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The map label for this gene is phoQ [H]

Identifier: 218709845

GI number: 218709845

Start: 2009014

End: 2010360

Strand: Direct

Name: phoQ [H]

Synonym: VS_1858

Alternate gene names: 218709845

Gene position: 2009014-2010360 (Clockwise)

Preceding gene: 218709844

Following gene: 218709848

Centisome position: 60.89

GC content: 46.4

Gene sequence:

>1347_bases
ATGAATCTAAAAAAACGAACACTTAAAAACGTCAGTCTAAAAAGCCGCTTGCTCCTCGCCGCGGCTTTTTGGCTAGGTGC
GATGATATTAGCGGCAGGCGTCGGAATACCTAAGTTGGTTAACGATTACTTGGTCGATGACGTCAAGCAACAGCTCAGCC
TAACCATGGACGAGTTAACCGCCAACATAGAAACCAACGACAGTGGTAACCTCATCATGGCAGAGCGTCTGTCTGACCCT
AGGTTTAACCAACCCTACAGTGGTATTTATTGGCGAGCCGCTACTCAAGACCAGATTATTCGATCTCGCTCGCTATGGGA
CAAAGACCTCACCATCAAGCGTTCGCCGATTCATACTTCAATCAAAGGGCCTGAGAAAGAAAAGCTGATTTACATCGAGC
AGGATATCTATCTGCCCGAACTGAACGATCCTGTCACGATCACCATAGGTATTGATGAAGACCCATTAGAATCCACACTG
ACCGAACTTACAGGTCAAGTCTGGTTGATTCTGATGTTGCTGTTTGTGGGCGTGCTGATGTTGATTGGTATTCAAGTCAG
CTGGTCACTATTGCCACTCAGTAAGATGCAACGTGAACTGGTGATGTTAAGAAACGGCGAGCAACAAGGATTAAGCGACA
ACTACCCGAAAGAGGTTTCTCCATTGGTTTCTGACCTCAATGCCCTACTGTTCCACTATCAAGAGTTATTGGAGCGAGCG
CGTAACCACGCGGGTAACTTATCTCATGCGTTGAAAACTCCGCTGTCGGTTCTGAAAAATGAGATAGAGCGACTTCCAGA
GGATGACAAGGCACTGCTGCAACAACCCATTAATCAGATTCAAAGCCAAATCGATTATCACCTTGGCCGAGCACGCATGG
CCGGTGCAATGAACATTCTTTCAGTGAAGTCTTCACCTTGTGAACGTGTTGAAGCTATCTCAATGGCATTTGATAAAGTC
TATGCCGCCAACGAAGTCACCATGATTAATGAGCTAGACTCTGAAATTGAAGTGGCGGTCGAAAAAACCGACCTTGATGA
AATGGTCGGCAACCTACTAGAGAACAATTACAAATGGGCGAGCAGCATTATCCGAGTCCATTCGAATGAACTCGATGATG
GCAACATTGAATTAGTGATTGAAGATGATGGCCAAGGCATTCCTGAAGAGAAGCTTGAGCAAGTGACCAAACGTGGTGTT
CGACTTGATGAAACCACACCGGGAACAGGCTTGGGGCTTAACATTGTGAATGAAATGGCACACAGCTACCGAGGCAGCCT
AACGCTCAGCAAGAGCTCTATGGGCGGATTGAAAGCCTCTCTGGTGCTTAAAATAAGCAAAGGTTAA

Upstream 100 bases:

>100_bases
CTGTATTTAATTAAGCTAAGACCAATCTCCAATTAGTGGGCAGCCTGTGCTGATCGTTGTTGTTCTCATAGCAAGATGAG
CAAAGACAGGCTGGTAACGT

Downstream 100 bases:

>100_bases
TAAGCTAAACGCGCTAAGTAAACCAAGTAAACCAAGTAAACACGATAAGCCCTAGCACAACGCTAGGGCTTAGTTCAATC
GACCTTACATACGACCCTAT

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNLKKRTLKNVSLKSRLLLAAAFWLGAMILAAGVGIPKLVNDYLVDDVKQQLSLTMDELTANIETNDSGNLIMAERLSDP
RFNQPYSGIYWRAATQDQIIRSRSLWDKDLTIKRSPIHTSIKGPEKEKLIYIEQDIYLPELNDPVTITIGIDEDPLESTL
TELTGQVWLILMLLFVGVLMLIGIQVSWSLLPLSKMQRELVMLRNGEQQGLSDNYPKEVSPLVSDLNALLFHYQELLERA
RNHAGNLSHALKTPLSVLKNEIERLPEDDKALLQQPINQIQSQIDYHLGRARMAGAMNILSVKSSPCERVEAISMAFDKV
YAANEVTMINELDSEIEVAVEKTDLDEMVGNLLENNYKWASSIIRVHSNELDDGNIELVIEDDGQGIPEEKLEQVTKRGV
RLDETTPGTGLGLNIVNEMAHSYRGSLTLSKSSMGGLKASLVLKISKG

Sequences:

>Translated_448_residues
MNLKKRTLKNVSLKSRLLLAAAFWLGAMILAAGVGIPKLVNDYLVDDVKQQLSLTMDELTANIETNDSGNLIMAERLSDP
RFNQPYSGIYWRAATQDQIIRSRSLWDKDLTIKRSPIHTSIKGPEKEKLIYIEQDIYLPELNDPVTITIGIDEDPLESTL
TELTGQVWLILMLLFVGVLMLIGIQVSWSLLPLSKMQRELVMLRNGEQQGLSDNYPKEVSPLVSDLNALLFHYQELLERA
RNHAGNLSHALKTPLSVLKNEIERLPEDDKALLQQPINQIQSQIDYHLGRARMAGAMNILSVKSSPCERVEAISMAFDKV
YAANEVTMINELDSEIEVAVEKTDLDEMVGNLLENNYKWASSIIRVHSNELDDGNIELVIEDDGQGIPEEKLEQVTKRGV
RLDETTPGTGLGLNIVNEMAHSYRGSLTLSKSSMGGLKASLVLKISKG
>Mature_448_residues
MNLKKRTLKNVSLKSRLLLAAAFWLGAMILAAGVGIPKLVNDYLVDDVKQQLSLTMDELTANIETNDSGNLIMAERLSDP
RFNQPYSGIYWRAATQDQIIRSRSLWDKDLTIKRSPIHTSIKGPEKEKLIYIEQDIYLPELNDPVTITIGIDEDPLESTL
TELTGQVWLILMLLFVGVLMLIGIQVSWSLLPLSKMQRELVMLRNGEQQGLSDNYPKEVSPLVSDLNALLFHYQELLERA
RNHAGNLSHALKTPLSVLKNEIERLPEDDKALLQQPINQIQSQIDYHLGRARMAGAMNILSVKSSPCERVEAISMAFDKV
YAANEVTMINELDSEIEVAVEKTDLDEMVGNLLENNYKWASSIIRVHSNELDDGNIELVIEDDGQGIPEEKLEQVTKRGV
RLDETTPGTGLGLNIVNEMAHSYRGSLTLSKSSMGGLKASLVLKISKG

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=309, Percent_Identity=29.126213592233, Blast_Score=138, Evalue=9e-34,
Organism=Escherichia coli, GI1788393, Length=247, Percent_Identity=22.2672064777328, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1789403, Length=301, Percent_Identity=26.578073089701, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790551, Length=275, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787894, Length=228, Percent_Identity=26.7543859649123, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790861, Length=211, Percent_Identity=28.436018957346, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=25.8928571428571, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50056; Mature: 50056

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLKKRTLKNVSLKSRLLLAAAFWLGAMILAAGVGIPKLVNDYLVDDVKQQLSLTMDELT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ANIETNDSGNLIMAERLSDPRFNQPYSGIYWRAATQDQIIRSRSLWDKDLTIKRSPIHTS
CCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCEEECCCCCCC
IKGPEKEKLIYIEQDIYLPELNDPVTITIGIDEDPLESTLTELTGQVWLILMLLFVGVLM
CCCCCCCEEEEEECCEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGIQVSWSLLPLSKMQRELVMLRNGEQQGLSDNYPKEVSPLVSDLNALLFHYQELLERA
HHHHHHHEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RNHAGNLSHALKTPLSVLKNEIERLPEDDKALLQQPINQIQSQIDYHLGRARMAGAMNIL
HHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
SVKSSPCERVEAISMAFDKVYAANEVTMINELDSEIEVAVEKTDLDEMVGNLLENNYKWA
ECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHEEEEECCCHHHHHHHHHHCCHHHH
SSIIRVHSNELDDGNIELVIEDDGQGIPEEKLEQVTKRGVRLDETTPGTGLGLNIVNEMA
HHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHH
HSYRGSLTLSKSSMGGLKASLVLKISKG
HHHCCCEEEECCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MNLKKRTLKNVSLKSRLLLAAAFWLGAMILAAGVGIPKLVNDYLVDDVKQQLSLTMDELT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ANIETNDSGNLIMAERLSDPRFNQPYSGIYWRAATQDQIIRSRSLWDKDLTIKRSPIHTS
CCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEECCHHHHHHHHHCCCCCCEEECCCCCCC
IKGPEKEKLIYIEQDIYLPELNDPVTITIGIDEDPLESTLTELTGQVWLILMLLFVGVLM
CCCCCCCEEEEEECCEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGIQVSWSLLPLSKMQRELVMLRNGEQQGLSDNYPKEVSPLVSDLNALLFHYQELLERA
HHHHHHHEEECCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
RNHAGNLSHALKTPLSVLKNEIERLPEDDKALLQQPINQIQSQIDYHLGRARMAGAMNIL
HHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
SVKSSPCERVEAISMAFDKVYAANEVTMINELDSEIEVAVEKTDLDEMVGNLLENNYKWA
ECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHEEEEECCCHHHHHHHHHHCCHHHH
SSIIRVHSNELDDGNIELVIEDDGQGIPEEKLEQVTKRGVRLDETTPGTGLGLNIVNEMA
HHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHH
HSYRGSLTLSKSSMGGLKASLVLKISKG
HHHCCCEEEECCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA