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The map label for this gene is msrA [H]

Identifier: 218710695

GI number: 218710695

Start: 2941754

End: 2942383

Strand: Direct

Name: msrA [H]

Synonym: VS_2776

Alternate gene names: 218710695

Gene position: 2941754-2942383 (Clockwise)

Preceding gene: 218710690

Following gene: 218710696

Centisome position: 89.16

GC content: 46.35

Gene sequence:

>630_bases
ATGCTAAACAAACAACAACTGGTTTCCGCAGCAACCGCATTACCGGGAAATGCTGACCCAATCCGAATCTCTGAGCGCCA
TTTCGTCAATCACACTGACTTGCTCAATGCTCCTACGGGTTCTCAACAAGAAGTCCTACTTGGTATGGGATGCTTCTGGG
GAGCTGAGCGTTTGTTCTGGCAGTTGAACGGCGTTATTTCAACATCTGTTGGCTACGCTGGTGGATACACGATTAACCCC
ACTTATGAGCAGGTATGTAGCGGACAAACTGGCCATACCGAAGTCGTTCGTATCATTTTTGATAGCGAACAAACATCTCT
CGCTCAAGTACTTGAAACCTTTTGGGAGCGTCATGACCCAACTCAAGGGATGCGCCAAGGCAACGATTTAGGGACTCAAT
ACCGTTCTGCGATATACACCTTCAGCGAAGAACAACAGACTATCGCTGAGCATTCTAAACGTGAATACCAACGAGCAATG
ACTGAATCATTAGGCAACGAAATCACAACGGAAGTTCTGCCAGCTGGAAAATATTTTTTCGCAGAAACCTACCACCAGCA
ATATCTAGCTAAAAATCCGAATGGTTATTGTGGATTGGGTGGAACAGGTGTGTGCTTCCCTCCGCAATAA

Upstream 100 bases:

>100_bases
TTAATCAATATTAACCGGCCATTAATATGAGCCTCCAGTTAATATAAACCTAGATCTAATGTTAACTAACGCGGTAAACG
TATGCGAAAAGGAATATAAC

Downstream 100 bases:

>100_bases
TGTGTTATACCAATCACAGTAAGTAAGTGATCATAAATAGCGCAGGAAAAATGCTTGAGAACAAGGCAGAAATTTTCGAT
AAGTAGTTATTCTACAATCA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MLNKQQLVSAATALPGNADPIRISERHFVNHTDLLNAPTGSQQEVLLGMGCFWGAERLFWQLNGVISTSVGYAGGYTINP
TYEQVCSGQTGHTEVVRIIFDSEQTSLAQVLETFWERHDPTQGMRQGNDLGTQYRSAIYTFSEEQQTIAEHSKREYQRAM
TESLGNEITTEVLPAGKYFFAETYHQQYLAKNPNGYCGLGGTGVCFPPQ

Sequences:

>Translated_209_residues
MLNKQQLVSAATALPGNADPIRISERHFVNHTDLLNAPTGSQQEVLLGMGCFWGAERLFWQLNGVISTSVGYAGGYTINP
TYEQVCSGQTGHTEVVRIIFDSEQTSLAQVLETFWERHDPTQGMRQGNDLGTQYRSAIYTFSEEQQTIAEHSKREYQRAM
TESLGNEITTEVLPAGKYFFAETYHQQYLAKNPNGYCGLGGTGVCFPPQ
>Mature_209_residues
MLNKQQLVSAATALPGNADPIRISERHFVNHTDLLNAPTGSQQEVLLGMGCFWGAERLFWQLNGVISTSVGYAGGYTINP
TYEQVCSGQTGHTEVVRIIFDSEQTSLAQVLETFWERHDPTQGMRQGNDLGTQYRSAIYTFSEEQQTIAEHSKREYQRAM
TESLGNEITTEVLPAGKYFFAETYHQQYLAKNPNGYCGLGGTGVCFPPQ

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=202, Percent_Identity=55.4455445544555, Blast_Score=232, Evalue=2e-61,
Organism=Homo sapiens, GI208609995, Length=183, Percent_Identity=57.9234972677596, Blast_Score=219, Evalue=1e-57,
Organism=Homo sapiens, GI208609993, Length=119, Percent_Identity=57.1428571428571, Blast_Score=149, Evalue=2e-36,
Organism=Escherichia coli, GI1790665, Length=210, Percent_Identity=54.2857142857143, Blast_Score=221, Evalue=2e-59,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=32.8767123287671, Blast_Score=91, Evalue=6e-19,
Organism=Saccharomyces cerevisiae, GI6320881, Length=160, Percent_Identity=35.625, Blast_Score=103, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=39.4366197183099, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45553131, Length=140, Percent_Identity=39.2857142857143, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24664631, Length=168, Percent_Identity=36.3095238095238, Blast_Score=90, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 23253; Mature: 23253

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNKQQLVSAATALPGNADPIRISERHFVNHTDLLNAPTGSQQEVLLGMGCFWGAERLFW
CCCHHHHHHHHHCCCCCCCCEEECCCHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
QLNGVISTSVGYAGGYTINPTYEQVCSGQTGHTEVVRIIFDSEQTSLAQVLETFWERHDP
HHCCHHCCCCCCCCCCEECCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCC
TQGMRQGNDLGTQYRSAIYTFSEEQQTIAEHSKREYQRAMTESLGNEITTEVLPAGKYFF
HHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHH
AETYHQQYLAKNPNGYCGLGGTGVCFPPQ
HHHHHHHHHHCCCCCEECCCCCCCCCCCC
>Mature Secondary Structure
MLNKQQLVSAATALPGNADPIRISERHFVNHTDLLNAPTGSQQEVLLGMGCFWGAERLFW
CCCHHHHHHHHHCCCCCCCCEEECCCHHCCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
QLNGVISTSVGYAGGYTINPTYEQVCSGQTGHTEVVRIIFDSEQTSLAQVLETFWERHDP
HHCCHHCCCCCCCCCCEECCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHCCCC
TQGMRQGNDLGTQYRSAIYTFSEEQQTIAEHSKREYQRAMTESLGNEITTEVLPAGKYFF
HHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHHH
AETYHQQYLAKNPNGYCGLGGTGVCFPPQ
HHHHHHHHHHCCCCCEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]