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The map label for this gene is mprA [H]

Identifier: 218531036

GI number: 218531036

Start: 3267692

End: 3268057

Strand: Reverse

Name: mprA [H]

Synonym: Mchl_3086

Alternate gene names: 218531036

Gene position: 3268057-3267692 (Counterclockwise)

Preceding gene: 218531037

Following gene: 218531034

Centisome position: 56.56

GC content: 66.39

Gene sequence:

>366_bases
ATGGCGCGCATCCTGCTCGTGGATGACGAGGATACGGTTCGCGGCTTCCTCAAGCGCGGGCTGGAGTTGGACGGTCACAC
CGTCGTCACGGCCATCGATGGCAGCGACGGCCTCGATCGCCTGTCGGAGGCCGGCGGCGGCTTCGACCTGATGTTGACCG
ATATTCGAATGCCGCTGATGGACGGTATCGCTTTGTCGCTCGCGGCCAAGCGCGACTACCCCGATCTCACGATCCTGCTG
ATGACGGGCTTTGCCGACCAGCGCGAACGCGCCCGCGGCCTCGATGCCATCGTCACCGACGTGCTGACCAAGCCCTTCTC
CCTGGCCGACCTGCGCTCCACCGTGACGCGGGCGCTGGCGGCCTAA

Upstream 100 bases:

>100_bases
ATGGAACTCTGTCGGCGCATGAGGCTTGACAGGCCGCGCTTCCCAGCGGTCACTCGGGCGCGACGATCCACATCGAAGGA
ACGGTAGAGGACGCCCGACC

Downstream 100 bases:

>100_bases
CGCATCGTCTCTCTGCCGAAAGCCGGCCACGACCTTTCGGGACGATGCACAAGAACCGTATCCGACCCGATTGCATCGGA
CCGGCGCATCCTTCGTCGGG

Product: response regulator receiver protein

Products: NADP; 2 glutathione [C]

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 121; Mature: 120

Protein sequence:

>121_residues
MARILLVDDEDTVRGFLKRGLELDGHTVVTAIDGSDGLDRLSEAGGGFDLMLTDIRMPLMDGIALSLAAKRDYPDLTILL
MTGFADQRERARGLDAIVTDVLTKPFSLADLRSTVTRALAA

Sequences:

>Translated_121_residues
MARILLVDDEDTVRGFLKRGLELDGHTVVTAIDGSDGLDRLSEAGGGFDLMLTDIRMPLMDGIALSLAAKRDYPDLTILL
MTGFADQRERARGLDAIVTDVLTKPFSLADLRSTVTRALAA
>Mature_120_residues
ARILLVDDEDTVRGFLKRGLELDGHTVVTAIDGSDGLDRLSEAGGGFDLMLTDIRMPLMDGIALSLAAKRDYPDLTILLM
TGFADQRERARGLDAIVTDVLTKPFSLADLRSTVTRALAA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790299, Length=124, Percent_Identity=35.4838709677419, Blast_Score=65, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=118, Percent_Identity=38.135593220339, Blast_Score=64, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 13077; Mature: 12946

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARILLVDDEDTVRGFLKRGLELDGHTVVTAIDGSDGLDRLSEAGGGFDLMLTDIRMPLM
CCEEEEECCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHCCCCEEEEEHHHHHHHH
DGIALSLAAKRDYPDLTILLMTGFADQRERARGLDAIVTDVLTKPFSLADLRSTVTRALA
HHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHC
A
C
>Mature Secondary Structure 
ARILLVDDEDTVRGFLKRGLELDGHTVVTAIDGSDGLDRLSEAGGGFDLMLTDIRMPLM
CEEEEECCCHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHCCCCEEEEEHHHHHHHH
DGIALSLAAKRDYPDLTILLMTGFADQRERARGLDAIVTDVLTKPFSLADLRSTVTRALA
HHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADPH2; oxidized glutathione [C]

Specific reaction: NADPH2 + oxidized glutathione = NADP + 2 glutathione [C]

General reaction: Oxidoreductases; Acting on NADH or NADPH; With a disulfide as acceptor [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA