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The map label for this gene is fbp [H]

Identifier: 218710690

GI number: 218710690

Start: 2934129

End: 2935139

Strand: Direct

Name: fbp [H]

Synonym: VS_2771

Alternate gene names: 218710690

Gene position: 2934129-2935139 (Clockwise)

Preceding gene: 218710684

Following gene: 218710695

Centisome position: 88.93

GC content: 45.99

Gene sequence:

>1011_bases
ATGTCTGAGATGCGCACCCTTGGTGAGTTCATTGTTGAGAAACAGAGTGACTTCCCCCATGCAAGCGGTGATCTATCATC
CCTTTTGTCGTCTATTCGACTTGCTGCAAAAATTGTTAACCGTGAGATCAACAAGGCTGGTCTAGTCGACATCACTGGCG
CTGTTGGTACAGACAACGTTCAAGGTGAAGAACAGCAAAAGCTAGACCTTTACGCGAACGACAAGTTTAAAGCGGCTCTA
GAGGCTCGTGATCAAGTTTGTGGTGTTGCAAGTGAAGAAGAAGACGAAGCTGTCGCCTTCAATAAAGAGCTCAACAAAAA
CGCAAAATACGTCGTTCTGATGGACCCACTTGATGGTTCTTCAAACATCGATGTCAATGTATCTGTTGGTACAATCTTCT
CTATCTATCGTCGAGTATCGCCTGTTGGTACCCCACCAACACAAGAAGACTTCCTACAGCCAGGACACAAGCAAGTAGCC
GCGGGGTACGTAATTTACGGCTCTTCAACTATGCTTGTTTACACAACTGGTGCAGGTGTAAATGGCTTCACCTACGACCC
ATCTCTGGGCACCTTCTGTCTGTCTCATGAAAACATGATGATCCCTGATGAAGGTAAGATTTATTCCATCAACGAAGGTA
ACTACATTCGCTTCCCTACGGGTGTTAAAAAGTACATCAAGTACTGCCAAGAAAATGAGCCAAGCGACAACCGCCCTTAC
ACATCACGTTACATCGGTTCTCTAGTATCAGATTTCCACCGTAATCTTCTGAAAGGCGGTATCTACTTATACCCGAGTAC
ACAAAGCCACCCTCAAGGTAAACTGCGTCTGCTGTACGAGTGCAACCCAATAGCCTTCATCATGGAGCAAGCTGGCGGTA
TTGCCTCCGATGGCGCCCAACGCATCATGGATATAAAACCAACAGAACTGCACCAACGTGTGCCTTTCTTTGTCGGTTCT
AAGAACATGGTGAAAAAGGTAGAAGAGTTCCTTGAACTTAACCGAGACTAA

Upstream 100 bases:

>100_bases
TAGAATTTAAGTAGGCGTCTAGGTGAATAAAGCCCGAGTAAGAGGCAAATTCTATAGTGCTCAAATCCCCCTAATATTGA
GAGAAGTTTAAGGAAATAAC

Downstream 100 bases:

>100_bases
TCGTCTCGCTTATTTTTCAAATTAACGCCATTAAAAAAGCCAGCATTTACATGCTGGCTTTTTGTTATCTACTGAGTTGA
TTATTGACTAGACTATCGAA

Product: fructose-1,6-bisphosphatase

Products: NA

Alternate protein names: FBPase class 1; D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 [H]

Number of amino acids: Translated: 336; Mature: 335

Protein sequence:

>336_residues
MSEMRTLGEFIVEKQSDFPHASGDLSSLLSSIRLAAKIVNREINKAGLVDITGAVGTDNVQGEEQQKLDLYANDKFKAAL
EARDQVCGVASEEEDEAVAFNKELNKNAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVSPVGTPPTQEDFLQPGHKQVA
AGYVIYGSSTMLVYTTGAGVNGFTYDPSLGTFCLSHENMMIPDEGKIYSINEGNYIRFPTGVKKYIKYCQENEPSDNRPY
TSRYIGSLVSDFHRNLLKGGIYLYPSTQSHPQGKLRLLYECNPIAFIMEQAGGIASDGAQRIMDIKPTELHQRVPFFVGS
KNMVKKVEEFLELNRD

Sequences:

>Translated_336_residues
MSEMRTLGEFIVEKQSDFPHASGDLSSLLSSIRLAAKIVNREINKAGLVDITGAVGTDNVQGEEQQKLDLYANDKFKAAL
EARDQVCGVASEEEDEAVAFNKELNKNAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVSPVGTPPTQEDFLQPGHKQVA
AGYVIYGSSTMLVYTTGAGVNGFTYDPSLGTFCLSHENMMIPDEGKIYSINEGNYIRFPTGVKKYIKYCQENEPSDNRPY
TSRYIGSLVSDFHRNLLKGGIYLYPSTQSHPQGKLRLLYECNPIAFIMEQAGGIASDGAQRIMDIKPTELHQRVPFFVGS
KNMVKKVEEFLELNRD
>Mature_335_residues
SEMRTLGEFIVEKQSDFPHASGDLSSLLSSIRLAAKIVNREINKAGLVDITGAVGTDNVQGEEQQKLDLYANDKFKAALE
ARDQVCGVASEEEDEAVAFNKELNKNAKYVVLMDPLDGSSNIDVNVSVGTIFSIYRRVSPVGTPPTQEDFLQPGHKQVAA
GYVIYGSSTMLVYTTGAGVNGFTYDPSLGTFCLSHENMMIPDEGKIYSINEGNYIRFPTGVKKYIKYCQENEPSDNRPYT
SRYIGSLVSDFHRNLLKGGIYLYPSTQSHPQGKLRLLYECNPIAFIMEQAGGIASDGAQRIMDIKPTELHQRVPFFVGSK
NMVKKVEEFLELNRD

Specific function: INVOLVED IN SEVERAL METABOLIC PATHWAYS. IN E.COLI AND YEAST IT IS NECESSARY FOR GROWTH ON SUBSTANCES SUCH AS GLYCEROL, SUCCINATE AND ACETATE. [C]

COG id: COG0158

COG function: function code G; Fructose-1,6-bisphosphatase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FBPase class 1 family [H]

Homologues:

Organism=Homo sapiens, GI22907028, Length=331, Percent_Identity=44.7129909365559, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI189083692, Length=332, Percent_Identity=44.578313253012, Blast_Score=278, Evalue=5e-75,
Organism=Homo sapiens, GI16579888, Length=332, Percent_Identity=44.578313253012, Blast_Score=278, Evalue=5e-75,
Organism=Escherichia coli, GI1790679, Length=328, Percent_Identity=75.609756097561, Blast_Score=519, Evalue=1e-149,
Organism=Caenorhabditis elegans, GI17508131, Length=326, Percent_Identity=47.239263803681, Blast_Score=311, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6323409, Length=333, Percent_Identity=41.4414414414414, Blast_Score=267, Evalue=2e-72,
Organism=Drosophila melanogaster, GI45550998, Length=331, Percent_Identity=48.9425981873112, Blast_Score=317, Evalue=8e-87,
Organism=Drosophila melanogaster, GI19921562, Length=331, Percent_Identity=48.9425981873112, Blast_Score=317, Evalue=1e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000146
- InterPro:   IPR020548 [H]

Pfam domain/function: PF00316 FBPase [H]

EC number: =3.1.3.11 [H]

Molecular weight: Translated: 37254; Mature: 37122

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00124 FBPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEMRTLGEFIVEKQSDFPHASGDLSSLLSSIRLAAKIVNREINKAGLVDITGAVGTDNV
CCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
QGEEQQKLDLYANDKFKAALEARDQVCGVASEEEDEAVAFNKELNKNAKYVVLMDPLDGS
CCCCHHCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCEEECHHCCCCCCEEEEECCCCCC
SNIDVNVSVGTIFSIYRRVSPVGTPPTQEDFLQPGHKQVAAGYVIYGSSTMLVYTTGAGV
CCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHEEEEEEEECCCEEEEEEECCCC
NGFTYDPSLGTFCLSHENMMIPDEGKIYSINEGNYIRFPTGVKKYIKYCQENEPSDNRPY
CCEEECCCCCEEEECCCCEECCCCCCEEEECCCCEEECCHHHHHHHHHHHCCCCCCCCCH
TSRYIGSLVSDFHRNLLKGGIYLYPSTQSHPQGKLRLLYECNPIAFIMEQAGGIASDGAQ
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCHH
RIMDIKPTELHQRVPFFVGSKNMVKKVEEFLELNRD
HHHCCCHHHHHHCCCEEECCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEMRTLGEFIVEKQSDFPHASGDLSSLLSSIRLAAKIVNREINKAGLVDITGAVGTDNV
CHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
QGEEQQKLDLYANDKFKAALEARDQVCGVASEEEDEAVAFNKELNKNAKYVVLMDPLDGS
CCCCHHCEEEEECCHHHHHHHHHHHHCCCCCCCCCCCEEECHHCCCCCCEEEEECCCCCC
SNIDVNVSVGTIFSIYRRVSPVGTPPTQEDFLQPGHKQVAAGYVIYGSSTMLVYTTGAGV
CCEEEEEEHHHHHHHHHHHCCCCCCCCHHHHHCCCCHHEEEEEEEECCCEEEEEEECCCC
NGFTYDPSLGTFCLSHENMMIPDEGKIYSINEGNYIRFPTGVKKYIKYCQENEPSDNRPY
CCEEECCCCCEEEECCCCEECCCCCCEEEECCCCEEECCHHHHHHHHHHHCCCCCCCCCH
TSRYIGSLVSDFHRNLLKGGIYLYPSTQSHPQGKLRLLYECNPIAFIMEQAGGIASDGAQ
HHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEECCCHHHHHHHCCCCCCCCHH
RIMDIKPTELHQRVPFFVGSKNMVKKVEEFLELNRD
HHHCCCHHHHHHCCCEEECCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA