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The map label for this gene is mazG [H]

Identifier: 218710560

GI number: 218710560

Start: 2797839

End: 2798672

Strand: Reverse

Name: mazG [H]

Synonym: VS_2610

Alternate gene names: 218710560

Gene position: 2798672-2797839 (Counterclockwise)

Preceding gene: 218710561

Following gene: 218710559

Centisome position: 84.83

GC content: 42.57

Gene sequence:

>834_bases
GTGAATAGGAAGAAAACGATGAATCACCCGATTGAACAACTTGAACAGATCATGACTAAGCTGCGCGATCCTGAAGGTGG
CTGTCCTTGGGATTTGAAACAAAATTTTGAAACCATTGTGCCGCATACTATCGAAGAGACCTACGAAGTGGTGGATGCGA
TTCACAACAAAGACTGGCCGAATCTACAAGAAGAGTTGGGTGACTTGCTGTTTCAGGTGATCTTCTACAGTCAATTAGCA
AAAGAGCAGGGCTTATTTGAGTTCTCTGATGTGGTCGACGGTATCAATGAGAAGCTGACGCGCCGTCATCCACACGTATT
TTCTGATACAGAGTTTGCCAGTGATGAAGAAATTAATGCCAACTGGGAAGCTGAAAAAGCCAAAGAGAAAGCACAGGCAG
GCAAAACTCAAGAAAGTATTCTAGACTCAATACCAAACTCTCTACCCGCACTTTCGCGTGCTACAAAAATTCAAAAGCAA
GTCGCGAAATTTGGCTTTGATTGGGACTCTATTGGCCCAGTCGCCGATAAGGTTTTAGAGGAAGTTGATGAGGTGCTAGA
AGAAGCGCTTCAAGTAACGCCAAACGAAGATTTAGTTGAAGAAGAGCTGGGTGATTTGTTGTTTGCTACCGTCAATTTAG
TGCGACATTTGGGTAAAAATCCAGAAACGGCTCTCAATAAAGCCAATCTGAAATTTTCACGCCGCTTTAAAGGTGTGGAA
CAAAAAGTTCGTCAGCAAGATAAAATTTTGACCGACTTTTCTCTACAACAGCTTGATTCCATATGGGATGAAGTCAAAGT
GGCGGAGAAAAGATCATCAAAGCTTTTATCATGA

Upstream 100 bases:

>100_bases
GCGTAATTTAGAGAATTAGACAGTATCAACAAAGGTGAGTGGTTTTGGCTGCTCACCTTTTTTAGTTTTAGTGAAGTTTT
AAATTTAAAAATCAAAGACA

Downstream 100 bases:

>100_bases
ATTGATTTGAAGCAAAAAATAAAAAATAGCAGTGTGATAGATTTCACGTTGTGGCGATAAGGGGCTTCTGGTATATTTTC
ATCCCGTCCAGAAGTAATCC

Product: nucleoside triphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNRKKTMNHPIEQLEQIMTKLRDPEGGCPWDLKQNFETIVPHTIEETYEVVDAIHNKDWPNLQEELGDLLFQVIFYSQLA
KEQGLFEFSDVVDGINEKLTRRHPHVFSDTEFASDEEINANWEAEKAKEKAQAGKTQESILDSIPNSLPALSRATKIQKQ
VAKFGFDWDSIGPVADKVLEEVDEVLEEALQVTPNEDLVEEELGDLLFATVNLVRHLGKNPETALNKANLKFSRRFKGVE
QKVRQQDKILTDFSLQQLDSIWDEVKVAEKRSSKLLS

Sequences:

>Translated_277_residues
MNRKKTMNHPIEQLEQIMTKLRDPEGGCPWDLKQNFETIVPHTIEETYEVVDAIHNKDWPNLQEELGDLLFQVIFYSQLA
KEQGLFEFSDVVDGINEKLTRRHPHVFSDTEFASDEEINANWEAEKAKEKAQAGKTQESILDSIPNSLPALSRATKIQKQ
VAKFGFDWDSIGPVADKVLEEVDEVLEEALQVTPNEDLVEEELGDLLFATVNLVRHLGKNPETALNKANLKFSRRFKGVE
QKVRQQDKILTDFSLQQLDSIWDEVKVAEKRSSKLLS
>Mature_277_residues
MNRKKTMNHPIEQLEQIMTKLRDPEGGCPWDLKQNFETIVPHTIEETYEVVDAIHNKDWPNLQEELGDLLFQVIFYSQLA
KEQGLFEFSDVVDGINEKLTRRHPHVFSDTEFASDEEINANWEAEKAKEKAQAGKTQESILDSIPNSLPALSRATKIQKQ
VAKFGFDWDSIGPVADKVLEEVDEVLEEALQVTPNEDLVEEELGDLLFATVNLVRHLGKNPETALNKANLKFSRRFKGVE
QKVRQQDKILTDFSLQQLDSIWDEVKVAEKRSSKLLS

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=263, Percent_Identity=54.7528517110266, Blast_Score=293, Evalue=6e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 31729; Mature: 31729

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRKKTMNHPIEQLEQIMTKLRDPEGGCPWDLKQNFETIVPHTIEETYEVVDAIHNKDWP
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCHHHHCCHHHHHHHHHHHHHHCCCCC
NLQEELGDLLFQVIFYSQLAKEQGLFEFSDVVDGINEKLTRRHPHVFSDTEFASDEEINA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NWEAEKAKEKAQAGKTQESILDSIPNSLPALSRATKIQKQVAKFGFDWDSIGPVADKVLE
CCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
EVDEVLEEALQVTPNEDLVEEELGDLLFATVNLVRHLGKNPETALNKANLKFSRRFKGVE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QKVRQQDKILTDFSLQQLDSIWDEVKVAEKRSSKLLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNRKKTMNHPIEQLEQIMTKLRDPEGGCPWDLKQNFETIVPHTIEETYEVVDAIHNKDWP
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCHHHHCCHHHHHHHHHHHHHHCCCCC
NLQEELGDLLFQVIFYSQLAKEQGLFEFSDVVDGINEKLTRRHPHVFSDTEFASDEEINA
CHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
NWEAEKAKEKAQAGKTQESILDSIPNSLPALSRATKIQKQVAKFGFDWDSIGPVADKVLE
CCCHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
EVDEVLEEALQVTPNEDLVEEELGDLLFATVNLVRHLGKNPETALNKANLKFSRRFKGVE
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
QKVRQQDKILTDFSLQQLDSIWDEVKVAEKRSSKLLS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]