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The map label for this gene is hisC [H]

Identifier: 218710005

GI number: 218710005

Start: 2169647

End: 2170687

Strand: Reverse

Name: hisC [H]

Synonym: VS_2024

Alternate gene names: 218710005

Gene position: 2170687-2169647 (Counterclockwise)

Preceding gene: 218710006

Following gene: 218710004

Centisome position: 65.79

GC content: 43.8

Gene sequence:

>1041_bases
ATGGAAAAGTTAGCAAGAAAACAAGTTCAGGCTCTAACACCTTACTTGTCTGCAAGACGAATTGGTGGCAGCGGAGATGT
ATGGTTGAACGCCAACGAATCTCCGTTTGATAACGAGTACACCTTAAATCTGACTCGGCTTAATCGCTACAGCGAGTGTC
AGCCTAAAGAGCTAATCGATGCTTACGCTCAATATGCGGGTGTTGCACCAGAGCAAACGTTGACTACTCGTGGTGCTGAC
GAAGGCATTGAACTACTGATTCGTGCTTTCTGTGAGCCGAACGAAGACGCTATTCTTTACTGCCCACCCACTTACGGTAT
GTACGCAATCAGTGCAGAGACGATTGGTGTTGAGCGTAAAGTGGTGCCTCTGACTTCTGAATGGCAATTGGATCTTCCTG
CTATTGAAGCTCAACTTGACAACGTAAAAGTGGTGTTTGTTTGTAGTCCAAATAACCCAACAGGTAACTTAGTTAACCGT
AAAGACATCGTTAAACTGCTTGAAATGACACAAGACAAAGCGATTGTGGTGATGGATGAAGCGTATATCGATTTCTGCCC
TGAAGCATCAACGGTGGATTTGCTTGCTCAGTATCCGAATCTAGCGATTCTTCGAACTCTCTCGAAAGCATTTGCTTTAG
CGGGTTTACGTTGTGGCTTTACGCTAGCGAACAAAGAGCTTATCGATTTATTGTTAAAAGTAATTGCTCCTTATCCAGTG
CCAATCCCTGTTGCTGACATTGCCGTTCAAGCTCTTTCAGAGCAAGGACTAGCGCGTGCTAAGTTCCAAGTTTTGGATTT
AAGTGCTAACCGAGCGTATTTACAAGCAGGTCTATTAGGCATGCCTCAAGTAACGGTATTTGATGGTTGGGGTAACTACC
TACTGGTTAAATTCCCGAACGGCGATGAGTTATTTAAAGCAGCTTGGGATACGGGCATCATTTTGCGTAATTCACCAATT
GAAGACTGTGTTCGTATTAGTATTGGTAATCGCGAAGAGTGCGAAAAGACACTTGGATTCATTCGTAACTTTTATCAGTA
A

Upstream 100 bases:

>100_bases
GGAAGCCGAAGGTTTGGACGCACACAAACGTGCGGTGACCATCCGAGTTGAAAAATTAAATCGATTTGAACAGCTAAATA
AAGCGAAATAAGGGTAGGGC

Downstream 100 bases:

>100_bases
CGAAAGGCTTACCAGTAATAACATTTGCCAGTTTGATTGGATTAATTGCAGGCTGGCAAGTGAAACCAATATTTTGGGTT
AGCGTTGATTTTAGCTAGGC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYTLNLTRLNRYSECQPKELIDAYAQYAGVAPEQTLTTRGAD
EGIELLIRAFCEPNEDAILYCPPTYGMYAISAETIGVERKVVPLTSEWQLDLPAIEAQLDNVKVVFVCSPNNPTGNLVNR
KDIVKLLEMTQDKAIVVMDEAYIDFCPEASTVDLLAQYPNLAILRTLSKAFALAGLRCGFTLANKELIDLLLKVIAPYPV
PIPVADIAVQALSEQGLARAKFQVLDLSANRAYLQAGLLGMPQVTVFDGWGNYLLVKFPNGDELFKAAWDTGIILRNSPI
EDCVRISIGNREECEKTLGFIRNFYQ

Sequences:

>Translated_346_residues
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYTLNLTRLNRYSECQPKELIDAYAQYAGVAPEQTLTTRGAD
EGIELLIRAFCEPNEDAILYCPPTYGMYAISAETIGVERKVVPLTSEWQLDLPAIEAQLDNVKVVFVCSPNNPTGNLVNR
KDIVKLLEMTQDKAIVVMDEAYIDFCPEASTVDLLAQYPNLAILRTLSKAFALAGLRCGFTLANKELIDLLLKVIAPYPV
PIPVADIAVQALSEQGLARAKFQVLDLSANRAYLQAGLLGMPQVTVFDGWGNYLLVKFPNGDELFKAAWDTGIILRNSPI
EDCVRISIGNREECEKTLGFIRNFYQ
>Mature_346_residues
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYTLNLTRLNRYSECQPKELIDAYAQYAGVAPEQTLTTRGAD
EGIELLIRAFCEPNEDAILYCPPTYGMYAISAETIGVERKVVPLTSEWQLDLPAIEAQLDNVKVVFVCSPNNPTGNLVNR
KDIVKLLEMTQDKAIVVMDEAYIDFCPEASTVDLLAQYPNLAILRTLSKAFALAGLRCGFTLANKELIDLLLKVIAPYPV
PIPVADIAVQALSEQGLARAKFQVLDLSANRAYLQAGLLGMPQVTVFDGWGNYLLVKFPNGDELFKAAWDTGIILRNSPI
EDCVRISIGNREECEKTLGFIRNFYQ

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=344, Percent_Identity=62.2093023255814, Blast_Score=431, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6322075, Length=375, Percent_Identity=32, Blast_Score=161, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38405; Mature: 38405

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYTLNLTRLNRYSECQPKELID
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHH
AYAQYAGVAPEQTLTTRGADEGIELLIRAFCEPNEDAILYCPPTYGMYAISAETIGVERK
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEHCCCCEE
VVPLTSEWQLDLPAIEAQLDNVKVVFVCSPNNPTGNLVNRKDIVKLLEMTQDKAIVVMDE
EEECCCCCEECCCHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEC
AYIDFCPEASTVDLLAQYPNLAILRTLSKAFALAGLRCGFTLANKELIDLLLKVIAPYPV
HHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCCC
PIPVADIAVQALSEQGLARAKFQVLDLSANRAYLQAGLLGMPQVTVFDGWGNYLLVKFPN
CCCHHHHHHHHHHHCCHHHEEEEEEEECCCHHHHHHCCCCCCEEEEEECCCCEEEEEECC
GDELFKAAWDTGIILRNSPIEDCVRISIGNREECEKTLGFIRNFYQ
CCHHHHHHCCCCEEEECCCHHHHHEECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKLARKQVQALTPYLSARRIGGSGDVWLNANESPFDNEYTLNLTRLNRYSECQPKELID
CCHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCEEEEEEECCCCCCCCHHHHHH
AYAQYAGVAPEQTLTTRGADEGIELLIRAFCEPNEDAILYCPPTYGMYAISAETIGVERK
HHHHHCCCCCCHHHHCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCEEEEEEEHCCCCEE
VVPLTSEWQLDLPAIEAQLDNVKVVFVCSPNNPTGNLVNRKDIVKLLEMTQDKAIVVMDE
EEECCCCCEECCCHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEC
AYIDFCPEASTVDLLAQYPNLAILRTLSKAFALAGLRCGFTLANKELIDLLLKVIAPYPV
HHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCCCC
PIPVADIAVQALSEQGLARAKFQVLDLSANRAYLQAGLLGMPQVTVFDGWGNYLLVKFPN
CCCHHHHHHHHHHHCCHHHEEEEEEEECCCHHHHHHCCCCCCEEEEEECCCCEEEEEECC
GDELFKAAWDTGIILRNSPIEDCVRISIGNREECEKTLGFIRNFYQ
CCHHHHHHCCCCEEEECCCHHHHHEECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA