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The map label for this gene is serS

Identifier: 218710023

GI number: 218710023

Start: 2190468

End: 2191775

Strand: Reverse

Name: serS

Synonym: VS_2043

Alternate gene names: 218710023

Gene position: 2191775-2190468 (Counterclockwise)

Preceding gene: 218710024

Following gene: 218710020

Centisome position: 66.43

GC content: 46.02

Gene sequence:

>1308_bases
ATGCTGGATTCTAAATTACTTCGAGCTGAGCTGGATGAAACAGCGGCAAAATTAGCACGTCGAGGCTTCCCCCTTGATGT
AGAGACAATTCGTGAACTTGAAGAAAAACGTAAGTCCCTTCAGATGAAAACTGAAGAGCTACAAGCGTTACGTAACTCTC
GATCGAAGTCCATTGGTCAAGCGAAAGCAAAAGGCGACCATGAAGAAGCTGAGCGTATCCTTGCAGAAGTAGGCAACTTA
GGCGCAGAACTAGACCAAGCTAAAGTAACATTGGCTGAGCTTCAATCTGAGCTAGAAACGATCACAATGTCAATTCCTAA
CCTACCTGACGCAGAAGTGCCAGATGGTAAAGATGAAGACGACAACGTAGAAGTTTCTCGTTGGGGTCAACCTAAGACTT
ACGACTTCGAAGTGAAAGATCACGTGGATCTTGGCGAAATGTCTGGCGGTCTTGATTTTGCTAGCGCAGTTAAAATCTCT
GGTTCTCGTTTCATCGTGATGAAAGGCAAATTCGCACGTCTACACCGTGCTATTGCTCAATTCATGCTGGACCTTCACAC
TGATGAGCACGGCTATACAGAAATGTACGTACCGTACCTAGTGAACCACGATAGCCTTTACGGTACTGGTCAACTTCCTA
AGTTCGGCGAAGACTTGTTCCACACAAGTCCGCTAACTGAGCAAGTAAGTGACGTGCCTCTTAAGACGTTATCGCTTATC
CCTACTGCGGAAGTGCCGGTAACGAACATGGTTCGTGACACGATTACTGATGAAGCTGAACTGCCACTTAAGATGACAGC
TCACACACCATGTTTCCGTTCTGAAGCGGGTTCTTACGGACGTGACACTCGTGGTCTTATCCGTATGCACCAATTCGACA
AAGTTGAATTAGTACAAATTACTAAGCCAGAAGACTCAATGGCAGCGCTTGAAGAGCTAACTGGTCACGCTGAGAAAGTA
CTTCAACTTCTAGAGCTTCCTTACCGTAAAGTGATTCTATGTACGGGTGACATGGGCTTCGGTTCTGCGAAAACTTACGA
CTTAGAAGTGTGGGTTCCAGCACAAGAGACATACCGTGAAATTTCTTCTTGTTCAAACATGTGGGATTTCCAAGCGCGTC
GTATGCAAGCTCGTTTCCGTCGTAAAGGCGAGAAGAAACCTGAACTTGTACACACACTTAACGGTTCTGGTCTTGCTGTT
GGTCGTACTATGGTTGCTATTCTTGAGAACAACCAAGAAGCAGATGGCCGTATTGCTATCCCAACAGTACTTCAACCATA
CATGGGCGGCGTAACGCACATCGGTTAA

Upstream 100 bases:

>100_bases
ATCGTTACAAATTGGTCGAAATAGCACCAGTTTTAGGGGTTTAGCAGTGATTCAGTAGCAATCTACTGAATATTCAAATA
ACTAAAGCATAGGATTAGCA

Downstream 100 bases:

>100_bases
TACCAATTTAGGTTCATCGAATTTAGATTAGTCTATCTCGTTAGAATTGTTAAAAGGCTTTGCTGTAATGGCAAAGCCTT
TTTTGTATGCGGACGTTGTT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLDSKLLRAELDETAAKLARRGFPLDVETIRELEEKRKSLQMKTEELQALRNSRSKSIGQAKAKGDHEEAERILAEVGNL
GAELDQAKVTLAELQSELETITMSIPNLPDAEVPDGKDEDDNVEVSRWGQPKTYDFEVKDHVDLGEMSGGLDFASAVKIS
GSRFIVMKGKFARLHRAIAQFMLDLHTDEHGYTEMYVPYLVNHDSLYGTGQLPKFGEDLFHTSPLTEQVSDVPLKTLSLI
PTAEVPVTNMVRDTITDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMAALEELTGHAEKV
LQLLELPYRKVILCTGDMGFGSAKTYDLEVWVPAQETYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENNQEADGRIAIPTVLQPYMGGVTHIG

Sequences:

>Translated_435_residues
MLDSKLLRAELDETAAKLARRGFPLDVETIRELEEKRKSLQMKTEELQALRNSRSKSIGQAKAKGDHEEAERILAEVGNL
GAELDQAKVTLAELQSELETITMSIPNLPDAEVPDGKDEDDNVEVSRWGQPKTYDFEVKDHVDLGEMSGGLDFASAVKIS
GSRFIVMKGKFARLHRAIAQFMLDLHTDEHGYTEMYVPYLVNHDSLYGTGQLPKFGEDLFHTSPLTEQVSDVPLKTLSLI
PTAEVPVTNMVRDTITDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMAALEELTGHAEKV
LQLLELPYRKVILCTGDMGFGSAKTYDLEVWVPAQETYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENNQEADGRIAIPTVLQPYMGGVTHIG
>Mature_435_residues
MLDSKLLRAELDETAAKLARRGFPLDVETIRELEEKRKSLQMKTEELQALRNSRSKSIGQAKAKGDHEEAERILAEVGNL
GAELDQAKVTLAELQSELETITMSIPNLPDAEVPDGKDEDDNVEVSRWGQPKTYDFEVKDHVDLGEMSGGLDFASAVKIS
GSRFIVMKGKFARLHRAIAQFMLDLHTDEHGYTEMYVPYLVNHDSLYGTGQLPKFGEDLFHTSPLTEQVSDVPLKTLSLI
PTAEVPVTNMVRDTITDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQITKPEDSMAALEELTGHAEKV
LQLLELPYRKVILCTGDMGFGSAKTYDLEVWVPAQETYREISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAV
GRTMVAILENNQEADGRIAIPTVLQPYMGGVTHIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=453, Percent_Identity=32.2295805739514, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI8923421, Length=406, Percent_Identity=28.8177339901478, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI225579074, Length=340, Percent_Identity=29.1176470588235, Blast_Score=162, Evalue=5e-40,
Organism=Escherichia coli, GI1787120, Length=435, Percent_Identity=71.9540229885058, Blast_Score=657, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=435, Percent_Identity=32.183908045977, Blast_Score=216, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17542084, Length=320, Percent_Identity=25.625, Blast_Score=121, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6321799, Length=411, Percent_Identity=29.683698296837, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320226, Length=413, Percent_Identity=29.7820823244552, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24581334, Length=324, Percent_Identity=35.8024691358025, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI17737985, Length=346, Percent_Identity=30.9248554913295, Blast_Score=138, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_VIBSL (B7VH19)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002417644.1
- GeneID:   7161598
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_2043
- HOGENOM:   HBG629391
- OMA:   AHWDLGP
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48647; Mature: 48647

Theoretical pI: Translated: 5.03; Mature: 5.03

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 296-296 BINDING 396-396

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDSKLLRAELDETAAKLARRGFPLDVETIRELEEKRKSLQMKTEELQALRNSRSKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKGDHEEAERILAEVGNLGAELDQAKVTLAELQSELETITMSIPNLPDAEVPDGKDED
HHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCC
DNVEVSRWGQPKTYDFEVKDHVDLGEMSGGLDFASAVKISGSRFIVMKGKFARLHRAIAQ
CCEEHEECCCCCCEEEEECCCCCHHHCCCCCCHHHHEEECCCEEEEECCHHHHHHHHHHH
FMLDLHTDEHGYTEMYVPYLVNHDSLYGTGQLPKFGEDLFHTSPLTEQVSDVPLKTLSLI
HHHHHCCCCCCCEEEEECEEECCCCCCCCCCCCCHHHHHHCCCCHHHHHHCCCHHHHCCC
PTAEVPVTNMVRDTITDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQI
CCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHCCCCEEEEEE
TKPEDSMAALEELTGHAEKVLQLLELPYRKVILCTGDMGFGSAKTYDLEVWVPAQETYRE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCHHHHHH
ISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAVGRTMVAILENNQEADGRIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEHHHHEEEEEECCCCCCCEEEC
PTVLQPYMGGVTHIG
HHHHHHHHCCCCCCC
>Mature Secondary Structure
MLDSKLLRAELDETAAKLARRGFPLDVETIRELEEKRKSLQMKTEELQALRNSRSKSIGQ
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKAKGDHEEAERILAEVGNLGAELDQAKVTLAELQSELETITMSIPNLPDAEVPDGKDED
HHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCC
DNVEVSRWGQPKTYDFEVKDHVDLGEMSGGLDFASAVKISGSRFIVMKGKFARLHRAIAQ
CCEEHEECCCCCCEEEEECCCCCHHHCCCCCCHHHHEEECCCEEEEECCHHHHHHHHHHH
FMLDLHTDEHGYTEMYVPYLVNHDSLYGTGQLPKFGEDLFHTSPLTEQVSDVPLKTLSLI
HHHHHCCCCCCCEEEEECEEECCCCCCCCCCCCCHHHHHHCCCCHHHHHHCCCHHHHCCC
PTAEVPVTNMVRDTITDEAELPLKMTAHTPCFRSEAGSYGRDTRGLIRMHQFDKVELVQI
CCCCCCHHHHHHHHHCCCCCCCEEEECCCCCHHHCCCCCCCCCHHHHHHHCCCCEEEEEE
TKPEDSMAALEELTGHAEKVLQLLELPYRKVILCTGDMGFGSAKTYDLEVWVPAQETYRE
ECCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEEEECCHHHHHH
ISSCSNMWDFQARRMQARFRRKGEKKPELVHTLNGSGLAVGRTMVAILENNQEADGRIAI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCEEHHHHEEEEEECCCCCCCEEEC
PTVLQPYMGGVTHIG
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA