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The map label for this gene is purM [H]

Identifier: 218710284

GI number: 218710284

Start: 2484989

End: 2486029

Strand: Direct

Name: purM [H]

Synonym: VS_2318

Alternate gene names: 218710284

Gene position: 2484989-2486029 (Clockwise)

Preceding gene: 218710282

Following gene: 218710285

Centisome position: 75.32

GC content: 46.59

Gene sequence:

>1041_bases
GTGAGTGGTAATACTTCTTCTCTAAGCTACAAAGACGCTGGTGTTGATATCGATGCAGGTAATGCACTAGTAGACCGTAT
TAAAGGTGCTGTTAAACGCACTCGTCGCCCTGAAGTAATGGGCGGTATTGGTGGCTTTGGCGCCCTATGTGAACTTCCAA
CGAAATACAAAGAGCCGGTACTTGTTTCAGGTACTGATGGTGTTGGTACTAAACTTCGCCTTGCTTTGGATCTGAAAAAA
CACGACACCATTGGTATCGACCTAGTGGCAATGTGTGTGAACGACTTAATCGTTCAAGGTGGTGAGCCGCTATTCTTCCT
AGACTACTACGCAACAGGTAAGCTAGATGTAGATACAGCAGCAGATGTTGTTTCTGGTATTGCTGAAGGCTGTGTTCAAG
CAGGTTGTGCACTGATCGGCGGTGAAACGGCTGAAATGCCAGGTATGTACGAAGGCGACGACTACGATGTAGCCGGCTTC
TGTGTTGGTGTTGTAGAAAAAGCTGACATCATCGACGGCACTAAAGTAGCTGCAGGCGACGCACTTATCGCTGTTGGCTC
AAGTGGTCCACACTCAAATGGTTACTCTTTGATTCGTAAAGTTCTAGAAGTTTCTGGAGCTGATAAGAGTGAAGAGCTAG
AAGGTCGCACTATCGGTGAACACCTACTAGAACCGACTAAGATTTACATCAAATCGGCACTTAAGATGATTGCAGAGCAT
GACATTCATGCTATCTCGCACATCACAGGTGGTGGTTTCTGGGAAAACATCCCACGCGTACTTCCTGAAGGTACTAAAGC
AGTGATTGATGGCAAGAGCTGGGAATGGCCTGCTATCTTCAACTGGCTACAAGAGAAAGGTAACGTGGAGACATTTGAAA
TGTACCGCACTTTCAACTGTGGTGTAGGCCTAGTTGTTGCTCTACCTAAAGATCAAGCAGACGCTGCTGTTGAACTGCTG
AAAGCCGAAGGCGAAAACGCTTGGGTTATCGGTGAGATCGCAAACGCTGAAGCTGGCGAAGAGCAAGTTGAAATCAAATA
A

Upstream 100 bases:

>100_bases
TATTCTAATAAAAAAAACCGCGCAAACGTTTGCTCTTCGTAATCAAGCCCTGTTAGAATAGCGCCGTTTTCACATCCAAC
TTAAGTTCGAGGACTATCCC

Downstream 100 bases:

>100_bases
GTGATACGCTCACTTACTTAGTTAATCAATGAGGACCTTATGGTCCTCATTTTGCTATTTGGCCCACAGAAAACCTTAGT
TTATGTAGGTACATTGTAAA

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MSGNTSSLSYKDAGVDIDAGNALVDRIKGAVKRTRRPEVMGGIGGFGALCELPTKYKEPVLVSGTDGVGTKLRLALDLKK
HDTIGIDLVAMCVNDLIVQGGEPLFFLDYYATGKLDVDTAADVVSGIAEGCVQAGCALIGGETAEMPGMYEGDDYDVAGF
CVGVVEKADIIDGTKVAAGDALIAVGSSGPHSNGYSLIRKVLEVSGADKSEELEGRTIGEHLLEPTKIYIKSALKMIAEH
DIHAISHITGGGFWENIPRVLPEGTKAVIDGKSWEWPAIFNWLQEKGNVETFEMYRTFNCGVGLVVALPKDQADAAVELL
KAEGENAWVIGEIANAEAGEEQVEIK

Sequences:

>Translated_346_residues
MSGNTSSLSYKDAGVDIDAGNALVDRIKGAVKRTRRPEVMGGIGGFGALCELPTKYKEPVLVSGTDGVGTKLRLALDLKK
HDTIGIDLVAMCVNDLIVQGGEPLFFLDYYATGKLDVDTAADVVSGIAEGCVQAGCALIGGETAEMPGMYEGDDYDVAGF
CVGVVEKADIIDGTKVAAGDALIAVGSSGPHSNGYSLIRKVLEVSGADKSEELEGRTIGEHLLEPTKIYIKSALKMIAEH
DIHAISHITGGGFWENIPRVLPEGTKAVIDGKSWEWPAIFNWLQEKGNVETFEMYRTFNCGVGLVVALPKDQADAAVELL
KAEGENAWVIGEIANAEAGEEQVEIK
>Mature_345_residues
SGNTSSLSYKDAGVDIDAGNALVDRIKGAVKRTRRPEVMGGIGGFGALCELPTKYKEPVLVSGTDGVGTKLRLALDLKKH
DTIGIDLVAMCVNDLIVQGGEPLFFLDYYATGKLDVDTAADVVSGIAEGCVQAGCALIGGETAEMPGMYEGDDYDVAGFC
VGVVEKADIIDGTKVAAGDALIAVGSSGPHSNGYSLIRKVLEVSGADKSEELEGRTIGEHLLEPTKIYIKSALKMIAEHD
IHAISHITGGGFWENIPRVLPEGTKAVIDGKSWEWPAIFNWLQEKGNVETFEMYRTFNCGVGLVVALPKDQADAAVELLK
AEGENAWVIGEIANAEAGEEQVEIK

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=346, Percent_Identity=47.6878612716763, Blast_Score=329, Evalue=2e-90,
Organism=Homo sapiens, GI209869995, Length=346, Percent_Identity=47.6878612716763, Blast_Score=329, Evalue=2e-90,
Organism=Homo sapiens, GI209869993, Length=346, Percent_Identity=47.6878612716763, Blast_Score=329, Evalue=2e-90,
Organism=Escherichia coli, GI1788845, Length=344, Percent_Identity=73.8372093023256, Blast_Score=540, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI17567511, Length=345, Percent_Identity=42.0289855072464, Blast_Score=260, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6321203, Length=335, Percent_Identity=48.0597014925373, Blast_Score=318, Evalue=6e-88,
Organism=Drosophila melanogaster, GI24582400, Length=305, Percent_Identity=40.9836065573771, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 36659; Mature: 36528

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGNTSSLSYKDAGVDIDAGNALVDRIKGAVKRTRRPEVMGGIGGFGALCELPTKYKEPV
CCCCCCCCEECCCCCEECCCHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCCCCCCCE
LVSGTDGVGTKLRLALDLKKHDTIGIDLVAMCVNDLIVQGGEPLFFLDYYATGKLDVDTA
EEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHH
ADVVSGIAEGCVQAGCALIGGETAEMPGMYEGDDYDVAGFCVGVVEKADIIDGTKVAAGD
HHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCC
ALIAVGSSGPHSNGYSLIRKVLEVSGADKSEELEGRTIGEHLLEPTKIYIKSALKMIAEH
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHCCCCHHHHHHCCHHHHHHHHHHHHHHHH
DIHAISHITGGGFWENIPRVLPEGTKAVIDGKSWEWPAIFNWLQEKGNVETFEMYRTFNC
HHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEECC
GVGLVVALPKDQADAAVELLKAEGENAWVIGEIANAEAGEEQVEIK
CCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECC
>Mature Secondary Structure 
SGNTSSLSYKDAGVDIDAGNALVDRIKGAVKRTRRPEVMGGIGGFGALCELPTKYKEPV
CCCCCCCEECCCCCEECCCHHHHHHHHHHHHHCCCCHHHCCCCCHHHHHCCCCCCCCCE
LVSGTDGVGTKLRLALDLKKHDTIGIDLVAMCVNDLIVQGGEPLFFLDYYATGKLDVDTA
EEECCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHH
ADVVSGIAEGCVQAGCALIGGETAEMPGMYEGDDYDVAGFCVGVVEKADIIDGTKVAAGD
HHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEECCC
ALIAVGSSGPHSNGYSLIRKVLEVSGADKSEELEGRTIGEHLLEPTKIYIKSALKMIAEH
EEEEECCCCCCCCHHHHHHHHHHHCCCCCCHHCCCCHHHHHHCCHHHHHHHHHHHHHHHH
DIHAISHITGGGFWENIPRVLPEGTKAVIDGKSWEWPAIFNWLQEKGNVETFEMYRTFNC
HHHHHHHCCCCCHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEECC
GVGLVVALPKDQADAAVELLKAEGENAWVIGEIANAEAGEEQVEIK
CCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA