Click here to switch to the map view.

The map label for this gene is grxC [C]

Identifier: 218710797

GI number: 218710797

Start: 3029317

End: 3030045

Strand: Direct

Name: grxC [C]

Synonym: VS_2880

Alternate gene names: 218710797

Gene position: 3029317-3030045 (Clockwise)

Preceding gene: 218710795

Following gene: 218710798

Centisome position: 91.82

GC content: 44.31

Gene sequence:

>729_bases
ATGTTTGCATCTAAAGAAGGTCAATCAATCCCTCAAGTAACATTCCCAACTCGCCAGGGCGATGCATGGGTTAACGTAAC
GACGGAAGAGCTATTCAAAGACAAGACAGTTATCGTATTCAGCTTACCAGGTGCGTTTACACCGACATGTTCTTCAAGCC
ACCTACCTCGTTACAACGAGCTACACTCTGTATTCAAAGATAACGGTGTTGATGACATTCTATGTGTTTCAGTAAACGAC
ACATTCGTAATGAACGCTTGGAAAGCAGACCAAGAAGCTGAAAAAATCACATTCATCCCAGATGGTAACGGTGATTTCAC
AGACGGTATGGGTATGCTAGTTGAGAAAAACGACATCGGCTTCGGCAAACGTTCATGGCGCTACAGCATGCTGGTTAAAA
ACGGCGTGGTAGAAAAAATGTTCATCGAAGAAGACGTACCAGGCGACCCGTTCAAGGTTTCTGATGCAGATACTATGCTT
AACTACATTGCTCCTGAGCACAAAGAGCAAGAGTCAATCACAGTATTCACTAAGCCAGGCTGTCCTTTCTGTATGAAAGC
GAAGCAGAACCTAATCGACAAAGGTTTGAACTACGAAGAAGTAGTACTAGGTAAAGACGCGACAACAGTAAGCCTACGTG
CAATCTCTGGTCGTACAACGGTTCCTCAAGTATTCATCGGTGGCAAACACATCGGTGGTAGCGAAGAACTTGAAGCTTTC
CTAGGTTAA

Upstream 100 bases:

>100_bases
AGGATTTGTCTAATAATGGGCTCAACGAAACGAAACAGAGCAAAGAAAAACGTTAAGCTCTGATAGAACAAAATTCAAAA
TACTATTTAAGGAAATCAAT

Downstream 100 bases:

>100_bases
TGACTTACCATCGATATAAGCTTAATCGTTAAGTTAACTAAGCAATATCAGCTAACCCACCCTCTTGTGGGTTAGCTATT
CCAAATACTCTTATCTGAGC

Product: peroxiredoxin family protein/glutaredoxin

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MFASKEGQSIPQVTFPTRQGDAWVNVTTEELFKDKTVIVFSLPGAFTPTCSSSHLPRYNELHSVFKDNGVDDILCVSVND
TFVMNAWKADQEAEKITFIPDGNGDFTDGMGMLVEKNDIGFGKRSWRYSMLVKNGVVEKMFIEEDVPGDPFKVSDADTML
NYIAPEHKEQESITVFTKPGCPFCMKAKQNLIDKGLNYEEVVLGKDATTVSLRAISGRTTVPQVFIGGKHIGGSEELEAF
LG

Sequences:

>Translated_242_residues
MFASKEGQSIPQVTFPTRQGDAWVNVTTEELFKDKTVIVFSLPGAFTPTCSSSHLPRYNELHSVFKDNGVDDILCVSVND
TFVMNAWKADQEAEKITFIPDGNGDFTDGMGMLVEKNDIGFGKRSWRYSMLVKNGVVEKMFIEEDVPGDPFKVSDADTML
NYIAPEHKEQESITVFTKPGCPFCMKAKQNLIDKGLNYEEVVLGKDATTVSLRAISGRTTVPQVFIGGKHIGGSEELEAF
LG
>Mature_242_residues
MFASKEGQSIPQVTFPTRQGDAWVNVTTEELFKDKTVIVFSLPGAFTPTCSSSHLPRYNELHSVFKDNGVDDILCVSVND
TFVMNAWKADQEAEKITFIPDGNGDFTDGMGMLVEKNDIGFGKRSWRYSMLVKNGVVEKMFIEEDVPGDPFKVSDADTML
NYIAPEHKEQESITVFTKPGCPFCMKAKQNLIDKGLNYEEVVLGKDATTVSLRAISGRTTVPQVFIGGKHIGGSEELEAF
LG

Specific function: The Disulfide Bond Functions As An Electron Carrier In The Glutathione-Dependent Synthesis Of Deoxyribonucleotides By The Enzyme Ribonucleotide Reductase. In Addition, It Is Also Involved In Reducing Some Disulfides In A Coupled System With Glutathione R

COG id: COG0678

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI6912238, Length=147, Percent_Identity=37.4149659863946, Blast_Score=95, Evalue=5e-20,
Organism=Escherichia coli, GI1790039, Length=70, Percent_Identity=41.4285714285714, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323138, Length=135, Percent_Identity=31.8518518518519, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI78706776, Length=150, Percent_Identity=42.6666666666667, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI78709078, Length=150, Percent_Identity=42.6666666666667, Blast_Score=101, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR011906
- InterPro:   IPR014025
- InterPro:   IPR013740
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin; PF08534 Redoxin [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 26750; Mature: 26750

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFASKEGQSIPQVTFPTRQGDAWVNVTTEELFKDKTVIVFSLPGAFTPTCSSSHLPRYNE
CCCCCCCCCCCEEECCCCCCCEEEEEEHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHH
LHSVFKDNGVDDILCVSVNDTFVMNAWKADQEAEKITFIPDGNGDFTDGMGMLVEKNDIG
HHHHHHCCCCCEEEEEEECCEEEEEECCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCC
FGKRSWRYSMLVKNGVVEKMFIEEDVPGDPFKVSDADTMLNYIAPEHKEQESITVFTKPG
CCCCCEEEEEEHHCCCCEEEEECCCCCCCCEEECCHHHHHHHHCCCCCCCCCEEEEECCC
CPFCMKAKQNLIDKGLNYEEVVLGKDATTVSLRAISGRTTVPQVFIGGKHIGGSEELEAF
CCHHHHHHHHHHHCCCCHHEEEECCCCCEEEEEEECCCCCCCEEEECCEECCCHHHHHHH
LG
CC
>Mature Secondary Structure
MFASKEGQSIPQVTFPTRQGDAWVNVTTEELFKDKTVIVFSLPGAFTPTCSSSHLPRYNE
CCCCCCCCCCCEEECCCCCCCEEEEEEHHHHHCCCEEEEEECCCCCCCCCCCCCCCCHHH
LHSVFKDNGVDDILCVSVNDTFVMNAWKADQEAEKITFIPDGNGDFTDGMGMLVEKNDIG
HHHHHHCCCCCEEEEEEECCEEEEEECCCCCCCCEEEEEECCCCCCCCCCEEEEEECCCC
FGKRSWRYSMLVKNGVVEKMFIEEDVPGDPFKVSDADTMLNYIAPEHKEQESITVFTKPG
CCCCCEEEEEEHHCCCCEEEEECCCCCCCCEEECCHHHHHHHHCCCCCCCCCEEEEECCC
CPFCMKAKQNLIDKGLNYEEVVLGKDATTVSLRAISGRTTVPQVFIGGKHIGGSEELEAF
CCHHHHHHHHHHHCCCCHHEEEECCCCCEEEEEEECCCCCCCEEEECCEECCCHHHHHHH
LG
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023 [H]