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The map label for this gene is acsA [H]

Identifier: 218710858

GI number: 218710858

Start: 3100422

End: 3102371

Strand: Direct

Name: acsA [H]

Synonym: VS_2942

Alternate gene names: 218710858

Gene position: 3100422-3102371 (Clockwise)

Preceding gene: 218710857

Following gene: 218710859

Centisome position: 93.97

GC content: 48.1

Gene sequence:

>1950_bases
ATGAGTGAAGCCCACGTTTATCCGGTAAAAGAAAATATTAAATCAACCACACACGCGGATAATGACACTTACCTAGCCAT
GTACCAGCAATCTGTTTCTGACCCTGAAGGCTTTTGGGGTGAACACGGAAAAATCGTTGATTGGATTAAACCTTTCACAC
AGGTAAAAAATACCTCTTTCGACCCTGGCCACATTGATATTCGCTGGTTTGAAGATGGCACGCTTAACGTTTCGGCTAAC
TGTATCGACCGCCACCTTGCTGAACGCGGCGATGAAGTCGCTATTATCTGGGAAGGCGATGACCCGGCGGATGACAAAAC
TCTAACTTTTAATGAACTACACAAAGAAGTGTGCCTGTTTTCGAATGCTCTGAAAGAGCAAGGCGTGCGCAAAGGCGATG
TGGTTTGTTTATACATGCCAATGGTTCCTGAAGCTGCAGTAGCCATGCTGGCGTGTACCCGTATAGGTGCGGTTCACACA
GTAGTATTTGGTGGTTTCTCACCAGAAGCACTGTCTGGTCGTATTATCGATTCAAATTCTAAAGTCGTTATCACTGCCGA
TGAAGGCGTGCGTGGCGGCCGTGCTGTTCCACTGAAGAAAAATGTCGATGAAGCACTGACGAATCCTGAAGTGAAGAACA
TCGAAAAGGTTGTAGTATTCAAACGTACTGGCGGCGATGTTGCATGGCACGAACACCGCGATGTGTGGTGGCACGATGCT
ATTGCTAATGTATCTGCAGATTGTCCTCCAGAAGAGATGAACGCAGAAGACCCACTATTCATCCTTTATACGTCAGGTTC
AACAGGCAAACCTAAGGGTGTTATGCACACCACAGGTGGTTACCTTGTTTATGCAGCAATGACCTTCAAATACGTATTCG
ATTACCAAGAAGGCGAAACTTTCTGGTGTACAGCCGATGTGGGTTGGATTACCGGTCACACATACCTTGTTTACGGGCCA
CTAGCCAATGGTGCAAAAACCATTCTGTTTGAAGGCGTGCCGAACTACCCGAACACAAGCCGCATGAGTGAAGTGGTCGA
TAAGCACCAAGTTAATATTCTTTATACGGCGCCAACAGCTATTCGTGCATTGATGGCGAAAGGCAATGAAGCCGTTGAAG
GCACGTCTCGTGACAGCCTAAGAATCATGGGCTCAGTGGGTGAACCTATCAACCCAGAGGCGTGGGAGTGGTACTACAAA
ACAATCGGTAATGAGCAGTCTCCAATTGTTGATACATGGTGGCAAACAGAAACGGGTGGTATCTTAATCGCACCACTACC
GGGGGCAACCGATCTAAAACCGGGCTCAGCGACGCGTCCATTCTTCGGTGTGCAACCGGCGCTGGTTGATAACATGGGTA
ACATCATTGAGGGTGCAACAGACGGCAACCTAGTGATTCTTGACTCTTGGCCAGGCCAGATGCGTACCGTTCACGGCGAT
CATGACCGTTTCGAACAAACTTACTTCTCGACCTTTAAAGGCATGTACTTCACCAGTGATGGTGCTCGTCGTGATGAAGA
CGGTTACTACTGGATTACTGGCCGTGTTGATGACGTTCTGAACGTATCAGGCCACCGTATGGGTACCGCTGAGATTGAAT
CGGCTCTAGTCGCATTTGATAAGATCGCAGAGGCTGCGATTGTAGGTATCCCTCATGATATTAAAGGCCAAGCGATTTAC
GCTTACATCACGTTGAATGATGGTGAATTTCCGACCGCAGAGCTTCATAAAGAAGTGAAAGACTGGGTACGCAAAGAGAT
AGGCCCAATCGCAACGCCAGATGTACTGCACTGGACCGACTCATTACCAAAAACTCGTTCAGGTAAAATCATGCGTCGTA
TCCTGCGTAAGATTGCCACTGGCGATACTGGCAACCTAGGCGATACGTCGACACTGGCAGACCCAAGCGTGGTCGATAAG
CTGATTGCAGAGAAAGCGGAACTGGCATAA

Upstream 100 bases:

>100_bases
TCGAGAGTGATAACACAAAGATGGTTCTGTAATAGACCTAGAAACTGAACACAAAGGAAGTTGCCAGTTCATTAGGAATG
TAGGCACAAGGAGAGATGCA

Downstream 100 bases:

>100_bases
GCAACCCGTCACATTACGTAATTACTGTTTAAAACAGCGCCTTTCTAAACCGTCACCTATGTGGCGGTTTTTTTATGGCT
GATCTTGATCTCAAATATCC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 649; Mature: 648

Protein sequence:

>649_residues
MSEAHVYPVKENIKSTTHADNDTYLAMYQQSVSDPEGFWGEHGKIVDWIKPFTQVKNTSFDPGHIDIRWFEDGTLNVSAN
CIDRHLAERGDEVAIIWEGDDPADDKTLTFNELHKEVCLFSNALKEQGVRKGDVVCLYMPMVPEAAVAMLACTRIGAVHT
VVFGGFSPEALSGRIIDSNSKVVITADEGVRGGRAVPLKKNVDEALTNPEVKNIEKVVVFKRTGGDVAWHEHRDVWWHDA
IANVSADCPPEEMNAEDPLFILYTSGSTGKPKGVMHTTGGYLVYAAMTFKYVFDYQEGETFWCTADVGWITGHTYLVYGP
LANGAKTILFEGVPNYPNTSRMSEVVDKHQVNILYTAPTAIRALMAKGNEAVEGTSRDSLRIMGSVGEPINPEAWEWYYK
TIGNEQSPIVDTWWQTETGGILIAPLPGATDLKPGSATRPFFGVQPALVDNMGNIIEGATDGNLVILDSWPGQMRTVHGD
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFDKIAEAAIVGIPHDIKGQAIY
AYITLNDGEFPTAELHKEVKDWVRKEIGPIATPDVLHWTDSLPKTRSGKIMRRILRKIATGDTGNLGDTSTLADPSVVDK
LIAEKAELA

Sequences:

>Translated_649_residues
MSEAHVYPVKENIKSTTHADNDTYLAMYQQSVSDPEGFWGEHGKIVDWIKPFTQVKNTSFDPGHIDIRWFEDGTLNVSAN
CIDRHLAERGDEVAIIWEGDDPADDKTLTFNELHKEVCLFSNALKEQGVRKGDVVCLYMPMVPEAAVAMLACTRIGAVHT
VVFGGFSPEALSGRIIDSNSKVVITADEGVRGGRAVPLKKNVDEALTNPEVKNIEKVVVFKRTGGDVAWHEHRDVWWHDA
IANVSADCPPEEMNAEDPLFILYTSGSTGKPKGVMHTTGGYLVYAAMTFKYVFDYQEGETFWCTADVGWITGHTYLVYGP
LANGAKTILFEGVPNYPNTSRMSEVVDKHQVNILYTAPTAIRALMAKGNEAVEGTSRDSLRIMGSVGEPINPEAWEWYYK
TIGNEQSPIVDTWWQTETGGILIAPLPGATDLKPGSATRPFFGVQPALVDNMGNIIEGATDGNLVILDSWPGQMRTVHGD
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFDKIAEAAIVGIPHDIKGQAIY
AYITLNDGEFPTAELHKEVKDWVRKEIGPIATPDVLHWTDSLPKTRSGKIMRRILRKIATGDTGNLGDTSTLADPSVVDK
LIAEKAELA
>Mature_648_residues
SEAHVYPVKENIKSTTHADNDTYLAMYQQSVSDPEGFWGEHGKIVDWIKPFTQVKNTSFDPGHIDIRWFEDGTLNVSANC
IDRHLAERGDEVAIIWEGDDPADDKTLTFNELHKEVCLFSNALKEQGVRKGDVVCLYMPMVPEAAVAMLACTRIGAVHTV
VFGGFSPEALSGRIIDSNSKVVITADEGVRGGRAVPLKKNVDEALTNPEVKNIEKVVVFKRTGGDVAWHEHRDVWWHDAI
ANVSADCPPEEMNAEDPLFILYTSGSTGKPKGVMHTTGGYLVYAAMTFKYVFDYQEGETFWCTADVGWITGHTYLVYGPL
ANGAKTILFEGVPNYPNTSRMSEVVDKHQVNILYTAPTAIRALMAKGNEAVEGTSRDSLRIMGSVGEPINPEAWEWYYKT
IGNEQSPIVDTWWQTETGGILIAPLPGATDLKPGSATRPFFGVQPALVDNMGNIIEGATDGNLVILDSWPGQMRTVHGDH
DRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFDKIAEAAIVGIPHDIKGQAIYA
YITLNDGEFPTAELHKEVKDWVRKEIGPIATPDVLHWTDSLPKTRSGKIMRRILRKIATGDTGNLGDTSTLADPSVVDKL
IAEKAELA

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=669, Percent_Identity=50.8221225710015, Blast_Score=689, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=682, Percent_Identity=49.8533724340176, Blast_Score=684, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=625, Percent_Identity=49.28, Blast_Score=629, Evalue=1e-180,
Organism=Homo sapiens, GI13375727, Length=635, Percent_Identity=36.3779527559055, Blast_Score=396, Evalue=1e-110,
Organism=Homo sapiens, GI42544132, Length=541, Percent_Identity=27.3567467652495, Blast_Score=183, Evalue=5e-46,
Organism=Homo sapiens, GI31982927, Length=649, Percent_Identity=24.4992295839753, Blast_Score=183, Evalue=5e-46,
Organism=Homo sapiens, GI38505220, Length=516, Percent_Identity=29.6511627906977, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI122937307, Length=551, Percent_Identity=25.7713248638838, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI115511026, Length=545, Percent_Identity=26.605504587156, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI58082049, Length=530, Percent_Identity=24.1509433962264, Blast_Score=143, Evalue=5e-34,
Organism=Homo sapiens, GI157311624, Length=530, Percent_Identity=23.3962264150943, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI157311622, Length=530, Percent_Identity=23.3962264150943, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI187761345, Length=403, Percent_Identity=25.5583126550869, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI187761343, Length=403, Percent_Identity=25.5583126550869, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI42544134, Length=359, Percent_Identity=24.5125348189415, Blast_Score=93, Evalue=6e-19,
Organism=Homo sapiens, GI195947378, Length=404, Percent_Identity=25.2475247524752, Blast_Score=93, Evalue=7e-19,
Organism=Homo sapiens, GI156151445, Length=391, Percent_Identity=24.5524296675192, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1790505, Length=649, Percent_Identity=73.6517719568567, Blast_Score=1035, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=631, Percent_Identity=35.6576862123613, Blast_Score=399, Evalue=1e-112,
Organism=Escherichia coli, GI1788107, Length=587, Percent_Identity=23.679727427598, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI221142682, Length=532, Percent_Identity=21.8045112781955, Blast_Score=90, Evalue=4e-19,
Organism=Escherichia coli, GI145693145, Length=125, Percent_Identity=32, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI71983001, Length=643, Percent_Identity=50.3888024883359, Blast_Score=641, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71982997, Length=642, Percent_Identity=50.4672897196262, Blast_Score=640, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=604, Percent_Identity=22.1854304635762, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17559526, Length=576, Percent_Identity=23.7847222222222, Blast_Score=104, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17538037, Length=582, Percent_Identity=23.5395189003436, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17557194, Length=576, Percent_Identity=22.5694444444444, Blast_Score=94, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=520, Percent_Identity=21.9230769230769, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI32563687, Length=519, Percent_Identity=22.7360308285164, Blast_Score=86, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6323182, Length=640, Percent_Identity=47.65625, Blast_Score=619, Evalue=1e-178,
Organism=Saccharomyces cerevisiae, GI6319264, Length=635, Percent_Identity=47.0866141732283, Blast_Score=585, Evalue=1e-168,
Organism=Saccharomyces cerevisiae, GI6319699, Length=370, Percent_Identity=23.7837837837838, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24667955, Length=664, Percent_Identity=51.6566265060241, Blast_Score=682, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=55.8718861209964, Blast_Score=637, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=56.3461538461538, Blast_Score=596, Evalue=1e-170,
Organism=Drosophila melanogaster, GI21355225, Length=635, Percent_Identity=34.8031496062992, Blast_Score=384, Evalue=1e-106,
Organism=Drosophila melanogaster, GI18859661, Length=548, Percent_Identity=24.8175182481752, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24656500, Length=538, Percent_Identity=23.7918215613383, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24581924, Length=530, Percent_Identity=20.9433962264151, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71625; Mature: 71494

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEAHVYPVKENIKSTTHADNDTYLAMYQQSVSDPEGFWGEHGKIVDWIKPFTQVKNTSF
CCCCEEEEHHHHCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
DPGHIDIRWFEDGTLNVSANCIDRHLAERGDEVAIIWEGDDPADDKTLTFNELHKEVCLF
CCCEEEEEEECCCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHH
SNALKEQGVRKGDVVCLYMPMVPEAAVAMLACTRIGAVHTVVFGGFSPEALSGRIIDSNS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCHHCCCEEEECCC
KVVITADEGVRGGRAVPLKKNVDEALTNPEVKNIEKVVVFKRTGGDVAWHEHRDVWWHDA
EEEEECCCCCCCCEECCCCCCHHHHHCCCCHHCCEEEEEEEECCCCCEEECCCCCCHHHH
IANVSADCPPEEMNAEDPLFILYTSGSTGKPKGVMHTTGGYLVYAAMTFKYVFDYQEGET
HHCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEEEEEEEEEEEECCCCE
FWCTADVGWITGHTYLVYGPLANGAKTILFEGVPNYPNTSRMSEVVDKHQVNILYTAPTA
EEEEECCCEEECCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAKGNEAVEGTSRDSLRIMGSVGEPINPEAWEWYYKTIGNEQSPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECEECCCCC
ILIAPLPGATDLKPGSATRPFFGVQPALVDNMGNIIEGATDGNLVILDSWPGQMRTVHGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCCCCCCEEEEECCCCCEEEECCC
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFD
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
KIAEAAIVGIPHDIKGQAIYAYITLNDGEFPTAELHKEVKDWVRKEIGPIATPDVLHWTD
HHHHHEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCC
SLPKTRSGKIMRRILRKIATGDTGNLGDTSTLADPSVVDKLIAEKAELA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEAHVYPVKENIKSTTHADNDTYLAMYQQSVSDPEGFWGEHGKIVDWIKPFTQVKNTSF
CCCEEEEHHHHCCCCCCCCCCCEEEEEHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCC
DPGHIDIRWFEDGTLNVSANCIDRHLAERGDEVAIIWEGDDPADDKTLTFNELHKEVCLF
CCCEEEEEEECCCCEEEEHHHHHHHHHHCCCEEEEEECCCCCCCCCEEEHHHHHHHHHHH
SNALKEQGVRKGDVVCLYMPMVPEAAVAMLACTRIGAVHTVVFGGFSPEALSGRIIDSNS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHCCEEEEEECCCCCHHCCCEEEECCC
KVVITADEGVRGGRAVPLKKNVDEALTNPEVKNIEKVVVFKRTGGDVAWHEHRDVWWHDA
EEEEECCCCCCCCEECCCCCCHHHHHCCCCHHCCEEEEEEEECCCCCEEECCCCCCHHHH
IANVSADCPPEEMNAEDPLFILYTSGSTGKPKGVMHTTGGYLVYAAMTFKYVFDYQEGET
HHCCCCCCCHHHCCCCCCEEEEEECCCCCCCCCEEECCCCEEEEEEEEEEEEEEECCCCE
FWCTADVGWITGHTYLVYGPLANGAKTILFEGVPNYPNTSRMSEVVDKHQVNILYTAPTA
EEEEECCCEEECCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAKGNEAVEGTSRDSLRIMGSVGEPINPEAWEWYYKTIGNEQSPIVDTWWQTETGG
HHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCCCCCEEECEECCCCC
ILIAPLPGATDLKPGSATRPFFGVQPALVDNMGNIIEGATDGNLVILDSWPGQMRTVHGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCCCCCCEEEEECCCCCEEEECCC
HDRFEQTYFSTFKGMYFTSDGARRDEDGYYWITGRVDDVLNVSGHRMGTAEIESALVAFD
HHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHHHHHHHHHHH
KIAEAAIVGIPHDIKGQAIYAYITLNDGEFPTAELHKEVKDWVRKEIGPIATPDVLHWTD
HHHHHEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEECCC
SLPKTRSGKIMRRILRKIATGDTGNLGDTSTLADPSVVDKLIAEKAELA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]