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The map label for this gene is irlR [H]

Identifier: 218709844

GI number: 218709844

Start: 2008252

End: 2008911

Strand: Direct

Name: irlR [H]

Synonym: VS_1857

Alternate gene names: 218709844

Gene position: 2008252-2008911 (Clockwise)

Preceding gene: 218709843

Following gene: 218709845

Centisome position: 60.87

GC content: 46.82

Gene sequence:

>660_bases
ATGAAAATTTTAGTCGTTGAAGACGAACCTCGTTTGGGCCAACAAATTATAGACACCCTTGAGGGAGCCGACTGGGTTCC
TGAGCTTTCTCAAGACGGTATCGACGCACTCTACCGTGCAACATCGGAAGAGTGGGATGCAATCGTTCTCGATTTAGGGC
TACCTAAGCTTGACGGCCTAACCGTATTAAAAGGTATTCGAGACGAAAACATCAATACGCCAGTGATTATCCTAAGTGCT
CGTGACACGCTAACCCAACGTGTCGAGGGCTTGAACGCAGGTGCTGATGACTATCTAACTAAGCCATTTGAAATGGTCGA
GCTGATTGCCCGTATCCGTGCTCAACTACGCCGAGCGTCAGGCAGTGCTGCTCCTATACTTCAAATTGGTGATCTCAGCC
TAGACACACGCAGCTCTAAAGTGTTGTGGCAAGGTCAAGCTGTTAGCCTCACAGCGCTTGAATATAAAGTGGTCGCTTAT
TTCATGCATAACCAAAACAAAGTTATCTCGCGCACTGAGTTGGTTGAACACATCTACAAGCAAGATTTTGACCGCGACTC
AAACACGGTTGAAGTTTTCATCGGTCGTATTCGTAAGAAAATCGCACCTAAGATCATCAAAACCGTTCGCGGGCTTGGCT
ACCAACTGAATGCTGAATAA

Upstream 100 bases:

>100_bases
AACGCTGAAACGTTAGAAATGCTGATGATTAAAGGTCGCAACTTTAAAGAAGCGATCAAAAACTCCCACGAATAATAAAT
AACTATAAAAAGAGTGATAC

Downstream 100 bases:

>100_bases
TGCTGTATTTAATTAAGCTAAGACCAATCTCCAATTAGTGGGCAGCCTGTGCTGATCGTTGTTGTTCTCATAGCAAGATG
AGCAAAGACAGGCTGGTAAC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 219; Mature: 219

Protein sequence:

>219_residues
MKILVVEDEPRLGQQIIDTLEGADWVPELSQDGIDALYRATSEEWDAIVLDLGLPKLDGLTVLKGIRDENINTPVIILSA
RDTLTQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRASGSAAPILQIGDLSLDTRSSKVLWQGQAVSLTALEYKVVAY
FMHNQNKVISRTELVEHIYKQDFDRDSNTVEVFIGRIRKKIAPKIIKTVRGLGYQLNAE

Sequences:

>Translated_219_residues
MKILVVEDEPRLGQQIIDTLEGADWVPELSQDGIDALYRATSEEWDAIVLDLGLPKLDGLTVLKGIRDENINTPVIILSA
RDTLTQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRASGSAAPILQIGDLSLDTRSSKVLWQGQAVSLTALEYKVVAY
FMHNQNKVISRTELVEHIYKQDFDRDSNTVEVFIGRIRKKIAPKIIKTVRGLGYQLNAE
>Mature_219_residues
MKILVVEDEPRLGQQIIDTLEGADWVPELSQDGIDALYRATSEEWDAIVLDLGLPKLDGLTVLKGIRDENINTPVIILSA
RDTLTQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRASGSAAPILQIGDLSLDTRSSKVLWQGQAVSLTALEYKVVAY
FMHNQNKVISRTELVEHIYKQDFDRDSNTVEVFIGRIRKKIAPKIIKTVRGLGYQLNAE

Specific function: Member of the two-component regulatory system irlR/irlS. May be involved in invasion of eukaryotic cells and heavy-metal resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=38.1165919282511, Blast_Score=167, Evalue=4e-43,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=38.9140271493213, Blast_Score=153, Evalue=8e-39,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=38.7387387387387, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=39.9082568807339, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=34.8623853211009, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=35.5555555555556, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=33.920704845815, Blast_Score=124, Evalue=5e-30,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=33.1858407079646, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=29.5964125560538, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=31.140350877193, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=31.4159292035398, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=28.3185840707965, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=28.5106382978723, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=25.3275109170306, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=30.8411214953271, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24544; Mature: 24544

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILVVEDEPRLGQQIIDTLEGADWVPELSQDGIDALYRATSEEWDAIVLDLGLPKLDGL
CEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCH
TVLKGIRDENINTPVIILSARDTLTQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRAS
HHHHCCCCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCC
GSAAPILQIGDLSLDTRSSKVLWQGQAVSLTALEYKVVAYFMHNQNKVISRTELVEHIYK
CCCCCEEEECCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QDFDRDSNTVEVFIGRIRKKIAPKIIKTVRGLGYQLNAE
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCC
>Mature Secondary Structure
MKILVVEDEPRLGQQIIDTLEGADWVPELSQDGIDALYRATSEEWDAIVLDLGLPKLDGL
CEEEEECCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCH
TVLKGIRDENINTPVIILSARDTLTQRVEGLNAGADDYLTKPFEMVELIARIRAQLRRAS
HHHHCCCCCCCCCCEEEEECHHHHHHHHHCCCCCCHHHHCCHHHHHHHHHHHHHHHHHCC
GSAAPILQIGDLSLDTRSSKVLWQGQAVSLTALEYKVVAYFMHNQNKVISRTELVEHIYK
CCCCCEEEECCCCCCCCCCEEEECCCEEEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
QDFDRDSNTVEVFIGRIRKKIAPKIIKTVRGLGYQLNAE
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9393784 [H]