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The map label for this gene is ggt [H]

Identifier: 218710967

GI number: 218710967

Start: 3225482

End: 3227239

Strand: Direct

Name: ggt [H]

Synonym: VS_3081

Alternate gene names: 218710967

Gene position: 3225482-3227239 (Clockwise)

Preceding gene: 218710966

Following gene: 218710968

Centisome position: 97.76

GC content: 49.54

Gene sequence:

>1758_bases
ATGCAGTGGAAAACAAAACTAACAACCCTCGCCACTTCTACCCTACTTTTTGCCTCTCACGTCAGTTGGGCAAATCAAGC
TGCCGATTCCGTCGCACCCGAACAAAGTAGTGGTTTAGAAACCAAACAACTCGTTAAAGCCAATGACTGGATGGTCACAG
CAGCCAACCCATTAGCAACACAGGCTGGAGCTGATGTGCTTGCTCGTGGTGGTAACGCCATTGATGCCATGGTTGCCGTT
CAGCTTATGCTTGGCTTAGTAGAACCTCAGTCATCAGGTATTGGTGGCGGCGCGTTCCTTGTTTATTTTGATGGCAAGGA
CAAGCAACTCAAAACCTACGATGGCCGTGAAACCGCGCCGCTTGATGCCACACCACGTCTATTCCAAGACGAAAACGGCC
AACCGCTTAAATTCTATGATGCCGTGGTTGGCGGTCGTTCTGTTGGCACGCCAGGCACAGTGCAATTACTGTGGGACACT
CATCAGAAATACGGCAAGCTCGAATGGGCATCACTGATTAAGCCTATTGCTCAACTGGCTGAAGAAGGTTTCACTATCAG
CCCACGTTTAGCCACCTTGATTGAGAATGACCAAGAGCGACTAAGCCGCTTTGCCACTACCAAAGCCTACTTCTTCAATG
CTGATGGCAGCCCGAAAGCCGCTGGCACGCAACTTAAGAACCCTGAATACGCGGCAACGTTAAACGCTATTTCGAAGAAC
GGCGCTAAGGCCTTCTATCAGGGTGAGATCTCTGCCGACATCATTAACACAGTACAAACAGCGAAAGGTAACCCGGGCGT
ATTGGCACAGAAAGACTTCGACGCTTATTCGATCAAGCAGCGCGAGCCGGTTTGTTCTGCTTATGAAAGCTACCAAGTGT
GCGGAATGGGTCCACCAAGTTCAGGGGCATTAACGGTTGGGCAGATTTTAGCGATGACCGAGCAGTTTGACCTCAAATCA
TGGGGACCAAACGATGCGAAGTCTTGGCAGGTGTTAGCAGACGCTTCTCGCCTAGCCTTTGCTGACCGTGGTATGTACAT
GGCCGATCAAGATTACGTACCGATACCTACCCAAGGGTTAGTCAATACTGACTATTTGCAGGAACGTGCCCAGTTAATTA
CCGCAGGCAAGGCATTAGAAAGCGCACCATCGGGCACACCACCGTGGGATCATGCAATGCTGCAAAGCCAAGATGTTTCT
ATTGAATTGCCGTCCACCAGCCACTTCAATATTGTTGATAGCGATGGCAATGTCGTTTCGATGACCACCACCATTGAGAA
TGCCTTTGGCTCACGCTTGATGGTTAGAGGTTTCCTACTCAACAACGAACTGACGGATTTCTCATTCAAGACCCATAACG
ATGGTAAGCCTATCGCCAACCGACTTGAACCGGGTAAGCGTCCGCGCTCTTCAATGGCACCGACCATCATCATGCAAGAC
GATAAACCTTACATGGCAATTGGCTCTCCGGGAGGCAGCCGTATCATAGGTTATGTGGCACAAGCGATCATTGCGCATAC
CCAATGGGACATGGATATTCAGCAAGCCATCAATCAACCACACTTCCTAAACCGCTTCGGTACCTTAGATTTAGAAAAAG
GAACATCAGCGGAAAACTTCAAACCTGAGCTAGAAAAGATGGGATTTGAGGTCAACGTTCGCGATCTTAACTCTGGTTTA
CACGCGATTCGCATCACAAAAGATGGTTTAGAAGGCGCTGCAGACCCTCGTCGTGAAGGTGCAGCCATTGGTCAGTAG

Upstream 100 bases:

>100_bases
ATCGCTTAAATTCGAATCAAGATTACAATTCGTTAACAATGCTCTGGCTATCTCATCTTTCCACTGCCAATCTAGCTCTG
CATATTAAAAGGAGAAGATC

Downstream 100 bases:

>100_bases
GGAATAATCCTCCCTTTTTACTCGCTGCCTTGTGCGAGATCTCTCACAAGGTAGTGAGTAAATATCGATATTTGATGACG
AAATTAGTCACCTAGATATC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 585; Mature: 585

Protein sequence:

>585_residues
MQWKTKLTTLATSTLLFASHVSWANQAADSVAPEQSSGLETKQLVKANDWMVTAANPLATQAGADVLARGGNAIDAMVAV
QLMLGLVEPQSSGIGGGAFLVYFDGKDKQLKTYDGRETAPLDATPRLFQDENGQPLKFYDAVVGGRSVGTPGTVQLLWDT
HQKYGKLEWASLIKPIAQLAEEGFTISPRLATLIENDQERLSRFATTKAYFFNADGSPKAAGTQLKNPEYAATLNAISKN
GAKAFYQGEISADIINTVQTAKGNPGVLAQKDFDAYSIKQREPVCSAYESYQVCGMGPPSSGALTVGQILAMTEQFDLKS
WGPNDAKSWQVLADASRLAFADRGMYMADQDYVPIPTQGLVNTDYLQERAQLITAGKALESAPSGTPPWDHAMLQSQDVS
IELPSTSHFNIVDSDGNVVSMTTTIENAFGSRLMVRGFLLNNELTDFSFKTHNDGKPIANRLEPGKRPRSSMAPTIIMQD
DKPYMAIGSPGGSRIIGYVAQAIIAHTQWDMDIQQAINQPHFLNRFGTLDLEKGTSAENFKPELEKMGFEVNVRDLNSGL
HAIRITKDGLEGAADPRREGAAIGQ

Sequences:

>Translated_585_residues
MQWKTKLTTLATSTLLFASHVSWANQAADSVAPEQSSGLETKQLVKANDWMVTAANPLATQAGADVLARGGNAIDAMVAV
QLMLGLVEPQSSGIGGGAFLVYFDGKDKQLKTYDGRETAPLDATPRLFQDENGQPLKFYDAVVGGRSVGTPGTVQLLWDT
HQKYGKLEWASLIKPIAQLAEEGFTISPRLATLIENDQERLSRFATTKAYFFNADGSPKAAGTQLKNPEYAATLNAISKN
GAKAFYQGEISADIINTVQTAKGNPGVLAQKDFDAYSIKQREPVCSAYESYQVCGMGPPSSGALTVGQILAMTEQFDLKS
WGPNDAKSWQVLADASRLAFADRGMYMADQDYVPIPTQGLVNTDYLQERAQLITAGKALESAPSGTPPWDHAMLQSQDVS
IELPSTSHFNIVDSDGNVVSMTTTIENAFGSRLMVRGFLLNNELTDFSFKTHNDGKPIANRLEPGKRPRSSMAPTIIMQD
DKPYMAIGSPGGSRIIGYVAQAIIAHTQWDMDIQQAINQPHFLNRFGTLDLEKGTSAENFKPELEKMGFEVNVRDLNSGL
HAIRITKDGLEGAADPRREGAAIGQ
>Mature_585_residues
MQWKTKLTTLATSTLLFASHVSWANQAADSVAPEQSSGLETKQLVKANDWMVTAANPLATQAGADVLARGGNAIDAMVAV
QLMLGLVEPQSSGIGGGAFLVYFDGKDKQLKTYDGRETAPLDATPRLFQDENGQPLKFYDAVVGGRSVGTPGTVQLLWDT
HQKYGKLEWASLIKPIAQLAEEGFTISPRLATLIENDQERLSRFATTKAYFFNADGSPKAAGTQLKNPEYAATLNAISKN
GAKAFYQGEISADIINTVQTAKGNPGVLAQKDFDAYSIKQREPVCSAYESYQVCGMGPPSSGALTVGQILAMTEQFDLKS
WGPNDAKSWQVLADASRLAFADRGMYMADQDYVPIPTQGLVNTDYLQERAQLITAGKALESAPSGTPPWDHAMLQSQDVS
IELPSTSHFNIVDSDGNVVSMTTTIENAFGSRLMVRGFLLNNELTDFSFKTHNDGKPIANRLEPGKRPRSSMAPTIIMQD
DKPYMAIGSPGGSRIIGYVAQAIIAHTQWDMDIQQAINQPHFLNRFGTLDLEKGTSAENFKPELEKMGFEVNVRDLNSGL
HAIRITKDGLEGAADPRREGAAIGQ

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=485, Percent_Identity=29.8969072164948, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI73915090, Length=485, Percent_Identity=29.8969072164948, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI73915096, Length=485, Percent_Identity=29.8969072164948, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI73915094, Length=485, Percent_Identity=29.8969072164948, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI113429324, Length=478, Percent_Identity=28.4518828451883, Blast_Score=169, Evalue=7e-42,
Organism=Homo sapiens, GI113429326, Length=486, Percent_Identity=29.2181069958848, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI109148539, Length=595, Percent_Identity=28.2352941176471, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI153266885, Length=519, Percent_Identity=24.8554913294798, Blast_Score=135, Evalue=8e-32,
Organism=Homo sapiens, GI153266901, Length=520, Percent_Identity=24.6153846153846, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI30581157, Length=128, Percent_Identity=41.40625, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI30581155, Length=128, Percent_Identity=41.40625, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI218505805, Length=127, Percent_Identity=36.2204724409449, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1789856, Length=550, Percent_Identity=35.4545454545455, Blast_Score=305, Evalue=6e-84,
Organism=Caenorhabditis elegans, GI212646519, Length=592, Percent_Identity=31.4189189189189, Blast_Score=224, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI72000294, Length=592, Percent_Identity=31.4189189189189, Blast_Score=224, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17542894, Length=555, Percent_Identity=30.990990990991, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI193208247, Length=558, Percent_Identity=29.5698924731183, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI193208245, Length=563, Percent_Identity=29.8401420959147, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17506189, Length=545, Percent_Identity=28.6238532110092, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17564448, Length=433, Percent_Identity=26.7898383371824, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI72001495, Length=236, Percent_Identity=27.5423728813559, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI72001497, Length=236, Percent_Identity=27.5423728813559, Blast_Score=89, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6323330, Length=544, Percent_Identity=27.2058823529412, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI18859893, Length=549, Percent_Identity=28.2331511839709, Blast_Score=192, Evalue=4e-49,
Organism=Drosophila melanogaster, GI161077496, Length=491, Percent_Identity=26.4765784114053, Blast_Score=165, Evalue=9e-41,
Organism=Drosophila melanogaster, GI24642670, Length=555, Percent_Identity=26.3063063063063, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24642666, Length=555, Percent_Identity=26.3063063063063, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI161077878, Length=555, Percent_Identity=26.3063063063063, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI161077880, Length=555, Percent_Identity=26.3063063063063, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45551474, Length=555, Percent_Identity=26.3063063063063, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI18859741, Length=484, Percent_Identity=22.7272727272727, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 63338; Mature: 63338

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQWKTKLTTLATSTLLFASHVSWANQAADSVAPEQSSGLETKQLVKANDWMVTAANPLAT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEECCCCHHH
QAGADVLARGGNAIDAMVAVQLMLGLVEPQSSGIGGGAFLVYFDGKDKQLKTYDGRETAP
HCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCC
LDATPRLFQDENGQPLKFYDAVVGGRSVGTPGTVQLLWDTHQKYGKLEWASLIKPIAQLA
CCCCCHHHCCCCCCCEEEHHHHHCCCCCCCCCEEEEEEECHHHHCCCHHHHHHHHHHHHH
EEGFTISPRLATLIENDQERLSRFATTKAYFFNADGSPKAAGTQLKNPEYAATLNAISKN
HCCCEECCHHHHHHCCCHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCC
GAKAFYQGEISADIINTVQTAKGNPGVLAQKDFDAYSIKQREPVCSAYESYQVCGMGPPS
CCCEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCEEECCCCCC
SGALTVGQILAMTEQFDLKSWGPNDAKSWQVLADASRLAFADRGMYMADQDYVPIPTQGL
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCEEECCCCCCCCCCCC
VNTDYLQERAQLITAGKALESAPSGTPPWDHAMLQSQDVSIELPSTSHFNIVDSDGNVVS
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEECCCCCCEEEEECCCCEEE
MTTTIENAFGSRLMVRGFLLNNELTDFSFKTHNDGKPIANRLEPGKRPRSSMAPTIIMQD
EEEEHHHHHCCEEEEEEEEECCCCCCCEEEECCCCCHHHHHCCCCCCCCCCCCCEEEEEC
DKPYMAIGSPGGSRIIGYVAQAIIAHTQWDMDIQQAINQPHFLNRFGTLDLEKGTSAENF
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCCEEECCCCCCCCC
KPELEKMGFEVNVRDLNSGLHAIRITKDGLEGAADPRREGAAIGQ
CCHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQWKTKLTTLATSTLLFASHVSWANQAADSVAPEQSSGLETKQLVKANDWMVTAANPLAT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCEEEECCCCHHH
QAGADVLARGGNAIDAMVAVQLMLGLVEPQSSGIGGGAFLVYFDGKDKQLKTYDGRETAP
HCCCHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCEEEECCCCCCCC
LDATPRLFQDENGQPLKFYDAVVGGRSVGTPGTVQLLWDTHQKYGKLEWASLIKPIAQLA
CCCCCHHHCCCCCCCEEEHHHHHCCCCCCCCCEEEEEEECHHHHCCCHHHHHHHHHHHHH
EEGFTISPRLATLIENDQERLSRFATTKAYFFNADGSPKAAGTQLKNPEYAATLNAISKN
HCCCEECCHHHHHHCCCHHHHHHHHHCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCC
GAKAFYQGEISADIINTVQTAKGNPGVLAQKDFDAYSIKQREPVCSAYESYQVCGMGPPS
CCCEEEECCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCHHHHHHCCEEECCCCCC
SGALTVGQILAMTEQFDLKSWGPNDAKSWQVLADASRLAFADRGMYMADQDYVPIPTQGL
CCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHHCCCEEECCCCCCCCCCCC
VNTDYLQERAQLITAGKALESAPSGTPPWDHAMLQSQDVSIELPSTSHFNIVDSDGNVVS
CCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCEEECCCCCCEEEEECCCCEEE
MTTTIENAFGSRLMVRGFLLNNELTDFSFKTHNDGKPIANRLEPGKRPRSSMAPTIIMQD
EEEEHHHHHCCEEEEEEEEECCCCCCCEEEECCCCCHHHHHCCCCCCCCCCCCCEEEEEC
DKPYMAIGSPGGSRIIGYVAQAIIAHTQWDMDIQQAINQPHFLNRFGTLDLEKGTSAENF
CCCEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHCCCEEECCCCCCCCC
KPELEKMGFEVNVRDLNSGLHAIRITKDGLEGAADPRREGAAIGQ
CCHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA