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The map label for this gene is fklB [H]

Identifier: 218710720

GI number: 218710720

Start: 2965080

End: 2965700

Strand: Direct

Name: fklB [H]

Synonym: VS_2803

Alternate gene names: 218710720

Gene position: 2965080-2965700 (Clockwise)

Preceding gene: 218710717

Following gene: 218710721

Centisome position: 89.87

GC content: 47.34

Gene sequence:

>621_bases
ATGTCTGAAGTAAAATTTGAAACTGTAGAGCAAAAAGCTAGCTACGGTATCGGTCTACAAATGGGCCAACAACTTGCTGG
TTCTGGTCTTGAAGGCCTAAACGTTGATGCAATCGCTGCTGGTATCGCAACAGCTCTAGTTGGCGACATGCCAGCTATCG
AAGTTGACGAAATCAACAACGCACTACAAGAGCTACACACTCGTGGTGAAGCTGCACGTCAAGAACTAGCTAAAGCTGCT
GCTGCTGACGGCGAAGCTTTCCTAGCTGACAACGCTCTTCGTTCAGAAGTTACAGTTCTTGAGTCTGGTCTTCAGTACGA
AGTACTAACTGAAGGTACTGGCGAAATCCCAACTGCAGACAAGCAAGTGCGCGTTCACTACCACGGCGAACTAACTGACG
GTACAGTTTTCGATAGCTCTGTATCTCGCGGTCAACCTGCTGAATTCCCAGTAACTGGCGTAATTCAAGGTTGGGTACAA
GCTCTACAAATGATGCCTGTTGGCTCTAAGTGGAAGCTATACATCCCTCAAGATCTAGCATACGGTGAGCGTGGCGCAGG
TGCTGCAATCCCACCATTTGCTGCTCTAGTATTCGAAGTAGAACTTCTAGCAATTCTTTAA

Upstream 100 bases:

>100_bases
GGACACGGTAAAGCGTAAGTGATCAGAGGCTAGCCGTTTATTCAGGCTGCTAATACTGGTATTCTTACCCTTTTCGTACT
GACAAAAAGAGTGACTTTTC

Downstream 100 bases:

>100_bases
TTTCTATAAAAACCTTTAGTAAAACAAAAAACTATAGGTAAATTAGACTGAATTAGCTCAACGGCGATGTGACTACATCG
CCGTTTTTCGTTTATAGTGA

Product: FKBP-type peptidyl-prolyl cis-trans isomerases 1

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSEVKFETVEQKASYGIGLQMGQQLAGSGLEGLNVDAIAAGIATALVGDMPAIEVDEINNALQELHTRGEAARQELAKAA
AADGEAFLADNALRSEVTVLESGLQYEVLTEGTGEIPTADKQVRVHYHGELTDGTVFDSSVSRGQPAEFPVTGVIQGWVQ
ALQMMPVGSKWKLYIPQDLAYGERGAGAAIPPFAALVFEVELLAIL

Sequences:

>Translated_206_residues
MSEVKFETVEQKASYGIGLQMGQQLAGSGLEGLNVDAIAAGIATALVGDMPAIEVDEINNALQELHTRGEAARQELAKAA
AADGEAFLADNALRSEVTVLESGLQYEVLTEGTGEIPTADKQVRVHYHGELTDGTVFDSSVSRGQPAEFPVTGVIQGWVQ
ALQMMPVGSKWKLYIPQDLAYGERGAGAAIPPFAALVFEVELLAIL
>Mature_205_residues
SEVKFETVEQKASYGIGLQMGQQLAGSGLEGLNVDAIAAGIATALVGDMPAIEVDEINNALQELHTRGEAARQELAKAAA
ADGEAFLADNALRSEVTVLESGLQYEVLTEGTGEIPTADKQVRVHYHGELTDGTVFDSSVSRGQPAEFPVTGVIQGWVQA
LQMMPVGSKWKLYIPQDLAYGERGAGAAIPPFAALVFEVELLAIL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI206725530, Length=85, Percent_Identity=56.4705882352941, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI17149844, Length=85, Percent_Identity=56.4705882352941, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI17149842, Length=85, Percent_Identity=56.4705882352941, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=43.3962264150943, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=43.3962264150943, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4503729, Length=99, Percent_Identity=43.4343434343434, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=37.7358490566038, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI192448443, Length=85, Percent_Identity=47.0588235294118, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI87082390, Length=206, Percent_Identity=60.6796116504854, Blast_Score=256, Evalue=6e-70,
Organism=Escherichia coli, GI1789745, Length=214, Percent_Identity=35.981308411215, Blast_Score=112, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=43.3962264150943, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17540882, Length=86, Percent_Identity=47.6744186046512, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17561782, Length=99, Percent_Identity=40.4040404040404, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=87, Percent_Identity=56.3218390804598, Blast_Score=88, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=110, Percent_Identity=40.9090909090909, Blast_Score=79, Evalue=4e-16,
Organism=Drosophila melanogaster, GI281363946, Length=84, Percent_Identity=52.3809523809524, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17352457, Length=84, Percent_Identity=52.3809523809524, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24583150, Length=106, Percent_Identity=42.4528301886792, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=41.5094339622642, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21356629, Length=86, Percent_Identity=47.6744186046512, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24647110, Length=97, Percent_Identity=42.2680412371134, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21784; Mature: 21653

Theoretical pI: Translated: 4.08; Mature: 4.08

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVKFETVEQKASYGIGLQMGQQLAGSGLEGLNVDAIAAGIATALVGDMPAIEVDEINN
CCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
ALQELHTRGEAARQELAKAAAADGEAFLADNALRSEVTVLESGLQYEVLTEGTGEIPTAD
HHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
KQVRVHYHGELTDGTVFDSSVSRGQPAEFPVTGVIQGWVQALQMMPVGSKWKLYIPQDLA
CEEEEEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHC
YGERGAGAAIPPFAALVFEVELLAIL
CCCCCCCCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEVKFETVEQKASYGIGLQMGQQLAGSGLEGLNVDAIAAGIATALVGDMPAIEVDEINN
CCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHH
ALQELHTRGEAARQELAKAAAADGEAFLADNALRSEVTVLESGLQYEVLTEGTGEIPTAD
HHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCC
KQVRVHYHGELTDGTVFDSSVSRGQPAEFPVTGVIQGWVQALQMMPVGSKWKLYIPQDLA
CEEEEEECCCCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEECCCHHC
YGERGAGAAIPPFAALVFEVELLAIL
CCCCCCCCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]