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The map label for this gene is deoA [H]

Identifier: 218710425

GI number: 218710425

Start: 2632525

End: 2633922

Strand: Reverse

Name: deoA [H]

Synonym: VS_2462

Alternate gene names: 218710425

Gene position: 2633922-2632525 (Counterclockwise)

Preceding gene: 218710426

Following gene: 218710424

Centisome position: 79.83

GC content: 46.21

Gene sequence:

>1398_bases
GTGGTGTTAAGTCACTCCATATTACCTCTTTCCCTACAAACCATACTCACTAGAGTTTGGGAGGCACTAATGTATCTACC
TCAAGAAATTATTCGCAGAAAACGTGATGGTGAAGTCCTAACGACTGAAGAAATTAACTTCTTCATTCAAGGCGTGGCTA
AAAATACCGTTTCTGAAGGCCAAATTGCCGCATTCGCAATGGCTATCTTTTTTAATGAAATGACGATGCCAGAACGTATC
GCACTGACGTGTGCAATGCGTGATTCGGGCATGGTGATTGACTGGAGCCACATGAACTTTGATGGCCCAATCGTTGATAA
GCACTCTACTGGTGGTGTTGGTGACGTAACTTCTCTGATGCTTGGCCCTATGGTGGCAGCATGTGGTGGTTTCGTTCCAA
TGATCTCTGGTCGTGGTTTAGGTCACACTGGCGGTACGCTAGACAAACTTGAATCTATCCCTGGTTACAATATTACACCC
ACCAACGATGTGTTTGGTGCTGTAACCAAAGAAGCTGGCGTAGCGATCATCGGCCAAACTGGTGATTTAGCGCCAGCTGA
TAAGCGCGTTTACGCGACTCGAGATATCACGGCAACAGTCGACAACATCTCGTTGATCACAGCTTCAATTTTGTCTAAGA
AATTGGCTGCTGGTCTTGATTCTTTAGTGATGGACGTAAAAGTAGGTTCAGGCGCATTCATGCCGACTTACGAAGCGTCT
GAAGAGTTAGCAAAATCTATCGTTGCAGTAGCAAACGGCGCGGGTACTAAAACAACGGCAATCCTAACGGACATGAACCA
AGTTCTGGCTTCTTCAGCGGGTAACGCAGTAGAAGTACGTGAAGCGGTTCAATTTCTAACCGGCGAATATCGTAACCCTC
GTTTGCTAGAAATTACGATGGCATCGTGTGCTGAAATGCTGGTTCTGGGTAACCTTGCAAAAGATTCAGACGAAGCGCGT
GAAAAACTGATGGCAGTACTGGATAACGGTAAAGCAGCAGAGTGCTTCGGTAAAATGGTAGCGGGCCTTGGTGGTCCAAC
TGATTTCGTAACGAAGTACGATAACTACCTAGAAAAAGCAGAAATTGTTAAACCAGTGTATGCGCTAGAAAGCGGTGTAG
TATCAGCGATGGATACGCGTGCAATTGGTATGGCTGTCGTTGGTATGGGCGGTGGTCGCCGCGTAGCAACAGACAGCATT
GATTACGCAGTCGGTTTTGATAGCTTCATTCGCCTTGGCGAAGTAGCAAGTGACGATAAACCATTAGCAATGATTCATGC
TCGCAATGAACAACAGTGGCAAGAAGCTGCAAAAGCATTACAAAATGCAATCACTGTGGGCGGAGAATATACAGCAACGC
CAGACGTTTACCGTCAGATTCGTTCTGAAGACGTGTAA

Upstream 100 bases:

>100_bases
AACTAACCTTCTTAATACATTAGAAGTGACAGACGAAACTGCAGATCCAGCAGCATACTAATTTCCCTATCGGGTATAAC
AATAAAGTCTGTTTGATGGA

Downstream 100 bases:

>100_bases
ATAACAGGTATCGGCATACCTTGTGTATGCCGATAAACAGAGTTCTGGTGCAAAGAGCAATAAGTTGGTGAAGAAAATGA
AAAGAGCATTTATTTTAGTT

Product: thymidine phosphorylase

Products: NA

Alternate protein names: TdRPase [H]

Number of amino acids: Translated: 465; Mature: 465

Protein sequence:

>465_residues
MVLSHSILPLSLQTILTRVWEALMYLPQEIIRRKRDGEVLTTEEINFFIQGVAKNTVSEGQIAAFAMAIFFNEMTMPERI
ALTCAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLMLGPMVAACGGFVPMISGRGLGHTGGTLDKLESIPGYNITP
TNDVFGAVTKEAGVAIIGQTGDLAPADKRVYATRDITATVDNISLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEAS
EELAKSIVAVANGAGTKTTAILTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLLEITMASCAEMLVLGNLAKDSDEAR
EKLMAVLDNGKAAECFGKMVAGLGGPTDFVTKYDNYLEKAEIVKPVYALESGVVSAMDTRAIGMAVVGMGGGRRVATDSI
DYAVGFDSFIRLGEVASDDKPLAMIHARNEQQWQEAAKALQNAITVGGEYTATPDVYRQIRSEDV

Sequences:

>Translated_465_residues
MVLSHSILPLSLQTILTRVWEALMYLPQEIIRRKRDGEVLTTEEINFFIQGVAKNTVSEGQIAAFAMAIFFNEMTMPERI
ALTCAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLMLGPMVAACGGFVPMISGRGLGHTGGTLDKLESIPGYNITP
TNDVFGAVTKEAGVAIIGQTGDLAPADKRVYATRDITATVDNISLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEAS
EELAKSIVAVANGAGTKTTAILTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLLEITMASCAEMLVLGNLAKDSDEAR
EKLMAVLDNGKAAECFGKMVAGLGGPTDFVTKYDNYLEKAEIVKPVYALESGVVSAMDTRAIGMAVVGMGGGRRVATDSI
DYAVGFDSFIRLGEVASDDKPLAMIHARNEQQWQEAAKALQNAITVGGEYTATPDVYRQIRSEDV
>Mature_465_residues
MVLSHSILPLSLQTILTRVWEALMYLPQEIIRRKRDGEVLTTEEINFFIQGVAKNTVSEGQIAAFAMAIFFNEMTMPERI
ALTCAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLMLGPMVAACGGFVPMISGRGLGHTGGTLDKLESIPGYNITP
TNDVFGAVTKEAGVAIIGQTGDLAPADKRVYATRDITATVDNISLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEAS
EELAKSIVAVANGAGTKTTAILTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLLEITMASCAEMLVLGNLAKDSDEAR
EKLMAVLDNGKAAECFGKMVAGLGGPTDFVTKYDNYLEKAEIVKPVYALESGVVSAMDTRAIGMAVVGMGGGRRVATDSI
DYAVGFDSFIRLGEVASDDKPLAMIHARNEQQWQEAAKALQNAITVGGEYTATPDVYRQIRSEDV

Specific function: The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis [H]

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=430, Percent_Identity=37.906976744186, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI4503445, Length=430, Percent_Identity=37.906976744186, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI166158922, Length=430, Percent_Identity=37.906976744186, Blast_Score=257, Evalue=2e-68,
Organism=Escherichia coli, GI1790842, Length=438, Percent_Identity=71.0045662100457, Blast_Score=623, Evalue=1e-180,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872
- InterPro:   IPR013465 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.4 [H]

Molecular weight: Translated: 49573; Mature: 49573

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLSHSILPLSLQTILTRVWEALMYLPQEIIRRKRDGEVLTTEEINFFIQGVAKNTVSEG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCC
QIAAFAMAIFFNEMTMPERIALTCAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLM
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCCCCEECCCCCCCCHHHHHHH
LGPMVAACGGFVPMISGRGLGHTGGTLDKLESIPGYNITPTNDVFGAVTKEAGVAIIGQT
HHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEECC
GDLAPADKRVYATRDITATVDNISLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEAS
CCCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHCHHHHHEEEEECCCCCCCCCHHH
EELAKSIVAVANGAGTKTTAILTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLLEITM
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEH
ASCAEMLVLGNLAKDSDEAREKLMAVLDNGKAAECFGKMVAGLGGPTDFVTKYDNYLEKA
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EIVKPVYALESGVVSAMDTRAIGMAVVGMGGGRRVATDSIDYAVGFDSFIRLGEVASDDK
HHHHHHHHHHHCHHHHHHHHHHCEEEEECCCCCEEECCCCCHHCCHHHHHHHHCCCCCCC
PLAMIHARNEQQWQEAAKALQNAITVGGEYTATPDVYRQIRSEDV
CEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MVLSHSILPLSLQTILTRVWEALMYLPQEIIRRKRDGEVLTTEEINFFIQGVAKNTVSEG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCCCC
QIAAFAMAIFFNEMTMPERIALTCAMRDSGMVIDWSHMNFDGPIVDKHSTGGVGDVTSLM
HHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEECCCCCCCCEECCCCCCCCHHHHHHH
LGPMVAACGGFVPMISGRGLGHTGGTLDKLESIPGYNITPTNDVFGAVTKEAGVAIIGQT
HHHHHHHHCCCHHHHCCCCCCCCCCCHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEECC
GDLAPADKRVYATRDITATVDNISLITASILSKKLAAGLDSLVMDVKVGSGAFMPTYEAS
CCCCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHHCHHHHHEEEEECCCCCCCCCHHH
EELAKSIVAVANGAGTKTTAILTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLLEITM
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEEEH
ASCAEMLVLGNLAKDSDEAREKLMAVLDNGKAAECFGKMVAGLGGPTDFVTKYDNYLEKA
HHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
EIVKPVYALESGVVSAMDTRAIGMAVVGMGGGRRVATDSIDYAVGFDSFIRLGEVASDDK
HHHHHHHHHHHCHHHHHHHHHHCEEEEECCCCCEEECCCCCHHCCHHHHHHHHCCCCCCC
PLAMIHARNEQQWQEAAKALQNAITVGGEYTATPDVYRQIRSEDV
CEEEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]