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The map label for this gene is trpC [H]

Identifier: 218709950

GI number: 218709950

Start: 2112381

End: 2113832

Strand: Direct

Name: trpC [H]

Synonym: VS_1969

Alternate gene names: 218709950

Gene position: 2112381-2113832 (Clockwise)

Preceding gene: 218709949

Following gene: 218709951

Centisome position: 64.03

GC content: 46.56

Gene sequence:

>1452_bases
ATGACACAGACTACCGATAAATTGTCGACCCACGTTTCAGTCAAAGAAGCTGAAATGGCGGAAGTACTAGCAAAAATCGT
TCGTGATAAATACCAATGGGTTGAAGCGCGTAAGCAGACTCAACCACTGGACGAGTTTAAAGCGTCACTAACTGCAACAG
ACCGCAGCTTTTATGATGCACTGAGCGGCGAGCAAACCGTTTTCATCACTGAATGTAAGAAGGCATCACCGTCAAAAGGT
TTAATCCGTGACGAGTTTGATTTGGACTACATTGCATCGGTTTACAACAACCACGCCAACGCGATTTCAGTGCTGACAGA
CGAGAAATACTTCCAAGGTGACTTTGAGTTTTTACCTAAGGTTCGCAGCATTGCTAAGCAGCCTATCCTGTGTAAAGACT
TCATGGTTGATACCTACCAAGTTTACTTAGCTCGTCACTACTCTGCAGATGCTATCTTGTTGATGCTATCGGTATTAGAT
GACGAAGAGTACCAAGCACTGGCGGAAGTTGCTCACTCGCTCAACATGGGTGTCCTAACCGAAGTCAGTAACGAAGAAGA
GCTTCACCGCGCAGTCGCTTTAAAAGCAAAAGTGATCGGCATTAATAACCGTAACCTGCGTGACCTTTCGACTGATTTGA
ACCGTACCAAAGAGTTGGCTCCGCTGATTCGCGAACTGGCTACAAACGCAGTCGTGATTTCAGAGTCTGGCATCTACACA
CATCAACAAGTTCGAGATCTTTCAACGTTTGCAGATGGTTTCTTAATCGGCAGCTCTCTGATGGCTGAAAAGAACCTAGA
GCTTGCAGTGCGTAAAGTAACACTCGGTGAAAACAAGGTGTGTGGTTTAACTCACTCTGACGATGCCGCGAAGGCTTATC
AAGCTGGTGCGGTGTTCGGTGGTTTGATTTTCGTTGAAGCGTCTAAGCGTCATGTGGATATCGAAGCGGCTCGTTTAACC
ATGAGTGGCGCACCGCTGAACTACGTGGGTGTGTTCCAAAACCACAGCGTAGCAGACGTTACGAAAACGGTATCTGAGCT
AGGCCTATTCGCTGTGCAACTGCACGGTGATGAGTCTCAAGCATTTGTTGATGAGTTAAAACAATCAATACCTGAAAGCG
TTGAGGTTTGGAAAGCTTACGGTGTGGCTTCTGGTGGTGAAAACGGTGCTAAAAGCGCGCTACCAGAATTACTGAAAAGC
AACGTGACTCGTCACCTGCTAGATACTAAAGTGGGTTCTCAAACGGGTGGTACTGGCCAAGCGTTCGATTGGAGCCTAAT
CAACAACCAAAGCGCAATTATGTTAGCGGGTGGCCTAAACCCAGAAAACGCTAACCAAGCCGCTAAGTTAGGTTGTTTAG
GATTAGACCTAAACTCTGGCGTTGAATCAGCTCCAGGTAAAAAAGACGCAGACAAACTGCAACGCGCTTTTGCAGCGATT
CGTAATTACTAG

Upstream 100 bases:

>100_bases
CCAACGCACAGCAAGCGATTGACGCAATGAACTCTGGCAAAGCGTACGAGCTTGTACAAAAGCTTGCTGCACACGCCTAA
CGAACGACGAGACAAAGAAC

Downstream 100 bases:

>100_bases
CACAAGCTCGCGCTAGAAATTAGAAAGCAGAAACTAAAAACATATTTGTGGGCTTTGCCTTTTGCGAAGCTCAAGCAAGA
TTAAATGACTTGGTGTGAAG

Product: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: Indole-3-glycerol phosphate synthase; IGPS; N-(5'-phospho-ribosyl)anthranilate isomerase; PRAI [H]

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTQTTDKLSTHVSVKEAEMAEVLAKIVRDKYQWVEARKQTQPLDEFKASLTATDRSFYDALSGEQTVFITECKKASPSKG
LIRDEFDLDYIASVYNNHANAISVLTDEKYFQGDFEFLPKVRSIAKQPILCKDFMVDTYQVYLARHYSADAILLMLSVLD
DEEYQALAEVAHSLNMGVLTEVSNEEELHRAVALKAKVIGINNRNLRDLSTDLNRTKELAPLIRELATNAVVISESGIYT
HQQVRDLSTFADGFLIGSSLMAEKNLELAVRKVTLGENKVCGLTHSDDAAKAYQAGAVFGGLIFVEASKRHVDIEAARLT
MSGAPLNYVGVFQNHSVADVTKTVSELGLFAVQLHGDESQAFVDELKQSIPESVEVWKAYGVASGGENGAKSALPELLKS
NVTRHLLDTKVGSQTGGTGQAFDWSLINNQSAIMLAGGLNPENANQAAKLGCLGLDLNSGVESAPGKKDADKLQRAFAAI
RNY

Sequences:

>Translated_483_residues
MTQTTDKLSTHVSVKEAEMAEVLAKIVRDKYQWVEARKQTQPLDEFKASLTATDRSFYDALSGEQTVFITECKKASPSKG
LIRDEFDLDYIASVYNNHANAISVLTDEKYFQGDFEFLPKVRSIAKQPILCKDFMVDTYQVYLARHYSADAILLMLSVLD
DEEYQALAEVAHSLNMGVLTEVSNEEELHRAVALKAKVIGINNRNLRDLSTDLNRTKELAPLIRELATNAVVISESGIYT
HQQVRDLSTFADGFLIGSSLMAEKNLELAVRKVTLGENKVCGLTHSDDAAKAYQAGAVFGGLIFVEASKRHVDIEAARLT
MSGAPLNYVGVFQNHSVADVTKTVSELGLFAVQLHGDESQAFVDELKQSIPESVEVWKAYGVASGGENGAKSALPELLKS
NVTRHLLDTKVGSQTGGTGQAFDWSLINNQSAIMLAGGLNPENANQAAKLGCLGLDLNSGVESAPGKKDADKLQRAFAAI
RNY
>Mature_482_residues
TQTTDKLSTHVSVKEAEMAEVLAKIVRDKYQWVEARKQTQPLDEFKASLTATDRSFYDALSGEQTVFITECKKASPSKGL
IRDEFDLDYIASVYNNHANAISVLTDEKYFQGDFEFLPKVRSIAKQPILCKDFMVDTYQVYLARHYSADAILLMLSVLDD
EEYQALAEVAHSLNMGVLTEVSNEEELHRAVALKAKVIGINNRNLRDLSTDLNRTKELAPLIRELATNAVVISESGIYTH
QQVRDLSTFADGFLIGSSLMAEKNLELAVRKVTLGENKVCGLTHSDDAAKAYQAGAVFGGLIFVEASKRHVDIEAARLTM
SGAPLNYVGVFQNHSVADVTKTVSELGLFAVQLHGDESQAFVDELKQSIPESVEVWKAYGVASGGENGAKSALPELLKSN
VTRHLLDTKVGSQTGGTGQAFDWSLINNQSAIMLAGGLNPENANQAAKLGCLGLDLNSGVESAPGKKDADKLQRAFAAIR
NY

Specific function: Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the trpF domain; the second reaction is catalyzed by the synthase, coded by the trpC domain [H]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the trpF family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=467, Percent_Identity=59.9571734475375, Blast_Score=550, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6322638, Length=238, Percent_Identity=33.6134453781513, Blast_Score=109, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6320210, Length=219, Percent_Identity=32.4200913242009, Blast_Score=85, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR001240
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS; PF00697 PRAI [H]

EC number: =4.1.1.48; =5.3.1.24 [H]

Molecular weight: Translated: 52745; Mature: 52614

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTTDKLSTHVSVKEAEMAEVLAKIVRDKYQWVEARKQTQPLDEFKASLTATDRSFYDA
CCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHH
LSGEQTVFITECKKASPSKGLIRDEFDLDYIASVYNNHANAISVLTDEKYFQGDFEFLPK
CCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCHHHCCCHHHHHH
VRSIAKQPILCKDFMVDTYQVYLARHYSADAILLMLSVLDDEEYQALAEVAHSLNMGVLT
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEE
EVSNEEELHRAVALKAKVIGINNRNLRDLSTDLNRTKELAPLIRELATNAVVISESGIYT
ECCCHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
HQQVRDLSTFADGFLIGSSLMAEKNLELAVRKVTLGENKVCGLTHSDDAAKAYQAGAVFG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEECCCCCCHHHHHHHHHHHEE
GLIFVEASKRHVDIEAARLTMSGAPLNYVGVFQNHSVADVTKTVSELGLFAVQLHGDESQ
EEEEEECCCCEEEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCEEEEEEECCCHH
AFVDELKQSIPESVEVWKAYGVASGGENGAKSALPELLKSNVTRHLLDTKVGSQTGGTGQ
HHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AFDWSLINNQSAIMLAGGLNPENANQAAKLGCLGLDLNSGVESAPGKKDADKLQRAFAAI
CEEEEEECCCCEEEEECCCCCCCCCHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
RNY
HCC
>Mature Secondary Structure 
TQTTDKLSTHVSVKEAEMAEVLAKIVRDKYQWVEARKQTQPLDEFKASLTATDRSFYDA
CCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHH
LSGEQTVFITECKKASPSKGLIRDEFDLDYIASVYNNHANAISVLTDEKYFQGDFEFLPK
CCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEECCHHHCCCHHHHHH
VRSIAKQPILCKDFMVDTYQVYLARHYSADAILLMLSVLDDEEYQALAEVAHSLNMGVLT
HHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEE
EVSNEEELHRAVALKAKVIGINNRNLRDLSTDLNRTKELAPLIRELATNAVVISESGIYT
ECCCHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCH
HQQVRDLSTFADGFLIGSSLMAEKNLELAVRKVTLGENKVCGLTHSDDAAKAYQAGAVFG
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCEECCCCCCHHHHHHHHHHHEE
GLIFVEASKRHVDIEAARLTMSGAPLNYVGVFQNHSVADVTKTVSELGLFAVQLHGDESQ
EEEEEECCCCEEEEEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHCEEEEEEECCCHH
AFVDELKQSIPESVEVWKAYGVASGGENGAKSALPELLKSNVTRHLLDTKVGSQTGGTGQ
HHHHHHHHHCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
AFDWSLINNQSAIMLAGGLNPENANQAAKLGCLGLDLNSGVESAPGKKDADKLQRAFAAI
CEEEEEECCCCEEEEECCCCCCCCCHHHHHEEEEECCCCCCCCCCCCCCHHHHHHHHHHH
RNY
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1773058; 12620739 [H]