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The map label for this gene is holC [H]

Identifier: 218710651

GI number: 218710651

Start: 2899131

End: 2899580

Strand: Direct

Name: holC [H]

Synonym: VS_2731

Alternate gene names: 218710651

Gene position: 2899131-2899580 (Clockwise)

Preceding gene: 218710650

Following gene: 218710652

Centisome position: 87.87

GC content: 42.89

Gene sequence:

>450_bases
ATGCAGACTGCCACATTTTACATTGTGTCTTCAGACAGCCCACAAGCCAGCGAAGAGGGTTTTGCTCACTACGTGTTGTT
TCTTGCTCAGCATTTTGCAAAACAAGGCGCTAAACTTTATCTCAACTGTAACGATAAAGTTCATGCTGAGCGTATCGCTG
AAGTTTTTTGGCAGGTAGAGCCTACTGAATTTATCGCGCACAACTTGGTTGGCGAAGGTCCAAAATATTCAACGAATATT
GAGATAGGCCATCAAGGAGTCAAACCTAATTGGAACCGCCAATTGGTAATAAATCTGGCCGATAATCATACAACCTTTGC
GAACGCCTTTGCTCAGGTGATAGACTTCGTTCCTTGCGAAGAAAAAGCTAAGCAACTCGCTCGAGAAAGGTATAAAATTT
ACCGTCAGGCTGGATATCAGCTACAAACTATCGAGATTCAACATCCATAG

Upstream 100 bases:

>100_bases
ATAGAAAGGGCCTACGGGCCCTTTTTTAATAAGCGTTATTTGCTAGCTCCTGTTGACCAAGTAACATTGGTTTCCACGAT
TCCAAGTTCGAGTATTCAGT

Downstream 100 bases:

>100_bases
TCAAACCTCATAGTTAAAGCTATCTTTGAATTTAGATTCAAGAAGCTTCACTTATGAAGTTTGACCACGATTAACCATTC
ACAGTATCCGTTATAAGAGC

Product: DNA polymerase III subunit chi

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MQTATFYIVSSDSPQASEEGFAHYVLFLAQHFAKQGAKLYLNCNDKVHAERIAEVFWQVEPTEFIAHNLVGEGPKYSTNI
EIGHQGVKPNWNRQLVINLADNHTTFANAFAQVIDFVPCEEKAKQLARERYKIYRQAGYQLQTIEIQHP

Sequences:

>Translated_149_residues
MQTATFYIVSSDSPQASEEGFAHYVLFLAQHFAKQGAKLYLNCNDKVHAERIAEVFWQVEPTEFIAHNLVGEGPKYSTNI
EIGHQGVKPNWNRQLVINLADNHTTFANAFAQVIDFVPCEEKAKQLARERYKIYRQAGYQLQTIEIQHP
>Mature_149_residues
MQTATFYIVSSDSPQASEEGFAHYVLFLAQHFAKQGAKLYLNCNDKVHAERIAEVFWQVEPTEFIAHNLVGEGPKYSTNI
EIGHQGVKPNWNRQLVINLADNHTTFANAFAQVIDFVPCEEKAKQLARERYKIYRQAGYQLQTIEIQHP

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2927

COG function: function code L; DNA polymerase III, chi subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1790709, Length=143, Percent_Identity=37.0629370629371, Blast_Score=109, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007459 [H]

Pfam domain/function: PF04364 DNA_pol3_chi [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 17067; Mature: 17067

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTATFYIVSSDSPQASEEGFAHYVLFLAQHFAKQGAKLYLNCNDKVHAERIAEVFWQVE
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCC
PTEFIAHNLVGEGPKYSTNIEIGHQGVKPNWNRQLVINLADNHTTFANAFAQVIDFVPCE
HHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCH
EKAKQLARERYKIYRQAGYQLQTIEIQHP
HHHHHHHHHHHHHHHHCCCEEEEEEECCC
>Mature Secondary Structure
MQTATFYIVSSDSPQASEEGFAHYVLFLAQHFAKQGAKLYLNCNDKVHAERIAEVFWQVE
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHCCC
PTEFIAHNLVGEGPKYSTNIEIGHQGVKPNWNRQLVINLADNHTTFANAFAQVIDFVPCE
HHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCH
EKAKQLARERYKIYRQAGYQLQTIEIQHP
HHHHHHHHHHHHHHHHCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8389364; 8246893; 7610040; 9278503; 2670557; 8505305; 1575709 [H]