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The map label for this gene is uvrC [H]

Identifier: 218709937

GI number: 218709937

Start: 2098762

End: 2099820

Strand: Reverse

Name: uvrC [H]

Synonym: VS_1955

Alternate gene names: 218709937

Gene position: 2099820-2098762 (Counterclockwise)

Preceding gene: 218709938

Following gene: 218709936

Centisome position: 63.64

GC content: 45.23

Gene sequence:

>1059_bases
GTGACCAACTTGTTTGACTCAGTCTCATTCCTCAAGACAGTAACAGAGCAGCCCGGCGTTTATCGAATGTATAACGCCGA
GGCTGTTGTTATTTACGTCGGTAAAGCTAAGAACCTCAAAAAACGCCTTTCCAGTTATTTCCGTAAAAAAGTCGACAGTG
AAAAAACACGCGCTTTAGTCAGCAATATCGACAAAATCGATGTCACTGTAACGCACACGGAAACAGAAGCGCTCATCCTT
GAGCATAACTACATCAAGCAGTACTTGCCTAAATACAACGTACTTTTGCGTGATGATAAGTCGTACCCTTATATTTTTAT
TAGCGGTCACAAGCATCCTCGTTTGTCGATGCATCGTGGTGCTAAAAAGAAAAAGGGCGAATACTTTGGTCCTTACCCTG
ATTCCGGCGCTGTGCGTGAGACGTTGCACCTACTACAAAAAATCTTTCCTGCTCGCCAGTGTGAAGATACGGTTTATGCC
AACAGAACGCGCCCGTGTTTGATGTATCAGATTGGCCGTTGTGCTGCGCCATGTGTCAGCTCAATCATCTCTGATGAAGA
GTACAGTGAACTTATCGACTACGTTCGTCTGTTCTTGCAAGGGAAGGACAAGTTAGTCCTTGAGACGCTCATCGAAAAGA
TGGACACAGCAAGCCGAGAGCTTCGCTTTGAGCAAGCTGCCGCGTTCCGTGACCAAATCCAAGCGATTCGACGCGTGCAA
GAACAACAATATGTATCCGACGATTCAATGGAAGATATGGACGTGTTGGGCTTTGCTCAAGAGAATGGCGTAGCGTGTAT
TCATATCTTGATGATTCGCCAAGGCAAGGTTTTAGGCAGTAGAAGCCATTTCCCTAAAATTCCCAACAATACGGTGCGAG
AAGAGGTTTTTTCGAGCTTTTTAAGCCAATACTATCTTGCGCATAATGAAGCGAGAACCATCCCAACTCGTTTGATTCTC
AATGCCGATTTGATGGAAGATATCACACCGATTCAAGAAGCCTTGTGTGAAGTGGCGGGTCGTAAGATTCACTTCAATAC
CAACCCTTCAGGTACTTGA

Upstream 100 bases:

>100_bases
GTTCAGTAAGCTGGATATCAGTGGCGATGTAGAGCTGACGCATTTAGCGATTAGACATGGAATGTTAGACACTGAGACCC
TTTAACACTGAGATCGTATA

Downstream 100 bases:

>100_bases
GGTCGTTACCTTAAACTCTCGAATACCAATGCATTGACGGCTATTACCACCAAGATTAATCACAAGATGACCATCAACCA
GCGCTTTAAAGAGCTTCAAG

Product: putative excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MTNLFDSVSFLKTVTEQPGVYRMYNAEAVVIYVGKAKNLKKRLSSYFRKKVDSEKTRALVSNIDKIDVTVTHTETEALIL
EHNYIKQYLPKYNVLLRDDKSYPYIFISGHKHPRLSMHRGAKKKKGEYFGPYPDSGAVRETLHLLQKIFPARQCEDTVYA
NRTRPCLMYQIGRCAAPCVSSIISDEEYSELIDYVRLFLQGKDKLVLETLIEKMDTASRELRFEQAAAFRDQIQAIRRVQ
EQQYVSDDSMEDMDVLGFAQENGVACIHILMIRQGKVLGSRSHFPKIPNNTVREEVFSSFLSQYYLAHNEARTIPTRLIL
NADLMEDITPIQEALCEVAGRKIHFNTNPSGT

Sequences:

>Translated_352_residues
MTNLFDSVSFLKTVTEQPGVYRMYNAEAVVIYVGKAKNLKKRLSSYFRKKVDSEKTRALVSNIDKIDVTVTHTETEALIL
EHNYIKQYLPKYNVLLRDDKSYPYIFISGHKHPRLSMHRGAKKKKGEYFGPYPDSGAVRETLHLLQKIFPARQCEDTVYA
NRTRPCLMYQIGRCAAPCVSSIISDEEYSELIDYVRLFLQGKDKLVLETLIEKMDTASRELRFEQAAAFRDQIQAIRRVQ
EQQYVSDDSMEDMDVLGFAQENGVACIHILMIRQGKVLGSRSHFPKIPNNTVREEVFSSFLSQYYLAHNEARTIPTRLIL
NADLMEDITPIQEALCEVAGRKIHFNTNPSGT
>Mature_351_residues
TNLFDSVSFLKTVTEQPGVYRMYNAEAVVIYVGKAKNLKKRLSSYFRKKVDSEKTRALVSNIDKIDVTVTHTETEALILE
HNYIKQYLPKYNVLLRDDKSYPYIFISGHKHPRLSMHRGAKKKKGEYFGPYPDSGAVRETLHLLQKIFPARQCEDTVYAN
RTRPCLMYQIGRCAAPCVSSIISDEEYSELIDYVRLFLQGKDKLVLETLIEKMDTASRELRFEQAAAFRDQIQAIRRVQE
QQYVSDDSMEDMDVLGFAQENGVACIHILMIRQGKVLGSRSHFPKIPNNTVREEVFSSFLSQYYLAHNEARTIPTRLILN
ADLMEDITPIQEALCEVAGRKIHFNTNPSGT

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=351, Percent_Identity=62.962962962963, Blast_Score=474, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 40451; Mature: 40320

Theoretical pI: Translated: 8.52; Mature: 8.52

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2 ; PS00034 PAIRED_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNLFDSVSFLKTVTEQPGVYRMYNAEAVVIYVGKAKNLKKRLSSYFRKKVDSEKTRALV
CCCHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHH
SNIDKIDVTVTHTETEALILEHNYIKQYLPKYNVLLRDDKSYPYIFISGHKHPRLSMHRG
HCCCEEEEEEEECCCCEEEEEHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCHHHCC
AKKKKGEYFGPYPDSGAVRETLHLLQKIFPARQCEDTVYANRTRPCLMYQIGRCAAPCVS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHCHHHHCCCCCCHHHHHHHHHHHHHHH
SIISDEEYSELIDYVRLFLQGKDKLVLETLIEKMDTASRELRFEQAAAFRDQIQAIRRVQ
HHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQQYVSDDSMEDMDVLGFAQENGVACIHILMIRQGKVLGSRSHFPKIPNNTVREEVFSSF
HHHHCCCCCCCCHHHHCCCCCCCCEEEEEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
LSQYYLAHNEARTIPTRLILNADLMEDITPIQEALCEVAGRKIHFNTNPSGT
HHHHHHHHCCHHCCHHHHEECHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC
>Mature Secondary Structure 
TNLFDSVSFLKTVTEQPGVYRMYNAEAVVIYVGKAKNLKKRLSSYFRKKVDSEKTRALV
CCHHHHHHHHHHHHCCCCEEEEECCCEEEEEECCCHHHHHHHHHHHHHHHCHHHHHHHH
SNIDKIDVTVTHTETEALILEHNYIKQYLPKYNVLLRDDKSYPYIFISGHKHPRLSMHRG
HCCCEEEEEEEECCCCEEEEEHHHHHHHCCCCCEEEECCCCCCEEEEECCCCCCCHHHCC
AKKKKGEYFGPYPDSGAVRETLHLLQKIFPARQCEDTVYANRTRPCLMYQIGRCAAPCVS
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHCHHHHCHHHHCCCCCCHHHHHHHHHHHHHHH
SIISDEEYSELIDYVRLFLQGKDKLVLETLIEKMDTASRELRFEQAAAFRDQIQAIRRVQ
HHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EQQYVSDDSMEDMDVLGFAQENGVACIHILMIRQGKVLGSRSHFPKIPNNTVREEVFSSF
HHHHCCCCCCCCHHHHCCCCCCCCEEEEEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHHH
LSQYYLAHNEARTIPTRLILNADLMEDITPIQEALCEVAGRKIHFNTNPSGT
HHHHHHHHCCHHCCHHHHEECHHHHHHHHHHHHHHHHHCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]