Click here to switch to the map view.

The map label for this gene is dsbD [H]

Identifier: 218710099

GI number: 218710099

Start: 2278451

End: 2280547

Strand: Reverse

Name: dsbD [H]

Synonym: VS_2120

Alternate gene names: 218710099

Gene position: 2280547-2278451 (Counterclockwise)

Preceding gene: 218710100

Following gene: 218710098

Centisome position: 69.12

GC content: 45.97

Gene sequence:

>2097_bases
ATGCCTAAAAGCAAAATGTCATTGCGCTTTGTTGTGCTTTGGCTATTCGTTGCGTTGTGTTCAACATTCACTGTGAACGC
AAGTGCGAGCGAATCGATGACTCCTGTTACAACGGGTTGGATGCAAGACAAGTTACATCCGTATGTAGAAACGCGTTTTG
TCATGACAGGACAAATTAATAAAGAAGATAAAACCGCGGCGGGTTATCTGGAAGTGAACCTTTCTGATGAATGGAAAACT
TACTGGAGAAGTCCTGGCGAAGGAGGCATTGCGCCCAAAATTAAATGGGCTGACTCTAAGAACGTTTCGCAACTGCAATG
GTTTTGGAAGTTTCCTCAACGCTTCAACTTGCTCGGCATAGATACGCTAGGCTACAAGCACAACATCATCTTTCCGATGA
ATCTTCATATTGATGATATGAACAAACCTGTTGAGCTCCATGCAGTGCTGACGATGTCTTCATGCACCACCATATGTATT
CTCACGGATTTTGACATCAACTTGGTGTTTAACCCAAGTGAGATGACCGTGAATAACGACGCGATGCTTGTCTACGCAAA
AGTAATGAGCGAAGTGCCGAAAGACTCACCGCTTGTAGAGGGTACATCTACGATTTGGGATGCTCACAAGTCGCAACTTC
AAGTTATTGCTGCACATAAAATTGGTTGGACTGCACCCGATATAATCGTGGATGGTGATTCAGATGAAATGCAAGATGCT
GAATTTGGTATTCCTCACATTGAAATTGAAGGTAACCAAGCCATTGCGACTTATGACGTAAGCAGCTGGATGGGCACACC
CGATCTCAACAACCAACACATTCGTGTCAGCATCAAAGACAAAGACTTCATTACAGAATACCCAGCCACTGTTACCAACG
GCATAGTGGGTAATAGCTCTATGATAAGTATGGTGCTTTTGGCGCTATTAGGTGGGTTGATTCTCAATATCATGCCCTGT
GTATTCCCTGTACTTGGAATGAAACTGAGTGGGGTTATTTCTGCTCAAGGCATGGCAAGAAAACAGGTTAGGTTCCAATT
CCTTGCATCTGCGAGTGGCATCCTCGCATCCTTCTGGTTAATCGCCACTTTCTTGGCTGTGTTAAAAATATCAGGCAGCG
TTATCGGTTGGGGAATTCAGTTCCAAAACGGTTGGTTTATCGGTGGGATGTTTATCGTCACAGCCCTTTTCAGCGCCAAC
ATGTTAGGGCTTTTCGAGATCCGTCTTTCATCGAATACCAATACGTGGATGGCAACCAAGGGAGACAGTAGTTACGTCGG
ACACTTTACACAAGGCATGTTCGCAACGCTATTGGCTACGCCATGTTCTGCTCCATTTCTTGGGACAGCCGTTGCATTTG
CTCTTGCCACGACTATCCCGACGATGTTTGGTATTTTCACCGCACTTGCCGTTGGTATGGCACTTCCATGGATCATCGTT
GCTGCATTCCCATCGATAGCTTTGGCGCTGCCTAAACCAGGAGCATGGATGAACCGTGTTAAATACCTGTTCGGCGGAAT
GATGCTAATCACTAGCGTTTGGCTCTTTAGCTTGCTTCGACCTCATGTCCCTCAATTGTGGCTATACGCAATACTGGCGG
TCAGTGTTTGCCTATTGCTTGTCAGGTTGGTTCAAGTGCATGGAATCAAGACTGCGGGTGCTGTTGCCTTGCTGCTGTTG
AGTGTTATCTCTGCCTCGTTATTTGTCGAGAAGGCAACATCCAAAATTCTGCCACCAGAACCTGAGTGGGAAGCTTTGTC
GACCGTAGCCATTGATGATCATGTTGCTAACGACAAAGTAGTTTTCGTTGATGTTACCGCTGATTGGTGCGTGACTTGTA
AAGCAAACAAGATCGGGGTTCTCTTACAAGATCCTGTTTACAGCGTATTGACTGAAGGTGATGTAGTGCCGATGGAGGGC
GATTGGACAGTCCCAAGTGATAGTGTCACGTCATACCTACAAGATCACAACCGTTTCGGTGTTCCGTTCAACATGGTTTA
TGGCCCTAACGCTCCGGAAGGTATTGAGCTTCCTGTCATCTTAACCAGTGATGCGGTGATGGAAGCCATTGAGAAAGCAA
AAGGTGGTGACGAATGA

Upstream 100 bases:

>100_bases
AAGGTAGGCGCATCCATCTCAAGGTCTGTGTCTTTAAAGAATGAGAATAAGAGCGTTTAACTAACACTCATATTATTCAT
TTTTTAAGGAAAAATTAGAC

Downstream 100 bases:

>100_bases
TGAGAAAAAAAGCTAAGGCAAAACCTCAGTCCAAAAAGCAGAAGTTGAGATCGGCATTACTGTATACCTTGTTCGCATTG
GTCGTGGTCTTTGGTGTTGA

Product: putative suppressor for copper-sensitivity B precursor

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 698; Mature: 697

Protein sequence:

>698_residues
MPKSKMSLRFVVLWLFVALCSTFTVNASASESMTPVTTGWMQDKLHPYVETRFVMTGQINKEDKTAAGYLEVNLSDEWKT
YWRSPGEGGIAPKIKWADSKNVSQLQWFWKFPQRFNLLGIDTLGYKHNIIFPMNLHIDDMNKPVELHAVLTMSSCTTICI
LTDFDINLVFNPSEMTVNNDAMLVYAKVMSEVPKDSPLVEGTSTIWDAHKSQLQVIAAHKIGWTAPDIIVDGDSDEMQDA
EFGIPHIEIEGNQAIATYDVSSWMGTPDLNNQHIRVSIKDKDFITEYPATVTNGIVGNSSMISMVLLALLGGLILNIMPC
VFPVLGMKLSGVISAQGMARKQVRFQFLASASGILASFWLIATFLAVLKISGSVIGWGIQFQNGWFIGGMFIVTALFSAN
MLGLFEIRLSSNTNTWMATKGDSSYVGHFTQGMFATLLATPCSAPFLGTAVAFALATTIPTMFGIFTALAVGMALPWIIV
AAFPSIALALPKPGAWMNRVKYLFGGMMLITSVWLFSLLRPHVPQLWLYAILAVSVCLLLVRLVQVHGIKTAGAVALLLL
SVISASLFVEKATSKILPPEPEWEALSTVAIDDHVANDKVVFVDVTADWCVTCKANKIGVLLQDPVYSVLTEGDVVPMEG
DWTVPSDSVTSYLQDHNRFGVPFNMVYGPNAPEGIELPVILTSDAVMEAIEKAKGGDE

Sequences:

>Translated_698_residues
MPKSKMSLRFVVLWLFVALCSTFTVNASASESMTPVTTGWMQDKLHPYVETRFVMTGQINKEDKTAAGYLEVNLSDEWKT
YWRSPGEGGIAPKIKWADSKNVSQLQWFWKFPQRFNLLGIDTLGYKHNIIFPMNLHIDDMNKPVELHAVLTMSSCTTICI
LTDFDINLVFNPSEMTVNNDAMLVYAKVMSEVPKDSPLVEGTSTIWDAHKSQLQVIAAHKIGWTAPDIIVDGDSDEMQDA
EFGIPHIEIEGNQAIATYDVSSWMGTPDLNNQHIRVSIKDKDFITEYPATVTNGIVGNSSMISMVLLALLGGLILNIMPC
VFPVLGMKLSGVISAQGMARKQVRFQFLASASGILASFWLIATFLAVLKISGSVIGWGIQFQNGWFIGGMFIVTALFSAN
MLGLFEIRLSSNTNTWMATKGDSSYVGHFTQGMFATLLATPCSAPFLGTAVAFALATTIPTMFGIFTALAVGMALPWIIV
AAFPSIALALPKPGAWMNRVKYLFGGMMLITSVWLFSLLRPHVPQLWLYAILAVSVCLLLVRLVQVHGIKTAGAVALLLL
SVISASLFVEKATSKILPPEPEWEALSTVAIDDHVANDKVVFVDVTADWCVTCKANKIGVLLQDPVYSVLTEGDVVPMEG
DWTVPSDSVTSYLQDHNRFGVPFNMVYGPNAPEGIELPVILTSDAVMEAIEKAKGGDE
>Mature_697_residues
PKSKMSLRFVVLWLFVALCSTFTVNASASESMTPVTTGWMQDKLHPYVETRFVMTGQINKEDKTAAGYLEVNLSDEWKTY
WRSPGEGGIAPKIKWADSKNVSQLQWFWKFPQRFNLLGIDTLGYKHNIIFPMNLHIDDMNKPVELHAVLTMSSCTTICIL
TDFDINLVFNPSEMTVNNDAMLVYAKVMSEVPKDSPLVEGTSTIWDAHKSQLQVIAAHKIGWTAPDIIVDGDSDEMQDAE
FGIPHIEIEGNQAIATYDVSSWMGTPDLNNQHIRVSIKDKDFITEYPATVTNGIVGNSSMISMVLLALLGGLILNIMPCV
FPVLGMKLSGVISAQGMARKQVRFQFLASASGILASFWLIATFLAVLKISGSVIGWGIQFQNGWFIGGMFIVTALFSANM
LGLFEIRLSSNTNTWMATKGDSSYVGHFTQGMFATLLATPCSAPFLGTAVAFALATTIPTMFGIFTALAVGMALPWIIVA
AFPSIALALPKPGAWMNRVKYLFGGMMLITSVWLFSLLRPHVPQLWLYAILAVSVCLLLVRLVQVHGIKTAGAVALLLLS
VISASLFVEKATSKILPPEPEWEALSTVAIDDHVANDKVVFVDVTADWCVTCKANKIGVLLQDPVYSVLTEGDVVPMEGD
WTVPSDSVTSYLQDHNRFGVPFNMVYGPNAPEGIELPVILTSDAVMEAIEKAKGGDE

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=376, Percent_Identity=25.7978723404255, Blast_Score=77, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 76393; Mature: 76262

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS00071 GAPDH ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKSKMSLRFVVLWLFVALCSTFTVNASASESMTPVTTGWMQDKLHPYVETRFVMTGQIN
CCCCHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCHHHHHCCCHHHEEEEEEECCC
KEDKTAAGYLEVNLSDEWKTYWRSPGEGGIAPKIKWADSKNVSQLQWFWKFPQRFNLLGI
CCCCCEEEEEEEECCHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEE
DTLGYKHNIIFPMNLHIDDMNKPVELHAVLTMSSCTTICILTDFDINLVFNPSEMTVNND
EECCCCCEEEEEEEEEECCCCCCEEEEEEEEECCCCEEEEEEECCEEEEECCCCEEECCC
AMLVYAKVMSEVPKDSPLVEGTSTIWDAHKSQLQVIAAHKIGWTAPDIIVDGDSDEMQDA
CEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHEEEEEEECCCCCCCCEEEECCCCCCCHH
EFGIPHIEIEGNQAIATYDVSSWMGTPDLNNQHIRVSIKDKDFITEYPATVTNGIVGNSS
HCCCCEEEECCCEEEEEEEHHHCCCCCCCCCCEEEEEECCCCHHHHCCCHHHCCCCCCHH
MISMVLLALLGGLILNIMPCVFPVLGMKLSGVISAQGMARKQVRFQFLASASGILASFWL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
IATFLAVLKISGSVIGWGIQFQNGWFIGGMFIVTALFSANMLGLFEIRLSSNTNTWMATK
HHHHHHHHHHCCCEEEEEEEECCCEEEHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEC
GDSSYVGHFTQGMFATLLATPCSAPFLGTAVAFALATTIPTMFGIFTALAVGMALPWIIV
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAFPSIALALPKPGAWMNRVKYLFGGMMLITSVWLFSLLRPHVPQLWLYAILAVSVCLLL
HHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VRLVQVHGIKTAGAVALLLLSVISASLFVEKATSKILPPEPEWEALSTVAIDDHVANDKV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEEEECCCCCCCEE
VFVDVTADWCVTCKANKIGVLLQDPVYSVLTEGDVVPMEGDWTVPSDSVTSYLQDHNRFG
EEEEECCCEEEEEECCCEEEEECCCHHHHHCCCCEEECCCCCCCCCHHHHHHHHHCCCCC
VPFNMVYGPNAPEGIELPVILTSDAVMEAIEKAKGGDE
CCEEEEECCCCCCCCEEEEEECCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PKSKMSLRFVVLWLFVALCSTFTVNASASESMTPVTTGWMQDKLHPYVETRFVMTGQIN
CCCHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCCCCHHHHHCCCHHHEEEEEEECCC
KEDKTAAGYLEVNLSDEWKTYWRSPGEGGIAPKIKWADSKNVSQLQWFWKFPQRFNLLGI
CCCCCEEEEEEEECCHHHHHHHCCCCCCCCCCEEEECCCCCHHHHHHHHHCCCCCCEEEE
DTLGYKHNIIFPMNLHIDDMNKPVELHAVLTMSSCTTICILTDFDINLVFNPSEMTVNND
EECCCCCEEEEEEEEEECCCCCCEEEEEEEEECCCCEEEEEEECCEEEEECCCCEEECCC
AMLVYAKVMSEVPKDSPLVEGTSTIWDAHKSQLQVIAAHKIGWTAPDIIVDGDSDEMQDA
CEEEEEHHHHHCCCCCCCCCCCHHHHHHHHHHEEEEEEECCCCCCCCEEEECCCCCCCHH
EFGIPHIEIEGNQAIATYDVSSWMGTPDLNNQHIRVSIKDKDFITEYPATVTNGIVGNSS
HCCCCEEEECCCEEEEEEEHHHCCCCCCCCCCEEEEEECCCCHHHHCCCHHHCCCCCCHH
MISMVLLALLGGLILNIMPCVFPVLGMKLSGVISAQGMARKQVRFQFLASASGILASFWL
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCEEECCCHHHHHHHHHHHHHHHHHHHHHHH
IATFLAVLKISGSVIGWGIQFQNGWFIGGMFIVTALFSANMLGLFEIRLSSNTNTWMATK
HHHHHHHHHHCCCEEEEEEEECCCEEEHHHHHHHHHHHCCCEEEEEEEECCCCCEEEEEC
GDSSYVGHFTQGMFATLLATPCSAPFLGTAVAFALATTIPTMFGIFTALAVGMALPWIIV
CCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAFPSIALALPKPGAWMNRVKYLFGGMMLITSVWLFSLLRPHVPQLWLYAILAVSVCLLL
HHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
VRLVQVHGIKTAGAVALLLLSVISASLFVEKATSKILPPEPEWEALSTVAIDDHVANDKV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEEEECCCCCCCEE
VFVDVTADWCVTCKANKIGVLLQDPVYSVLTEGDVVPMEGDWTVPSDSVTSYLQDHNRFG
EEEEECCCEEEEEECCCEEEEECCCHHHHHCCCCEEECCCCCCCCCHHHHHHHHHCCCCC
VPFNMVYGPNAPEGIELPVILTSDAVMEAIEKAKGGDE
CCEEEEECCCCCCCCEEEEEECCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA