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The map label for this gene is ykpB [H]

Identifier: 218531112

GI number: 218531112

Start: 3339124

End: 3340062

Strand: Reverse

Name: ykpB [H]

Synonym: Mchl_3162

Alternate gene names: 218531112

Gene position: 3340062-3339124 (Counterclockwise)

Preceding gene: 218531116

Following gene: 218531110

Centisome position: 57.81

GC content: 72.2

Gene sequence:

>939_bases
ATGCGGATACTCGTGGTCGGAGCCGGCGCGACGGGCGGCTATTTCGGGGCGCGGCTCGTGGAGGCCGGGCGGGACGTGAC
GTTTCTGGTGCGCCCGGCGCGCGCGGAAAAGCTGGCGGCGCGGGGCCTCTCGGTCCGTAGCCCGCTCGGCGACATCCGCA
TCGACGCGCCGAAGACCGTGAAGGCGGACGCGCTCGCCGGGGCCGGCCCGTTCGACCTCGTCCTCCTCTCGGCCAAGGCC
TACGACCTCGACTCGGTGGTCGCGGACGTGGCGCCGGCCGTCGGGCCCGGCACGGCGGTGCTTCCGATCCTCAACGGCCT
GCGCCATCTCGACGTGCTGGATCAGGCGTTCGGCGCCGACCACGTGTTGGGGGGAAGCTGCGCCATCGTCGCGACGCTGA
CGGGTGACGGCGAGATCCGGCAGATGACCGATCTGCACACGCTCACCTATGGCGAGCGCGACGGGACGCGCTCAGAGCGG
ATCGCACGCATCGAGGCGCAGATGGAGGGCGTGCGGTTCCAGCCGCGGGCCAGCGACAAGATCCTGCTGGAGATGTGGGA
GAAGTGGGTCTTCCTCGCGACGCTCGCCGGATCGACGACCCTGATGCGCTCGGCGCTCGGCGACATCGTCGCGGCGCCCG
GCGGCCGGGCCTTCATCGAGGCGCTCCACGACGAGTGCCAGGCGGTGGCCGGCGCCAACGGGAACGCCGCCCGCGAGAAG
GTCTTTGCCGGCGCCCGCAAGATGCTGACGGCGGAGGGCTCGGCTATGACCGCCTCGATGCTGCGCGACATCGAGGGCGG
CGCCCGCATCGAGGCCGACCACATCATCGGAGACCTGATCGCGCGCGGGCAGGCCAAGGGCGTGGAGACGCCGGTGCTCG
CCCGGGTGCTGACGCACCTCAAGGCCTACGAGCACCGGCGCGCCCGCGAGGCGGCCTAA

Upstream 100 bases:

>100_bases
ACGCCGACGTCTCGAAAATCACCAGCCGCATCCTCTTTTCGGCGGGGTGCGGGCGGCGAGGCTTCGGCGTATGTGAGGAC
GCAACAGGAAAGGGAGGACG

Downstream 100 bases:

>100_bases
CTGTCTCTCACGAAATTCCCGCTGCGCCGTCCTCGCCAAGGCGAGAACGGTCAGAGATCGGGAGTTTTGTGAAGCACTTG
AGCCGCCCCGCTTGCGCCGT

Product: 2-dehydropantoate 2-reductase

Products: 2-dehydropantoate; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MRILVVGAGATGGYFGARLVEAGRDVTFLVRPARAEKLAARGLSVRSPLGDIRIDAPKTVKADALAGAGPFDLVLLSAKA
YDLDSVVADVAPAVGPGTAVLPILNGLRHLDVLDQAFGADHVLGGSCAIVATLTGDGEIRQMTDLHTLTYGERDGTRSER
IARIEAQMEGVRFQPRASDKILLEMWEKWVFLATLAGSTTLMRSALGDIVAAPGGRAFIEALHDECQAVAGANGNAAREK
VFAGARKMLTAEGSAMTASMLRDIEGGARIEADHIIGDLIARGQAKGVETPVLARVLTHLKAYEHRRAREAA

Sequences:

>Translated_312_residues
MRILVVGAGATGGYFGARLVEAGRDVTFLVRPARAEKLAARGLSVRSPLGDIRIDAPKTVKADALAGAGPFDLVLLSAKA
YDLDSVVADVAPAVGPGTAVLPILNGLRHLDVLDQAFGADHVLGGSCAIVATLTGDGEIRQMTDLHTLTYGERDGTRSER
IARIEAQMEGVRFQPRASDKILLEMWEKWVFLATLAGSTTLMRSALGDIVAAPGGRAFIEALHDECQAVAGANGNAAREK
VFAGARKMLTAEGSAMTASMLRDIEGGARIEADHIIGDLIARGQAKGVETPVLARVLTHLKAYEHRRAREAA
>Mature_312_residues
MRILVVGAGATGGYFGARLVEAGRDVTFLVRPARAEKLAARGLSVRSPLGDIRIDAPKTVKADALAGAGPFDLVLLSAKA
YDLDSVVADVAPAVGPGTAVLPILNGLRHLDVLDQAFGADHVLGGSCAIVATLTGDGEIRQMTDLHTLTYGERDGTRSER
IARIEAQMEGVRFQPRASDKILLEMWEKWVFLATLAGSTTLMRSALGDIVAAPGGRAFIEALHDECQAVAGANGNAAREK
VFAGARKMLTAEGSAMTASMLRDIEGGARIEADHIIGDLIARGQAKGVETPVLARVLTHLKAYEHRRAREAA

Specific function: Catalyzes The NADPH-Dependent Reduction Of Ketopantoate Into Pantoic Acid. [C]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: 1.1.1.169

Molecular weight: Translated: 32880; Mature: 32880

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVGAGATGGYFGARLVEAGRDVTFLVRPARAEKLAARGLSVRSPLGDIRIDAPKTV
CEEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCCEEECCCCCC
KADALAGAGPFDLVLLSAKAYDLDSVVADVAPAVGPGTAVLPILNGLRHLDVLDQAFGAD
CHHHCCCCCCHHEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
HVLGGSCAIVATLTGDGEIRQMTDLHTLTYGERDGTRSERIARIEAQMEGVRFQPRASDK
CEECCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCH
ILLEMWEKWVFLATLAGSTTLMRSALGDIVAAPGGRAFIEALHDECQAVAGANGNAAREK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
VFAGARKMLTAEGSAMTASMLRDIEGGARIEADHIIGDLIARGQAKGVETPVLARVLTHL
HHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
KAYEHRRAREAA
HHHHHHHHHCCC
>Mature Secondary Structure
MRILVVGAGATGGYFGARLVEAGRDVTFLVRPARAEKLAARGLSVRSPLGDIRIDAPKTV
CEEEEEECCCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCCCCCCCEEECCCCCC
KADALAGAGPFDLVLLSAKAYDLDSVVADVAPAVGPGTAVLPILNGLRHLDVLDQAFGAD
CHHHCCCCCCHHEEEEECCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCC
HVLGGSCAIVATLTGDGEIRQMTDLHTLTYGERDGTRSERIARIEAQMEGVRFQPRASDK
CEECCCEEEEEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEECCCCCCH
ILLEMWEKWVFLATLAGSTTLMRSALGDIVAAPGGRAFIEALHDECQAVAGANGNAAREK
HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHH
VFAGARKMLTAEGSAMTASMLRDIEGGARIEADHIIGDLIARGQAKGVETPVLARVLTHL
HHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHH
KAYEHRRAREAA
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 4.0 {NADPH}} [C]

Substrates: (R)-pantoate; NADP+

Specific reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]