLPV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSPIVIFFVIQAIAGKSQAFATVGASLLGVILTGLYVAISMTSGGGAWDNAKKYIEDGHH
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHCCCC
GGKGSDAHKAAVTGDTVGDPYKDTAGPAVNPAIKITNIIALLLLAVLAHA
CCCCCCCCCCEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]