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The map label for this gene is uvrY [H]

Identifier: 218709938

GI number: 218709938

Start: 2099836

End: 2100480

Strand: Reverse

Name: uvrY [H]

Synonym: VS_1956

Alternate gene names: 218709938

Gene position: 2100480-2099836 (Counterclockwise)

Preceding gene: 218709940

Following gene: 218709937

Centisome position: 63.66

GC content: 42.79

Gene sequence:

>645_bases
TTGATAAATGTTTTCCTTGTAGATGATCACGAGCTGGTTCGCACAGGGATACGACGTATTATTGAAGACGTCCGTGGAAT
GAACGTAGCAGGGGAAGCTGAAAGCGGTGAAGATGCTGCAAAATGGTGTCGTACTAACAATACTGACGTTATTTTGATGG
ATATGAATATGCCTGGTATTGGTGGCTTAGAAGCAACCAAGAAAATCTTGCGTTTCAACCCTGATGTTAAAATCATCGTT
TTAACTGTTCATACGGAAAATCCGTTTCCAACTAAAGTGATGCAAGCTGGAGCTGCTGGTTACCTTACTAAAGGGGCAGG
TCCGGATGAAATGGTAAATGCAATTCGAGTGGTTAATAGTGGCCAACGATACATTTCGCCAGAAATTGCGCAGCAGATGG
CTTTGAGCCAATTCTCGCCTGCGTCTGAAAATCCATTCGCAGACTTATCTGAACGTGAGCTTCAAATCATGATGATGATT
ACCAAAGGTCAGAAAGTGACGGATATTTCAGAACAACTCAATCTAAGTCCTAAAACAGTCAACAGTTACCGCTACCGCTT
GTTCAGTAAGCTGGATATCAGTGGCGATGTAGAGCTGACGCATTTAGCGATTAGACATGGAATGTTAGACACTGAGACCC
TTTAA

Upstream 100 bases:

>100_bases
GTACTCAATGCTGCGATTCACTGTTCCTTTGTTCAATTGTTTCAAACAGATGAAATGACACAGTGGTTGCAGAGCCAATT
AATAGTGTGGAGATACAAGT

Downstream 100 bases:

>100_bases
CACTGAGATCGTATAGTGACCAACTTGTTTGACTCAGTCTCATTCCTCAAGACAGTAACAGAGCAGCCCGGCGTTTATCG
AATGTATAACGCCGAGGCTG

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MINVFLVDDHELVRTGIRRIIEDVRGMNVAGEAESGEDAAKWCRTNNTDVILMDMNMPGIGGLEATKKILRFNPDVKIIV
LTVHTENPFPTKVMQAGAAGYLTKGAGPDEMVNAIRVVNSGQRYISPEIAQQMALSQFSPASENPFADLSERELQIMMMI
TKGQKVTDISEQLNLSPKTVNSYRYRLFSKLDISGDVELTHLAIRHGMLDTETL

Sequences:

>Translated_214_residues
MINVFLVDDHELVRTGIRRIIEDVRGMNVAGEAESGEDAAKWCRTNNTDVILMDMNMPGIGGLEATKKILRFNPDVKIIV
LTVHTENPFPTKVMQAGAAGYLTKGAGPDEMVNAIRVVNSGQRYISPEIAQQMALSQFSPASENPFADLSERELQIMMMI
TKGQKVTDISEQLNLSPKTVNSYRYRLFSKLDISGDVELTHLAIRHGMLDTETL
>Mature_214_residues
MINVFLVDDHELVRTGIRRIIEDVRGMNVAGEAESGEDAAKWCRTNNTDVILMDMNMPGIGGLEATKKILRFNPDVKIIV
LTVHTENPFPTKVMQAGAAGYLTKGAGPDEMVNAIRVVNSGQRYISPEIAQQMALSQFSPASENPFADLSERELQIMMMI
TKGQKVTDISEQLNLSPKTVNSYRYRLFSKLDISGDVELTHLAIRHGMLDTETL

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=215, Percent_Identity=76.7441860465116, Blast_Score=350, Evalue=3e-98,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=34, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788521, Length=205, Percent_Identity=33.1707317073171, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786747, Length=201, Percent_Identity=25.3731343283582, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1788712, Length=208, Percent_Identity=24.5192307692308, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788546, Length=203, Percent_Identity=28.0788177339901, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=28.5714285714286, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23753; Mature: 23753

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVFLVDDHELVRTGIRRIIEDVRGMNVAGEAESGEDAAKWCRTNNTDVILMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCC
GGLEATKKILRFNPDVKIIVLTVHTENPFPTKVMQAGAAGYLTKGAGPDEMVNAIRVVNS
CCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHCCCCCEECCCCCHHHHHHHHHHHCC
GQRYISPEIAQQMALSQFSPASENPFADLSERELQIMMMITKGQKVTDISEQLNLSPKTV
CCCEECHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCEEECHHHHHCCCCCHH
NSYRYRLFSKLDISGDVELTHLAIRHGMLDTETL
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MINVFLVDDHELVRTGIRRIIEDVRGMNVAGEAESGEDAAKWCRTNNTDVILMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCEEEEEECCCCCC
GGLEATKKILRFNPDVKIIVLTVHTENPFPTKVMQAGAAGYLTKGAGPDEMVNAIRVVNS
CCHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHCCCCCEECCCCCHHHHHHHHHHHCC
GQRYISPEIAQQMALSQFSPASENPFADLSERELQIMMMITKGQKVTDISEQLNLSPKTV
CCCEECHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCEEECHHHHHCCCCCHH
NSYRYRLFSKLDISGDVELTHLAIRHGMLDTETL
HHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]