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The map label for this gene is hisD [H]

Identifier: 218710006

GI number: 218710006

Start: 2170697

End: 2172016

Strand: Reverse

Name: hisD [H]

Synonym: VS_2025

Alternate gene names: 218710006

Gene position: 2172016-2170697 (Counterclockwise)

Preceding gene: 218710007

Following gene: 218710005

Centisome position: 65.83

GC content: 47.27

Gene sequence:

>1320_bases
GTGACGATGAGAACCGTTGTTTGGCAATCTTTAAGTGAATCACAGCAAGACTCGGTATTAGAGCGTCCAGCTATTACTGA
AGGTGCAAACATCACAGCGACTGTTTCTGATGTTATTGCAAAAGTACGAAATGAAGGCGATGCCGCACTTAAGGAACTGA
CTGAAAAGTTTGATGGTGTGACTCCAGAATCTATCCGAGTTAGTTCGGGTGAGATCGAAGAGGCATGTGCTCGTCTAACA
CCAGAGATGAAGCAAGCGTTGGAGCAAGCTTACAGCAACATTGCTAAGTTTCATGAAGCTCAAAAGCCACAGCCAATTAA
GGTTGAAACACAGCCTGGTGTTGTGTGTGAGCAGGTGACGCGCGCGATTAATACTGTTGGACTTTATATTCCGGGGGGCA
GTGCGCCACTTCCGTCAACGGTTCTTATGTTAGGTGTACCTGCTCAAATTGCGGGTTGTCGTAAGGTTGTGCTTTGCTCA
CCTCCGCCCATCGCGGATGAAATCTTGTATGTCACTAATCTTTGTAAAATCGATGAGGTTTACAATGTTGGTGGTGGTCA
AGCCGTTGCTGCCATGGCTTACGGGACCGAGAGCGTTGCTAAGGTTGATAAGATCTTCGGCCCAGGTAACGCTTACGTAA
CGGAAGCTAAACGCCAAGTAAGTAACGACTTCCGTGGCGCTGCGATTGATATGCCTGCTGGCCCGTCTGAAGTGTTAGTG
ATTGCAGACGAAACTGCGGATGCTGACTTCATTGCTGCTGATCTACTGAGCCAAGCTGAACACGGGCCAGATTCACAGGT
TGTATTAGTAACACCATCACCAGTTATTGCCGACCAAGTAACCGATGCAGTTCAGAAGCAACTGAAAGAGCTGTCTCGTG
CGAACATCGCTCAGCAAGCATTGGCTTCAAGTCTAATCATCATTGCTGAATCGATCACTCAAGCGATTGCGATTTCGAAT
TTCTATGGTCCTGAGCACTTGATTGTTCAGACCAAGAGTCCACGAGAATTACTGCCGTTACTAGACAATGCTGGTTCAAT
CTTCTTGGGTGACTGGTCTCCAGAATCTGCAGGTGACTACGCATCAGGCACAAACCACGTTCTTCCGACTTACGGCTATA
CCAAGACTTATTCAAGCCTAGGTTTGGCGGATTTCTCTAAGCGTATGACGGTACAAGAGTTAACAGCTGATGGCTTACAA
GGCCTAGCGCCAACGGTAGTCACAATGGCGGAAGCCGAAGGTTTGGACGCACACAAACGTGCGGTGACCATCCGAGTTGA
AAAATTAAATCGATTTGAACAGCTAAATAAAGCGAAATAA

Upstream 100 bases:

>100_bases
TCGTAAGTACAGAGAACTTGTTCTGGGAAACTATGGAACAGCTGAAAGAGTTGGGTGCAAGCTCGATTCTAGTATTACCA
ATCGAAAAAATGATGGGGTA

Downstream 100 bases:

>100_bases
GGGTAGGGCATGGAAAAGTTAGCAAGAAAACAAGTTCAGGCTCTAACACCTTACTTGTCTGCAAGACGAATTGGTGGCAG
CGGAGATGTATGGTTGAACG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTMRTVVWQSLSESQQDSVLERPAITEGANITATVSDVIAKVRNEGDAALKELTEKFDGVTPESIRVSSGEIEEACARLT
PEMKQALEQAYSNIAKFHEAQKPQPIKVETQPGVVCEQVTRAINTVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCS
PPPIADEILYVTNLCKIDEVYNVGGGQAVAAMAYGTESVAKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLV
IADETADADFIAADLLSQAEHGPDSQVVLVTPSPVIADQVTDAVQKQLKELSRANIAQQALASSLIIIAESITQAIAISN
FYGPEHLIVQTKSPRELLPLLDNAGSIFLGDWSPESAGDYASGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTADGLQ
GLAPTVVTMAEAEGLDAHKRAVTIRVEKLNRFEQLNKAK

Sequences:

>Translated_439_residues
MTMRTVVWQSLSESQQDSVLERPAITEGANITATVSDVIAKVRNEGDAALKELTEKFDGVTPESIRVSSGEIEEACARLT
PEMKQALEQAYSNIAKFHEAQKPQPIKVETQPGVVCEQVTRAINTVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCS
PPPIADEILYVTNLCKIDEVYNVGGGQAVAAMAYGTESVAKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLV
IADETADADFIAADLLSQAEHGPDSQVVLVTPSPVIADQVTDAVQKQLKELSRANIAQQALASSLIIIAESITQAIAISN
FYGPEHLIVQTKSPRELLPLLDNAGSIFLGDWSPESAGDYASGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTADGLQ
GLAPTVVTMAEAEGLDAHKRAVTIRVEKLNRFEQLNKAK
>Mature_438_residues
TMRTVVWQSLSESQQDSVLERPAITEGANITATVSDVIAKVRNEGDAALKELTEKFDGVTPESIRVSSGEIEEACARLTP
EMKQALEQAYSNIAKFHEAQKPQPIKVETQPGVVCEQVTRAINTVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSP
PPIADEILYVTNLCKIDEVYNVGGGQAVAAMAYGTESVAKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLVI
ADETADADFIAADLLSQAEHGPDSQVVLVTPSPVIADQVTDAVQKQLKELSRANIAQQALASSLIIIAESITQAIAISNF
YGPEHLIVQTKSPRELLPLLDNAGSIFLGDWSPESAGDYASGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTADGLQG
LAPTVVTMAEAEGLDAHKRAVTIRVEKLNRFEQLNKAK

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=431, Percent_Identity=62.877030162413, Blast_Score=557, Evalue=1e-160,
Organism=Saccharomyces cerevisiae, GI6319819, Length=419, Percent_Identity=50.3579952267303, Blast_Score=404, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46821; Mature: 46689

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMRTVVWQSLSESQQDSVLERPAITEGANITATVSDVIAKVRNEGDAALKELTEKFDGV
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCCC
TPESIRVSSGEIEEACARLTPEMKQALEQAYSNIAKFHEAQKPQPIKVETQPGVVCEQVT
CCCCEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHH
RAINTVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPPPIADEILYVTNLCKIDEV
HHHHHCEEEECCCCCCCCCCEEEECCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
YNVGGGQAVAAMAYGTESVAKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLV
HCCCCCCEEEHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEE
IADETADADFIAADLLSQAEHGPDSQVVLVTPSPVIADQVTDAVQKQLKELSRANIAQQA
EEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LASSLIIIAESITQAIAISNFYGPEHLIVQTKSPRELLPLLDNAGSIFLGDWSPESAGDY
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCC
ASGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTADGLQGLAPTVVTMAEAEGLDAHKR
CCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
AVTIRVEKLNRFEQLNKAK
EEEEEHHHHHHHHHHHCCC
>Mature Secondary Structure 
TMRTVVWQSLSESQQDSVLERPAITEGANITATVSDVIAKVRNEGDAALKELTEKFDGV
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHCCCHHHHHHHHHHHCCC
TPESIRVSSGEIEEACARLTPEMKQALEQAYSNIAKFHEAQKPQPIKVETQPGVVCEQVT
CCCCEEECCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHH
RAINTVGLYIPGGSAPLPSTVLMLGVPAQIAGCRKVVLCSPPPIADEILYVTNLCKIDEV
HHHHHCEEEECCCCCCCCCCEEEECCCHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHH
YNVGGGQAVAAMAYGTESVAKVDKIFGPGNAYVTEAKRQVSNDFRGAAIDMPAGPSEVLV
HCCCCCCEEEHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCEEE
IADETADADFIAADLLSQAEHGPDSQVVLVTPSPVIADQVTDAVQKQLKELSRANIAQQA
EEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LASSLIIIAESITQAIAISNFYGPEHLIVQTKSPRELLPLLDNAGSIFLGDWSPESAGDY
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCCEEEECCCCCCCCCC
ASGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTADGLQGLAPTVVTMAEAEGLDAHKR
CCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHH
AVTIRVEKLNRFEQLNKAK
EEEEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]