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The map label for this gene is hemC [H]

Identifier: 218710949

GI number: 218710949

Start: 3199920

End: 3200858

Strand: Direct

Name: hemC [H]

Synonym: VS_3052

Alternate gene names: 218710949

Gene position: 3199920-3200858 (Clockwise)

Preceding gene: 218710947

Following gene: 218710950

Centisome position: 96.99

GC content: 47.71

Gene sequence:

>939_bases
ATGACAAATTCAGCACCAATCCGTATCGCGACCAGAAAAAGCCCTCTTGCCCTTTGGCAGGCATACTTTGTAAGGGATGC
ACTGCAAGCTGCTCACCCTGGTTTAGAGGTTGAGTTGGTAACTATGGTGACCAAAGGTGACATCATCCTAGACACGCCAC
TTGCTAAGGTAGGCGGTAAAGGGCTATTCGTTAAAGAACTTGAAGTAGCAATGCTAGAAGGTCGTGCTGATCTAGCGGTT
CACTCAATGAAAGACGTACCGGTCGACTTCCCTGAAGGTCTAGGTCTAGTAACGATTTGTGAGCGCGAAGATCCTCGTGA
TGCTTTCGTATCAAATACTTACAACAACATCGATGAGTTACCACAAGGTGCTGTCGTAGGTACATGCAGCCTGCGTCGTC
AATGTCAGTTGCTAGAATACCGCCCAGATCTCATCATCAAAGAGCTGCGTGGCAACGTTGGTACTCGTCTAGGTAAACTC
GATGATGGTCAATACGATGCTATCGTGCTGGCGGCAGCTGGCCTTAAGCGATTAGAGCTAGAAGAGCGTATCCGTAGCTT
TATCGAACCTGAACAGTCTCTACCTGCTGTAGGGCAAGGCGCTGTTGGTATTGAGTGTCGTCTAGATGATGAACGTCTAA
TCAAGCTTCTTGAGCCACTGAACCACAAAGACACAGCCGATCGTGTGCTATGCGAACGTGCAATGAACCTAACTCTAGAA
GGTGGTTGTCAGGTTCCTATCGGTAGCTACTCATTATTAGATGGCGATAATATCTGGCTACGTGCATTAGTAGGCGAACC
AGATGGTTCTAAAATGGTTCGTGGTGAGATCTCTGGCCTTCGCAAAGATGCAGAAGCACTTGGCGTTACTCTGGCAAATC
AATTGCTGGATGATGGCGCGAGAGAAATCTTAACCAAGCTCTACGCTGACCAAGAATAA

Upstream 100 bases:

>100_bases
AAATTCCCTCTGCTATCAAAGTATCGAATGATCAAACAGTAAGAATTTTCGCCTCACAATGGTAGGATTAGCCTATTACA
GAACCTATATCGGAAACACC

Downstream 100 bases:

>100_bases
CTATGACAGTGTTGGTGACTCGTCCCGGTTCAGAGGGACAATCGCTTTGCCAACAACTAGCGGATGAAGGGATTCAAGCA
ATCCATCATCCGCTTATTCG

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTNSAPIRIATRKSPLALWQAYFVRDALQAAHPGLEVELVTMVTKGDIILDTPLAKVGGKGLFVKELEVAMLEGRADLAV
HSMKDVPVDFPEGLGLVTICEREDPRDAFVSNTYNNIDELPQGAVVGTCSLRRQCQLLEYRPDLIIKELRGNVGTRLGKL
DDGQYDAIVLAAAGLKRLELEERIRSFIEPEQSLPAVGQGAVGIECRLDDERLIKLLEPLNHKDTADRVLCERAMNLTLE
GGCQVPIGSYSLLDGDNIWLRALVGEPDGSKMVRGEISGLRKDAEALGVTLANQLLDDGAREILTKLYADQE

Sequences:

>Translated_312_residues
MTNSAPIRIATRKSPLALWQAYFVRDALQAAHPGLEVELVTMVTKGDIILDTPLAKVGGKGLFVKELEVAMLEGRADLAV
HSMKDVPVDFPEGLGLVTICEREDPRDAFVSNTYNNIDELPQGAVVGTCSLRRQCQLLEYRPDLIIKELRGNVGTRLGKL
DDGQYDAIVLAAAGLKRLELEERIRSFIEPEQSLPAVGQGAVGIECRLDDERLIKLLEPLNHKDTADRVLCERAMNLTLE
GGCQVPIGSYSLLDGDNIWLRALVGEPDGSKMVRGEISGLRKDAEALGVTLANQLLDDGAREILTKLYADQE
>Mature_311_residues
TNSAPIRIATRKSPLALWQAYFVRDALQAAHPGLEVELVTMVTKGDIILDTPLAKVGGKGLFVKELEVAMLEGRADLAVH
SMKDVPVDFPEGLGLVTICEREDPRDAFVSNTYNNIDELPQGAVVGTCSLRRQCQLLEYRPDLIIKELRGNVGTRLGKLD
DGQYDAIVLAAAGLKRLELEERIRSFIEPEQSLPAVGQGAVGIECRLDDERLIKLLEPLNHKDTADRVLCERAMNLTLEG
GCQVPIGSYSLLDGDNIWLRALVGEPDGSKMVRGEISGLRKDAEALGVTLANQLLDDGAREILTKLYADQE

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=331, Percent_Identity=39.2749244712991, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI66933009, Length=331, Percent_Identity=39.2749244712991, Blast_Score=221, Evalue=5e-58,
Organism=Escherichia coli, GI48994974, Length=303, Percent_Identity=73.5973597359736, Blast_Score=454, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319996, Length=320, Percent_Identity=39.375, Blast_Score=202, Evalue=5e-53,
Organism=Drosophila melanogaster, GI20130425, Length=255, Percent_Identity=42.7450980392157, Blast_Score=200, Evalue=8e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 34154; Mature: 34023

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSAPIRIATRKSPLALWQAYFVRDALQAAHPGLEVELVTMVTKGDIILDTPLAKVGGK
CCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEECCHHHHCCC
GLFVKELEVAMLEGRADLAVHSMKDVPVDFPEGLGLVTICEREDPRDAFVSNTYNNIDEL
CEEHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHCCHHHHHHC
PQGAVVGTCSLRRQCQLLEYRPDLIIKELRGNVGTRLGKLDDGQYDAIVLAAAGLKRLEL
CCCCEEEEHHHHHHHHHHHCCHHHHHHHHHCHHHHHCCCCCCCCCCEEEEECCCCHHHHH
EERIRSFIEPEQSLPAVGQGAVGIECRLDDERLIKLLEPLNHKDTADRVLCERAMNLTLE
HHHHHHHHCCHHCCCCCCCCCEEEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEC
GGCQVPIGSYSLLDGDNIWLRALVGEPDGSKMVRGEISGLRKDAEALGVTLANQLLDDGA
CCCCCCCCCEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REILTKLYADQE
HHHHHHHHCCCC
>Mature Secondary Structure 
TNSAPIRIATRKSPLALWQAYFVRDALQAAHPGLEVELVTMVTKGDIILDTPLAKVGGK
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCEEEECCHHHHCCC
GLFVKELEVAMLEGRADLAVHSMKDVPVDFPEGLGLVTICEREDPRDAFVSNTYNNIDEL
CEEHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHHCCHHHHHHC
PQGAVVGTCSLRRQCQLLEYRPDLIIKELRGNVGTRLGKLDDGQYDAIVLAAAGLKRLEL
CCCCEEEEHHHHHHHHHHHCCHHHHHHHHHCHHHHHCCCCCCCCCCEEEEECCCCHHHHH
EERIRSFIEPEQSLPAVGQGAVGIECRLDDERLIKLLEPLNHKDTADRVLCERAMNLTLE
HHHHHHHHCCHHCCCCCCCCCEEEEEEECHHHHHHHHHCCCCCCHHHHHHHHHHHCCEEC
GGCQVPIGSYSLLDGDNIWLRALVGEPDGSKMVRGEISGLRKDAEALGVTLANQLLDDGA
CCCCCCCCCEEEECCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
REILTKLYADQE
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA