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The map label for this gene is hemE [H]

Identifier: 218710875

GI number: 218710875

Start: 3117512

End: 3118633

Strand: Reverse

Name: hemE [H]

Synonym: VS_2959

Alternate gene names: 218710875

Gene position: 3118633-3117512 (Counterclockwise)

Preceding gene: 218710876

Following gene: 218710872

Centisome position: 94.52

GC content: 46.08

Gene sequence:

>1122_bases
GTGTTAGAATACTTGCCATCAAAACTAGACAAGATTGAATTGGAATTTAACGGAATGACCGAATTAAAAAACGATCGCTA
TTTACGCGCACTTTTAAAACAGCCTGTTGATTACACACCGGTATGGATGATGCGCCAAGCTGGCCGCTATCTTCCAGAGT
ACAAAGCAACGCGCGCTGAAGCGGGCGATTTCATGTCTTTGTGCAAAAACGCTGAACTAGCATCAGAAGTAACACTTCAA
CCTTTACGTCGTTTCCCGCTTGATGCGGCAATCTTGTTCTCTGACATCCTAACTATCCCAGATGCGATGGGTTTAGGTTT
GTACTTCGAAACAGGTGAAGGCCCTAAGTTTGAACGCCCTATCACATGTAAAGCTGACGTAGAAAAAATTGGCCTACCTG
ATCCTGAAGGTGAACTTCAATACGTAATGAATGCCGTTCGTCAGATCCGTAAAGACCTGAAAGGCGAAGTGCCACTGATT
GGTTTCTCTGGTAGCCCTTGGACATTGGCAACTTACATGGTTGAAGGCAGCAGCTCGAAGGCGTTCACTAAGATCAAGAA
GATGATGTATGCAGAGCCACAAACGCTGCACTTACTTCTAGATAAGCTGGCTGACACTGTTATTGAATACCTGAACGCGC
AAATTAAAGCAGGCGCACAATCGGTAATGGTATTCGACACATGGGGTGGTGTACTTACTCCGCGTGACTACAACCTGTTC
TCACTGCAGTACATGCACAAAATTGTCGATGGCCTAATTCGTGAAAATGAAGGTCGCCGTGTACCGGTTACTCTGTTCAC
TAAGAACGGTGGCATGTGGCTAGAATCTATCGCAGCGACTGGCTGTGATGCAGTTGGGCTAGACTGGACAATCAATATTG
CTGATGCAAAAGCACGTATTGGCGATAAAGTGGCTCTACAAGGCAACATGGACCCATCAGTACTTTACGCACAACCTGAG
CGTATTCGTGAAGAAGTCGGCACTATCCTTGAAGGTTTTGGTGACGGCGGTACTGGCCACGTATTTAACCTTGGCCATGG
TATTCACCTAGATGTGCCACCAGAAAATGCTGGTGTATTTGTGGACGCAGTTCACGACCTATCTAAGCCATACCATAAGT
AA

Upstream 100 bases:

>100_bases
TTTTTAACATGCTCCTGTAATTGGGCGCAAATTAAGCATGGATTTAAAAGTTAATAACTTGATCTAGGTTGCAAAGCACA
CAGCTTTTACCCTTCAATCA

Downstream 100 bases:

>100_bases
TTCAGTATGTGTTTTTAGAAAAAGCGCTGTCGAGAAATCGGCAGCGCTTTTTTATTATCTTTCTATCCACACTCAATATC
GGCTAAATCATCGTTGATGT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MLEYLPSKLDKIELEFNGMTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAELASEVTLQ
PLRRFPLDAAILFSDILTIPDAMGLGLYFETGEGPKFERPITCKADVEKIGLPDPEGELQYVMNAVRQIRKDLKGEVPLI
GFSGSPWTLATYMVEGSSSKAFTKIKKMMYAEPQTLHLLLDKLADTVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNLF
SLQYMHKIVDGLIRENEGRRVPVTLFTKNGGMWLESIAATGCDAVGLDWTINIADAKARIGDKVALQGNMDPSVLYAQPE
RIREEVGTILEGFGDGGTGHVFNLGHGIHLDVPPENAGVFVDAVHDLSKPYHK

Sequences:

>Translated_373_residues
MLEYLPSKLDKIELEFNGMTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAELASEVTLQ
PLRRFPLDAAILFSDILTIPDAMGLGLYFETGEGPKFERPITCKADVEKIGLPDPEGELQYVMNAVRQIRKDLKGEVPLI
GFSGSPWTLATYMVEGSSSKAFTKIKKMMYAEPQTLHLLLDKLADTVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNLF
SLQYMHKIVDGLIRENEGRRVPVTLFTKNGGMWLESIAATGCDAVGLDWTINIADAKARIGDKVALQGNMDPSVLYAQPE
RIREEVGTILEGFGDGGTGHVFNLGHGIHLDVPPENAGVFVDAVHDLSKPYHK
>Mature_373_residues
MLEYLPSKLDKIELEFNGMTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAEAGDFMSLCKNAELASEVTLQ
PLRRFPLDAAILFSDILTIPDAMGLGLYFETGEGPKFERPITCKADVEKIGLPDPEGELQYVMNAVRQIRKDLKGEVPLI
GFSGSPWTLATYMVEGSSSKAFTKIKKMMYAEPQTLHLLLDKLADTVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNLF
SLQYMHKIVDGLIRENEGRRVPVTLFTKNGGMWLESIAATGCDAVGLDWTINIADAKARIGDKVALQGNMDPSVLYAQPE
RIREEVGTILEGFGDGGTGHVFNLGHGIHLDVPPENAGVFVDAVHDLSKPYHK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III [H]

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI71051616, Length=359, Percent_Identity=47.6323119777159, Blast_Score=326, Evalue=2e-89,
Organism=Escherichia coli, GI2367337, Length=355, Percent_Identity=81.6901408450704, Blast_Score=608, Evalue=1e-175,
Organism=Saccharomyces cerevisiae, GI6320252, Length=353, Percent_Identity=39.0934844192635, Blast_Score=267, Evalue=3e-72,
Organism=Drosophila melanogaster, GI221330099, Length=361, Percent_Identity=41.2742382271468, Blast_Score=286, Evalue=2e-77,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=41.4985590778098, Blast_Score=280, Evalue=9e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006361
- InterPro:   IPR000257 [H]

Pfam domain/function: PF01208 URO-D [H]

EC number: =4.1.1.37 [H]

Molecular weight: Translated: 41521; Mature: 41521

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS00906 UROD_1 ; PS00907 UROD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEYLPSKLDKIELEFNGMTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAE
CCCCCCCCCCEEEEEECCCHHCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHH
AGDFMSLCKNAELASEVTLQPLRRFPLDAAILFSDILTIPDAMGLGLYFETGEGPKFERP
HHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCC
ITCKADVEKIGLPDPEGELQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGSSSK
EECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCH
AFTKIKKMMYAEPQTLHLLLDKLADTVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNLF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCCCHH
SLQYMHKIVDGLIRENEGRRVPVTLFTKNGGMWLESIAATGCDAVGLDWTINIADAKARI
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEEEECHHHHC
GDKVALQGNMDPSVLYAQPERIREEVGTILEGFGDGGTGHVFNLGHGIHLDVPPENAGVF
CCEEEEECCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCEE
VDAVHDLSKPYHK
EEEHHHHCCCCCC
>Mature Secondary Structure
MLEYLPSKLDKIELEFNGMTELKNDRYLRALLKQPVDYTPVWMMRQAGRYLPEYKATRAE
CCCCCCCCCCEEEEEECCCHHCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHH
AGDFMSLCKNAELASEVTLQPLRRFPLDAAILFSDILTIPDAMGLGLYFETGEGPKFERP
HHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCC
ITCKADVEKIGLPDPEGELQYVMNAVRQIRKDLKGEVPLIGFSGSPWTLATYMVEGSSSK
EECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEEEEEEECCCCH
AFTKIKKMMYAEPQTLHLLLDKLADTVIEYLNAQIKAGAQSVMVFDTWGGVLTPRDYNLF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEECCCCCCHH
SLQYMHKIVDGLIRENEGRRVPVTLFTKNGGMWLESIAATGCDAVGLDWTINIADAKARI
HHHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEEEECHHHHC
GDKVALQGNMDPSVLYAQPERIREEVGTILEGFGDGGTGHVFNLGHGIHLDVPPENAGVF
CCEEEEECCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCEEEECCCEEEEECCCCCCCEE
VDAVHDLSKPYHK
EEEHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA