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The map label for this gene is pcm

Identifier: 218710552

GI number: 218710552

Start: 2790241

End: 2790867

Strand: Reverse

Name: pcm

Synonym: VS_2601

Alternate gene names: 218710552

Gene position: 2790867-2790241 (Counterclockwise)

Preceding gene: 218710553

Following gene: 218710551

Centisome position: 84.59

GC content: 45.45

Gene sequence:

>627_bases
GTGAGTAATCCACAAGCTGAGCGCTTAGTTACTTTTCTGATAGAAAATGGTATTCAGGATCAAAAGGTTCTTGATGCTAT
TTACTTACTACCGAGAGAGAGCTTTTTATCACAGGCTATGCATCACCAGGCCTATGATAATAATGCGCTGCCTATCGGGC
AGGGGCAGACAATTTCTCAGCCTTACATTGTTGCTAAAATGACCGAGCTGCTTGAGTTACAACAAGACAGCCGCGTTTTG
GAGATCGGAACGGGTTCTGGTTATCAAACGGCTGTTTTGGCTCAGTTGGTTGATCACGTGTATTCGGTTGAAAGAATAAA
GTCGCTACAATGGGATGCTAAGCGTAGGTTGAAGCAACTTGATTTCTACAACATCTCAACCAAGCACGGTGATGGTTGGC
AAGGTTGGTCTTCTAAGGCGCCTTTTGATGCGATTATTGTCACCGCTGCTGCAGAGTCGATCCCTCAAGCGCTTTTGCAG
CAGTTGAAAGATGGAGGCCGCTTATTAATTCCGGTCGGAGATGACGAACAACAACTGTTGAAGATTGTTCGCCACGGCGA
TGAGTTCTTATCGAGTGTTATCGAGATGGTGCGATTTGTACCTCTTGTACCTGGTGAGTTAGCTTAA

Upstream 100 bases:

>100_bases
CGCCATTGAACATGGTTTTGTGTCGGTAACACCACTACAAGTTGATCTGACGGCACATGAGTCGTTGGGTGCGATGACTA
CATGGTTAGGGGATAAATAA

Downstream 100 bases:

>100_bases
TAAAATTATTAATGGTGTAGGTGGATAGAAAGTCGATGCGTTCGAAGGTTTTTAAAGGAAGTTCTCTACTGCTTAGCTGT
GCACTTGTTGGGTGTGCGGC

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 208; Mature: 207

Protein sequence:

>208_residues
MSNPQAERLVTFLIENGIQDQKVLDAIYLLPRESFLSQAMHHQAYDNNALPIGQGQTISQPYIVAKMTELLELQQDSRVL
EIGTGSGYQTAVLAQLVDHVYSVERIKSLQWDAKRRLKQLDFYNISTKHGDGWQGWSSKAPFDAIIVTAAAESIPQALLQ
QLKDGGRLLIPVGDDEQQLLKIVRHGDEFLSSVIEMVRFVPLVPGELA

Sequences:

>Translated_208_residues
MSNPQAERLVTFLIENGIQDQKVLDAIYLLPRESFLSQAMHHQAYDNNALPIGQGQTISQPYIVAKMTELLELQQDSRVL
EIGTGSGYQTAVLAQLVDHVYSVERIKSLQWDAKRRLKQLDFYNISTKHGDGWQGWSSKAPFDAIIVTAAAESIPQALLQ
QLKDGGRLLIPVGDDEQQLLKIVRHGDEFLSSVIEMVRFVPLVPGELA
>Mature_207_residues
SNPQAERLVTFLIENGIQDQKVLDAIYLLPRESFLSQAMHHQAYDNNALPIGQGQTISQPYIVAKMTELLELQQDSRVLE
IGTGSGYQTAVLAQLVDHVYSVERIKSLQWDAKRRLKQLDFYNISTKHGDGWQGWSSKAPFDAIIVTAAAESIPQALLQQ
LKDGGRLLIPVGDDEQQLLKIVRHGDEFLSSVIEMVRFVPLVPGELA

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=176, Percent_Identity=35.7954545454545, Blast_Score=90, Evalue=1e-18,
Organism=Escherichia coli, GI1789100, Length=208, Percent_Identity=62.5, Blast_Score=270, Evalue=4e-74,
Organism=Caenorhabditis elegans, GI71983477, Length=198, Percent_Identity=31.8181818181818, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193207222, Length=140, Percent_Identity=34.2857142857143, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17981723, Length=208, Percent_Identity=32.2115384615385, Blast_Score=85, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_VIBSL (B7VK62)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002418173.1
- ProteinModelPortal:   B7VK62
- SMR:   B7VK62
- GeneID:   7162121
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_2601
- HOGENOM:   HBG699907
- OMA:   YSVERIR
- ProtClustDB:   PRK00312
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 23251; Mature: 23120

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 59-59

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNPQAERLVTFLIENGIQDQKVLDAIYLLPRESFLSQAMHHQAYDNNALPIGQGQTISQ
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PYIVAKMTELLELQQDSRVLEIGTGSGYQTAVLAQLVDHVYSVERIKSLQWDAKRRLKQL
CHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DFYNISTKHGDGWQGWSSKAPFDAIIVTAAAESIPQALLQQLKDGGRLLIPVGDDEQQLL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHH
KIVRHGDEFLSSVIEMVRFVPLVPGELA
HHHHCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SNPQAERLVTFLIENGIQDQKVLDAIYLLPRESFLSQAMHHQAYDNNALPIGQGQTISQ
CCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
PYIVAKMTELLELQQDSRVLEIGTGSGYQTAVLAQLVDHVYSVERIKSLQWDAKRRLKQL
CHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
DFYNISTKHGDGWQGWSSKAPFDAIIVTAAAESIPQALLQQLKDGGRLLIPVGDDEQQLL
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHH
KIVRHGDEFLSSVIEMVRFVPLVPGELA
HHHHCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA