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The map label for this gene is dsdC [H]

Identifier: 218710155

GI number: 218710155

Start: 2333049

End: 2333921

Strand: Reverse

Name: dsdC [H]

Synonym: VS_2185

Alternate gene names: 218710155

Gene position: 2333921-2333049 (Counterclockwise)

Preceding gene: 218710157

Following gene: 218710154

Centisome position: 70.74

GC content: 44.67

Gene sequence:

>873_bases
ATGGCTAACCATCAATCTTTACTGAGAAACCTTCATACATTTAATGTTGCTGCAGAGAAAATGAGCTTTACGCTAGCCGC
GAAAAAGTTGCATCTGACTCAGGGAGCCGTTAGCCATCGAATCAAAGTGTTGGAAGGAGAGCTTGGGTTTAACTTATTTG
TGCGAGGCACTCGTAAACTGGAATTGACCGAAGAAGGGCAACGCTTTCAACGCACGTTATCGAAGTCGTTGAGCTCTATT
TTTGGCGAGATCGAAGACATTACCAACACAGACTTGTATGGTCAGATCAATATCGGTACCAGTCCTGCCTTCGCTAACAG
TTGGTTGCTACCAAGGCTAGCTGATTTCAAACAGCGATACCCAAAGTTCAACCTCAATATTTTCTCTCAAGAAGAGCAAG
ACTTTCATCAAAATCATCTCGATGTCGCCATTTACTATGGTGCTGAAGATCTCAAAGACATGCATCGACAGCGCCTGTTT
GGTGAAAAGTATATTCCGGTATGTACACCGAGTTACGCGGCTGAGCACGACATCTTTGATGATGGCTTAGAATCGCTGCA
CCGGATTAATTTCATTCATGCACTAGGGTCAGATGTATGGCAGCGTTGGATTAAACACCACGGCTTGGATGTGAACTTGT
TTGAGCAATTTTACTGCGTGAGCCACCGAGATATGGGCGTACAGAGTGCTCTGCATAATATCGGCGTGGCAATGGGGCGC
TATCATTTTGTAAAGCCGTACATTGAGACTGGTGAGCTCATAACGCCTTATCCAAGTATGGATACTGATAAAGGATACGA
ATTGATCTGTCCGTTAGGCACTGAAAAGCGACCTAAGGTAAGAACGTTTATTAAGTGGCTAGAGGGGCAGTAA

Upstream 100 bases:

>100_bases
CAGGATTTTAAGTAACTGCGGCTATTAGAAACTTATTTCTTAATGCAAACAAACGAAACGGGTAGTAGTATGAATTAAAA
TTTTTAATGCATGAGTTCGT

Downstream 100 bases:

>100_bases
CGCTAGGTTAGTTAATTTAGCAATTAGATAGTTCAAAACAGAATTTATTATCTTTATAACCATCCATCATAATAAGCTCT
ATAAATAACGGATTATAGAA

Product: transcriptional regulator

Products: NA

Alternate protein names: D-serine deaminase activator [H]

Number of amino acids: Translated: 290; Mature: 289

Protein sequence:

>290_residues
MANHQSLLRNLHTFNVAAEKMSFTLAAKKLHLTQGAVSHRIKVLEGELGFNLFVRGTRKLELTEEGQRFQRTLSKSLSSI
FGEIEDITNTDLYGQINIGTSPAFANSWLLPRLADFKQRYPKFNLNIFSQEEQDFHQNHLDVAIYYGAEDLKDMHRQRLF
GEKYIPVCTPSYAAEHDIFDDGLESLHRINFIHALGSDVWQRWIKHHGLDVNLFEQFYCVSHRDMGVQSALHNIGVAMGR
YHFVKPYIETGELITPYPSMDTDKGYELICPLGTEKRPKVRTFIKWLEGQ

Sequences:

>Translated_290_residues
MANHQSLLRNLHTFNVAAEKMSFTLAAKKLHLTQGAVSHRIKVLEGELGFNLFVRGTRKLELTEEGQRFQRTLSKSLSSI
FGEIEDITNTDLYGQINIGTSPAFANSWLLPRLADFKQRYPKFNLNIFSQEEQDFHQNHLDVAIYYGAEDLKDMHRQRLF
GEKYIPVCTPSYAAEHDIFDDGLESLHRINFIHALGSDVWQRWIKHHGLDVNLFEQFYCVSHRDMGVQSALHNIGVAMGR
YHFVKPYIETGELITPYPSMDTDKGYELICPLGTEKRPKVRTFIKWLEGQ
>Mature_289_residues
ANHQSLLRNLHTFNVAAEKMSFTLAAKKLHLTQGAVSHRIKVLEGELGFNLFVRGTRKLELTEEGQRFQRTLSKSLSSIF
GEIEDITNTDLYGQINIGTSPAFANSWLLPRLADFKQRYPKFNLNIFSQEEQDFHQNHLDVAIYYGAEDLKDMHRQRLFG
EKYIPVCTPSYAAEHDIFDDGLESLHRINFIHALGSDVWQRWIKHHGLDVNLFEQFYCVSHRDMGVQSALHNIGVAMGRY
HFVKPYIETGELITPYPSMDTDKGYELICPLGTEKRPKVRTFIKWLEGQ

Specific function: Regulates the expression of the dsd operon for D-serine deaminase (dsdA) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788706, Length=292, Percent_Identity=36.3013698630137, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789173, Length=289, Percent_Identity=31.4878892733564, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1786448, Length=290, Percent_Identity=27.2413793103448, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693193, Length=298, Percent_Identity=28.8590604026846, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI157672245, Length=177, Percent_Identity=32.7683615819209, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786401, Length=178, Percent_Identity=30.3370786516854, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1789440, Length=266, Percent_Identity=25.187969924812, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787806, Length=185, Percent_Identity=27.5675675675676, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790262, Length=255, Percent_Identity=23.1372549019608, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788748, Length=167, Percent_Identity=25.1497005988024, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787128, Length=295, Percent_Identity=23.0508474576271, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693105, Length=126, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081978, Length=180, Percent_Identity=27.7777777777778, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011781
- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33490; Mature: 33358

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANHQSLLRNLHTFNVAAEKMSFTLAAKKLHLTQGAVSHRIKVLEGELGFNLFVRGTRKL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCEEE
ELTEEGQRFQRTLSKSLSSIFGEIEDITNTDLYGQINIGTSPAFANSWLLPRLADFKQRY
EECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHC
PKFNLNIFSQEEQDFHQNHLDVAIYYGAEDLKDMHRQRLFGEKYIPVCTPSYAAEHDIFD
CCCCEEEECCCHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
DGLESLHRINFIHALGSDVWQRWIKHHGLDVNLFEQFYCVSHRDMGVQSALHNIGVAMGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YHFVKPYIETGELITPYPSMDTDKGYELICPLGTEKRPKVRTFIKWLEGQ
HHEECCHHCCCCEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure 
ANHQSLLRNLHTFNVAAEKMSFTLAAKKLHLTQGAVSHRIKVLEGELGFNLFVRGTRKL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCEEE
ELTEEGQRFQRTLSKSLSSIFGEIEDITNTDLYGQINIGTSPAFANSWLLPRLADFKQRY
EECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHC
PKFNLNIFSQEEQDFHQNHLDVAIYYGAEDLKDMHRQRLFGEKYIPVCTPSYAAEHDIFD
CCCCEEEECCCHHHHHHCCCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
DGLESLHRINFIHALGSDVWQRWIKHHGLDVNLFEQFYCVSHRDMGVQSALHNIGVAMGR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
YHFVKPYIETGELITPYPSMDTDKGYELICPLGTEKRPKVRTFIKWLEGQ
HHEECCHHCCCCEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7592420; 9205837; 9278503 [H]