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The map label for this gene is guaB [H]

Identifier: 218531116

GI number: 218531116

Start: 3342852

End: 3344342

Strand: Reverse

Name: guaB [H]

Synonym: Mchl_3166

Alternate gene names: 218531116

Gene position: 3344342-3342852 (Counterclockwise)

Preceding gene: 218531120

Following gene: 218531112

Centisome position: 57.88

GC content: 69.42

Gene sequence:

>1491_bases
ATGGCCCGTATCAGCGCTGACTCGATCATCGAGGGCCTGACCTTCGACGACGTGCTGCTGCGCCCCGCCGCCTCTTCGGT
GATGCCGGGCGAGGTCGATATCGCCAGCCGCCTCACCCGCACGATCCGGCTCAACATGCCGATCATCGCCTCGGCAATGG
ACACCGTGACCGAGGCGCCGATGGCCATCGCCATGGCGCAGAACGGCGGTCTCGGCGTGATCCACCGCAATCTCGAGCCG
GCCGAGCAGGCCGAGCAGGTCCGCCTCGTCAAGAAGTACGAGTCGGGCATGGTGCTCAACCCGATCACCATCCACCCCGA
CGAGACCCTCGCCGACGCCTTCGAGGTGATGAAGCGGAACCGGATCTCCGGCATCCCGGTGGTCGAGCGCGGCCCCAACG
GCTCGCGCGGCAAGCTCGTCGGTATCCTGACCAACCGCGACGTGCGCTTCGCGACCAATGCCGGCCAGCCCGTGGCCGAG
CTCATGACCCGCGACCGGCTCATCACCGTGCGCGAGGGCGTGACGCAGGACGAGGCCAAGCGGCTGCTGCACCAATTCCG
CATCGAGAAGCTGCTCGTGGTCGATGACCACTACCGCTGCATCGGCCTCATCACCGTCAAGGACATCGAGAAGCAGGTCA
CCTATCCCAACGCCGTCAAGGACGAGCAGGGCCGGCTGCGGGTCGCGGCGGCGACCACCACGGGCGATGCCGGCTTCGAG
CGGGCCGAGCGCCTGATCGATGCGGGCTGCGACGTGGTCGTGGTCGACACCGCCCACGGCCATTCCCGCAAGGTGCTCGA
CAGCGTCGCCCGGGTGAAGCAGCTCTCCAACGCCGTGCAGATCATCGCCGGCAACGTCGCCACCGCCGAGGGCGCCCGCG
CCCTGATCGATGCCGGTGCCGACGCGATCAAGGTCGGCATTGGACCGGGCTCGATCTGCACCACCCGCATCGTCGCCGGT
GTCGGCGTGCCCCAGCTCACAGCGCTCATGGAAGCGGTCGAGGCGGCGCACGGCGCCGACGTGCCGGTGATCGCCGATGG
CGGCATCAAGTTCTCGGGCGATCTCGCCAAGGCGATCGCGGCCGGCGCCTCGGTGGCGATGCTGGGCTCGCTGCTGGCGG
GCACCGACGAGGCGCCGGGCGAGGTGTTCCTCTACCAGGGCCGCTCCTACAAGAGCTACCGCGGCATGGGCTCGGTCGGC
GCGATGGCGCGCGGCTCGGCCGACCGCTATTTCCAGGCCGAGGTCAACGACACCCACAAGCTCGTGCCGGAGGGGATCGA
AGGTCAGGTGCCCTACAAGGGTCCGGTCGCGGCGGTGCTGCACCAGCTCGCCGGGGGCCTGCGCGCGGCGATGGGCTATG
TCGGCGCCCCGACGGTGCCGGAGTTCCAGGAGCGGGCGCAGTTCGTGCGCATCACCAATGCCGGCCTGCGCGAGAGCCAC
GTCCACGACGTGACGATCACCCGCGAGAGCCCGAACTATCCCAGCCGCTGA

Upstream 100 bases:

>100_bases
TGCGTGCGCGGGGCGCCCATGATACTGGCCCCTGCCAACCCGATCCCGCTGGCCGCGACCTTCCGGCCCGGCGCAACACT
CGTCTCCGGAGTTGGTTTCC

Downstream 100 bases:

>100_bases
TGATGGAGCCGCGCGGTTCCGTTCGGGAATCGCGCGGCGCCGCAGTCAGCGTGCCTCAGGAAACGCCTGATCACCGATCG
TCTCCGATCCGGGCACGGCG

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 496; Mature: 495

Protein sequence:

>496_residues
MARISADSIIEGLTFDDVLLRPAASSVMPGEVDIASRLTRTIRLNMPIIASAMDTVTEAPMAIAMAQNGGLGVIHRNLEP
AEQAEQVRLVKKYESGMVLNPITIHPDETLADAFEVMKRNRISGIPVVERGPNGSRGKLVGILTNRDVRFATNAGQPVAE
LMTRDRLITVREGVTQDEAKRLLHQFRIEKLLVVDDHYRCIGLITVKDIEKQVTYPNAVKDEQGRLRVAAATTTGDAGFE
RAERLIDAGCDVVVVDTAHGHSRKVLDSVARVKQLSNAVQIIAGNVATAEGARALIDAGADAIKVGIGPGSICTTRIVAG
VGVPQLTALMEAVEAAHGADVPVIADGGIKFSGDLAKAIAAGASVAMLGSLLAGTDEAPGEVFLYQGRSYKSYRGMGSVG
AMARGSADRYFQAEVNDTHKLVPEGIEGQVPYKGPVAAVLHQLAGGLRAAMGYVGAPTVPEFQERAQFVRITNAGLRESH
VHDVTITRESPNYPSR

Sequences:

>Translated_496_residues
MARISADSIIEGLTFDDVLLRPAASSVMPGEVDIASRLTRTIRLNMPIIASAMDTVTEAPMAIAMAQNGGLGVIHRNLEP
AEQAEQVRLVKKYESGMVLNPITIHPDETLADAFEVMKRNRISGIPVVERGPNGSRGKLVGILTNRDVRFATNAGQPVAE
LMTRDRLITVREGVTQDEAKRLLHQFRIEKLLVVDDHYRCIGLITVKDIEKQVTYPNAVKDEQGRLRVAAATTTGDAGFE
RAERLIDAGCDVVVVDTAHGHSRKVLDSVARVKQLSNAVQIIAGNVATAEGARALIDAGADAIKVGIGPGSICTTRIVAG
VGVPQLTALMEAVEAAHGADVPVIADGGIKFSGDLAKAIAAGASVAMLGSLLAGTDEAPGEVFLYQGRSYKSYRGMGSVG
AMARGSADRYFQAEVNDTHKLVPEGIEGQVPYKGPVAAVLHQLAGGLRAAMGYVGAPTVPEFQERAQFVRITNAGLRESH
VHDVTITRESPNYPSR
>Mature_495_residues
ARISADSIIEGLTFDDVLLRPAASSVMPGEVDIASRLTRTIRLNMPIIASAMDTVTEAPMAIAMAQNGGLGVIHRNLEPA
EQAEQVRLVKKYESGMVLNPITIHPDETLADAFEVMKRNRISGIPVVERGPNGSRGKLVGILTNRDVRFATNAGQPVAEL
MTRDRLITVREGVTQDEAKRLLHQFRIEKLLVVDDHYRCIGLITVKDIEKQVTYPNAVKDEQGRLRVAAATTTGDAGFER
AERLIDAGCDVVVVDTAHGHSRKVLDSVARVKQLSNAVQIIAGNVATAEGARALIDAGADAIKVGIGPGSICTTRIVAGV
GVPQLTALMEAVEAAHGADVPVIADGGIKFSGDLAKAIAAGASVAMLGSLLAGTDEAPGEVFLYQGRSYKSYRGMGSVGA
MARGSADRYFQAEVNDTHKLVPEGIEGQVPYKGPVAAVLHQLAGGLRAAMGYVGAPTVPEFQERAQFVRITNAGLRESHV
HDVTITRESPNYPSR

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=454, Percent_Identity=42.511013215859, Blast_Score=326, Evalue=3e-89,
Organism=Homo sapiens, GI156616279, Length=451, Percent_Identity=42.7937915742794, Blast_Score=325, Evalue=6e-89,
Organism=Homo sapiens, GI34328930, Length=451, Percent_Identity=42.7937915742794, Blast_Score=325, Evalue=7e-89,
Organism=Homo sapiens, GI34328928, Length=451, Percent_Identity=42.7937915742794, Blast_Score=325, Evalue=8e-89,
Organism=Homo sapiens, GI66933016, Length=484, Percent_Identity=39.8760330578512, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI217035152, Length=445, Percent_Identity=42.6966292134831, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI217035148, Length=451, Percent_Identity=41.9068736141907, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI217035150, Length=451, Percent_Identity=39.9113082039911, Blast_Score=288, Evalue=1e-77,
Organism=Homo sapiens, GI50541956, Length=300, Percent_Identity=37.3333333333333, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI50541954, Length=300, Percent_Identity=37.3333333333333, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI50541952, Length=300, Percent_Identity=37.3333333333333, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI50541948, Length=300, Percent_Identity=37.3333333333333, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI156104880, Length=250, Percent_Identity=39.6, Blast_Score=169, Evalue=6e-42,
Organism=Escherichia coli, GI1788855, Length=484, Percent_Identity=58.6776859504132, Blast_Score=524, Evalue=1e-150,
Organism=Escherichia coli, GI1786293, Length=249, Percent_Identity=39.3574297188755, Blast_Score=174, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71994385, Length=500, Percent_Identity=34, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI71994389, Length=426, Percent_Identity=36.6197183098592, Blast_Score=258, Evalue=7e-69,
Organism=Caenorhabditis elegans, GI17560440, Length=245, Percent_Identity=38.7755102040816, Blast_Score=172, Evalue=4e-43,
Organism=Saccharomyces cerevisiae, GI6323585, Length=464, Percent_Identity=39.8706896551724, Blast_Score=320, Evalue=4e-88,
Organism=Saccharomyces cerevisiae, GI6323464, Length=463, Percent_Identity=40.1727861771058, Blast_Score=314, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6322012, Length=463, Percent_Identity=38.4449244060475, Blast_Score=313, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6319352, Length=340, Percent_Identity=38.8235294117647, Blast_Score=238, Evalue=2e-63,
Organism=Saccharomyces cerevisiae, GI6319353, Length=119, Percent_Identity=35.2941176470588, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=39.5876288659794, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=39.5876288659794, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=39.7291196388262, Blast_Score=294, Evalue=1e-79,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52728; Mature: 52597

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARISADSIIEGLTFDDVLLRPAASSVMPGEVDIASRLTRTIRLNMPIIASAMDTVTEAP
CCCCCHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHCC
MAIAMAQNGGLGVIHRNLEPAEQAEQVRLVKKYESGMVLNPITIHPDETLADAFEVMKRN
EEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEECCEEECCCHHHHHHHHHHHHC
RISGIPVVERGPNGSRGKLVGILTNRDVRFATNAGQPVAELMTRDRLITVREGVTQDEAK
CCCCCCEEECCCCCCCCCEEEEEECCCEEEECCCCCHHHHHHHCCCEEEECCCCCHHHHH
RLLHQFRIEKLLVVDDHYRCIGLITVKDIEKQVTYPNAVKDEQGRLRVAAATTTGDAGFE
HHHHHHHHCEEEEEECCCEEEEEEEEHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHH
RAERLIDAGCDVVVVDTAHGHSRKVLDSVARVKQLSNAVQIIAGNVATAEGARALIDAGA
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCC
DAIKVGIGPGSICTTRIVAGVGVPQLTALMEAVEAAHGADVPVIADGGIKFSGDLAKAIA
CEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEECCCEEECCHHHHHHH
AGASVAMLGSLLAGTDEAPGEVFLYQGRSYKSYRGMGSVGAMARGSADRYFQAEVNDTHK
CCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEECCCCCHH
LVPEGIEGQVPYKGPVAAVLHQLAGGLRAAMGYVGAPTVPEFQERAQFVRITNAGLRESH
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEEECCCCCCCC
VHDVTITRESPNYPSR
CEEEEEEECCCCCCCC
>Mature Secondary Structure 
ARISADSIIEGLTFDDVLLRPAASSVMPGEVDIASRLTRTIRLNMPIIASAMDTVTEAP
CCCCHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHEEECCCHHHHHHHHHHHCC
MAIAMAQNGGLGVIHRNLEPAEQAEQVRLVKKYESGMVLNPITIHPDETLADAFEVMKRN
EEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEECCEEECCCHHHHHHHHHHHHC
RISGIPVVERGPNGSRGKLVGILTNRDVRFATNAGQPVAELMTRDRLITVREGVTQDEAK
CCCCCCEEECCCCCCCCCEEEEEECCCEEEECCCCCHHHHHHHCCCEEEECCCCCHHHHH
RLLHQFRIEKLLVVDDHYRCIGLITVKDIEKQVTYPNAVKDEQGRLRVAAATTTGDAGFE
HHHHHHHHCEEEEEECCCEEEEEEEEHHHHHHCCCCCCCCCCCCCEEEEEEECCCCHHHH
RAERLIDAGCDVVVVDTAHGHSRKVLDSVARVKQLSNAVQIIAGNVATAEGARALIDAGA
HHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCC
DAIKVGIGPGSICTTRIVAGVGVPQLTALMEAVEAAHGADVPVIADGGIKFSGDLAKAIA
CEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCEEECCCEEECCHHHHHHH
AGASVAMLGSLLAGTDEAPGEVFLYQGRSYKSYRGMGSVGAMARGSADRYFQAEVNDTHK
CCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCHHHCCCCCCEEEECCCCCHH
LVPEGIEGQVPYKGPVAAVLHQLAGGLRAAMGYVGAPTVPEFQERAQFVRITNAGLRESH
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHEEEEECCCCCCCC
VHDVTITRESPNYPSR
CEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA