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The map label for this gene is pepA [H]

Identifier: 218710650

GI number: 218710650

Start: 2898159

End: 2899031

Strand: Direct

Name: pepA [H]

Synonym: VS_2730

Alternate gene names: 218710650

Gene position: 2898159-2899031 (Clockwise)

Preceding gene: 218710649

Following gene: 218710651

Centisome position: 87.84

GC content: 46.62

Gene sequence:

>873_bases
GTGAAAACTAAGATCATTGGCGAAGAAGAGATGGAAAAGCTGGGTATGACTTCATACTTAGCGGTAGGCCGTGGTTCTAA
GAACGAATCTATGATGTCTATCATGGAATATAAAGGTGCTGCTGACCCAGATGCAAAACCGATTGTTCTAGTCGGTAAAG
GTCTTACTTTCGATTCAGGCGGTATTTCGCTTAAGCCTGGTGAAGGTATGGATGAGATGAAGTACGACATGTGTGGTGCG
GCTTCTGTATTCGGTACAATGAAGGCACTAGCTAAACTGAACCTACCGATTAATGTAGTTGGTATCCTAGCAGGTTGTGA
AAACATGCCAGGCAGCAATGCTTACCGCCCAGGTGATATCCTAACGACCATGTCAGGCCAAACAGTTGAAGTGTTAAACA
CGGATGCAGAAGGTCGCTTGGTTCTATGTGATGCACTTACTTACGTTGAACGCTTTGAACCAGACTGTGTTGTCGATGTA
GCAACACTCACTGGCGCGTGTGTGATGGCGTTAGGTCACCACATCAGTGCTGTACTATCTAATCACAACCCACTATCTCA
CGAATTAGTGAATGCTTCTGAGCAAGCAAGTGACAGAGCATGGCGCATGCCAATGGCCGATGAGTACCATGAGCAACTGA
CAAGTCCATTTGCTGATATGGCAAATATCGGTGGCCGACCTGCTGGTACAATCACCGCAGCATGTTTCTTATCTAAATTT
GCTAAAAAGTACCACTGGGCACACATTGACAGTGCCGGCACAGCTTGGAAGTCAGGCGCAGCGAAAGGCTCGACAGGTCG
TCCTGTCTCAATGCTAGTCCAATTCTTATTGAACCGCAGCGGCCATGAGACTGAAGAGCAATCTTCAAAATAA

Upstream 100 bases:

>100_bases
CGTCTAAAGATCTAGGCAACATGCCACCTAACATCGCAAATCCTGCTTACCTTGCTTCTCAAGCTCGTAAGCTCGTCGCT
TGGCCGATGATTACGAGACA

Downstream 100 bases:

>100_bases
TAGAAAGGGCCTACGGGCCCTTTTTTAATAAGCGTTATTTGCTAGCTCCTGTTGACCAAGTAACATTGGTTTCCACGATT
CCAAGTTCGAGTATTCAGTA

Product: hypothetical protein

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MKTKIIGEEEMEKLGMTSYLAVGRGSKNESMMSIMEYKGAADPDAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGA
ASVFGTMKALAKLNLPINVVGILAGCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPDCVVDV
ATLTGACVMALGHHISAVLSNHNPLSHELVNASEQASDRAWRMPMADEYHEQLTSPFADMANIGGRPAGTITAACFLSKF
AKKYHWAHIDSAGTAWKSGAAKGSTGRPVSMLVQFLLNRSGHETEEQSSK

Sequences:

