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The map label for this gene is lpxK

Identifier: 218710041

GI number: 218710041

Start: 2210164

End: 2211171

Strand: Reverse

Name: lpxK

Synonym: VS_2061

Alternate gene names: 218710041

Gene position: 2211171-2210164 (Counterclockwise)

Preceding gene: 218710042

Following gene: 218710040

Centisome position: 67.02

GC content: 45.63

Gene sequence:

>1008_bases
GTGATCGAAAAAATTTGGTTTAACAATCACCCATTAAAATACTTTCTCTGGCCGCTATTGTGGCCATTGAGTCTGCTGTT
CAAAATGATCAGCGGTCAACGTCGTGATGCTTATCTATCGGGGAAAAAAGAGACCTATCGCCCGCCTTTACCCGTGATTG
TTGTTGGTAATATCACCGCTGGCGGCAATGGCAAAACACCGGTTGTGATTTGGTTGGTAGAGATGCTTCAGGCTCACGGT
TTTAAGCCAGGTGTTGTTTCTCGAGGTTATGGGGCGAAAGCACCAAACTATCCGTTAGTGTTGGATGAAAACACGCCAGC
AGAGCACTCTGGTGATGAGCCTCGTTTGATTCGTAAGCGAACTGGTGCGCCTGTAGCGGTTGACCCTGTGCGCGCAAACG
CAGTAAAGGCTTTGCTGAGCGAAGGGGTTAATGTCATCATCACTGACGACGGCCTTCAGCATTATGCACTTGAACGCGAT
ATTGAATTTGCTGTTATCGACGGTGCGAGACGCTTTGGTAGTGAGTGCCTAATTCCTTTGGGCCCATTAAGAGAGCCTAT
GTCTCGTTTAGATGACGTAGACTTTTTGGTTAATAATGGCGGTAAAGCGCACGGGCGAGAGTTCTCGATGTCTTTGCTTC
CAAGCCAAGCGGTTAACCTGAAGACGGGTCAGAAAAGGTCTGTGGCAGAATTACAGAAGCTGGTGGCTTTTGCTGGTATC
GGTCACCCACCACGCTTTTTCAAAACATTGGAAAACCTTGATGGTGACGTGGTTTACACGCAGGGCTTCGCTGACCATCA
AGATTTTGATAAAGATGAACTTCATGCCTTGGCAAAAAAAGGTATGAATATGATTATGACAGAAAAAGACGCTGTAAAAT
GCGAAGAATATGCGCAAGATAACTGGTGGTATCTTCCAGTTTCTGCGCAGTTTGATGAAGATTCGCAACAGCAAATTTTA
AAAAGAATAAAAGAGGTTATGGAATACTATGGATCACCGTCTACTTGA

Upstream 100 bases:

>100_bases
ATATTGTAGAAAGAGGTGCACATGCCGAGCTCATCGCCCTTGATGGCGCTTATGCACAACTACACCGAATTCAGTTCAGC
GGATAAGATTAGGTCTTGTT

Downstream 100 bases:

>100_bases
GATCGTTGCTTGCCCTGTATGTAAAGGTAAACTAACTTTTGACAAGGATAAGCAAGAGCTTGTTTGTAAAATTGATCGCC
TTGCTTACCCAATTAAAGAG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MIEKIWFNNHPLKYFLWPLLWPLSLLFKMISGQRRDAYLSGKKETYRPPLPVIVVGNITAGGNGKTPVVIWLVEMLQAHG
FKPGVVSRGYGAKAPNYPLVLDENTPAEHSGDEPRLIRKRTGAPVAVDPVRANAVKALLSEGVNVIITDDGLQHYALERD
IEFAVIDGARRFGSECLIPLGPLREPMSRLDDVDFLVNNGGKAHGREFSMSLLPSQAVNLKTGQKRSVAELQKLVAFAGI
GHPPRFFKTLENLDGDVVYTQGFADHQDFDKDELHALAKKGMNMIMTEKDAVKCEEYAQDNWWYLPVSAQFDEDSQQQIL
KRIKEVMEYYGSPST

Sequences:

>Translated_335_residues
MIEKIWFNNHPLKYFLWPLLWPLSLLFKMISGQRRDAYLSGKKETYRPPLPVIVVGNITAGGNGKTPVVIWLVEMLQAHG
FKPGVVSRGYGAKAPNYPLVLDENTPAEHSGDEPRLIRKRTGAPVAVDPVRANAVKALLSEGVNVIITDDGLQHYALERD
IEFAVIDGARRFGSECLIPLGPLREPMSRLDDVDFLVNNGGKAHGREFSMSLLPSQAVNLKTGQKRSVAELQKLVAFAGI
GHPPRFFKTLENLDGDVVYTQGFADHQDFDKDELHALAKKGMNMIMTEKDAVKCEEYAQDNWWYLPVSAQFDEDSQQQIL
KRIKEVMEYYGSPST
>Mature_335_residues
MIEKIWFNNHPLKYFLWPLLWPLSLLFKMISGQRRDAYLSGKKETYRPPLPVIVVGNITAGGNGKTPVVIWLVEMLQAHG
FKPGVVSRGYGAKAPNYPLVLDENTPAEHSGDEPRLIRKRTGAPVAVDPVRANAVKALLSEGVNVIITDDGLQHYALERD
IEFAVIDGARRFGSECLIPLGPLREPMSRLDDVDFLVNNGGKAHGREFSMSLLPSQAVNLKTGQKRSVAELQKLVAFAGI
GHPPRFFKTLENLDGDVVYTQGFADHQDFDKDELHALAKKGMNMIMTEKDAVKCEEYAQDNWWYLPVSAQFDEDSQQQIL
KRIKEVMEYYGSPST

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=325, Percent_Identity=53.2307692307692, Blast_Score=347, Evalue=7e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_VIBSL (B7VH37)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002417662.1
- GeneID:   7161616
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_2061
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   PRK00652
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 37536; Mature: 37536

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKIWFNNHPLKYFLWPLLWPLSLLFKMISGQRRDAYLSGKKETYRPPLPVIVVGNITA
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCEEEEECEEE
GGNGKTPVVIWLVEMLQAHGFKPGVVSRGYGAKAPNYPLVLDENTPAEHSGDEPRLIRKR
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHH
TGAPVAVDPVRANAVKALLSEGVNVIITDDGLQHYALERDIEFAVIDGARRFGSECLIPL
CCCCEEECCHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCEEEEECCHHHCCCCCCCCC
GPLREPMSRLDDVDFLVNNGGKAHGREFSMSLLPSQAVNLKTGQKRSVAELQKLVAFAGI
CHHHHHHHHHCCHHEEECCCCCCCCCEEEHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GHPPRFFKTLENLDGDVVYTQGFADHQDFDKDELHALAKKGMNMIMTEKDAVKCEEYAQD
CCCHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHCCC
NWWYLPVSAQFDEDSQQQILKRIKEVMEYYGSPST
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIEKIWFNNHPLKYFLWPLLWPLSLLFKMISGQRRDAYLSGKKETYRPPLPVIVVGNITA
CCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCEEEEECEEE
GGNGKTPVVIWLVEMLQAHGFKPGVVSRGYGAKAPNYPLVLDENTPAEHSGDEPRLIRKR
CCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCHHHHHH
TGAPVAVDPVRANAVKALLSEGVNVIITDDGLQHYALERDIEFAVIDGARRFGSECLIPL
CCCCEEECCHHHHHHHHHHHCCCEEEEECCCCHHHHHHCCCEEEEECCHHHCCCCCCCCC
GPLREPMSRLDDVDFLVNNGGKAHGREFSMSLLPSQAVNLKTGQKRSVAELQKLVAFAGI
CHHHHHHHHHCCHHEEECCCCCCCCCEEEHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCC
GHPPRFFKTLENLDGDVVYTQGFADHQDFDKDELHALAKKGMNMIMTEKDAVKCEEYAQD
CCCHHHHHHHHCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCEEEECCHHHHHHHHCCC
NWWYLPVSAQFDEDSQQQILKRIKEVMEYYGSPST
CCEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA