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The map label for this gene is nagC [H]

Identifier: 218710229

GI number: 218710229

Start: 2430730

End: 2431944

Strand: Direct

Name: nagC [H]

Synonym: VS_2262

Alternate gene names: 218710229

Gene position: 2430730-2431944 (Clockwise)

Preceding gene: 218710228

Following gene: 218710230

Centisome position: 73.67

GC content: 45.76

Gene sequence:

>1215_bases
ATGAATGGCGGACAAATAGGTAACGTAGACTTAGTTAAACAACTAAACAGTGCGGCGGTATACCGACTAATAGACCAGCA
AGGGCCTATCAGTCGTATACAAGTGGCTGATGTAAGCCAACTCGCACCGGCAAGTGTTACAAAAATTACCCGCCAACTTT
TGGAGCGCGGCCTCATTAAAGAGGTTGCGCAACAAGCGTCTACTGGCGGTAGACGCGCGATCTCCCTAACCACAGAAGTC
GACCCTTTTCATTCTGTCGCTGTACGCTTAGGTAGAGACTATATTCAAATAAGCCTTCATGACCTTGGCGGTCGTGAGTT
GGCTTTCCAACAACAAGACCTGGATTATTCAGACCAATCAGACCTTACACAAGGCTTAGTCAATAACCTCAAGGCTTTCA
TTGCTGAGCATCAGCCAAAGATCGACCAACTGATTGCCATTGGTGTCACCCTTCCAGGCTTGGTTAACCCAACAACCGGT
GTTGTTGAGTACATGCCAAATACGGACATCGATAACCTCGCATTGAGCGACATTATTCGCGACACTTTCCATGTGGCTTG
TTTTGTTGGTAATGACGTTAGAGGAATGGCGCTTGCTGAGCACTACTTCGGTGCAAGTAAAGACAGTCAAGATTCTATTT
TGGTCAGTGTGCACCGTGGTACGGGTGCTGGTATTATCGTTAATGGCCAGGTTTTCTTAGGCCATAACCGTAACGTGGGT
GAAATTGGTCATATCCAAATTGATCCGCTAGGAGAACAGTGCCAGTGTGGTAACTTCGGTTGTCTTGAAACCGTAGCGGC
AAACCCTGCCATTGTTGATCGAGTACAGAAGCTCATTAAGCAAGGCTATGAATCTTCTTTAACGGAACTTGAACATATTA
CGATTCAAGATGTTTGTGACCACGCAATCAATGGCGATGAACTCGCGAAACAAAGCTTAGTTCGAGTAGGAAACCAGTTA
GGTAAGGCTATCGCGATGACGATTAACCTGTTTAACCCTCAGAAAGTTATCATTGCTGGTGATATTACGAAGGCACAAGA
GATTGTTTTCCCTGCAATTAAGCGCAATGTAGAGAATCAGTCGTTAACGACTTTCCATAGCGGCCTGCCTATTGTAGCAT
CACAGATCGATAAACATCCTACGATGGGAGCCTTTGCCATGATTAAGCGCGCCATGCTCAACGGTGTGTTACTGCAAAAG
CTTCTTGAAGACTAA

Upstream 100 bases:

>100_bases
GTCGAATCAAAAAAGGCATGGTTGCAAATCTAGCTGTATTTGACCGAGACTTTAACGTTAAAGCGACTGTTGTTAATGGA
CAATACGAGCACAATTAAGT

Downstream 100 bases:

>100_bases
AGAAAACAATTCTGATTTTCCGCGGGCCGTGTTTGTATAAACACGGCCCGTTTTTTTAAGCTAGGGAACTACAACAACAA
GTTATGGAACTTATATTAAT

Product: N-acetylglucosamine repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MNGGQIGNVDLVKQLNSAAVYRLIDQQGPISRIQVADVSQLAPASVTKITRQLLERGLIKEVAQQASTGGRRAISLTTEV
DPFHSVAVRLGRDYIQISLHDLGGRELAFQQQDLDYSDQSDLTQGLVNNLKAFIAEHQPKIDQLIAIGVTLPGLVNPTTG
VVEYMPNTDIDNLALSDIIRDTFHVACFVGNDVRGMALAEHYFGASKDSQDSILVSVHRGTGAGIIVNGQVFLGHNRNVG
EIGHIQIDPLGEQCQCGNFGCLETVAANPAIVDRVQKLIKQGYESSLTELEHITIQDVCDHAINGDELAKQSLVRVGNQL
GKAIAMTINLFNPQKVIIAGDITKAQEIVFPAIKRNVENQSLTTFHSGLPIVASQIDKHPTMGAFAMIKRAMLNGVLLQK
LLED

Sequences:

>Translated_404_residues
MNGGQIGNVDLVKQLNSAAVYRLIDQQGPISRIQVADVSQLAPASVTKITRQLLERGLIKEVAQQASTGGRRAISLTTEV
DPFHSVAVRLGRDYIQISLHDLGGRELAFQQQDLDYSDQSDLTQGLVNNLKAFIAEHQPKIDQLIAIGVTLPGLVNPTTG
VVEYMPNTDIDNLALSDIIRDTFHVACFVGNDVRGMALAEHYFGASKDSQDSILVSVHRGTGAGIIVNGQVFLGHNRNVG
EIGHIQIDPLGEQCQCGNFGCLETVAANPAIVDRVQKLIKQGYESSLTELEHITIQDVCDHAINGDELAKQSLVRVGNQL
GKAIAMTINLFNPQKVIIAGDITKAQEIVFPAIKRNVENQSLTTFHSGLPIVASQIDKHPTMGAFAMIKRAMLNGVLLQK
LLED
>Mature_404_residues
MNGGQIGNVDLVKQLNSAAVYRLIDQQGPISRIQVADVSQLAPASVTKITRQLLERGLIKEVAQQASTGGRRAISLTTEV
DPFHSVAVRLGRDYIQISLHDLGGRELAFQQQDLDYSDQSDLTQGLVNNLKAFIAEHQPKIDQLIAIGVTLPGLVNPTTG
VVEYMPNTDIDNLALSDIIRDTFHVACFVGNDVRGMALAEHYFGASKDSQDSILVSVHRGTGAGIIVNGQVFLGHNRNVG
EIGHIQIDPLGEQCQCGNFGCLETVAANPAIVDRVQKLIKQGYESSLTELEHITIQDVCDHAINGDELAKQSLVRVGNQL
GKAIAMTINLFNPQKVIIAGDITKAQEIVFPAIKRNVENQSLTTFHSGLPIVASQIDKHPTMGAFAMIKRAMLNGVLLQK
LLED

Specific function: Acts as a repressor of the nagEBACD operon and acts both as an activator and a repressor for the transcription of the glmSU operon [H]

COG id: COG1940

COG function: function code KG; Transcriptional regulator/sugar kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ROK (nagC/xylR) family [H]

Homologues:

Organism=Homo sapiens, GI298566325, Length=210, Percent_Identity=27.1428571428571, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI298566315, Length=208, Percent_Identity=27.8846153846154, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI4885285, Length=208, Percent_Identity=27.8846153846154, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI190014632, Length=208, Percent_Identity=27.8846153846154, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786891, Length=401, Percent_Identity=59.6009975062344, Blast_Score=490, Evalue=1e-140,
Organism=Escherichia coli, GI1787878, Length=401, Percent_Identity=36.4089775561097, Blast_Score=294, Evalue=9e-81,
Organism=Escherichia coli, GI87082127, Length=334, Percent_Identity=21.2574850299401, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI87081733, Length=211, Percent_Identity=23.696682464455, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1790522, Length=274, Percent_Identity=25.5474452554745, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000835
- InterPro:   IPR000600
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01047 MarR; PF00480 ROK [H]

EC number: NA

Molecular weight: Translated: 43773; Mature: 43773

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS01125 ROK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGGQIGNVDLVKQLNSAAVYRLIDQQGPISRIQVADVSQLAPASVTKITRQLLERGLIK
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCHHHHHHHHHHHHHHHHH
EVAQQASTGGRRAISLTTEVDPFHSVAVRLGRDYIQISLHDLGGRELAFQQQDLDYSDQS
HHHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCHH
DLTQGLVNNLKAFIAEHQPKIDQLIAIGVTLPGLVNPTTGVVEYMPNTDIDNLALSDIIR
HHHHHHHHHHHHHHHHCCCCHHHHEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHH
DTFHVACFVGNDVRGMALAEHYFGASKDSQDSILVSVHRGTGAGIIVNGQVFLGHNRNVG
HHHEEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEECEEEECCCCCCC
EIGHIQIDPLGEQCQCGNFGCLETVAANPAIVDRVQKLIKQGYESSLTELEHITIQDVCD
CCCCEEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAINGDELAKQSLVRVGNQLGKAIAMTINLFNPQKVIIAGDITKAQEIVFPAIKRNVENQ
HCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCCC
SLTTFHSGLPIVASQIDKHPTMGAFAMIKRAMLNGVLLQKLLED
CHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNGGQIGNVDLVKQLNSAAVYRLIDQQGPISRIQVADVSQLAPASVTKITRQLLERGLIK
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHCCHHHHHHHHHHHHHHHHH
EVAQQASTGGRRAISLTTEVDPFHSVAVRLGRDYIQISLHDLGGRELAFQQQDLDYSDQS
HHHHHHCCCCCEEEEEEECCCHHHHHHHHHCCCEEEEEEECCCCCEEEEECCCCCCCCHH
DLTQGLVNNLKAFIAEHQPKIDQLIAIGVTLPGLVNPTTGVVEYMPNTDIDNLALSDIIR
HHHHHHHHHHHHHHHHCCCCHHHHEEECCCCCCCCCCCCCCEEECCCCCHHHHHHHHHHH
DTFHVACFVGNDVRGMALAEHYFGASKDSQDSILVSVHRGTGAGIIVNGQVFLGHNRNVG
HHHEEEEEECCCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEECEEEECCCCCCC
EIGHIQIDPLGEQCQCGNFGCLETVAANPAIVDRVQKLIKQGYESSLTELEHITIQDVCD
CCCCEEECCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HAINGDELAKQSLVRVGNQLGKAIAMTINLFNPQKVIIAGDITKAQEIVFPAIKRNVENQ
HCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHCCCCCC
SLTTFHSGLPIVASQIDKHPTMGAFAMIKRAMLNGVLLQKLLED
CHHHHHCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]