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The map label for this gene is ppiD [H]

Identifier: 218710170

GI number: 218710170

Start: 2348462

End: 2350327

Strand: Reverse

Name: ppiD [H]

Synonym: VS_2200

Alternate gene names: 218710170

Gene position: 2350327-2348462 (Counterclockwise)

Preceding gene: 218710171

Following gene: 218710169

Centisome position: 71.24

GC content: 44.8

Gene sequence:

>1866_bases
ATGATGGATCGATTACGCGAAGGCGTGAATAGCATCGCGGTAAAAATTATCCTTGGGTTGATTATCCTGTCATTCGTATT
CGCAGGTGTAGGCAGCTACATCACCGGTGGCGGTAACAACGCAGCAGCTAAAGTTGGCAACACAGAAATTGCTCGTGGTG
AGTTCGAACAAGCTTACCAAAACGAACGTAATCGCATGCAATCTCAACTTGGCGATTACTTCGCTCAAATGCTTGCAGAC
CCTGCATACGTGGAGTCTTTCCGTAAGTCAGTACTTGATCGCATGATCAACGATGTTCTACTTGAGCAGCAAGCAGAATC
TCTAGGCCTACGAATCAGTGATTCTCAAATCCGTACCATGATTCTAGAAATGCCTCAGTTCCAAACGGCTGGTCAATTCG
ACCAAGAAGTTTACCAATCAGCATTACGTCGTGCAGGTTTCAGCGCAGAAAGCTTCGCAGAATACATGCGTCGTGATCTA
ATGCGTAACCAGCTTGTCACTGCGCTTCAAGGCAGTGAATTTGTTCTTCAAGGCGAAATTGATATTCAGAGCAAGCTTAT
TGCTCAAACTCGTGACATTCGCACAGTGACACTGTCTGTTGCTGACCTAGCGAAAACCATCGAGTTAACTGACGAGCAAA
TCGAACAGTATTACCAAGAGAACCCTGCGGCTTACACTCGTCCAGAGCAGGCTAAGGTATCTTACATCGAACTTTCTGCT
GAAGCACTTAAATCGCAACTTGAAGTTAGCGATGAGGAAGCACAGAAATATTACCAAGAGCATCTAGACAAGTACTCTAC
TGAAGAGCAACGTAAAGTTAGCCACATTCTAGTTCAAGGTGATGACGAAGCGAAAGCTCAGTCTATCCTAGACGAGCTAA
ATGCAGGTGCTGATTTTGCTACGCTAGCAGAAGAAAAATCTGACGACTTCGGTAGTGCAGATGTTGGCGGTGACCTAGGT
TGGATTGAACGCGATGTTATGGACCCAGCATTCGAAGAGGCGGCTTTCGCTCTTGAGAATATTGGCGATACGACTGGCTT
AGTTAAATCTGATTTTGGCTACCACATCATCAAGCTAGACGAAGTAAAAGCATCTCAAGCTCAGCCTTACACTGAAGTTG
CTACTGATATTAAGCAAGAGCTTCTAGACCAACACGCCGTTGATCAGTTCTACGAGCAACAAACTGAACTTGAAAAAGTA
GCGTTTGAATTCCCAGATTCTCTAGACGACTCTGCTGAAGCTATCAACGCGAAGATCACGACGACTGATTTCATCTCTCA
AGCTGACGCTCCAGAAGTTCTGATGACGCCTGCAGTAATGCAAGCTATCTTGAGCCCTGAAGTGAAAGAAGACGGTTTGA
ACTCTGAAGTTATCGAAGTGGCTCCTGAGCACGTTATTGTTGTACGTGTAGAAGAGACTCGCGACGAAACAGTTCTTCCT
TTAGCAGAAGTGAAAGATCAAGTTGTAGCTGCATTGTCTGCTGTAAAAGCAGAGCAACAAGCGGTAGAGCTAGGTGTTTC
TCTAGTAAACGAACTTAAGCAAGGTAATGAAGCGGTACTGGCGGATAACAGCCTTGAGTTTACTGAACTTGAAACCATTG
ACCGTAATTCTCCATTAGCTGCATCTGTATTCGCTCTAGTGAAACCAGAAGCCGGCCAAGCTGTGTTCGGTCAATCTAAA
GATCAAGACGGTAACATCGTTGTTGTTGAGCTTTCTAAAGTAACGGCTGAAATCAACCCAGCTTACAGCACACAACTTGG
TGCACAGTTAGAGCGCGTTGGTAATCAACAAGACCTTACTAATGTACTAAACGTACTGCGTAAAAATTCAGACGTTGAAT
ACTACATCGTTGGTCAAGCTCAATAA

Upstream 100 bases:

>100_bases
TATGCGCATCCTACTGATGCGCATTTCTTTTTCTGATAATATCGCGTGAATAGATTTTTATTTTGAAGCCAATGCTTCAT
ATCCGGAGAGCACTTAAATT

Downstream 100 bases:

>100_bases
GCTTTGAATTTACTCGGTAGTCTTCTGCCGAGTAATGCAACTTGAGAATGCAACTTGAAAGTAGTGCAGCAACTCGGTTT
GCGAGCTAGCTAACAAATTG

Product: peptidyl-prolyl cis-trans isomerase D

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 621; Mature: 621

Protein sequence:

>621_residues
MMDRLREGVNSIAVKIILGLIILSFVFAGVGSYITGGGNNAAAKVGNTEIARGEFEQAYQNERNRMQSQLGDYFAQMLAD
PAYVESFRKSVLDRMINDVLLEQQAESLGLRISDSQIRTMILEMPQFQTAGQFDQEVYQSALRRAGFSAESFAEYMRRDL
MRNQLVTALQGSEFVLQGEIDIQSKLIAQTRDIRTVTLSVADLAKTIELTDEQIEQYYQENPAAYTRPEQAKVSYIELSA
EALKSQLEVSDEEAQKYYQEHLDKYSTEEQRKVSHILVQGDDEAKAQSILDELNAGADFATLAEEKSDDFGSADVGGDLG
WIERDVMDPAFEEAAFALENIGDTTGLVKSDFGYHIIKLDEVKASQAQPYTEVATDIKQELLDQHAVDQFYEQQTELEKV
AFEFPDSLDDSAEAINAKITTTDFISQADAPEVLMTPAVMQAILSPEVKEDGLNSEVIEVAPEHVIVVRVEETRDETVLP
LAEVKDQVVAALSAVKAEQQAVELGVSLVNELKQGNEAVLADNSLEFTELETIDRNSPLAASVFALVKPEAGQAVFGQSK
DQDGNIVVVELSKVTAEINPAYSTQLGAQLERVGNQQDLTNVLNVLRKNSDVEYYIVGQAQ

Sequences:

>Translated_621_residues
MMDRLREGVNSIAVKIILGLIILSFVFAGVGSYITGGGNNAAAKVGNTEIARGEFEQAYQNERNRMQSQLGDYFAQMLAD
PAYVESFRKSVLDRMINDVLLEQQAESLGLRISDSQIRTMILEMPQFQTAGQFDQEVYQSALRRAGFSAESFAEYMRRDL
MRNQLVTALQGSEFVLQGEIDIQSKLIAQTRDIRTVTLSVADLAKTIELTDEQIEQYYQENPAAYTRPEQAKVSYIELSA
EALKSQLEVSDEEAQKYYQEHLDKYSTEEQRKVSHILVQGDDEAKAQSILDELNAGADFATLAEEKSDDFGSADVGGDLG
WIERDVMDPAFEEAAFALENIGDTTGLVKSDFGYHIIKLDEVKASQAQPYTEVATDIKQELLDQHAVDQFYEQQTELEKV
AFEFPDSLDDSAEAINAKITTTDFISQADAPEVLMTPAVMQAILSPEVKEDGLNSEVIEVAPEHVIVVRVEETRDETVLP
LAEVKDQVVAALSAVKAEQQAVELGVSLVNELKQGNEAVLADNSLEFTELETIDRNSPLAASVFALVKPEAGQAVFGQSK
DQDGNIVVVELSKVTAEINPAYSTQLGAQLERVGNQQDLTNVLNVLRKNSDVEYYIVGQAQ
>Mature_621_residues
MMDRLREGVNSIAVKIILGLIILSFVFAGVGSYITGGGNNAAAKVGNTEIARGEFEQAYQNERNRMQSQLGDYFAQMLAD
PAYVESFRKSVLDRMINDVLLEQQAESLGLRISDSQIRTMILEMPQFQTAGQFDQEVYQSALRRAGFSAESFAEYMRRDL
MRNQLVTALQGSEFVLQGEIDIQSKLIAQTRDIRTVTLSVADLAKTIELTDEQIEQYYQENPAAYTRPEQAKVSYIELSA
EALKSQLEVSDEEAQKYYQEHLDKYSTEEQRKVSHILVQGDDEAKAQSILDELNAGADFATLAEEKSDDFGSADVGGDLG
WIERDVMDPAFEEAAFALENIGDTTGLVKSDFGYHIIKLDEVKASQAQPYTEVATDIKQELLDQHAVDQFYEQQTELEKV
AFEFPDSLDDSAEAINAKITTTDFISQADAPEVLMTPAVMQAILSPEVKEDGLNSEVIEVAPEHVIVVRVEETRDETVLP
LAEVKDQVVAALSAVKAEQQAVELGVSLVNELKQGNEAVLADNSLEFTELETIDRNSPLAASVFALVKPEAGQAVFGQSK
DQDGNIVVVELSKVTAEINPAYSTQLGAQLERVGNQQDLTNVLNVLRKNSDVEYYIVGQAQ

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=581, Percent_Identity=38.5542168674699, Blast_Score=396, Evalue=1e-111,
Organism=Escherichia coli, GI1786238, Length=89, Percent_Identity=41.5730337078652, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 68652; Mature: 68652

Theoretical pI: Translated: 4.03; Mature: 4.03

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMDRLREGVNSIAVKIILGLIILSFVFAGVGSYITGGGNNAAAKVGNTEIARGEFEQAYQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCHHHHHHHHHHHH
NERNRMQSQLGDYFAQMLADPAYVESFRKSVLDRMINDVLLEQQAESLGLRISDSQIRTM
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHH
ILEMPQFQTAGQFDQEVYQSALRRAGFSAESFAEYMRRDLMRNQLVTALQGSEFVLQGEI
HHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
DIQSKLIAQTRDIRTVTLSVADLAKTIELTDEQIEQYYQENPAAYTRPEQAKVSYIELSA
CHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
EALKSQLEVSDEEAQKYYQEHLDKYSTEEQRKVSHILVQGDDEAKAQSILDELNAGADFA
HHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHEEECCCHHHHHHHHHHHCCCCCHH
TLAEEKSDDFGSADVGGDLGWIERDVMDPAFEEAAFALENIGDTTGLVKSDFGYHIIKLD
HHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEE
EVKASQAQPYTEVATDIKQELLDQHAVDQFYEQQTELEKVAFEFPDSLDDSAEAINAKIT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEE
TTDFISQADAPEVLMTPAVMQAILSPEVKEDGLNSEVIEVAPEHVIVVRVEETRDETVLP
HHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCCCCCHHHHCCCCEEEEEEEECCCCCCCCC
LAEVKDQVVAALSAVKAEQQAVELGVSLVNELKQGNEAVLADNSLEFTELETIDRNSPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCCCHH
ASVFALVKPEAGQAVFGQSKDQDGNIVVVELSKVTAEINPAYSTQLGAQLERVGNQQDLT
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHCCCHHHHH
NVLNVLRKNSDVEYYIVGQAQ
HHHHHHHCCCCCEEEEEECCC
>Mature Secondary Structure
MMDRLREGVNSIAVKIILGLIILSFVFAGVGSYITGGGNNAAAKVGNTEIARGEFEQAYQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCCCHHHHHHHHHHHH
NERNRMQSQLGDYFAQMLADPAYVESFRKSVLDRMINDVLLEQQAESLGLRISDSQIRTM
HHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECHHHHHHH
ILEMPQFQTAGQFDQEVYQSALRRAGFSAESFAEYMRRDLMRNQLVTALQGSEFVLQGEI
HHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
DIQSKLIAQTRDIRTVTLSVADLAKTIELTDEQIEQYYQENPAAYTRPEQAKVSYIELSA
CHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
EALKSQLEVSDEEAQKYYQEHLDKYSTEEQRKVSHILVQGDDEAKAQSILDELNAGADFA
HHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHEEECCCHHHHHHHHHHHCCCCCHH
TLAEEKSDDFGSADVGGDLGWIERDVMDPAFEEAAFALENIGDTTGLVKSDFGYHIIKLD
HHHHHCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEE
EVKASQAQPYTEVATDIKQELLDQHAVDQFYEQQTELEKVAFEFPDSLDDSAEAINAKIT
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCEEE
TTDFISQADAPEVLMTPAVMQAILSPEVKEDGLNSEVIEVAPEHVIVVRVEETRDETVLP
HHHHHHCCCCCHHHHHHHHHHHHHCCCHHCCCCCCHHHHCCCCEEEEEEEECCCCCCCCC
LAEVKDQVVAALSAVKAEQQAVELGVSLVNELKQGNEAVLADNSLEFTELETIDRNSPLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHCCCCCCHH
ASVFALVKPEAGQAVFGQSKDQDGNIVVVELSKVTAEINPAYSTQLGAQLERVGNQQDLT
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHCCCCHHHHHHHHHHHCCCHHHHH
NVLNVLRKNSDVEYYIVGQAQ
HHHHHHHCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]