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The map label for this gene is nagA [H]

Identifier: 218710228

GI number: 218710228

Start: 2429591

End: 2430727

Strand: Direct

Name: nagA [H]

Synonym: VS_2261

Alternate gene names: 218710228

Gene position: 2429591-2430727 (Clockwise)

Preceding gene: 218710225

Following gene: 218710229

Centisome position: 73.64

GC content: 44.5

Gene sequence:

>1137_bases
ATGTACGCGCTAAGTAACTGTAAAATTTACACTGGTAGTGATGTTCTAACCGATCATGCTGTCGTAATAGAAAATGAACT
GATCAAAAAAGTCTGTCCTATCTCTGAATTGCCAGAAGGAATTGAGGTTCGCGATCTAAACGGAGCAAACCTAAGCCCAG
GTTTCATTGACTTACAGCTGAATGGTTGTGGTGGTGTAATGCTTAACGATGAGATCACGGCAGAAACAATGCAGATCATG
CACGAAGCAAACCTTAAATCAGGCTGTACTAGCTTCTTGCCTACGCTCATCACCTCTTCAGACGAAGATATGCGTGCAGT
TATTACTGCAGCTCGTGAATATCACAACCAGTACCAAAACCAATCACTAGGTCTGCACCTTGAAGGTCCATATCTAAACG
TTGCAAAAAAAGGCATTCATAGCGTCGATCACATTCGTAAATCAGACAGCGAAATGATTGAACTGATTTGCGAGAACAGC
GACCTAGTTGCAAAAGTAACATTGGCACCAGAGCTTAATGATCCAGAACATATCGAGCGCCTACACAAAGCTGGCGTTGT
CGTTTCAATCGGCCATACAAACGCGACTTACGCAGAAGCTCGACAAAGTTTCGAATCTGGTATCACTTTCGCTACTCACC
TGTTCAATGCGATGACCCCTATGGTCGGTCGTGAACCTGGCGTTGTTGGCGCGATTTACGACACGCCAGAAGTTTATGCA
GGTATCATCGCCGACGGCTTCCACGTTGATTACGCAAACATCAGAATTGCGCACAAAATCAAGGGAGAAAAGTTAGTATT
AGTGACGGATGCCACAGCTCCTGCAGGTGCTGACATGGAATACTTTATTTTTGTCGGTAAGAAAGTATATTACCGAGATG
GTAAGTGTGTTGATGAAAACGGCACACTGGGCGGCTCAGCTCTGACTATGATTGAAGCAGTTCAGAATACAGTTGAGCAC
GCTGGTATCGCTTTAGACGAAGCTCTTCGCATGGCTACGCTATACCCAGCTACGGCTATCGGTGTAGAAAGCAAGCTAGG
TCGAATCAAAAAAGGCATGGTTGCAAATCTAGCTGTATTTGACCGAGACTTTAACGTTAAAGCGACTGTTGTTAATGGAC
AATACGAGCACAATTAA

Upstream 100 bases:

>100_bases
ATAAAAGATAAATCGTTACGTAAATGATGCTCGCAAACTAAGTCCACATTTAGGTAACGAACAAATTTAAAAGATCTCAC
GAAATAAGGATTAGCTGACT

Downstream 100 bases:

>100_bases
GTATGAATGGCGGACAAATAGGTAACGTAGACTTAGTTAAACAACTAAACAGTGCGGCGGTATACCGACTAATAGACCAG
CAAGGGCCTATCAGTCGTAT

Product: N-acetylglucosamine-6-phosphate deacetylase

Products: NA

Alternate protein names: GlcNAc 6-P deacetylase [H]

Number of amino acids: Translated: 378; Mature: 378

Protein sequence:

>378_residues
MYALSNCKIYTGSDVLTDHAVVIENELIKKVCPISELPEGIEVRDLNGANLSPGFIDLQLNGCGGVMLNDEITAETMQIM
HEANLKSGCTSFLPTLITSSDEDMRAVITAAREYHNQYQNQSLGLHLEGPYLNVAKKGIHSVDHIRKSDSEMIELICENS
DLVAKVTLAPELNDPEHIERLHKAGVVVSIGHTNATYAEARQSFESGITFATHLFNAMTPMVGREPGVVGAIYDTPEVYA
GIIADGFHVDYANIRIAHKIKGEKLVLVTDATAPAGADMEYFIFVGKKVYYRDGKCVDENGTLGGSALTMIEAVQNTVEH
AGIALDEALRMATLYPATAIGVESKLGRIKKGMVANLAVFDRDFNVKATVVNGQYEHN

Sequences:

>Translated_378_residues
MYALSNCKIYTGSDVLTDHAVVIENELIKKVCPISELPEGIEVRDLNGANLSPGFIDLQLNGCGGVMLNDEITAETMQIM
HEANLKSGCTSFLPTLITSSDEDMRAVITAAREYHNQYQNQSLGLHLEGPYLNVAKKGIHSVDHIRKSDSEMIELICENS
DLVAKVTLAPELNDPEHIERLHKAGVVVSIGHTNATYAEARQSFESGITFATHLFNAMTPMVGREPGVVGAIYDTPEVYA
GIIADGFHVDYANIRIAHKIKGEKLVLVTDATAPAGADMEYFIFVGKKVYYRDGKCVDENGTLGGSALTMIEAVQNTVEH
AGIALDEALRMATLYPATAIGVESKLGRIKKGMVANLAVFDRDFNVKATVVNGQYEHN
>Mature_378_residues
MYALSNCKIYTGSDVLTDHAVVIENELIKKVCPISELPEGIEVRDLNGANLSPGFIDLQLNGCGGVMLNDEITAETMQIM
HEANLKSGCTSFLPTLITSSDEDMRAVITAAREYHNQYQNQSLGLHLEGPYLNVAKKGIHSVDHIRKSDSEMIELICENS
DLVAKVTLAPELNDPEHIERLHKAGVVVSIGHTNATYAEARQSFESGITFATHLFNAMTPMVGREPGVVGAIYDTPEVYA
GIIADGFHVDYANIRIAHKIKGEKLVLVTDATAPAGADMEYFIFVGKKVYYRDGKCVDENGTLGGSALTMIEAVQNTVEH
AGIALDEALRMATLYPATAIGVESKLGRIKKGMVANLAVFDRDFNVKATVVNGQYEHN

Specific function: N-acetylglucosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI21361513, Length=415, Percent_Identity=31.3253012048193, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI224922791, Length=422, Percent_Identity=31.042654028436, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1786892, Length=376, Percent_Identity=61.7021276595745, Blast_Score=488, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17553768, Length=387, Percent_Identity=31.5245478036176, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI19920392, Length=388, Percent_Identity=31.4432989690722, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI281361140, Length=402, Percent_Identity=30.0995024875622, Blast_Score=159, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR003764
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.1.25 [H]

Molecular weight: Translated: 41085; Mature: 41085

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYALSNCKIYTGSDVLTDHAVVIENELIKKVCPISELPEGIEVRDLNGANLSPGFIDLQL
CCEECCCEEEECCCCCCCCEEEEHHHHHHHHCCHHHCCCCCEEEECCCCCCCCCEEEEEE
NGCGGVMLNDEITAETMQIMHEANLKSGCTSFLPTLITSSDEDMRAVITAAREYHNQYQN
CCCCCEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
QSLGLHLEGPYLNVAKKGIHSVDHIRKSDSEMIELICENSDLVAKVTLAPELNDPEHIER
CCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHH
LHKAGVVVSIGHTNATYAEARQSFESGITFATHLFNAMTPMVGREPGVVGAIYDTPEVYA
HHHCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHH
GIIADGFHVDYANIRIAHKIKGEKLVLVTDATAPAGADMEYFIFVGKKVYYRDGKCVDEN
HHHCCCEEEEEEEEEEEEEECCCEEEEEECCCCCCCCCEEEEEEECCEEEEECCEEECCC
GTLGGSALTMIEAVQNTVEHAGIALDEALRMATLYPATAIGVESKLGRIKKGMVANLAVF
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHCHHHHHHHHHCCCEEEEEEE
DRDFNVKATVVNGQYEHN
ECCCCEEEEEECCCCCCC
>Mature Secondary Structure
MYALSNCKIYTGSDVLTDHAVVIENELIKKVCPISELPEGIEVRDLNGANLSPGFIDLQL
CCEECCCEEEECCCCCCCCEEEEHHHHHHHHCCHHHCCCCCEEEECCCCCCCCCEEEEEE
NGCGGVMLNDEITAETMQIMHEANLKSGCTSFLPTLITSSDEDMRAVITAAREYHNQYQN
CCCCCEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
QSLGLHLEGPYLNVAKKGIHSVDHIRKSDSEMIELICENSDLVAKVTLAPELNDPEHIER
CCCCEEECCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHH
LHKAGVVVSIGHTNATYAEARQSFESGITFATHLFNAMTPMVGREPGVVGAIYDTPEVYA
HHHCCEEEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHH
GIIADGFHVDYANIRIAHKIKGEKLVLVTDATAPAGADMEYFIFVGKKVYYRDGKCVDEN
HHHCCCEEEEEEEEEEEEEECCCEEEEEECCCCCCCCCEEEEEEECCEEEEECCEEECCC
GTLGGSALTMIEAVQNTVEHAGIALDEALRMATLYPATAIGVESKLGRIKKGMVANLAVF
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCHHHHCHHHHHHHHHCCCEEEEEEE
DRDFNVKATVVNGQYEHN
ECCCCEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9301118; 10952301 [H]