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The map label for this gene is sthA [H]

Identifier: 218710901

GI number: 218710901

Start: 3153271

End: 3154671

Strand: Direct

Name: sthA [H]

Synonym: VS_3003

Alternate gene names: 218710901

Gene position: 3153271-3154671 (Clockwise)

Preceding gene: 218710898

Following gene: 218710907

Centisome position: 95.57

GC content: 45.9

Gene sequence:

>1401_bases
ATGTCGCACTCCAACCACTTTGATGTAATCGTAATTGGTAGTGGCCCCGGAGGAGAAGGGGCAGCGATGGGATTAACCAA
AGCCGGGTTGAACGTTGCTATCATTGAAAAAGAGAGCAGCGTTGGTGGTGGTTGTACCCACTGGGGGACCATTCCTTCCA
AAGCACTGCGTCATGCCGTAAGTCGTATTATTGAATTCAACAGTAACCCTCTGTTTTGTCAGAACAATAAAAGTATCCAC
TCAACATTTTCCAATATTCTGGGGCATGCTAAATCGGTCATCGACAAACAGACTCGCTTGCGCCAAGGTTTCTACGATCG
CAACCAATGCACGTTAGTCTTCGGTACTGCACGTTTTATCGATACCCACACGATCTCCGTAATGCAAAGCGACGGTACTG
AAGAACACTACAGCGCAGACAAATTTGTTATCGCGACAGGTTCTCGCCCTTATCAGCCAGACAACGTCGACTTCATGCAT
GAACGTGTCTACGACAGCGATTCAATTCTTTCTCTTAAACACGATCCTCAGCACATCATCATCTATGGTGCTGGTGTTAT
CGGCTGTGAATACGCCTCTATATTTCGCGGTTTAGGCGTTAAAACCGATCTCATTAATACTCGCGACCGCCTGTTGTCCT
TCTTAGATAACGAAACCTCAGATGCACTTTCTTACCACTTCTGGAACAGTGGTGTTGTTATTCGTAACGATGAGACCTTT
GAAAAAATTGAAGGAACTGATGATGGTGTAATCATTCACCTAGAGTCAGGTAAAAAAATGCGTGCCGATTGCCTACTGTA
TGCCAATGGTCGAACGGGCAATACAGATAAACTGAACCTTGGTGCGGTTGGCTTAGAAGCGGACTCTCGTGGACAAGTAT
CAGTCAACAGCAACTACCAAACCAGTGTTGAACATGTTTACGCTGTCGGTGATGTGATTGGGTATCCTAGCCTAGCAAGT
GCTGCTTATGACCAAGGTCGATTTGTGGCCCAAGCCGTGGTGAAAGGTGAAGCAGAACGACACCTTATCGAAGACATCCC
AACAGGTATCTACACCATTCCTGAGATCAGCTCTGTCGGTAAAACCGAGCAAGAGCTTACTGCAGCTAAAGTACCGTATG
AAGTGGGACGTTCTTCATTCAAGCACTTAGCTCGCGCTCAAATTGCAGGTAAAGATATTGGTAGCTTGAAGATACTTTTC
CATCGTGAAACTAAAGAGATTTTAGGTATCCACGTGTTTGGTGAACGTGCCGCTGAAATCATTCACATTGGTCAGGCGAT
CATGGAACAAAAAGGTGAAGCCAACACCATCGAATACTTTGTGAATACTACCTTTAACTATCCGACGATGGCCGAGGCGT
ATCGCGTCGCAGCGCTTAACGGACTTAACCGTTTATTCTAA

Upstream 100 bases:

>100_bases
ATCTCACCGACTCTCTGATGCCCTTTTCATGTACCCAGGAACAGAATCAGTTAAAATCTCGCTAAAGCAATGTTAATCAA
ATATAACAAGGAAGATATCT

Downstream 100 bases:

>100_bases
ACAAAGAACCAACAGGACTATTTGACCACCTGTAGGCAAAATACATAAACAGCAAGCCATGAGCTTGCTGTTTTTATTTT
TCGTTCCCTGAACTAAGCTA

Product: soluble pyridine nucleotide transhydrogenase

Products: NA

Alternate protein names: STH; NAD(P)(+) transhydrogenase [B-specific] [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MSHSNHFDVIVIGSGPGGEGAAMGLTKAGLNVAIIEKESSVGGGCTHWGTIPSKALRHAVSRIIEFNSNPLFCQNNKSIH
STFSNILGHAKSVIDKQTRLRQGFYDRNQCTLVFGTARFIDTHTISVMQSDGTEEHYSADKFVIATGSRPYQPDNVDFMH
ERVYDSDSILSLKHDPQHIIIYGAGVIGCEYASIFRGLGVKTDLINTRDRLLSFLDNETSDALSYHFWNSGVVIRNDETF
EKIEGTDDGVIIHLESGKKMRADCLLYANGRTGNTDKLNLGAVGLEADSRGQVSVNSNYQTSVEHVYAVGDVIGYPSLAS
AAYDQGRFVAQAVVKGEAERHLIEDIPTGIYTIPEISSVGKTEQELTAAKVPYEVGRSSFKHLARAQIAGKDIGSLKILF
HRETKEILGIHVFGERAAEIIHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Sequences:

>Translated_466_residues
MSHSNHFDVIVIGSGPGGEGAAMGLTKAGLNVAIIEKESSVGGGCTHWGTIPSKALRHAVSRIIEFNSNPLFCQNNKSIH
STFSNILGHAKSVIDKQTRLRQGFYDRNQCTLVFGTARFIDTHTISVMQSDGTEEHYSADKFVIATGSRPYQPDNVDFMH
ERVYDSDSILSLKHDPQHIIIYGAGVIGCEYASIFRGLGVKTDLINTRDRLLSFLDNETSDALSYHFWNSGVVIRNDETF
EKIEGTDDGVIIHLESGKKMRADCLLYANGRTGNTDKLNLGAVGLEADSRGQVSVNSNYQTSVEHVYAVGDVIGYPSLAS
AAYDQGRFVAQAVVKGEAERHLIEDIPTGIYTIPEISSVGKTEQELTAAKVPYEVGRSSFKHLARAQIAGKDIGSLKILF
HRETKEILGIHVFGERAAEIIHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
>Mature_465_residues
SHSNHFDVIVIGSGPGGEGAAMGLTKAGLNVAIIEKESSVGGGCTHWGTIPSKALRHAVSRIIEFNSNPLFCQNNKSIHS
TFSNILGHAKSVIDKQTRLRQGFYDRNQCTLVFGTARFIDTHTISVMQSDGTEEHYSADKFVIATGSRPYQPDNVDFMHE
RVYDSDSILSLKHDPQHIIIYGAGVIGCEYASIFRGLGVKTDLINTRDRLLSFLDNETSDALSYHFWNSGVVIRNDETFE
KIEGTDDGVIIHLESGKKMRADCLLYANGRTGNTDKLNLGAVGLEADSRGQVSVNSNYQTSVEHVYAVGDVIGYPSLASA
AYDQGRFVAQAVVKGEAERHLIEDIPTGIYTIPEISSVGKTEQELTAAKVPYEVGRSSFKHLARAQIAGKDIGSLKILFH
RETKEILGIHVFGERAAEIIHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF

Specific function: Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [H]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI91199540, Length=472, Percent_Identity=28.6016949152542, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI22035672, Length=363, Percent_Identity=29.4765840220386, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI50301238, Length=463, Percent_Identity=26.3498920086393, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI291045266, Length=435, Percent_Identity=24.1379310344828, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI33519430, Length=406, Percent_Identity=24.8768472906404, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI33519428, Length=406, Percent_Identity=24.8768472906404, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI33519426, Length=406, Percent_Identity=24.8768472906404, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI148277071, Length=321, Percent_Identity=27.1028037383178, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI148277065, Length=406, Percent_Identity=24.8768472906404, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI291045268, Length=316, Percent_Identity=25, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI21389617, Length=253, Percent_Identity=26.8774703557312, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI65787454, Length=253, Percent_Identity=26.8774703557312, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI226437568, Length=253, Percent_Identity=26.8774703557312, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87082354, Length=466, Percent_Identity=75.9656652360515, Blast_Score=753, Evalue=0.0,
Organism=Escherichia coli, GI1786307, Length=469, Percent_Identity=29.4243070362473, Blast_Score=188, Evalue=6e-49,
Organism=Escherichia coli, GI1789915, Length=452, Percent_Identity=28.5398230088496, Blast_Score=157, Evalue=2e-39,
Organism=Escherichia coli, GI87081717, Length=467, Percent_Identity=26.7665952890792, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI32565766, Length=475, Percent_Identity=29.6842105263158, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI17557007, Length=472, Percent_Identity=25.4237288135593, Blast_Score=114, Evalue=9e-26,
Organism=Caenorhabditis elegans, GI71983429, Length=409, Percent_Identity=27.1393643031785, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71983419, Length=409, Percent_Identity=27.1393643031785, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71982272, Length=488, Percent_Identity=24.7950819672131, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17559934, Length=257, Percent_Identity=24.5136186770428, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321091, Length=481, Percent_Identity=27.2349272349272, Blast_Score=169, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6325166, Length=472, Percent_Identity=28.6016949152542, Blast_Score=153, Evalue=7e-38,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=26.6524520255864, Blast_Score=147, Evalue=5e-36,
Organism=Drosophila melanogaster, GI21358499, Length=470, Percent_Identity=30, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24640549, Length=484, Percent_Identity=28.099173553719, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24640553, Length=484, Percent_Identity=28.099173553719, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24640551, Length=484, Percent_Identity=28.099173553719, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI17737741, Length=487, Percent_Identity=26.2833675564682, Blast_Score=128, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR004099
- InterPro:   IPR001327
- InterPro:   IPR022962 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.6.1.1 [H]

Molecular weight: Translated: 51110; Mature: 50979

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSNHFDVIVIGSGPGGEGAAMGLTKAGLNVAIIEKESSVGGGCTHWGTIPSKALRHAV
CCCCCCEEEEEEECCCCCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
SRIIEFNSNPLFCQNNKSIHSTFSNILGHAKSVIDKQTRLRQGFYDRNQCTLVFGTARFI
HHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEE
DTHTISVMQSDGTEEHYSADKFVIATGSRPYQPDNVDFMHERVYDSDSILSLKHDPQHII
ECEEEEEEECCCCHHHCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCEEE
IYGAGVIGCEYASIFRGLGVKTDLINTRDRLLSFLDNETSDALSYHFWNSGVVIRNDETF
EEECCHHHHHHHHHHHCCCCEEHHHCHHHHHHHHHCCCCCCCEEEEEECCCEEEECCCHH
EKIEGTDDGVIIHLESGKKMRADCLLYANGRTGNTDKLNLGAVGLEADSRGQVSVNSNYQ
HHHCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEEEEEEEEECCCCCCCEEECCCCC
TSVEHVYAVGDVIGYPSLASAAYDQGRFVAQAVVKGEAERHLIEDIPTGIYTIPEISSVG
HHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCEEECCCCHHCC
KTEQELTAAKVPYEVGRSSFKHLARAQIAGKDIGSLKILFHRETKEILGIHVFGERAAEI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHEEEEEECHHHHHH
IHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHSNHFDVIVIGSGPGGEGAAMGLTKAGLNVAIIEKESSVGGGCTHWGTIPSKALRHAV
CCCCCEEEEEEECCCCCCCCCCEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
SRIIEFNSNPLFCQNNKSIHSTFSNILGHAKSVIDKQTRLRQGFYDRNQCTLVFGTARFI
HHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEE
DTHTISVMQSDGTEEHYSADKFVIATGSRPYQPDNVDFMHERVYDSDSILSLKHDPQHII
ECEEEEEEECCCCHHHCCCCEEEEEECCCCCCCCCCHHHHHHHCCCCCEEEEECCCCEEE
IYGAGVIGCEYASIFRGLGVKTDLINTRDRLLSFLDNETSDALSYHFWNSGVVIRNDETF
EEECCHHHHHHHHHHHCCCCEEHHHCHHHHHHHHHCCCCCCCEEEEEECCCEEEECCCHH
EKIEGTDDGVIIHLESGKKMRADCLLYANGRTGNTDKLNLGAVGLEADSRGQVSVNSNYQ
HHHCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCCEEEEEEEEECCCCCCCEEECCCCC
TSVEHVYAVGDVIGYPSLASAAYDQGRFVAQAVVKGEAERHLIEDIPTGIYTIPEISSVG
HHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHHHHHCCHHHHHHHHCCCCEEECCCCHHCC
KTEQELTAAKVPYEVGRSSFKHLARAQIAGKDIGSLKILFHRETKEILGIHVFGERAAEI
CCHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCHHEEEEEECHHHHHH
IHIGQAIMEQKGEANTIEYFVNTTFNYPTMAEAYRVAALNGLNRLF
HHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]