Click here to switch to the map view.

The map label for this gene is hupA [H]

Identifier: 218710870

GI number: 218710870

Start: 3113450

End: 3113782

Strand: Reverse

Name: hupA [H]

Synonym: VS_2954

Alternate gene names: 218710870

Gene position: 3113782-3113450 (Counterclockwise)

Preceding gene: 218710872

Following gene: 218710869

Centisome position: 94.38

GC content: 40.54

Gene sequence:

>333_bases
ATGGGGCATTTATGTTTTAGAGTGAATCGAATTCAAAAATACAAAGAAGGGAAACCTAAAATGAACAAGACTCAATTAAT
CGACTTTATTGCTGAAAAAGCGGACCTTTCTAAAGCACAAGCTAAAGCTGCTCTAGAAGCGACTCTTGGCGGTGTTACAG
ATGCTCTTAAAGATGGCGATCAAGTTCAGCTAATTGGTTTTGGTACTTTTAAAGTAAACCACCGTGCAGCTCGCACTGGT
CGTAACCCAAAAACTGGTGACGAGATCCAAATCGCTGCTGCAAATGTTCCAGCATTTGTTGCAGGTAAAGCGCTGAAAGA
TTCAGTGAAATAA

Upstream 100 bases:

>100_bases
GGCTTGCTCAGTAAAATCAGTAACAAATTGTGAGTTATTACTCATATTATGGCTAAAACTACGGCATTAGAGCTAAAGAT
CGACGACAAACCTTTGCCAG

Downstream 100 bases:

>100_bases
TCTAAACTGTACCGAGGTAGTCGTATTCCACCTCGGTACAGGTTTTTATGAAAAAAGCATTTCTTCTCGTTTCACTATTA
TCTACATTTCTCATTGGCTG

Product: DNA-binding protein HU-alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MGHLCFRVNRIQKYKEGKPKMNKTQLIDFIAEKADLSKAQAKAALEATLGGVTDALKDGDQVQLIGFGTFKVNHRAARTG
RNPKTGDEIQIAAANVPAFVAGKALKDSVK

Sequences:

>Translated_110_residues
MGHLCFRVNRIQKYKEGKPKMNKTQLIDFIAEKADLSKAQAKAALEATLGGVTDALKDGDQVQLIGFGTFKVNHRAARTG
RNPKTGDEIQIAAANVPAFVAGKALKDSVK
>Mature_109_residues
GHLCFRVNRIQKYKEGKPKMNKTQLIDFIAEKADLSKAQAKAALEATLGGVTDALKDGDQVQLIGFGTFKVNHRAARTGR
NPKTGDEIQIAAANVPAFVAGKALKDSVK

Specific function: Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions [H]

COG id: COG0776

COG function: function code L; Bacterial nucleoid DNA-binding protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial histone-like protein family [H]

Homologues:

Organism=Escherichia coli, GI1790433, Length=90, Percent_Identity=80, Blast_Score=151, Evalue=1e-38,
Organism=Escherichia coli, GI1786644, Length=89, Percent_Identity=67.4157303370787, Blast_Score=117, Evalue=1e-28,
Organism=Escherichia coli, GI1787141, Length=88, Percent_Identity=36.3636363636364, Blast_Score=72, Evalue=7e-15,
Organism=Escherichia coli, GI1788005, Length=90, Percent_Identity=38.8888888888889, Blast_Score=70, Evalue=4e-14,

Paralogues:

None

Copy number: 1380 Molecules/Cell In: Growth-Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000119
- InterPro:   IPR020816
- InterPro:   IPR010992 [H]

Pfam domain/function: PF00216 Bac_DNA_binding [H]

EC number: NA

Molecular weight: Translated: 11852; Mature: 11721

Theoretical pI: Translated: 10.57; Mature: 10.57

Prosite motif: PS00045 HISTONE_LIKE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHLCFRVNRIQKYKEGKPKMNKTQLIDFIAEKADLSKAQAKAALEATLGGVTDALKDGD
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QVQLIGFGTFKVNHRAARTGRNPKTGDEIQIAAANVPAFVAGKALKDSVK
EEEEEEEEEEEECCHHHHCCCCCCCCCEEEEEECCCCHHHHCHHHHCCCC
>Mature Secondary Structure 
GHLCFRVNRIQKYKEGKPKMNKTQLIDFIAEKADLSKAQAKAALEATLGGVTDALKDGD
CCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
QVQLIGFGTFKVNHRAARTGRNPKTGDEIQIAAANVPAFVAGKALKDSVK
EEEEEEEEEEEECCHHHHCCCCCCCCCEEEEEECCCCHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1508695 [H]