>Translated_290_residues
MKTKIIGEEEMEKLGMTSYLAVGRGSKNESMMSIMEYKGAADPDAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGA
ASVFGTMKALAKLNLPINVVGILAGCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPDCVVDV
ATLTGACVMALGHHISAVLSNHNPLSHELVNASEQASDRAWRMPMADEYHEQLTSPFADMANIGGRPAGTITAACFLSKF
AKKYHWAHIDSAGTAWKSGAAKGSTGRPVSMLVQFLLNRSGHETEEQSSK
>Mature_290_residues
MKTKIIGEEEMEKLGMTSYLAVGRGSKNESMMSIMEYKGAADPDAKPIVLVGKGLTFDSGGISLKPGEGMDEMKYDMCGA
ASVFGTMKALAKLNLPINVVGILAGCENMPGSNAYRPGDILTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPDCVVDV
ATLTGACVMALGHHISAVLSNHNPLSHELVNASEQASDRAWRMPMADEYHEQLTSPFADMANIGGRPAGTITAACFLSKF
AKKYHWAHIDSAGTAWKSGAAKGSTGRPVSMLVQFLLNRSGHETEEQSSK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=276, Percent_Identity=44.5652173913043, Blast_Score=236, Evalue=2e-62,
Organism=Homo sapiens, GI47155554, Length=279, Percent_Identity=33.6917562724014, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1790710, Length=284, Percent_Identity=75, Blast_Score=479, Evalue=1e-137,
Organism=Escherichia coli, GI87082123, Length=282, Percent_Identity=39.3617021276596, Blast_Score=181, Evalue=5e-47,
Organism=Caenorhabditis elegans, GI17556903, Length=264, Percent_Identity=32.9545454545455, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17565172, Length=161, Percent_Identity=35.4037267080745, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI21355725, Length=272, Percent_Identity=36.7647058823529, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24661038, Length=286, Percent_Identity=36.013986013986, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI20129969, Length=284, Percent_Identity=35.2112676056338, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24662227, Length=277, Percent_Identity=36.8231046931408, Blast_Score=173, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21355645, Length=277, Percent_Identity=34.2960288808664, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24662223, Length=277, Percent_Identity=34.2960288808664, Blast_Score=163, Evalue=1e-40,
Organism=Drosophila melanogaster, GI19922386, Length=276, Percent_Identity=34.4202898550725, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI161077148, Length=275, Percent_Identity=30.5454545454545, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI20130057, Length=275, Percent_Identity=30.5454545454545, Blast_Score=151, Evalue=4e-37,
Organism=Drosophila melanogaster, GI20129963, Length=280, Percent_Identity=32.8571428571429, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI221379063, Length=282, Percent_Identity=34.7517730496454, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI221379062, Length=282, Percent_Identity=34.7517730496454, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI21357381, Length=282, Percent_Identity=34.7517730496454, Blast_Score=128, Evalue=4e-30,
Organism=Drosophila melanogaster, GI24646701, Length=217, Percent_Identity=31.7972350230415, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24646703, Length=217, Percent_Identity=31.7972350230415, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21358201, Length=217, Percent_Identity=31.7972350230415, Blast_Score=90, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 30973; Mature: 30973

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
5.9 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKIIGEEEMEKLGMTSYLAVGRGSKNESMMSIMEYKGAADPDAKPIVLVGKGLTFDSG
CCCCCCCHHHHHHHCCHHHEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCEECCC
GISLKPGEGMDEMKYDMCGAASVFGTMKALAKLNLPINVVGILAGCENMPGSNAYRPGDI
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCE
LTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPDCVVDVATLTGACVMALGHHISAVLS
EEECCCCEEEEEECCCCCCEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
NHNPLSHELVNASEQASDRAWRMPMADEYHEQLTSPFADMANIGGRPAGTITAACFLSKF
CCCCHHHHHHCCHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AKKYHWAHIDSAGTAWKSGAAKGSTGRPVSMLVQFLLNRSGHETEEQSSK
HHHHCCCEECCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHCCC
>Mature Secondary Structure
MKTKIIGEEEMEKLGMTSYLAVGRGSKNESMMSIMEYKGAADPDAKPIVLVGKGLTFDSG
CCCCCCCHHHHHHHCCHHHEEECCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCEECCC
GISLKPGEGMDEMKYDMCGAASVFGTMKALAKLNLPINVVGILAGCENMPGSNAYRPGDI
CEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHCCCCCCCCCCCCCCCE
LTTMSGQTVEVLNTDAEGRLVLCDALTYVERFEPDCVVDVATLTGACVMALGHHISAVLS
EEECCCCEEEEEECCCCCCEEEHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHH
NHNPLSHELVNASEQASDRAWRMPMADEYHEQLTSPFADMANIGGRPAGTITAACFLSKF
CCCCHHHHHHCCHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
AKKYHWAHIDSAGTAWKSGAAKGSTGRPVSMLVQFLLNRSGHETEEQSSK
HHHHCCCEECCCCCHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA